In vivo function of a differentiation inhibitor, Id2

IUBMB Life

Volumn 51, Issue 4, 2001, Pages 207-214

  Yokota, Y ^a   Mori, S ^a   Narumi, O ^a   Kitajima, K ^a  

^a UNIVERSITY OF FUKUI   (Japan)

Author keywords

Basic helix loop helix transcription factor; Differentiation; Helix loop helix protein; Id2; Mammary epithelial cells; Natural killer cells; Proliferation

Indexed keywords

HELIX LOOP HELIX PROTEIN; INHIBITOR OF DIFFERENTIATION 2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

CELL DIFFERENTIATION; CELL TYPE; IN VIVO STUDY; NONHUMAN; PHENOTYPE; PROTEIN FAMILY; PROTEIN MOTIF; REGULATORY MECHANISM; REVIEW; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION;

ANIMALS; CELL DIFFERENTIATION; DNA-BINDING PROTEINS; FEMALE; HELIX-LOOP-HELIX MOTIFS; INHIBITOR OF DIFFERENTIATION PROTEIN 2; KILLER CELLS, NATURAL; LYMPHOID TISSUE; MAMMARY GLANDS, ANIMAL; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; PHENOTYPE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, RETINOIC ACID; RECEPTORS, THYROID HORMONE; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS;

EID: 0034844151     PISSN: 15216543     EISSN: None     Source Type: Journal    
DOI: 10.1080/152165401753311744     Document Type: Review

References (39)

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3. bHLH factors in muscle development: Dead lines and commitments, what to leave in and what to leave out
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7. Regulation of Gl progression by E2A and Id helix-loop-helix proteins
8. Regulation of the expression of cyclin-dependent kinase inhibitor p21 by E2A and Id proteins
9. The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein
10. Id2 specifically alters regulation of the cell cycle by tumor suppressor proteins
11. Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2
12. Lactation defect in mice lacking the helix-loop-helix inhibitor Id2
13. The helix-loop-helix inhibitor Id2 and cell differentiation control
14. Id2 is a Retinoblastoma protein target and mediates signalling by Myc oncoproteins
15. Commitment to natural killer cells requires the helix-loop-helix inhibitor Id2
16. Development and maturation of secondary lymphoid tissues
17. Alymphoplasia is caused by a point mutation in the mouse gene encoding NF-κB-inducing kinase
18. + cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells
19. − cells in the embryonic intestine induces the organizing center of Peyer's patches
20. − cells are found in fetal liver
21. The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens
22. Early T lymphocyte progenitors
23. Commitment of common T/natural killer (NK) progenitors to unipotent T and NK progenitors in the murine fetal thymus revealed by a single progenitor assay
24. B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2 and HEB
25. E2A deficiency leads to abnormalities in αβ T-cell development and to rapid development of T-cell lymphomas
26. Functional replacement of the mouse E2A gene with a human HEB cDNA
27. Massive apoptosis of thymocytes in T-cell-deficient Id1 transgenic mice
28. Overexpression of the Helix-Loop-Helix protein Id2 blocks T cell development at multiple stages
29. Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3
30. Disruption of αβ but not of γδ T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors
31. Requirement for membrane lymphotoxin in natural killer cell development
32. Multiple deficiencies underlie NK cell inactivity in lymphotoxin-α gene-targeted mice
33. Requirement for RORγ in thymocyte survival and lymphoid organ development
34. Retinoid-related orphan receptor gamma (RORγ) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis
35. Think globally, act locally: The making of a mouse mammary gland
36. Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumor xenografts
37. The Rb/E2F pathway: Expanding roles and emerging paradigms
38. The helix-loop-helix protein Id2 is overexpressed in human pancreatic cancer