Altered inactivation of commensal LPS due to acyloxyacyl hydrolase deficiency in colonic dendritic cells impairs mucosal Th17 immunity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 1, 2014, Pages 373-378

  Janelsins, Brian M ^a   Lu, Mingfang ^a,b   Datta, Sandip K ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b FUDAN UNIVERSITY   (China)

Author keywords

Endotoxin tolerance; Gut immunity; Oral immunization; T cell polarization; Toll like receptor

Indexed keywords

ACYLOXYACYL HYDROLASE; HYDROLASE; LIPOPOLYSACCHARIDE; UNCLASSIFIED DRUG;

ACYLOXYACYL HYDROLASE DEFICIENCY; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELLULAR IMMUNITY; COLON MUCOSA; COMMENSAL; CONTROLLED STUDY; DENDRITIC CELL; ENZYME DEFICIENCY; GRAM NEGATIVE BACTERIUM; INTESTINE FLORA; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; TH17 CELL;

ENDOTOXIN TOLERANCE; GUT IMMUNITY; ORAL IMMUNIZATION; T CELL POLARIZATION; TOLL-LIKE RECEPTOR;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD; ANTIGENS, CD11B; BONE MARROW CELLS; CARBOXYLIC ESTER HYDROLASES; CD4-POSITIVE T-LYMPHOCYTES; COLON; DENDRITIC CELLS; ENDOTOXINS; FEMALE; FLOW CYTOMETRY; INFLAMMATION; INTEGRIN ALPHA CHAINS; INTERLEUKIN-6; INTESTINAL MUCOSA; LIPOPOLYSACCHARIDES; LUNG; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENOTYPE; RECOMBINANT PROTEINS; T-LYMPHOCYTES; TH17 CELLS; TOLL-LIKE RECEPTORS;

EID: 84891917667     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1311987111     Document Type: Article

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