Antibody to mCLCA3 suppresses symptoms in a mouse model of asthma

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Song, Liqiang ^a   Liu, Dapeng ^a   Wu, Changgui ^a   Wu, Shouzhen ^b   Yang, Junlan ^a   Ren, Fangping ^a   Li, Yan ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALCIAN BLUE; CALCIUM ACTIVATED CHLORIDE CHANNEL; CALCIUM ACTIVATED CHLORIDE CHANNEL ANTIBODY; GAMMA INTERFERON; INTERLEUKIN 13; MUCIN 5AC; OVALBUMIN; PLACEBO; POLYCLONAL ANTIBODY; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ALLERGIC AIRWAY INFLAMMATION; ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL HYPERPLASIA; CELLULAR DISTRIBUTION; CHRONIC INFLAMMATION; CLCA3 GENE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFICACY; DRUG TARGETING; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; GENE IDENTIFICATION; GENE LOCATION; GOBLET CELL; IMMUNOHISTOCHEMISTRY; LUNG LAVAGE; LUNG PARENCHYMA; MOUSE; MOUSE MODEL; MUCUS SECRETION; NICK END LABELING; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STAINING; WESTERN BLOTTING;

ANIMALS; ANTIBODIES; APOPTOSIS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CHLORIDE CHANNELS; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; GOBLET CELLS; HYPERPLASIA; INFLAMMATION; MICE; MICE, INBRED BALB C; MUCIN 5AC; MUCOPROTEINS; OVALBUMIN; RESPIRATORY SYSTEM;

EID: 84891955061     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0082367     Document Type: Article

References (35)

1. Royce SG, Cheng V, Samuel CS, Tang ML (2012) The regulation of fibrosis in airway remodeling in asthma. Mol Cell Endocrinol 351: 167-175. doi:10.1016/j.mce.2012.01.007. PubMed: 22266540.
2. Wong C, Ho C, Ko F, Chan C, Ho A et al. (2001) Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-gamma, IL-4, IL-10 and IL-13) in patients with allergic asthma. Clinical and Experimental Immunology 125: 177-183. (Pubitemid 32758425)
3. Hauber H-P, Lavigne F, Hung H-L, Levitt RC, Hamid Q (2010) Effect of Th2 type cytokines on hCLCA1 and mucus expression in cystic fibrosis airways. Journal of Cystic Fibrosis 9: 277-279. doi:10.1016/j.jcf. 2010.05.002. PubMed: 20542744.
4. Zhou Y, Dong Q, Louahed J, Dragwa C, Savio D et al. (2001) Characterization of a calcium-activated chloride channel as a shared target of Th2 cytokine pathways and its potential involvement in asthma. Am J Respir Cell Mol Biol 25: 486-491. doi:10.1165/ajrcmb. 25.4.4578. PubMed: 11694454. (Pubitemid 33037681)
5. Komiya T, Tanigawa Y, Hirohashi S (1999) Cloning and identification of the gene gob-5, which is expressed in intestinal goblet cells in mice. Biochem Biophys Res Commun 255: 347-351. doi:10.1006/bbrc. 1999.0168. PubMed: 10049711. (Pubitemid 29292262)
6. Nakanishi A, Morita S, Iwashita H, Sagiya Y, Ashida Y et al. (2001) Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma. Proc Natl Acad Sci U S A 98: 5175-5180. doi:10.1073/pnas.081510898. PubMed: 11296262. (Pubitemid 32397102)
7. Vignola AM, Chanez P, Chiappara G, Siena L, Merendino A et al. (1999) Evaluation of apoptosis of eosinophils, macrophages, and T lymphocytes in mucosal biopsy specimens of patients with asthma and chronic bronchitis. J Allergy Clin Immunol 103: 563-573. doi:10.1016/S0091-6749(99)70225-3. PubMed: 10200002. (Pubitemid 29295559)
8. Pauli BU, Abdel-Ghany M, Cheng HC, Gruber AD, Archibald HA et al. (2000) Molecular characteristics and functional diversity of CLCA family members. Clin Exp Pharmacol Physiol 27: 901-905. doi:10.1046/j.1440-1681.2000.03358.x. PubMed: 11071307.
9. Gaspar KJ, Racette KJ, Gordon JR, Loewen ME, Forsyth GW (2000) Cloning a chloride conductance mediator from the apical membrane of porcine ileal enterocytes. Physiol Genomics 3: 101-111. PubMed: 11015605.
10. Patel AC, Brett TJ, Holtzman MJ (2009) The role of CLCA proteins in inflammatory airway disease. Annu Rev Physiol 71: 425-449. doi: 10.1146/annurev.physiol.010908.163253. PubMed: 18954282.
11. Leverkoehne I, Gruber AD (2002) The murine mCLCA3 (alias gob-5) protein is located in the mucin granule membranes of intestinal, respiratory, and uterine goblet cells. J Histochem Cytochem 50: 829-838. PubMed: 12019299. (Pubitemid 34721451)
12. Hoshino M, Morita S, Iwashita H, Sagiya Y, Nagi T et al. (2002) Increased expression of the human Ca2+-activated Cl- channel 1 (CaCC1) gene in the asthmatic airway. Am J Respir Crit Care Med 165: 1132-1136. doi:10.1164/ajrccm. 165.8.2107068. PubMed: 11956057. (Pubitemid 34415823)
13. Toda M, Tulic MK, Levitt RC, Hamid Q (2002) A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma. J Allergy Clin Immunol 109: 246-250. doi:10.1067/mai.2002.121555. PubMed: 11842292. (Pubitemid 34158288)
14. Robichaud A, Tuck SA, Kargman S, Tam J, Wong E et al. (2005) Gob-5 is not essential for mucus overproduction in preclinical murine models of allergic asthma. Am J Respir Cell Mol Biol 33: 303-314. doi: 10.1165/rcmb.2004-0372OC. PubMed: 15947424. (Pubitemid 41254298)
15. Song LQ, Li Y, Li WN, Zhang W, Qi HW et al. (2013) Safety and Immunogenicity of a DNA Vaccine Encoding Human Calcium-Activated Chloride Channel 1 (hCLCA1) in Asthmatic Mice. Int Arch Allergy Immunol 161: 243-251. doi:10.1159/000345972. PubMed: 23548383.
16. Mushaben EM, Brandt EB, Hershey GKK, Le Cras TD (2013) Differential effects of rapamycin and dexamethasone in mouse models of established allergic asthma. PLOS ONE 8: e54426. doi:10.1371/journal.pone.0054426. PubMed: 23349887.
17. Le Cras TD, Acciani TH, Mushaben EM, Kramer EL, Pastura PA et al. (2011) Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma. Am J Physiol Lung Cell Mol Physiol 300: L414-L421. doi:10.1152/ajplung.00346.2010. PubMed: 21224214.
18. Beilke LD, Aleksunes LM, Olson ER, Besselsen DG, Klaassen CD et al. (2009) Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice. Toxicol Lett 188: 38-44. doi:10.1016/j.toxlet.2009.03.005. PubMed: 19433268.
19. Duan W, Chan JH, Wong CH, Leung BP, Wong WF (2004) Antiinflammatory effects of mitogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse model. Journal of Immunology 172: 7053-7059. PubMed: 15153527. (Pubitemid 38669147)
20. Marino R, Thuraisingam T, Camateros P, Kanagaratham C, Xu YZ et al. (2011) Secretory leukocyte protease inhibitor plays an important role in the regulation of allergic asthma in mice. J Immunol 186: 4433-4442. doi:10.4049/jimmunol.1001539. PubMed: 21335488.
21. Klein E, Weigel J, Buford MC, Holian A, Wells SM (2010) Asymmetric dimethylarginine potentiates lung inflammation in a mouse model of allergic asthma. Am J Physiol Lung Cell Mol Physiol 299: L816-L825. doi:10.1152/ajplung. 00188.2010. PubMed: 20889675.
22. Zhang X, Chen W, De Paiva CS, Corrales RM, Volpe EA et al. (2011) Interferon-γ Exacerbates Dry Eye-Induced Apoptosis in Conjunctiva through Dual Apoptotic Pathways. Investigative Ophthalmology and Visual Science 52: 6279-6285. doi:10.1167/iovs.10-7081.
23. Iwashita J, Hongo K, Ito Y, Abe T, Murata J (2013) Regulation of MUC5AC mucin production by the cell attachment dependent pathway involving integrin β1 in NCI-H292 human lung epithelial cells.
24. Kline JN, Waldschmidt TJ, Businga TR, Lemish JE, Weinstock JV et al. (1998) Cutting edge: modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma. Journal of Immunology 160: 2555-2559. PubMed: 9510150. (Pubitemid 28136702)
25. Kondo M, Tamaoki J, Takeyama K, Nakata J, Nagai A (2002) Interleukin-13 induces goblet cell differentiation in primary cell culture from Guinea pig tracheal epithelium. Am J Respir Cell Mol Biol 27: 536-541. doi:10.1165/rcmb. 4682. PubMed: 12397012. (Pubitemid 35301807)
26. Dhanabal M, Ramchandran R, Waterman MJ, Lu H, Knebelmann B et al. (1999) Endostatin induces endothelial cell apoptosis. J Biol Chem 274: 11721-11726. doi:10.1074/jbc.274.17.11721. PubMed: 10206987.
27. Sentman CL, Shutter JR, Hockenbery D, Kanagawa O, Korsmeyer SJ (1991) bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67: 879-888. doi: 10.1016/0092-8674(91)90361-2. PubMed: 1835668. (Pubitemid 121001502)
28. Masoli M, Fabian D, Holt S, Beasley R (2004) The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 59: 469-478. doi:10.1111/j.1398-9995.2004.00526.x. PubMed: 15080825. (Pubitemid 38580764)
29. Elias JA, Lee CG, Zheng T, Ma B, Homer RJ et al. (2003) New insights into the pathogenesis of asthma. J Clin Invest 111: 291-297. doi: 10.1172/JCI200317748. PubMed: 12569150. (Pubitemid 36182201)
30. Groneberg DA, Eynott PR, Lim S, Oates T, Wu R et al. (2002) Expression of respiratory mucins in fatal status asthmaticus and mild asthma. Histopathology 40: 367-373. doi:10.1046/j.1365-2559.2002.01378.x. PubMed: 11943022. (Pubitemid 34595588)
31. Kuyper LM, Paré PD, Hogg JC, Lambert RK, Ionescu D et al. (2003) Characterization of airway plugging in fatal asthma. Am J Med 115: 6-11. doi:10.1016/S0002-9343(03)00241-9. PubMed: 12867228. (Pubitemid 36831115)
32. Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM et al. (2004) The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 350: 2645-2653. doi:10.1056/NEJMoa032158. PubMed: 15215480. (Pubitemid 38787999)
33. Larché M, Robinson DS, Kay AB (2003) The role of T lymphocytes in the pathogenesis of asthma. J Allergy Clin Immunol 111: 450-463. doi: 10.1067/mai.2003.169. PubMed: 12642820. (Pubitemid 36337859)
34. Knudson CM, Korsmeyer SJ (1997) Bcl-2 and Bax function independently to regulate cell death. Nat Genet 16: 358-363. doi: 10.1038/ng0897-358. PubMed: 9241272. (Pubitemid 27323300)
35. Antonsson B, Conti F, Ciavatta A, Montessuit S, Lewis S et al. (1997) Inhibition of Bax channel-forming activity by Bcl-2. Science 277: 370-372. doi:10.1126/science.277.5324.370. PubMed: 9219694. (Pubitemid 27450709)