Mice deficient in Sfrp1 exhibit increased adiposity, dysregulated glucose metabolism, and enhanced macrophage infiltration

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Gauger, Kelly J ^a,b   Bassa, Lotfi M ^b   Henchey, Elizabeth M ^a   Wyman, Josephine ^a   Bentley, Brooke ^a   Brown, Melissa ^b   Shimono, Akihiko ^c   Schneider, Sallie S ^a,b  

^a BAYSTATE MEDICAL CENTER   (United States)

^b UNIVERSITY OF MASSACHUSETTS   (United States)

^c Trans Genic   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; GLUCOSE TRANSPORTER 2; GLUCOSE TRANSPORTER 4; INTERLEUKIN 6; MESSENGER RNA; PROTEIN NMNAT; SECRETED FRIZZLED RELATED PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CHREB; TRANSCRIPTION FACTOR LXR ALPHA; TRANSCRIPTION FACTOR NR1H3; TRANSCRIPTION FACTOR SREBPF1; TRANSFORMING GROWTH FACTOR BETA2; UNCLASSIFIED DRUG; CYTOKINE; GLUCOSE; GLUCOSE TRANSPORTER; INSULIN; MEMBRANE PROTEIN; SFRP1 PROTEIN, MOUSE; SIGNAL PEPTIDE;

ACACA GENE; ACLY GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; BODY MASS; CONTROLLED STUDY; ELOVL GENE; FASN GENE; FATTY LIVER; FEMALE; G6PC GENE; GENE EXPRESSION; GLUCONEOGENESIS; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; INFLAMMATION; INSULIN RELEASE; LIPID DIET; LIPOGENESIS; MACROPHAGE FUNCTION; MACROPHAGE INFILTRATION; MOUSE; NONHUMAN; OBESITY; PCK1 GENE; PROTEIN EXPRESSION; SCD1 GENE; SLC2A2 GENE; SLC2A4 GENE; SREBPF1 GENE; TISSUE EXPANSION; UPREGULATION; WEIGHT GAIN; WHITE ADIPOSE TISSUE; ANIMAL; BODY WEIGHT; CYTOLOGY; DEFICIENCY; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMAN; IMMUNOLOGY; MACROPHAGE; METABOLISM; OVARY; PATHOLOGY; SECRETION (PROCESS); UDDER;

ADIPOSE TISSUE, WHITE; ADIPOSITY; ANIMALS; BODY WEIGHT; CYTOKINES; DIET, HIGH-FAT; FATTY LIVER; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOSE; GLUCOSE TRANSPORT PROTEINS, FACILITATIVE; HOMEOSTASIS; HUMANS; INSULIN; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPOGENESIS; MACROPHAGES; MAMMARY GLANDS, ANIMAL; MEMBRANE PROTEINS; MICE; OBESITY; OVARY;

EID: 84891914472     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0078320     Document Type: Article

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