Co-ordinated autophagy with resveratrol and γ-tocotrienol confers synergetic cardioprotection

Journal of Cellular and Molecular Medicine

Volumn 14, Issue 10, 2010, Pages 2506-2518

  Lekli, Istvan ^a,b   Ray, Diptarka ^a   Mukherjee, Subhendu ^a   Gurusamy, Narasimman ^a   Ahsan, Md Kaimul ^a   Juhasz, Bela ^b   Bak, Istvan ^b   Tosaki, Arpad ^b   Gherghiceanu, Mihaela ^c   Popescu, Lawrence M ^c   Das, Dipak K ^a  

^a UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

Autophagy; Resveratrol; Tocotrienol

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; CARDIOTONIC AGENT; CHROMAN DERIVATIVE; DRUG DERIVATIVE; PLASTOCHROMANOL 8; RESVERATROL; STILBENE DERIVATIVE;

ANIMAL; APOPTOSIS; ARTICLE; AUTOPHAGY; COMPARATIVE STUDY; DRUG POTENTIATION; HEART INFARCTION; MALE; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; AUTOPHAGY; CARDIOTONIC AGENTS; CHROMANS; DRUG SYNERGISM; MALE; MYOCARDIAL INFARCTION; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SIGNAL TRANSDUCTION; STILBENES; VITAMIN E;

RATTUS; VITACEAE;

EID: 77958601200     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2009.00921.x     Document Type: Article

References (40)

1. Das DK, Maulik N. Resveratrol in cardioprotection: a therapeutic promise of alternative medicine. Mol Interv. 2006; 6: 36-47.
2. Goswami SK, Das DK. Resveratrol and chemoprevention. Cancer Lett. 2009; 18: 1-6.
3. Das DK, Sato M, Ray PS, et al Cardioprotection of red wine: role of polyphenolic antioxidants. Drugs Exp Clin Res. 1999; 25: 115-20.
4. Giovannini L, Migliori M, Longoni BM, et al Resveratrol, a polyphenol found in wine, reduces ischemia reperfusion injury in rat kidneys. J Cardiovasc Pharmacol. 2001; 37: 262-70.
5. Das S, Tosaki A, Bagchi D, et al Potentiation of a survival signal in the ischemic heart by resveratrol through p38 mitogen-activated protein kinase/mitogen- and stress-activated protein kinase 1/cAMP response element-binding protein signaling. J Pharmacol Exp Ther. 2006; 317: 980-8.
6. Raval AP, Lin HW, Dave KR, et al Resveratrol and ischemic preconditioning in the brain. Curr Med Chem. 2008; 15: 1545-51.
7. Bezstarosti K, Das S, Lamers JM, et al Differential proteomic profiling to study the mechanism of cardiac pharmacological preconditioning by resveratrol. J Cell Mol Med. 2006; 10: 896-907.
8. Dudley J, Das S, Mukherjee S, et al Resveratrol, a unique phytoalexin present in red wine, delivers either survival signal or death signal to the ischemic myocardium depending on dose. J Nutr Biochem. 2009; 20: 443-52.
9. Dudley JI, Lekli I, Mukherjee S, et al Does white wine qualify for French paradox? Comparison of the cardioprotective effects of red and white wines and their constituents: resveratrol, tyrosol, and hydroxytyrosol. J Agric Food Chem. 2008; 22: 9362-73.
10. Sen CK, Khanna S, Roy S. Tocotrienol: the natural vitamin E to defend the nervous system? Ann N Y Acad Sci. 2004; 1031: 127-42.
11. Das M, Das S, Wang P, et al Caveolin and proteasome in tocotrienol mediated myocardial protection. Cell Physiol Biochem. 2008; 22: 287-94.
12. Das S, Lekli I, Das M, et al Cardioprotection with palm oil tocotrienols: comparision of different isomers. Am J Physiol Heart Circ Physiol. 2008; 294: H970-8.
13. Opipari AW Jr, Tan L, Boitano AE, et al Resveratrol-induced autophagocytosis in ovarian cancer cells. Cancer Res. 2004; 64: 696-703.
14. Trincheri NF, Follo C, Nicotra G, et al Resveratrol-induced apoptosis depends on the lipid kinase activity of Vps34 and on the formation of autophagolysosomes. Carcinogenesis. 2008; 29: 381-9.
15. Rickmann M, Vaquero EC, Malagelada JR, et al Tocotrienols induce apoptosis and autophagy in rat pancreatic stellate cells through the mitochondrial death pathway. Gastroenterology. 2007; 132: 2518-32.
16. Yan L, Vatner DE, Kim SJ, et al Autophagy in chronically ischemic myocardium. Proc Natl Acad Sci USA. 2005; 102: 13807-12.
17. Lekli I, Szabo G, Juhasz B, et al Protective mechanisms of resveratrol against ischemia-reperfusion-induced damage in hearts obtained from Zucker obese rats: the role of GLUT-4 and endothelin. Am J Physiol Heart Circ Physiol. 2008; 294: H859-66.
18. Mukherjee S, Gangopadhyay H, Das DK. Broccoli: a unique vegetable that protects mammalian hearts through the redox cycling of the thioredoxin superfamily. J Agric Food Chem. 2008; 56: 609-17.
19. Eskelinen EL. To be or not to be? Examples of incorrect identification of autophagic compartments in conventional transmission electron microscopy of mammalian cells. Autophagy. 2008; 4: 257-60.
20. Klionsky DJ, Abeliovich H, Agostinis P, et al Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. 2008; 4: 151-75.
21. Gurusamy N, Lekli I, Gorbunov NV, et al Cardioprotection by adaptation to ischaemia augments autophagy in association with BAG-1 protein. J Cell Mol Med. 2009; 13: 373-87.
22. Hamacher-Brady A, Brady NR, Gottlieb RA. Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes. J Biol Chem. 2006; 281: 29776-87.
23. Yitzhaki S, Huang C, Liu W, et al Autophagy is required for preconditioning by the adenosine A1 receptor-selective agonist CCPA. Basic Res Cardiol. 2009; 104: 157-67.
24. Gurusamy N, Das DK. Autophagy, redox signaling and ventricular remodeling. Antioxid Redox Signal. 2009; 11: 1975-88.
25. Gottlieb RA, Finley KD, Mentzer RM Jr. Cardioprotection requires taking out the trash. Basic Res Cardiol. 2009; 104: 169-80.
26. Das S, Das DK. Resveratrol: a therapeutic promise for cardiovascular diseases. Recent Pat Cardiovasc Drug Discov. 2007; 2: 133-8.
27. Xi J, Wang H, Mueller RA, et al Mechanism for resveratrol-induced cardioprotection against reperfusion injury involves glycogen synthase kinase 3beta and mitochondrial permeability transition pore. Eur J Pharmacol. 2009; 604: 111-6.
28. Boya P, Kroemer G. Beclin 1: a BH3-only protein that fails to induce apoptosis. Oncogene. 2009; 28: 2125-7.
29. Zalckvar E, Berissi H, Eisenstein M, et al Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-X(L). Autophagy. 2009; 5: 720-2.
30. Matsui Y, Takagi H, Qu X, et al Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res. 2007; 100: 914-22.
31. Pimkina J, Humbey O, Zilfou JT, et al ARF induces autophagy by virtue of interaction with Bcl-xl. J Biol Chem. 2009; 284: 2803-10.
32. Scarlatti F, Maffei R, Beau I, et al Non-canonical autophagy: an exception or an underestimated form of autophagy? Autophagy. 2008; 4: 1083-5.
33. Kabeya Y, Mizushima N, Ueno T, et al LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 2000; 19: 5720-8.
34. Kadowaki M, Karim MR. Cytosolic LC3 ratio as a quantitative index of macroautophagy. Methods Enzymol. 2009; 452:199-213.
35. Karim MR, Kanazawa T, Daigaku Y, et al Cytosolic LC3 ratio as a sensitive index of macroautophagy in isolated rat hepatocytes and H4-II-E cells. Autophagy. 2007; 3: 553-60.
36. Ito S, Koshikawa N, Mochizuki S, et al 3-Methyladenine suppresses cell migration and invasion of HT1080 fibrosarcoma cells through inhibiting phosphoinositide 3-kinases independently of autophagy inhibition. Int J Oncol. 2007; 31: 261-8.
37. Itakura E, Kishi C, Inoue K, et al Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell. 2008; 19: 5360-72.
38. Seglen PO, Gordon PB. 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci USA. 1982; 79: 1889-92.
39. Stroikin Y, Dalen H, Loof S, et al Inhibition of autophagy with 3-methyladenine results in impaired turnover of lysosomes and accumulation of lipofuscin-like material. Eur J Cell Biol. 2004; 83: 583-90.
40. Gutierrez MG, Master SS, Singh SB, et al Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell. 2004; 119: 753-66.