CD14 mediates Toll-like Receptor 4 (TLR4) endocytosis and Spleen Tyrosine Kinase (Syk) and Interferon Regulatory Transcription Factor 3 (IRF3) activation in epithelial cells and impairs neutrophil infiltration and pseudomonas aeruginosa killing in vivo

Journal of Biological Chemistry

Volumn 289, Issue 2, 2014, Pages 1174-1182

  Roy, Sanhita ^a,b   Karmakar, Mausita ^a   Pearlman, Eric ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b L V PRASAD EYE INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CORNEAL EPITHELIAL CELLS; EPITHELIAL CELLS; HUMAN EPITHELIAL CELLS; NEUTROPHIL INFILTRATION; PSEUDOMONAS AERUGINOSA; SPLEEN TYROSINE KINASE; TOLL-LIKE RECEPTOR 4; TRANSCRIPTION FACTOR-3;

AMINO ACIDS; BACTERIA; CELLS; MOLECULAR BIOLOGY;

INTERFERONS;

ALPHA CHEMOKINE; BETA INTERFERON; CD14 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; LIPOPOLYSACCHARIDE BINDING PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN KINASE SYK; RANTES; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; BACTERIAL CLEARANCE; BACTERICIDAL ACTIVITY; CELL SURFACE; CONTROLLED STUDY; CORNEA CELL; CORNEA STROMA; CYTOKINE PRODUCTION; ENDOCYTOSIS; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; INTERNALIZATION; KERATITIS; MACROPHAGE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SIGNAL TRANSDUCTION;

CORNEA; EPITHELIAL CELL; INFLAMMATION; LIPOPOLYSACCHARIDE (LPS); NEUTROPHIL; PSEUDOMONAS AERUGINOSA; TOLL-LIKE RECEPTORS (TLRS);

ANIMALS; ANTIGENS, CD14; BLOTTING, WESTERN; CELL LINE; CELLS, CULTURED; CHEMOKINE CCL5; CORNEA; ENDOCYTOSIS; EPITHELIAL CELLS; HOST-PATHOGEN INTERACTIONS; HUMANS; INTERFERON REGULATORY FACTOR-3; INTERFERON-BETA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHIL INFILTRATION; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; TOLL-LIKE RECEPTOR 4;

EID: 84891937997     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.523167     Document Type: Article

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