γ-Tocotrienol-induced autophagy in malignant mammary cancer cells

Experimental Biology and Medicine

Volumn 239, Issue 1, 2014, Pages 33-44

  Tiwari, Roshan V ^a   Parajuli, Parash ^a   Sylvester, Paul W ^a  

^a UNIVERSITY OF LOUISIANA AT MONROE   (United States)

Author keywords

autophagy; breast cancer; mammalian target of rapamycin; Protein kinase B (Akt); Tocotrienol

Indexed keywords

ALPHA TOCOTRIENOL; BECLIN 1; CASPASE 3; DANSYLCADAVERINE; MICROTUBULE ASSOCIATED PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; ALPHA TOCOPHEROL; APOPTOSIS REGULATORY PROTEIN; BAX PROTEIN, HUMAN; BAX PROTEIN, MOUSE; BECN1 PROTEIN, HUMAN; BECN1 PROTEIN, MOUSE; CASP3 PROTEIN, HUMAN; CASP3 PROTEIN, MOUSE; CHROMAN DERIVATIVE; MAP1LC3 PROTEIN, MOUSE; MAP1LC3B PROTEIN, HUMAN; MEMBRANE PROTEIN; PARP1 PROTEIN, MOUSE; PLASTOCHROMANOL 8;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGY; BREAST CANCER; CELL PROLIFERATION; CELL VIABILITY; COLORIMETRY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; BREAST NEOPLASMS; DRUG EFFECTS; GENE EXPRESSION REGULATION; LIPOYLATION; MAMMARY NEOPLASMS, EXPERIMENTAL; METABOLISM; PATHOLOGY; TIME; TUMOR CELL LINE;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BCL-2-ASSOCIATED X PROTEIN; BREAST NEOPLASMS; CASPASE 3; CELL LINE, TUMOR; CHROMANS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIPOYLATION; MAMMARY NEOPLASMS, EXPERIMENTAL; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICROTUBULE-ASSOCIATED PROTEINS; POLY(ADP-RIBOSE) POLYMERASES; TIME FACTORS; VITAMIN E;

EID: 84891937288     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1177/1535370213511022     Document Type: Article

References (54)

1. Easton JB,Houghton PJ.mTOR and cancer therapy.Oncogene. 2006;25:6436-46.
2. Mathew R,Karantza-Wadsworth V,White E.Role of autophagy in cancer.Nat Rev Cancer. 2007;7:961-7.
3. Chen N,Karantza V.Autophagy as a therapeutic target in cancer.Cancer Biol Ther. 2011;11:157-68.
4. Zou M,Lu N,Hu C,Liu W,Sun Y,Wang X,You Q,Gu C,Xi T,Guo Q.Beclin 1-mediated autophagy in hepatocellular carcinoma cells: implication in anticancer efficiency of oroxylin a via inhibition of mTOR signaling.Cell Signal. 2012;24:1722-32.
5. Klionsky DJ.The molecular machinery of autophagy: unanswered questions.J Cell Sci. 2005;118:7-18.
6. Rabinowitz JD,White E.Autophagy and metabolism.Science. 2010;330:1344-8.
7. Kabeya Y,Mizushima N,Ueno T,Yamamoto A,Kirisako T,Noda T,Kominami E,Ohsumi Y,Yoshimori T.LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.EMBO J. 2000;19:5720-8.
8. Tassa A,Roux MP,Attaix D,Bechet DM.Class III phosphoinositide 3-kinase-Beclin1 complex mediates the amino acid-dependent regulation of autophagy in C2C12 myotubes.Biochem J. 2003;376:577-86.
9. Qu X,Yu J,Bhagat G,Furuya N,Hibshoosh H,Troxel A,Rosen J,Eskelinen EL,Mizushima N,Ohsumi Y,Cattoretti G,Levine B.Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene.J Clin Invest. 2003;112:1809-20.
10. McIntyre BS,Briski KP,Gapor A,Sylvester PW.Antiproliferative and apoptotic effects of tocopherols and tocotrienols on preneoplastic and neoplastic mouse mammary epithelial cells.Proc Soc Exp Biol Med. 2000;224:292-301.
11. McIntyre BS,Briski KP,Tirmenstein MA,Fariss MW,Gapor A,Sylvester PW.Antiproliferative and apoptotic effects of tocopherols and tocotrienols on normal mouse mammary epithelial cells.Lipids. 2000;35:171-80.
12. Sylvester PW,Kaddoumi A,Nazzal S,El Sayed KA.The value of tocotrienols in the prevention and treatment of cancer.J Am Coll Nutr. 2010;29:324 S-33 S.
13. Riedl SJ,Shi Y.Molecular mechanisms of caspase regulation during apoptosis.Nat Rev Mol Cell Biol. 2004;5:897-907.
14. Riedl SJ,Salvesen GS.The apoptosome: signalling platform of cell death.Nat Rev Mol Cell Biol. 2007;8:405-13.
15. Sylvester PW,Akl MR,Malaviya A,Parajuli P,Ananthula S,Tiwari RV,Ayoub NMBiofactors. 2013:.
16. Shah SJ,Sylvester PW.Gamma-tocotrienol inhibits neoplastic mammary epithelial cell proliferation by decreasing Akt and nuclear factor kappaB activity.Exp Biol Med. 2005;230:235-41.
17. Sylvester PWTrends in signal transduction research. Jennifer NM, ed. New York: Nove Science Publishers, Inc; 2007:173-90.
18. Rickmann M,Vaquero EC,Malagelada JR,Molero X.Tocotrienols induce apoptosis and autophagy in rat pancreatic stellate cells through the mitochondrial death pathway.Gastroenterology. 2007;132:2518-32.
19. Vaquero EC,Rickmann M,Molero X.Tocotrienols: balancing the mitochondrial crosstalk between apoptosis and autophagy.Autophagy. 2007;3:652-4.
20. Lekli I,Ray D,Mukherjee S,Gurusamy N,Ahsan MK,Juhasz B,Bak I,Tosaki A,Gherghiceanu M,Popescu LM,Das DK.Co-ordinated autophagy with resveratrol and gamma-tocotrienol confers synergetic cardioprotection.J Cell Mol Med. 2010;14:2506-18.
21. Jiang Q,Rao X,Kim CY,Freiser H,Zhang Q,Jiang Z,Li G.Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide.Int J Cancer. 2012;130:685-93.
22. Anderson LW,Danielson KG,Hosick HL.New cell line.Epithelial cell line and subline established from premalignant mouse mammary tissue. In Vitro. 1979;15:841-3.
23. Anderson LW,Danielson KG,Hosick HL.Metastatic potential of hyperplastic alveolar nodule derived mouse mammary tumor cells following intravenous inoculation.Eur J Cancer Clin Oncol. 1981;17:1001-8.
24. Danielson KG,Anderson LW,Hosick HL.Selection and characterization in culture of mammary tumor cells with distinctive growth properties in vivo.Cancer Res. 1980;40:1812-9.
25. Sylvester PWNew cell apoptosis research. Valentino RG, ed. New York: Nova Science Publisher, Inc; 2007:53-68.
26. Ayoub NM,Bachawal SV,Sylvester PW.Gamma-tocotrienol inhibits HGF-dependent mitogenesis and Met activation in highly malignant mammary tumour cells.Cell Prolif. 2011;44:516-26.
27. Shah S,Gapor A,Sylvester PW.Role of caspase-8 activation in mediating vitamin e-induced apoptosis in murine mammary cancer cells.Nutr Cancer. 2003;45:236-46.
28. Wali VB,Bachawal SV,Sylvester PW.Endoplasmic reticulum stress mediates gamma-tocotrienol-induced apoptosis in mammary tumor cells.Apoptosis. 2009;14:1366-77.
29. Biederbick A,Kern HF,Elsasser HP.Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles.Eur J Cell Biol. 1995;66:3-14.
30. Munafo DB,Colombo MI.A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation.J Cell Sci. 2001;114:3619-29.
31. Kanzawa T,Germano IM,Komata T,Ito H,Kondo Y,Kondo S.Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells.Cell Death Differ. 2004;11:448-57.
32. Bachawal SV,Wali VB,Sylvester PW.Combined gamma-tocotrienol and erlotinib/gefitinib treatment suppresses STAT and Akt signaling in murine mammary tumor cells.Anticancer Res. 2010;30:429-37.
33. Shirode AB,Sylvester PW.Mechanisms mediating the synergistic anticancer effects of combined gamma-tocotrienol and celecoxib treatment.J Bioanal Biomed. 2011;3:1-7.
34. Towbin H,Staehelin T,Gordon J.Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.Proc Natl Acad Sci U S A. 1979;76:4350-4.
35. Mizushima N,Levine B,Cuervo AM,Klionsky DJ.Autophagy fights disease through cellular self-digestion.Nature. 2008;451:1069-75.
36. Paglin S,Hollister T,Delohery T,Hackett N,McMahill M,Sphicas E,Domingo D,Yahalom J.A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles.Cancer Res. 2001;61:439-44.
37. Kihara A,Kabeya Y,Ohsumi Y,Yoshimori T.Beclin-phosphatidylinositol 3-kinase complex functions at the trans-golgi network.EMBO Rep. 2001;2:330-5.
38. Pattingre S,Tassa A,Qu X,Garuti R,Liang XH,Mizushima N,Packer M,Schneider MD,Levine B.Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy.Cell. 2005;122:927-39.
39. Yu L,Lenardo MJ,Baehrecke EH.Autophagy and caspases: a new cell death program.Cell Cycle. 2004;3:1124-6.
40. Colell A,Ricci JE,Tait S,Milasta S,Maurer U,Bouchier-Hayes L,Fitzgerald P,Guio-Carrion A,Waterhouse NJ,Li CW,Mari B,Barbry P,Newmeyer DD,Beere HM,Green DR.Gapdh and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation.Cell. 2007;129:983-97.
41. Raisova M,Hossini AM,Eberle J,Riebeling C,Wieder T,Sturm I,Daniel PT,Orfanos CE,Geilen CC.The Bax/Bcl-2 ratio determines the susceptibility of human melanoma cells to cd95/Fas-mediated apoptosis.J Invest Dermatol. 2001;117:333-40.
42. Scopa CD,Vagianos C,Kardamakis D,Kourelis TG,Kalofonos HP,Tsamandas AC.Bcl-2/Bax ratio as a predictive marker for therapeutic response to radiotherapy in patients with rectal cancer.Appl Immunohistochem Mol Morphol. 2001;9:329-34.
43. Perlman H,Zhang X,Chen MW,Walsh K,Buttyan R.An elevated Bax/Bcl-2 ratio corresponds with the onset of prostate epithelial cell apoptosis.Cell Death Differ. 1999;6:48-54.
44. Yin XM,Oltvai ZN,Korsmeyer SJ.Bh1 and Bh2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.Nature. 1994;369:321-23.
45. Reed JC.Dysregulation of apoptosis in cancer.J Clin Oncol. 1999;17:2941-53.
46. Kitada S,Krajewski S,Miyashita T,Krajewska M,Reed JC.Gamma-radiation induces upregulation of Bax protein and apoptosis in radiosensitive cells in vivo.Oncogene. 1996;12:187-92.
47. Sylvester PW,Shah SJ.Mechanisms mediating the antiproliferative and apoptotic effects of vitamin E in mammary cancer cells.Front Biosci. 2005;10:699-709.
48. Sylvester PW.Vitamin E and apoptosis.Vitam Horm. 2007;76:329-56.
49. Witton CJ,Reeves JR,Going JJ,Cooke TG,Bartlett JM.Expression of the HER1-4 family of receptor tyrosine kinases in breast cancer.J Pathol. 2003;200:290-7.
50. Singh BN,Kumar D,Shankar S,Srivastava RK.Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of pi3k/akt/mtor pathway in human pancreatic cancer stem cells.Biochem Pharmacol. 2012;84:1154-63.
51. Chiu HW,Fang WH,Chen YL,Wu MD,Yuan GF,Ho SY,Wang YJ.Monascuspiloin enhances the radiation sensitivity of human prostate cancer cells by stimulating endoplasmic reticulum stress and inducing autophagy.PLoS One. 2012;7:e40462-e40462.
52. Degtyarev M,De Maziere A,Orr C,Lin J,Lee BB,Tien JY,Prior WW,van Dijk S,Wu H,Gray DC,Davis DP,Stern HM,Murray LJ,Hoeflich KP,Klumperman J,Friedman LS,Lin K.Akt inhibition promotes autophagy and sensitizes pten-null tumors to lysosomotropic agents.J Cell Biol. 2008;183:101-16.
53. Gurpinar E,Grizzle WE,Shacka JJ,Mader BJ,Li N,Piazza NA,Russo S,Keeton AB,Piazza GA.A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagy.Mol Cancer Ther. 2013;12:663-74.
54. Galluzzi L,Maiuri MC,Vitale I,Zischka H,Castedo M,Zitvogel L,Kroemer G.Cell death modalities: classification and pathophysiological implications.Cell Death Differ. 2007;14:1237-43.