Association of the gene encoding wingless-type mammary tumor virus integration-site family member 5B (WNT5B) with type 2 diabetes

American Journal of Human Genetics

Volumn 75, Issue 5, 2004, Pages 832-843

  Kanazawa, Akio ^a   Tsukada, Syuuichi ^a   Sekine, Akihiro ^a   Tsunoda, Tatsuhiko ^a   Takahashi, Atsushi ^a   Kashiwagi, Atsunori ^b   Tanaka, Yasushi ^c   Babazono, Tetsuya ^d   Matsuda, Masafumi ^f   Kaku, Kohei ^f   Iwamoto, Yasuhiko ^d   Kawamori, Ryuzo ^c   Kikkawa, Ryuichi ^b   Nakamura, Yusuke ^a,e   Maeda, Shiro ^a  

^a INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^b SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^c JUNTENDO UNIVERSITY   (Japan)

^d TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

^f KAWASAKI MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

WNT PROTEIN;

ALLELE; ANIMAL MODEL; ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE PREDISPOSITION; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC CODE; GENETIC IDENTIFICATION; GENETIC STRAIN; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; PROADIPOCYTE; PROMOTER REGION; SIGNAL TRANSDUCTION; STATISTICAL ANALYSIS; VIRUS DNA CELL DNA INTERACTION;

ANIMALIA;

EID: 6344281175     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/425340     Document Type: Article

References (23)

1. Altshuler D, Hirschhorn JN, Klannemark M, Lindgren CM, Vohl MC, Nemesh J, Lane CR, Schaffner SF, Bolk S, Brewer C, Tuomi T, Gaudet D, Hudson TJ, Daly M, Groop L, Lander ES (2000) The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 26:76-80
2. Bennett CN, Ross SE, Longo KA, Bajnok L, Hemati N, Johnson KW, Harrison SD, MacDougald OA (2002) Regulation of Wnt signaling during adipogenesis. J Biol Chem 277:30998-31004
3. Cordell HJ, Clayton DG (2002) A unified stepwise regression procedure for evaluating the relative effects of polymorphisms within a gene using case/control or family data: application to HLA in type 1 diabetes. Am J Hum Genet 70:124-141
4. Devlin B, Risch N (1995) A comparison of linkage disequilibrium measures for fine-scale mapping. Genomics 29:311-322
5. Excoffier L, Slatkin M (1995) Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Mol Biol Evol 12:921-927
6. Fujino T, Asaba H, Kang MJ, Ikeda Y, Sone H, Takada S, Kim DH, Ioka RX, Ono M, Tomoyori H, Okubo M, Murase T, Kamataki A, Yamamoto J, Magoori K, Takahashi S, Miyamoto Y, Oishi H, Nose M, Okazaki M, Usui S, Imaizumi K, Yanagisawa M, Sakai J, Yamamoto TT (2003) Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. Proc Natl Acad Sci USA 100:229-234
7. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D (2002) The structure of haplotype blocks in the human genome. Science 296:2225-2229
8. Hara K, Boutin P, Mori Y, Tobe K, Dina C, Yasuda K, Yamauchi T, Otabe S, Okada T, Eto K, Kadowaki H, Hagura R, Akanuma Y, Yazaki Y, Nagai R, Taniyama M, Matsubara K, Yoda M, Nakano Y, Tomita M, Kimura S, Ito C, Froguel P, Kadowaki T (2002) Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 51:536-540
9. Hirakawa M, Tanaka T, Hashimoto Y, Kuroda M, Takagi T, Nakamura Y (2002) JSNP: a database of common gene variations in the Japanese population. Nucleic Acids Res 30:158-162
10. Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M, Hinokio Y, et al (2000) Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet 26:163-175
11. Jamali M, Rogerson PJ, Wilton S, Skerjanc IS (2001) Nkx2-5 activity is essential for cardiomyogenesis. J Biol Chem 276:42252-42258
12. Kahn BB (1998) Type 2 diabetes: when insulin secretion fails to compensate for insulin resistance. Cell 92:593-596
13. Kishida K, Shimomura I, Kondo H, Kuriyama H, Makino Y, Nishizawa H, Maeda N, Matsuda M, Ouchi N, Kihara S, Kurachi Y, Funahashi T, Matsuzawa Y (2001) Genomic structure and insulin-mediated repression of the aquaporin adipose (AQPap), adipose-specific glycerol channel. J Biol Chem 276:36251-36260
14. Longo KA, Kennell JA, Ochocinska MJ, Ross SE, Wright WS, MacDougald OA (2002) Wnt signaling protects 3T3-L1 pre-adipocytes from apoptosis through induction of insulin-like growth factors. J Biol Chem 277:38239-38244
15. Nielsen DM, Ehm MG, Weir BS (1998) Detecting marker-disease association by testing for Hardy-Weinberg disequilibrium at a marker locus. Am J Hum Genet 63:1531-1540
16. Ohnishi Y, Tanaka T, Ozaki K, Yamada R, Suzuki H, Nakamura Y (2001 ) A high-throughput SNP typing system for genome-wide association studies. J Hum Genet 46:471-477
17. Ross SE, Hemati N, Longo KA, Bennett CN, Lucas PC, Erickson RL, MacDougald OA (2000) Inhibition of adipogenesis by Wnt signaling. Science 289:950-953
18. Saito S, Iida A, Sekine A, Miura Y, Sakamoto T, Ogawa C, Kawauchi S, Higuchi S, Nakamura Y (2001) Identification of 197 genetic variations in six human methyltranferase genes in the Japanese population. J Hum Genet 46:529-537
19. Saitoh T, Katoh M (2001) Molecular cloning and characterization of human WNT5B on chromosome 12p13.3 region. Int J Oncol 19:347-351
20. Su F, Overholtzer M, Besser D, Levine AJ (2002) WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. Genes Dev 16:46-57
21. Tanaka N, Babazono T, Saito S, Sekine A, Tsunoda T, Haneda M, Tanaka Y, Fujioka T, Kaku K, Kawamori R, Kikkawa R, Iwamoto Y, Nakamura Y, Maeda S (2003) Association of solute carrier family 12 (sodium/chloride) member 3 with diabetic nephropathy, identified by genome-wide analyses of single nucleotide polymorphisms. Diabetes 52:2848-2853
22. Weir BS (1996) Genetic Data Analysis II. Sinauer Associates, Sunderland, Massachusetts
23. Yang Y, Topol L, Lee H, Wu J (2003) Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation. Development 130:1003-1015