메뉴 건너뛰기




Volumn 351, Issue 2, 2012, Pages 167-175

The regulation of fibrosis in airway remodeling in asthma

Author keywords

Airway remodeling; Asthma; Fibrosis; Relaxin; Therapy

Indexed keywords

ALLERGEN; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CGEN 25009; COLLAGEN; CR 002; CYTOKINE ANTIBODY; DEXAMETHASONE; FLUTICASONE PROPIONATE; FRESOLIMUMAB; GLUCOCORTICOID; HORMONE RECEPTOR; MATRIX METALLOPROTEINASE; OMALIZUMAB; ORNITHINE PHENYLACETATE; POLYPEPTIDE; PROTEIN RXFP1; PROTEIN RXFP2; RECOMBINANT PROTEIN; RELAXIN; SMAD2 PROTEIN; SMAD3 PROTEIN; THEOPHYLLINE; TISSUE INHIBITOR OF METALLOPROTEINASE; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

EID: 84857139903     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2012.01.007     Document Type: Review
Times cited : (97)

References (74)
  • 1
    • 84857139392 scopus 로고    scopus 로고
    • AIHW (Australian Centre for Asthma Monitoring). Asthma in Australia 2005, AIHW Asthma Series 2. AIHW Cat. No. ACM 6. AIHW, Canberra.
    • AIHW (Australian Centre for Asthma Monitoring), 2005. Asthma in Australia 2005, AIHW Asthma Series 2. AIHW Cat. No. ACM 6. AIHW, Canberra.
    • (2005)
  • 4
    • 55849148482 scopus 로고    scopus 로고
    • The cytokine network in asthma and chronic obstructive pulmonary disease
    • Barnes P.J. The cytokine network in asthma and chronic obstructive pulmonary disease. J. Clin. Invest. 2008, 118:3546-3556.
    • (2008) J. Clin. Invest. , vol.118 , pp. 3546-3556
    • Barnes, P.J.1
  • 6
    • 33644589069 scopus 로고    scopus 로고
    • International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides
    • Bathgate R.A., Ivell R., Sanborn B.M., Sherwood O.D., Summers R.J. International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides. Pharmacol. Rev. 2006, 58:7-31.
    • (2006) Pharmacol. Rev. , vol.58 , pp. 7-31
    • Bathgate, R.A.1    Ivell, R.2    Sanborn, B.M.3    Sherwood, O.D.4    Summers, R.J.5
  • 8
    • 37849000903 scopus 로고    scopus 로고
    • Airway smooth muscle growth in asthma: proliferation, hypertrophy, and migration
    • Bentley J.K., Hershenson M.B. Airway smooth muscle growth in asthma: proliferation, hypertrophy, and migration. Proc. Am. Thorac. Soc. 2008, 5:89-96.
    • (2008) Proc. Am. Thorac. Soc. , vol.5 , pp. 89-96
    • Bentley, J.K.1    Hershenson, M.B.2
  • 10
    • 47349123480 scopus 로고    scopus 로고
    • Asthma: a syndrome composed of heterogeneous diseases
    • (quiz 8-11, 50)
    • Borish L., Culp J.A. Asthma: a syndrome composed of heterogeneous diseases. Ann. Allergy Asthma Immunol. 2008, 101:1-8. (quiz 8-11, 50).
    • (2008) Ann. Allergy Asthma Immunol. , vol.101 , pp. 1-8
    • Borish, L.1    Culp, J.A.2
  • 11
    • 39849097080 scopus 로고    scopus 로고
    • Controversy surrounding the increased expression of TGF beta 1 in asthma
    • Bosse Y., Rola-Pleszczynski M. Controversy surrounding the increased expression of TGF beta 1 in asthma. Respir. Res. 2007, 8:66.
    • (2007) Respir. Res. , vol.8 , pp. 66
    • Bosse, Y.1    Rola-Pleszczynski, M.2
  • 12
    • 30744470159 scopus 로고    scopus 로고
    • The contribution of transforming growth factor-beta and epidermal growth factor signalling to airway remodelling in chronic asthma
    • Boxall C., Holgate S.T., Davies D.E. The contribution of transforming growth factor-beta and epidermal growth factor signalling to airway remodelling in chronic asthma. Eur. Respir. J. 2006, 27:208-229.
    • (2006) Eur. Respir. J. , vol.27 , pp. 208-229
    • Boxall, C.1    Holgate, S.T.2    Davies, D.E.3
  • 13
    • 40049107712 scopus 로고    scopus 로고
    • Immunologic and inflammatory mechanisms that drive asthma progression to remodeling
    • (quiz 571-2)
    • Broide D.H. Immunologic and inflammatory mechanisms that drive asthma progression to remodeling. J. Allergy Clin. Immunol. 2008, 121:560-570. (quiz 571-2).
    • (2008) J. Allergy Clin. Immunol. , vol.121 , pp. 560-570
    • Broide, D.H.1
  • 14
    • 23244456978 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 and disorders of the lung
    • Camoretti-Mercado B., Solway J. Transforming growth factor-beta1 and disorders of the lung. Cell Biochem. Biophys. 2005, 43:131-148.
    • (2005) Cell Biochem. Biophys. , vol.43 , pp. 131-148
    • Camoretti-Mercado, B.1    Solway, J.2
  • 16
    • 50049106293 scopus 로고    scopus 로고
    • Safety and efficacy of beta agonists
    • (discussion 623-4)
    • Donohue J.F. Safety and efficacy of beta agonists. Respir. Care 2008, 53:618-622. (discussion 623-4).
    • (2008) Respir. Care , vol.53 , pp. 618-622
    • Donohue, J.F.1
  • 17
    • 9444226989 scopus 로고    scopus 로고
    • Identification of the pregnancy hormone relaxin as glucocorticoid receptor agonist
    • Dschietzig T., Bartsch C., Stangl V., Baumann G., Stangl K. Identification of the pregnancy hormone relaxin as glucocorticoid receptor agonist. FASEB J. 2004, 18:1536-1538.
    • (2004) FASEB J. , vol.18 , pp. 1536-1538
    • Dschietzig, T.1    Bartsch, C.2    Stangl, V.3    Baumann, G.4    Stangl, K.5
  • 18
    • 23644461401 scopus 로고    scopus 로고
    • The pregnancy hormone relaxin binds to and activates the human glucocorticoid receptor
    • Dschietzig T., Bartsch C., Greinwald M., Baumann G., Stangl K. The pregnancy hormone relaxin binds to and activates the human glucocorticoid receptor. Ann. NY Acad. Sci. 2005, 1041:256-271.
    • (2005) Ann. NY Acad. Sci. , vol.1041 , pp. 256-271
    • Dschietzig, T.1    Bartsch, C.2    Greinwald, M.3    Baumann, G.4    Stangl, K.5
  • 19
    • 63049090896 scopus 로고    scopus 로고
    • RXFP1-inactive relaxin activates human glucocorticoid receptor: further investigations into the relaxin-GR pathway
    • Dschietzig T., Bartsch C., Baumann G., Stangl K. RXFP1-inactive relaxin activates human glucocorticoid receptor: further investigations into the relaxin-GR pathway. Regul. Pept. 2009, 154:77-84.
    • (2009) Regul. Pept. , vol.154 , pp. 77-84
    • Dschietzig, T.1    Bartsch, C.2    Baumann, G.3    Stangl, K.4
  • 20
    • 67349166150 scopus 로고    scopus 로고
    • Autoregulation of human relaxin-2 gene expression critically involves relaxin and glucocorticoid receptor binding to glucocorticoid response half-sites in the relaxin-2 promoter
    • Dschietzig T., Bartsch C., Wessler S., Baumann G., Stangl K. Autoregulation of human relaxin-2 gene expression critically involves relaxin and glucocorticoid receptor binding to glucocorticoid response half-sites in the relaxin-2 promoter. Regul. Pept. 2009, 155:163-173.
    • (2009) Regul. Pept. , vol.155 , pp. 163-173
    • Dschietzig, T.1    Bartsch, C.2    Wessler, S.3    Baumann, G.4    Stangl, K.5
  • 21
    • 18844401152 scopus 로고    scopus 로고
    • Epithelial stress and structural remodelling in childhood asthma
    • Fedorov I.A., Wilson S.J., Davies D.E., Holgate S.T. Epithelial stress and structural remodelling in childhood asthma. Thorax 2005, 60:389-394.
    • (2005) Thorax , vol.60 , pp. 389-394
    • Fedorov, I.A.1    Wilson, S.J.2    Davies, D.E.3    Holgate, S.T.4
  • 25
    • 33845939640 scopus 로고    scopus 로고
    • Comparison of signaling pathways activated by the relaxin family peptide receptors, RXFP1 and RXFP2, using reporter genes
    • Halls M.L., Bathgate R.A., Summers R.J. Comparison of signaling pathways activated by the relaxin family peptide receptors, RXFP1 and RXFP2, using reporter genes. J. Pharmacol. Exp. Ther. 2007, 320:281-290.
    • (2007) J. Pharmacol. Exp. Ther. , vol.320 , pp. 281-290
    • Halls, M.L.1    Bathgate, R.A.2    Summers, R.J.3
  • 26
    • 0034080463 scopus 로고    scopus 로고
    • Epithelial damage and response
    • Holgate S.T. Epithelial damage and response. Clin. Exp. Allergy 2000, 30(Suppl. 1):37-41.
    • (2000) Clin. Exp. Allergy , vol.30 , Issue.SUPPL. 1 , pp. 37-41
    • Holgate, S.T.1
  • 27
    • 36849031788 scopus 로고    scopus 로고
    • Epithelium dysfunction in asthma
    • (quiz 1245-6)
    • Holgate S.T. Epithelium dysfunction in asthma. J. Allergy Clin. Immunol. 2007, 120:1233-1244. (quiz 1245-6).
    • (2007) J. Allergy Clin. Immunol. , vol.120 , pp. 1233-1244
    • Holgate, S.T.1
  • 28
    • 34249337763 scopus 로고    scopus 로고
    • The epithelium takes centre stage in asthma and atopic dermatitis
    • Holgate S.T. The epithelium takes centre stage in asthma and atopic dermatitis. Trends Immunol. 2007, 28:248-251.
    • (2007) Trends Immunol. , vol.28 , pp. 248-251
    • Holgate, S.T.1
  • 29
    • 47949119866 scopus 로고    scopus 로고
    • Pathogenesis of asthma
    • Holgate S.T. Pathogenesis of asthma. Clin. Exp. Allergy 2008, 38:872-897.
    • (2008) Clin. Exp. Allergy , vol.38 , pp. 872-897
    • Holgate, S.T.1
  • 30
    • 40949121542 scopus 로고    scopus 로고
    • The airway epithelium is central to the pathogenesis of asthma
    • Holgate S.T. The airway epithelium is central to the pathogenesis of asthma. Allergol. Int. 2008, 57:1-10.
    • (2008) Allergol. Int. , vol.57 , pp. 1-10
    • Holgate, S.T.1
  • 33
    • 81255157548 scopus 로고    scopus 로고
    • Relaxin regulates myofibroblast contractility and protects against lung fibrosis
    • Huang X., Gai Y., Yang N., Lu B., Samuel C.S., Thannickal V.J., Zhou Y. Relaxin regulates myofibroblast contractility and protects against lung fibrosis. Am. J. Pathol. 2011, 179:2751-2765.
    • (2011) Am. J. Pathol. , vol.179 , pp. 2751-2765
    • Huang, X.1    Gai, Y.2    Yang, N.3    Lu, B.4    Samuel, C.S.5    Thannickal, V.J.6    Zhou, Y.7
  • 34
    • 13244259205 scopus 로고    scopus 로고
    • Airway remodeling in asthma
    • James A. Airway remodeling in asthma. Curr. Opin. Pulm. Med. 2005, 11:1-6.
    • (2005) Curr. Opin. Pulm. Med. , vol.11 , pp. 1-6
    • James, A.1
  • 35
    • 0035891664 scopus 로고    scopus 로고
    • Remodeling in asthma and chronic obstructive lung disease
    • Jeffery P.K. Remodeling in asthma and chronic obstructive lung disease. Am. J. Respir. Crit. Care Med. 2001, 164:S28-S38.
    • (2001) Am. J. Respir. Crit. Care Med. , vol.164
    • Jeffery, P.K.1
  • 36
    • 0033765726 scopus 로고    scopus 로고
    • Biopsy markers of airway inflammation and remodelling
    • Jeffery P.K., Laitinen A., Venge P. Biopsy markers of airway inflammation and remodelling. Respir. Med. 2000, 94(Suppl. F):S9-S15.
    • (2000) Respir. Med. , vol.94 , Issue.SUPPL. F
    • Jeffery, P.K.1    Laitinen, A.2    Venge, P.3
  • 37
    • 37049036891 scopus 로고    scopus 로고
    • The role of eosinophils in airway tissue remodelling in asthma
    • Kariyawasam H.H., Robinson D.S. The role of eosinophils in airway tissue remodelling in asthma. Curr. Opin. Immunol. 2007, 19:681-686.
    • (2007) Curr. Opin. Immunol. , vol.19 , pp. 681-686
    • Kariyawasam, H.H.1    Robinson, D.S.2
  • 38
    • 0033120966 scopus 로고    scopus 로고
    • Inhibition of matrix metalloproteinases prevents allergen-induced airway inflammation in a murine model of asthma
    • Kumagai K., Ohno I., Okada S., Ohkawara Y., Suzuki K., Shinya T., Nagase H., Iwata K., Shirato K. Inhibition of matrix metalloproteinases prevents allergen-induced airway inflammation in a murine model of asthma. J. Immunol. 1999, 162:4212-4219.
    • (1999) J. Immunol. , vol.162 , pp. 4212-4219
    • Kumagai, K.1    Ohno, I.2    Okada, S.3    Ohkawara, Y.4    Suzuki, K.5    Shinya, T.6    Nagase, H.7    Iwata, K.8    Shirato, K.9
  • 40
    • 34249792354 scopus 로고    scopus 로고
    • Inhibition of allergen-induced airway remodeling in Smad 3-deficient mice
    • Le A.V., Cho J.Y., Miller M., McElwain S., Golgotiu K., Broide D.H. Inhibition of allergen-induced airway remodeling in Smad 3-deficient mice. J. Immunol. 2007, 178:7310-7316.
    • (2007) J. Immunol. , vol.178 , pp. 7310-7316
    • Le, A.V.1    Cho, J.Y.2    Miller, M.3    McElwain, S.4    Golgotiu, K.5    Broide, D.H.6
  • 41
    • 2342590065 scopus 로고    scopus 로고
    • The global burden of asthma: executive summary of the GINA Dissemination Committee report
    • Masoli M., Fabian D., Holt S., Beasley R. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 2004, 59:469-478.
    • (2004) Allergy , vol.59 , pp. 469-478
    • Masoli, M.1    Fabian, D.2    Holt, S.3    Beasley, R.4
  • 42
    • 35649003903 scopus 로고    scopus 로고
    • Asthma therapy and airway remodeling
    • (quiz 1010-1)
    • Mauad T., Bel E.H., Sterk P.J. Asthma therapy and airway remodeling. J. Allergy Clin. Immunol. 2007, 120:997-1009. (quiz 1010-1).
    • (2007) J. Allergy Clin. Immunol. , vol.120 , pp. 997-1009
    • Mauad, T.1    Bel, E.H.2    Sterk, P.J.3
  • 43
    • 51749085131 scopus 로고    scopus 로고
    • Asthma, outdoor air quality and the Olympic Games
    • McKenzie D.C., Boulet L.P. Asthma, outdoor air quality and the Olympic Games. CMAJ 2008, 179:543-548.
    • (2008) CMAJ , vol.179 , pp. 543-548
    • McKenzie, D.C.1    Boulet, L.P.2
  • 45
    • 30944442868 scopus 로고    scopus 로고
    • Endogenous relaxin regulates collagen deposition in an animal model of allergic airway disease
    • Mookerjee I., Solly N.R., Royce S.G., Tregear G.W., Samuel C.S., Tang M.L. Endogenous relaxin regulates collagen deposition in an animal model of allergic airway disease. Endocrinology 2006, 147:754-761.
    • (2006) Endocrinology , vol.147 , pp. 754-761
    • Mookerjee, I.1    Solly, N.R.2    Royce, S.G.3    Tregear, G.W.4    Samuel, C.S.5    Tang, M.L.6
  • 46
    • 23644436540 scopus 로고    scopus 로고
    • Investigating the role of relaxin in the regulation of airway fibrosis in animal models of acute and chronic allergic airway disease
    • Mookerjee I., Tang M.L.K., Solly N., Tregear G.W., Samuel C.S. Investigating the role of relaxin in the regulation of airway fibrosis in animal models of acute and chronic allergic airway disease. Ann. NY Acad. Sci. 2005, 1041:194-196.
    • (2005) Ann. NY Acad. Sci. , vol.1041 , pp. 194-196
    • Mookerjee, I.1    Tang, M.L.K.2    Solly, N.3    Tregear, G.W.4    Samuel, C.S.5
  • 47
    • 53849126120 scopus 로고    scopus 로고
    • Interaction of TGF-beta with immune cells in airway disease
    • Moore B., Murphy R.F., Agrawal D.K. Interaction of TGF-beta with immune cells in airway disease. Curr. Mol. Med. 2008, 8:427-436.
    • (2008) Curr. Mol. Med. , vol.8 , pp. 427-436
    • Moore, B.1    Murphy, R.F.2    Agrawal, D.K.3
  • 48
    • 84857139394 scopus 로고    scopus 로고
    • National Heart Lung and Blood Institute. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma, NIH, Publication No. 07-4051.
    • National Heart Lung and Blood Institute, 2007. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma, NIH, Publication No. 07-4051.
    • (2007)
  • 49
    • 24644520068 scopus 로고    scopus 로고
    • Airway remodeling contributes to the progressive loss of lung function in asthma: an overview
    • (quiz 487)
    • Pascual R.M., Peters S.P. Airway remodeling contributes to the progressive loss of lung function in asthma: an overview. J. Allergy Clin. Immunol. 2005, 116:477-486. (quiz 487).
    • (2005) J. Allergy Clin. Immunol. , vol.116 , pp. 477-486
    • Pascual, R.M.1    Peters, S.P.2
  • 51
    • 0029786333 scopus 로고    scopus 로고
    • Identification of a negative glucocorticoid response element in the rat type 1 vasoactive intestinal polypeptide receptor gene
    • Pei L. Identification of a negative glucocorticoid response element in the rat type 1 vasoactive intestinal polypeptide receptor gene. J. Biol. Chem. 1996, 271:20879-20884.
    • (1996) J. Biol. Chem. , vol.271 , pp. 20879-20884
    • Pei, L.1
  • 53
    • 33745855449 scopus 로고    scopus 로고
    • Remodeling in asthma and chronic obstructive pulmonary disease
    • Postma D.S., Timens W. Remodeling in asthma and chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 2006, 3:434-439.
    • (2006) Proc. Am. Thorac. Soc. , vol.3 , pp. 434-439
    • Postma, D.S.1    Timens, W.2
  • 54
    • 46949098446 scopus 로고    scopus 로고
    • Asthma 2008: targeting immunoglobulin E to achieve disease control
    • Prenner B.M. Asthma 2008: targeting immunoglobulin E to achieve disease control. J. Asthma 2008, 45:429-436.
    • (2008) J. Asthma , vol.45 , pp. 429-436
    • Prenner, B.M.1
  • 57
    • 66649133714 scopus 로고    scopus 로고
    • Relaxin reverses airway remodeling and airway dysfunction in allergic airways disease
    • Royce S.G., Miao Y.R., Lee M., Samuel C.S., Tregear G.W., Tang M.L. Relaxin reverses airway remodeling and airway dysfunction in allergic airways disease. Endocrinology 2009, 150:2692-2699.
    • (2009) Endocrinology , vol.150 , pp. 2692-2699
    • Royce, S.G.1    Miao, Y.R.2    Lee, M.3    Samuel, C.S.4    Tregear, G.W.5    Tang, M.L.6
  • 60
    • 34548062188 scopus 로고    scopus 로고
    • Relaxin: antifibrotic properties and effects in models of disease
    • Samuel C.S. Relaxin: antifibrotic properties and effects in models of disease. Clin. Med. Res. 2005, 3:241-249.
    • (2005) Clin. Med. Res. , vol.3 , pp. 241-249
    • Samuel, C.S.1
  • 61
    • 33646522213 scopus 로고    scopus 로고
    • Relaxin in cardiovascular and renal disease
    • Samuel C.S., Hewitson T.D. Relaxin in cardiovascular and renal disease. Kidney Int. 2006, 69:1498-1502.
    • (2006) Kidney Int. , vol.69 , pp. 1498-1502
    • Samuel, C.S.1    Hewitson, T.D.2
  • 64
    • 33749265164 scopus 로고    scopus 로고
    • 'Relaxin' the stiffened heart and arteries: the therapeutic potential for relaxin in the treatment of cardiovascular disease
    • Samuel C.S., Du X.-J., Bathgate R.A.D., Summers R.J. 'Relaxin' the stiffened heart and arteries: the therapeutic potential for relaxin in the treatment of cardiovascular disease. Pharmacol. Ther. 2006, 112:529-552.
    • (2006) Pharmacol. Ther. , vol.112 , pp. 529-552
    • Samuel, C.S.1    Du, X.-J.2    Bathgate, R.A.D.3    Summers, R.J.4
  • 66
    • 62749129843 scopus 로고    scopus 로고
    • RXFP1 protects against airway fibrosis during homeostasis, but not against fibrosis associated with chronic allergic airways disease
    • Samuel C.S., Royce S.G., Chen B., Cao H., Gossen J.A., Tregear G.W., Tang M.L. RXFP1 protects against airway fibrosis during homeostasis, but not against fibrosis associated with chronic allergic airways disease. Endocrinology 2008, 150:1495-1502.
    • (2008) Endocrinology , vol.150 , pp. 1495-1502
    • Samuel, C.S.1    Royce, S.G.2    Chen, B.3    Cao, H.4    Gossen, J.A.5    Tregear, G.W.6    Tang, M.L.7
  • 69
    • 3042610399 scopus 로고    scopus 로고
    • Relaxin's physiological roles and other diverse actions
    • Sherwood O.D. Relaxin's physiological roles and other diverse actions. Endocr. Rev. 2004, 25:205-234.
    • (2004) Endocr. Rev. , vol.25 , pp. 205-234
    • Sherwood, O.D.1
  • 70
    • 50049094619 scopus 로고    scopus 로고
    • Inhaled corticosteroids in asthma management
    • (discussion 633-4)
    • Sobande P.O., Kercsmar C.M. Inhaled corticosteroids in asthma management. Respir. Care 2008, 53:625-633. (discussion 633-4).
    • (2008) Respir. Care , vol.53 , pp. 625-633
    • Sobande, P.O.1    Kercsmar, C.M.2
  • 71
    • 0030811225 scopus 로고    scopus 로고
    • Glucocorticoid-resistant asthma: pathogenesis and clinical implications for management
    • Szefler S.J., Leung D.Y. Glucocorticoid-resistant asthma: pathogenesis and clinical implications for management. Eur. Respir. J. 1997, 10:1640-1647.
    • (1997) Eur. Respir. J. , vol.10 , pp. 1640-1647
    • Szefler, S.J.1    Leung, D.Y.2
  • 72
    • 0037504020 scopus 로고    scopus 로고
    • Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: association with asthma severity, neutrophilic inflammation, and wound repair
    • Wenzel S.E., Balzar S., Cundall M., Chu H.W. Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: association with asthma severity, neutrophilic inflammation, and wound repair. J. Allergy Clin. Immunol. 2003, 111:1345-1352.
    • (2003) J. Allergy Clin. Immunol. , vol.111 , pp. 1345-1352
    • Wenzel, S.E.1    Balzar, S.2    Cundall, M.3    Chu, H.W.4
  • 73
    • 0034829351 scopus 로고    scopus 로고
    • Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo
    • Williams E.J., Benyon R.C., Trim N., Hadwin R., Grove B.H., Arthur M.J., Unemori E.N., Iredale J.P. Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo. Gut 2001, 49:577-583.
    • (2001) Gut , vol.49 , pp. 577-583
    • Williams, E.J.1    Benyon, R.C.2    Trim, N.3    Hadwin, R.4    Grove, B.H.5    Arthur, M.J.6    Unemori, E.N.7    Iredale, J.P.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.