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Volumn 47, Issue 12, 2012, Pages 1131-1141

Increased bioactive lipids content in human subcutaneous and epicardial fat tissue correlates with insulin resistance

Author keywords

Ceramide; Diabetes; Diacylglycerols; Long chain acyl CoA; Obesity

Indexed keywords

ACYL COENZYME A; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; MYRISTIC ACID; PALMITOLEIC ACID; SPHINGOLIPID; SULFONYLUREA; TRIACYLGLYCEROL;

EID: 84872263484     PISSN: 00244201     EISSN: 15589307     Source Type: Journal    
DOI: 10.1007/s11745-012-3722-x     Document Type: Article
Times cited : (53)

References (49)
  • 2
    • 0028787490 scopus 로고
    • A novel serum protein similar to C1q, produced exclusively in adipocytes
    • Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF (1995) A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 270:26746-26749
    • (1995) J Biol Chem , vol.270 , pp. 26746-26749
    • Scherer, P.E.1    Williams, S.2    Fogliano, M.3    Baldini, G.4    Lodish, H.F.5
  • 3
    • 0042025075 scopus 로고    scopus 로고
    • Expression of tumor necrosis factor (TNF)-alpha protein in the subcutaneous and visceral adipose tissue in correlation with adipocyte cell volume, serum TNF-alpha, soluble serum TNF-receptor-2 concentrations and C-peptide level
    • Winkler G, Kiss S, Keszthelyi L, Sápi Z, Ory I, Salamon F, Kovács M, Vargha P, Szekeres O, Speer G et al (2003) Expression of tumor necrosis factor (TNF)-alpha protein in the subcutaneous and visceral adipose tissue in correlation with adipocyte cell volume, serum TNF-alpha, soluble serum TNF-receptor-2 concentrations and C-peptide level. Eur J Endocrinol 149:129-135
    • (2003) Eur J Endocrinol , vol.149 , pp. 129-135
    • Winkler, G.1    Kiss, S.2    Keszthelyi, L.3    Sápi, Z.4    Ory, I.5    Salamon, F.6    Kovács, M.7    Vargha, P.8    Szekeres, O.9    Speer, G.10    Et Al.11
  • 4
    • 0022206133 scopus 로고
    • Lipids, diabetes, and coronary heart disease: Insights from the Framingham Study
    • Kannel WB (1985) Lipids, diabetes, and coronary heart disease: insights from the Framingham Study. Am Heart J 110:1100-1107
    • (1985) Am Heart J , vol.110 , pp. 1100-1107
    • Kannel, W.B.1
  • 5
    • 0026218111 scopus 로고
    • Obesity, fat distribution and cardiovascular disease
    • Larsson B (1991) Obesity, fat distribution and cardiovascular disease. Int J Obes 15(Suppl 2):53-57
    • (1991) Int J Obes , vol.15 , Issue.SUPPL. 2 , pp. 53-57
    • Larsson, B.1
  • 6
    • 34447515817 scopus 로고    scopus 로고
    • Epicardial adipose tissue as new cardio-metabolic risk marker and potential therapeutic target in the metabolic syndrome
    • Iacobellis G, Sharma AM (2007) Epicardial adipose tissue as new cardio-metabolic risk marker and potential therapeutic target in the metabolic syndrome. Curr Pharm Des 13:2180-2184
    • (2007) Curr Pharm Des , vol.13 , pp. 2180-2184
    • Iacobellis, G.1    Sharma, A.M.2
  • 8
    • 33845670428 scopus 로고    scopus 로고
    • Obesity and the heart: Redefinition of the relationship
    • Iacobellis G, Sharma AM (2007) Obesity and the heart: redefinition of the relationship. Obes Rev 8:35-39
    • (2007) Obes Rev , vol.8 , pp. 35-39
    • Iacobellis, G.1    Sharma, A.M.2
  • 9
    • 0034504237 scopus 로고    scopus 로고
    • Subcutaneous and visceral adipose tissue: Their relation to the metabolic syndrome
    • Wajchenberg BL (2000) Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 21: 697-738
    • (2000) Endocr Rev , vol.21 , pp. 697-738
    • Wajchenberg, B.L.1
  • 11
    • 6944237757 scopus 로고    scopus 로고
    • Adipokines: Inflammation and the pleiotropic role of white adipose tissue
    • Trayhurn P, Wood IS (2004) Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 92:347-355
    • (2004) Br J Nutr , vol.92 , pp. 347-355
    • Trayhurn, P.1    Wood, I.S.2
  • 13
    • 75549087688 scopus 로고    scopus 로고
    • Fat tissue and adiponectin: New players in critical care?
    • Owecki M (2009) Fat tissue and adiponectin: new players in critical care? Crit Care 13:174
    • (2009) Crit Care , vol.13 , pp. 174
    • Owecki, M.1
  • 14
    • 79955565366 scopus 로고    scopus 로고
    • Adipose tissue gene expression of adiponectin, tumor necrosis factor - A and leptin in metabolic syndrome patients with coronary artery disease
    • Gormez S, Demirkan A, Atalar F, Caynak B, Erdim R, Sozer V, Gunay D, Akpinar B, Ozbek U, Buyukdevrim AS (2011) Adipose tissue gene expression of adiponectin, tumor necrosis factor - a and leptin in metabolic syndrome patients with coronary artery disease. Intern Med 50:805-810
    • (2011) Intern Med , vol.50 , pp. 805-810
    • Gormez, S.1    Demirkan, A.2    Atalar, F.3    Caynak, B.4    Erdim, R.5    Sozer, V.6    Gunay, D.7    Akpinar, B.8    Ozbek, U.9    Buyukdevrim, A.S.10
  • 15
    • 34247556686 scopus 로고    scopus 로고
    • Adipose tissue as an endocrine organ
    • Ahima RS (2006) Adipose tissue as an endocrine organ. Obesity (Silver Spring) 14(Suppl 5):242S-249S
    • (2006) Obesity (Silver Spring) , vol.14 , Issue.SUPPL. 5
    • Ahima, R.S.1
  • 16
    • 0024820494 scopus 로고
    • Adipose tissue in the mammalian heart and pericardium: Structure, foetal development and biochemical properties
    • Marchington JM, Mattacks CA, Pond CM (1989) Adipose tissue in the mammalian heart and pericardium: structure, foetal development and biochemical properties. Comp Biochem Physiol B 94:225-232
    • (1989) Comp Biochem Physiol B , vol.94 , pp. 225-232
    • Marchington, J.M.1    Mattacks, C.A.2    Pond, C.M.3
  • 17
    • 0037184925 scopus 로고    scopus 로고
    • Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
    • Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, Bergeron R, Kim JK, Cushman SW, Cooney GJ et al (2002) Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 277:50230-50236
    • (2002) J Biol Chem , vol.277 , pp. 50230-50236
    • Yu, C.1    Chen, Y.2    Cline, G.W.3    Zhang, D.4    Zong, H.5    Wang, Y.6    Bergeron, R.7    Kim, J.K.8    Cushman, S.W.9    Cooney, G.J.10    Et Al.11
  • 18
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • Shulman GI (2000) Cellular mechanisms of insulin resistance. J Clin Invest 106:171-176
    • (2000) J Clin Invest , vol.106 , pp. 171-176
    • Shulman, G.I.1
  • 19
    • 46649108016 scopus 로고    scopus 로고
    • Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1
    • Shah C, Yang G, Lee I, Bielawski J, Hannun YA, Samad F (2008) Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1. J Biol Chem 283:13538-13548
    • (2008) J Biol Chem , vol.283 , pp. 13538-13548
    • Shah, C.1    Yang, G.2    Lee, I.3    Bielawski, J.4    Hannun, Y.A.5    Samad, F.6
  • 20
    • 31644443192 scopus 로고    scopus 로고
    • Ceramides in insulin resistance and lipotoxicity
    • Summers SA (2006) Ceramides in insulin resistance and lipotoxicity. Prog Lipid Res 45:42-72
    • (2006) Prog Lipid Res , vol.45 , pp. 42-72
    • Summers, S.A.1
  • 22
    • 3543141882 scopus 로고    scopus 로고
    • Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation
    • Augé N, Maupas-Schwalm F, Elbaz M, Thiers JC, Waysbort A, Itohara S, Krell HW, Salvayre R, Nègre-Salvayre A (2004) Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation. Circulation 110:571-578
    • (2004) Circulation , vol.110 , pp. 571-578
    • Augé, N.1    Maupas-Schwalm, F.2    Elbaz, M.3    Thiers, J.C.4    Waysbort, A.5    Itohara, S.6    Krell, H.W.7    Salvayre, R.8    Nègre-Salvayre, A.9
  • 23
    • 0342656966 scopus 로고    scopus 로고
    • Sphingomyelin metabolites in vascular cell signaling and atherogenesis
    • Augé N, Nègre-Salvayre A, Salvayre R, Levade T (2000) Sphingomyelin metabolites in vascular cell signaling and atherogenesis. Prog Lipid Res 39:207-229
    • (2000) Prog Lipid Res , vol.39 , pp. 207-229
    • Augé, N.1    Nègre-Salvayre, A.2    Salvayre, R.3    Levade, T.4
  • 24
    • 15444367538 scopus 로고    scopus 로고
    • Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice
    • Hojjati MR, Li Z, Zhou H, Tang S, Huan C, Ooi E, Lu S, Jiang XC (2005) Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice. J Biol Chem 280: 10284-10289
    • (2005) J Biol Chem , vol.280 , pp. 10284-10289
    • Hojjati, M.R.1    Li, Z.2    Zhou, H.3    Tang, S.4    Huan, C.5    Ooi, E.6    Lu, S.7    Jiang, X.C.8
  • 27
    • 84870299468 scopus 로고    scopus 로고
    • Sphingolipid content of human adipose tissue: Relationship to adiponectin and insulin resistance
    • doi:10.1038/oby.2012.126
    • Blachnio-Zabielska AU, Koutsari C, Tchkonia T, Jensen MD (2012) Sphingolipid content of human adipose tissue: relationship to adiponectin and insulin resistance. Obesity. doi:10.1038/oby.2012.126
    • (2012) Obesity
    • Blachnio-Zabielska, A.U.1    Koutsari, C.2    Tchkonia, T.3    Jensen, M.D.4
  • 28
    • 0029853098 scopus 로고    scopus 로고
    • Lipid mediators of insulin resistance: Ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes
    • Long SD, Pekala PH (1996) Lipid mediators of insulin resistance: ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes. Biochem J 319(Pt 1):179-184
    • (1996) Biochem J , vol.319 , Issue.PART 1 , pp. 179-184
    • Long, S.D.1    Pekala, P.H.2
  • 29
    • 84860497397 scopus 로고    scopus 로고
    • Diacylglycerol activation of protein kinase Ce and hepatic insulin resistance
    • Jornayvaz FR, Shulman GI (2012) Diacylglycerol activation of protein kinase Ce and hepatic insulin resistance. Cell Metab 15: 574-584
    • (2012) Cell Metab , vol.15 , pp. 574-584
    • Jornayvaz, F.R.1    Shulman, G.I.2
  • 30
    • 77956818284 scopus 로고    scopus 로고
    • Rapid measurement of plasma free fatty acid concentration and isotopic enrichment using LC/MS
    • Persson XM, Blachnio-Zabielska AU, Jensen MD (2010) Rapid measurement of plasma free fatty acid concentration and isotopic enrichment using LC/MS. J Lipid Res 51:2761-2765
    • (2010) J Lipid Res , vol.51 , pp. 2761-2765
    • Persson, X.M.1    Blachnio-Zabielska, A.U.2    Jensen, M.D.3
  • 31
    • 84859233338 scopus 로고    scopus 로고
    • A liquid chromatography/tandem mass spectrometry method for measuring the in vivo incorporation of plasma free fatty acids into intramyocellular ceramides in humans
    • Blachnio-Zabielska AU, Persson XM, Koutsari C, Zabielski P, Jensen MD (2012) A liquid chromatography/tandem mass spectrometry method for measuring the in vivo incorporation of plasma free fatty acids into intramyocellular ceramides in humans. Rapid Commun Mass Spectrom 26:1134-1140
    • (2012) Rapid Commun Mass Spectrom , vol.26 , pp. 1134-1140
    • Blachnio-Zabielska, A.U.1    Persson, X.M.2    Koutsari, C.3    Zabielski, P.4    Jensen, M.D.5
  • 32
    • 80052787429 scopus 로고    scopus 로고
    • Measuring long-chain acyl-coenzyme A concentrations and enrichment using liquid chromatography/tandem mass spectrometry with selected reaction monitoring
    • Blachnio-Zabielska AU, Koutsari C, Jensen MD (2011) Measuring long-chain acyl-coenzyme A concentrations and enrichment using liquid chromatography/tandem mass spectrometry with selected reaction monitoring. Rapid Commun Mass Spectrom 25:2223-2230
    • (2011) Rapid Commun Mass Spectrom , vol.25 , pp. 2223-2230
    • Blachnio-Zabielska, A.U.1    Koutsari, C.2    Jensen, M.D.3
  • 34
    • 77956040410 scopus 로고    scopus 로고
    • Saturated- and n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: Reversal and improvement of glucose tolerance by lipid metabolism inhibitors
    • Frangioudakis G, Garrard J, Raddatz K, Nadler JL, Mitchell TW, Schmitz-Peiffer C (2010) Saturated- and n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: reversal and improvement of glucose tolerance by lipid metabolism inhibitors. Endocrinology 151:4187-4196
    • (2010) Endocrinology , vol.151 , pp. 4187-4196
    • Frangioudakis, G.1    Garrard, J.2    Raddatz, K.3    Nadler, J.L.4    Mitchell, T.W.5    Schmitz-Peiffer, C.6
  • 36
    • 77957740947 scopus 로고    scopus 로고
    • Effect of high fat diet enriched with unsaturated and diet rich in saturated fatty acids on sphingolipid metabolism in rat skeletal muscle
    • Blachnio-Zabielska A, Baranowski M, Zabielski P, Gorski J (2010) Effect of high fat diet enriched with unsaturated and diet rich in saturated fatty acids on sphingolipid metabolism in rat skeletal muscle. J Cell Physiol 225:786-791
    • (2010) J Cell Physiol , vol.225 , pp. 786-791
    • Blachnio-Zabielska, A.1    Baranowski, M.2    Zabielski, P.3    Gorski, J.4
  • 37
    • 79955932521 scopus 로고    scopus 로고
    • Aerobic training in rats increases skeletal muscle sphin-gomyelinase and serine palmitoyltransferase activity. While decreasing ceramidase activity
    • Blachnio-Zabielska A, Zabielski P, Baranowski M, Gorski J (2011) Aerobic training in rats increases skeletal muscle sphin-gomyelinase and serine palmitoyltransferase activity. While decreasing ceramidase activity. Lipids 46:229-238
    • (2011) Lipids , vol.46 , pp. 229-238
    • Blachnio-Zabielska, A.1    Zabielski, P.2    Baranowski, M.3    Gorski, J.4
  • 38
    • 73949140458 scopus 로고    scopus 로고
    • Effects of streptozotocin-induced diabetes and elevation of plasma FFA on ceramide metabolism in rat skeletal muscle
    • Blachnio-Zabielska A, Zabielski P, Baranowski M, Gorski J (2010) Effects of streptozotocin-induced diabetes and elevation of plasma FFA on ceramide metabolism in rat skeletal muscle. Horm Metab Res 42:1-7
    • (2010) Horm Metab Res , vol.42 , pp. 1-7
    • Blachnio-Zabielska, A.1    Zabielski, P.2    Baranowski, M.3    Gorski, J.4
  • 39
    • 54849442052 scopus 로고    scopus 로고
    • Effect of exercise duration on the key pathways of cera-mide metabolism in rat skeletal muscles
    • Blachnio-Zabielska A, Baranowski M, Zabielski P, Gorski J (2008) Effect of exercise duration on the key pathways of cera-mide metabolism in rat skeletal muscles. J Cell Biochem 105: 776-784
    • (2008) J Cell Biochem , vol.105 , pp. 776-784
    • Blachnio-Zabielska, A.1    Baranowski, M.2    Zabielski, P.3    Gorski, J.4
  • 40
    • 0026623508 scopus 로고
    • Transcriptional repression of the C/EBP-alpha and GLUT4 genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is coordinate and independent of protein synthesis
    • Stephens JM, Pekala PH (1992) Transcriptional repression of the C/EBP-alpha and GLUT4 genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is coordinate and independent of protein synthesis. J Biol Chem 267:13580-13584
    • (1992) J Biol Chem , vol.267 , pp. 13580-13584
    • Stephens, J.M.1    Pekala, P.H.2
  • 41
    • 0025837140 scopus 로고
    • Transcriptional repression of the GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha
    • Stephens JM, Pekala PH (1991) Transcriptional repression of the GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. J Biol Chem 266:21839-21845
    • (1991) J Biol Chem , vol.266 , pp. 21839-21845
    • Stephens, J.M.1    Pekala, P.H.2
  • 45
    • 0037135626 scopus 로고    scopus 로고
    • The ceramide-centric universe of lipid-mediated cell regulation: Stress encounters of the lipid kind
    • Hannun YA, Obeid LM (2002) The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J Biol Chem 277:25847-25850
    • (2002) J Biol Chem , vol.277 , pp. 25847-25850
    • Hannun, Y.A.1    Obeid, L.M.2
  • 46
    • 33845336495 scopus 로고    scopus 로고
    • Ceramides and other bioactive sphingolipid backbones in health and disease: Lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy
    • Zheng W, Kollmeyer J, Symolon H, Momin A, Munter E, Wang E, Kelly S, Allegood JC, Liu Y, Peng Q et al (2006) Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy. Biochim Biophys Acta 1758: 1864-1884
    • (2006) Biochim Biophys Acta , vol.1758 , pp. 1864-1884
    • Zheng, W.1    Kollmeyer, J.2    Symolon, H.3    Momin, A.4    Munter, E.5    Wang, E.6    Kelly, S.7    Allegood, J.C.8    Liu, Y.9    Peng, Q.10    Et Al.11
  • 47
    • 34347361561 scopus 로고    scopus 로고
    • Crocetin attenuates palmitate-induced insulin insensitivity and disordered tumor necrosis factor-alpha and adiponectin expression in rat adipocytes
    • Xi L, Qian Z, Xu G, Zhou C, Sun S (2007) Crocetin attenuates palmitate-induced insulin insensitivity and disordered tumor necrosis factor-alpha and adiponectin expression in rat adipocytes. Br J Pharmacol 151:610-617
    • (2007) Br J Pharmacol , vol.151 , pp. 610-617
    • Xi, L.1    Qian, Z.2    Xu, G.3    Zhou, C.4    Sun, S.5
  • 49
    • 77950543816 scopus 로고    scopus 로고
    • Diacylglycerol-mediated insulin resistance
    • Erion DM, Shulman GI (2010) Diacylglycerol-mediated insulin resistance. Nat Med 16:400-402
    • (2010) Nat Med , vol.16 , pp. 400-402
    • Erion, D.M.1    Shulman, G.I.2


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