Gob-5 is not essential for mucus overproduction in preclinical murine models of allergic asthma

American Journal of Respiratory Cell and Molecular Biology

Volumn 33, Issue 3, 2005, Pages 303-314

  Robichaud, Annette ^a   Tuck, Stephanie A ^a   Kargman, Stacia ^a   Tam, John ^a   Wong, Elizabeth ^a   Abramovitz, Mark ^a   Mortimer, James ^a   Burston, Helen E ^a   Masson, Paul ^a   Hirota, Jeremy ^a   Slipetz, Deborah ^a   Kennedy, Brian ^a   O'Neill, Gary ^a   Xanthoudakis, Steven ^a,b  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b Merck Ctr for Therapeutic Research   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORIDE CHANNEL; INTERLEUKIN 13; MUCIN; OVALBUMIN;

ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLCA 1 GENE; CONTROLLED STUDY; DNA MICROARRAY; FEMALE; GENE; GENE EXPRESSION; GENE OVEREXPRESSION; GENOTYPE; GOB 5 GENE; GOBLET CELL; IN VITRO STUDY; INFLAMMATION; KNOCKOUT MOUSE; LUNG ALVEOLUS EPITHELIUM; MALE; METAPLASIA; MOUSE; MUCUS; NONHUMAN; PHENOTYPE; PROVOCATION TEST; REGULATORY MECHANISM;

ANIMALS; ASTHMA; CELLS, CULTURED; CHLORIDE CHANNELS; DISEASE MODELS, ANIMAL; FEMALE; GASTROINTESTINAL TRACT; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUCINS; MUCOPROTEINS; MUCUS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RESPIRATORY MUCOSA; RNA, SMALL INTERFERING;

ANIMALIA; MURINAE;

EID: 24344494809     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2004-0372OC     Document Type: Article

References (30)

1. Fahy JV. Goblet cell and mucin gene abnormalities in asthma. Chest 2002;122:320S-326S.
2. Rose MC, Nickola TJ, Voynow JA. Airway mucus obstruction: mucin glycoproteins, MUC gene regulation and goblet cell hyperplasia. Am J Respir Cell Mol Biol 2001;25:533-537.
3. Sheehan JK, Richardson PS, Fung DC, Howard M, Thornton DJ. Analysis of respiratory mucus glycoproteins in asthma: a detailed study from a patient who died in status asthmaticus. Am J Respir Cell Mol Biol 1995;13:748-756.
4. Thornton DJ, Carlstedt I, Howard M, Devine PL, Price MR, Sheehan JK. Respiratory mucins: identification of core proteins and glycoforms. Biochem J 1996;316:967-975.
5. Rogers DF. Mucus pathophysiology in COPD: differences to asthma, and pharmacotherapy. Monaldi Arch Chest Dis 2000;55:324-332.
6. Vestbo J. Epidemiological studies in mucus hypersecretion. Novartis Found Symp 2002;248:3-12.
7. Rogers DF. Mucoactive drugs for asthma and COPD: any place in therapy? Expert Opin Investig Drugs 2002;11:15-35.
8. Groneberg DA, Eynott PR, Lim S, Oates T, Wu R, Carlstedt I, Roberts P, McCann B, Nicholson AG, Harrison BD, et al. Expression of respiratory mucins in fatal status asthmaticus and mild asthma. Histopathology 2002;40:367-373.
9. Rogers DF. The airway goblet cell. Int J Biochem Cell Biol 2003;35:1-6.
10. Lee CG, Homer RJ, Cohn L, Link H, Jung S, Craft JE, Graham BS, Johnson TR, Elias JA. Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways. J Biol Chem 2002;277:35466-35474.
11. Zhu Z, Lee CG, Zheng T, Chupp G, Wang J, Homer RJ, Noble PW, Hamid Q, Elias JA. Airway inflammation and remodeling in asthma: lessons from interleukin 11 and interleukin 13 transgenic mice. Am J Respir Crit Care Med 2001;164:S67-S70.
12. Zuhdi AM, Piazza FM, Selby DM, Letwin N, Huang L, Rose MC. Muc-5/5ac mucin messenger RNA and protein expression is a marker of goblet cell metaplasia in murine airways. Am J Respir Cell Mol Biol 2000;22:253-260.
13. Nakanishi A, Morita S, Iwashita H, Sagiya Y, Ashida Y, Shirafuji H, Fujisawa Y, Nishimura O, Fujino M. Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma. Proc Natl Acad Sci USA 2001;98:5175-5180.
14. Zhou Y, Dong Q, Louahed J, Dragwa C, Savio D, Huang M, Weiss C, Tomer Y, McLane MP, Nicolaides NC, et al. Characterization of a calcium-activated chloride channel as a shared target of Th2 cytokine pathways and its potential involvement in asthma. Am J Respir Cell Mol Biol 2001;25:486-491.
15. Toda M, Tulic MK, Levitt RC, Hamid Q. A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma. J Allergy Clin Immunol 2002;109:246-250.
16. Hoshino M, Morita S, Iwashita H, Sagiya Y, Nagi T, Nakanishi A, Ashida Y, Nishimura O, Fujisawa Y, Fujino M. Increased expression of the human Ca2+-activated Cl- channel 1 (CaCC1) gene in the asthmatic airway. Am J Respir Crit Care Med 2002;165:1132-1136.
17. Hauber HP, Tsicopoulos A, Wallaert B, Griffin S, McElvaney NG, Daigneault P, Mueller Z, Olivenstein R, Holroyd KJ, Levitt RC, et al. Expression of HCLCA1 in cystic fibrosis lungs is associated with mucus overproduction. Eur Respir J 2004;23:846-850.
18. Dizier MH, Besse-Schmittler C, Guilloud-Bataille M, Annesi-Maesano I, Boussaha M, Bousquet J, Charpin D, Degioanni A, Gormand F, Grimfeld A, et al. Genome screen for asthma and related phenotypes in the French EGEA study. Am J Respir Crit Care Med 2000;162:1812-1818.
19. Hegab AE, Sakamoto T, Uchida Y, Nomura A, Ishii Y, Morishima Y, Mochizuki M, Kimura T, Saitoh W, Massoud HH, et al. CLCA1 gene polymorphisms in chronic obstructive pulmonary disease. J Med Genet 2004;41:e27.
20. Kamada F, Suzuki Y, Shao C, Tamari M, Hasegawa K, Hirota T, Shimizu M, Takahashi N, Mao XQ, Doi S, et al. Association of the hCLCA1 gene with childhood and adult asthma. Genes Immun 2004;5:540-547.
21. Gruber AD, Elble RC, Ji HL, Schreur KD, Fuller CM, Pauli BU. Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl- channel proteins. Genomics 1998;54:200-214.
22. Zhou Y, Levitt RC, Nicolaides NC, Jones S, McLane M. Mucin synthesis inhibitors. Patent 2002.09/920,287
23. Hamelmann E, Schwarze J, Takeda K, Oshiba A, Larsen GL, Irvin CG, Gelfand EW. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med 1997;156:766-775.
24. Hughes TR, Marton MJ, Jones AR, Roberts CJ, Stoughton R, Armour CD, Bennett HA, Coffey E, Dai H, He YD, et al. Functional discovery via a compendium of expression profiles. Cell 2000;102:109-126.
25. Nadel JA. Role of epidermal growth factor receptor activation in regulating mucin synthesis. Respir Res 2001;2:85-89.
26. Zimmermann N, King NE, Laporte J, Yang M, Mishra A, Pope SM, Muntel EE, Witte DP, Pegg AA, Foster PS, et al. Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. J Clin Invest 2003;111:1863-1874.
27. Vercelli D. Arginase: marker, effector, or candidate gene for asthma? J Clin Invest 2003;111:1815-1817.
28. King NE, Rothenberg ME, Zimmermann N. Arginine in Asthma and Lung Inflammation. J Nutr 2004;134:2830S-2836S.
29. Zhou Y, Shapiro M, Dong Q, Louahed J, Weiss C, Wan S, Chen Q, Dragwa C, Savio D, Huang M, et al. A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction. Novartis Found Symp 2002;248:150-165.
30. Kuperman DA, Lewis CC, Rodriguez MW, Yang YH, Erle DJ. Genomics and siRNA partnered to investigate IL-13 effects on airway epithelial cells in vivo [abstract]. Am J Respir Crit Care Med 2004;169:A536.