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Volumn 11, Issue 6, 2009, Pages

Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CYCLIN DEPENDENT KINASE INHIBITOR 2A; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; SECRETED FRIZZLED RELATED PROTEIN 1; TELOMERASE; MEMBRANE PROTEIN; RASSF1 PROTEIN, HUMAN; SFRP1 PROTEIN, HUMAN; SIGNAL PEPTIDE; TUMOR SUPPRESSOR PROTEIN;

EID: 77954609358     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr2457     Document Type: Article
Times cited : (25)

References (45)
  • 2
    • 0021742115 scopus 로고
    • Human malignant tumours of the breast, as compared to their respective normal tissue, have elevated expression of the Harvey ras oncogene
    • Spandidos DA, Agnantis NJ. Human malignant tumours of the breast, as compared to their respective normal tissue, have elevated expression of the Harvey ras oncogene. Anticancer Res 1984, 4:269-272.
    • (1984) Anticancer Res , vol.4 , pp. 269-272
    • Spandidos, D.A.1    Agnantis, N.J.2
  • 3
    • 0023189452 scopus 로고
    • Quantitation of Harvey ras p21 enhanced expression in human breast and colon carcinomas
    • Hand PH, Vilasi V, Thor A, Ohuchi N, Schlom J. Quantitation of Harvey ras p21 enhanced expression in human breast and colon carcinomas. J Natl Cancer Inst 1987, 79:59-65.
    • (1987) J Natl Cancer Inst , vol.79 , pp. 59-65
    • Hand, P.H.1    Vilasi, V.2    Thor, A.3    Ohuchi, N.4    Schlom, J.5
  • 4
    • 0024553109 scopus 로고
    • Evidence of enhancement of the ras oncogene protein product (p21) in a spectrum of human tumors
    • 10.1002/ijc.2910430315, 2784420
    • De Biasi F, Del Sal G, Hand PH. Evidence of enhancement of the ras oncogene protein product (p21) in a spectrum of human tumors. Int J Cancer 1989, 43:431-435. 10.1002/ijc.2910430315, 2784420.
    • (1989) Int J Cancer , vol.43 , pp. 431-435
    • De Biasi, F.1    Del Sal, G.2    Hand, P.H.3
  • 5
    • 0022597111 scopus 로고
    • Expression of the 21,000 molecular weight ras protein in a spectrum of benign and malignant human mammary tissues
    • Ohuchi N, Thor A, Page DL, Hand PH, Halter SA, Schlom J. Expression of the 21,000 molecular weight ras protein in a spectrum of benign and malignant human mammary tissues. Cancer Res 1986, 46:2511-2519.
    • (1986) Cancer Res , vol.46 , pp. 2511-2519
    • Ohuchi, N.1    Thor, A.2    Page, D.L.3    Hand, P.H.4    Halter, S.A.5    Schlom, J.6
  • 6
    • 48849083854 scopus 로고    scopus 로고
    • Silent assassin: oncogenic ras directs epigenetic inactivation of target genes
    • 10.1126/stke.113pe14, 18385037
    • Cheng X. Silent assassin: oncogenic ras directs epigenetic inactivation of target genes. Sci Signal 2008, 1:pe14. 10.1126/stke.113pe14, 18385037.
    • (2008) Sci Signal , vol.1
    • Cheng, X.1
  • 8
    • 33746033715 scopus 로고    scopus 로고
    • Pattern of expression of genes linked to epigenetic silencing in human breast cancer
    • 10.1016/j.humpath.2006.04.013, 16867861
    • Munot K, Bell SM, Lane S, Horgan K, Hanby AM, Speirs V. Pattern of expression of genes linked to epigenetic silencing in human breast cancer. Hum Pathol 2006, 37:989-999. 10.1016/j.humpath.2006.04.013, 16867861.
    • (2006) Hum Pathol , vol.37 , pp. 989-999
    • Munot, K.1    Bell, S.M.2    Lane, S.3    Horgan, K.4    Hanby, A.M.5    Speirs, V.6
  • 10
    • 47249164378 scopus 로고    scopus 로고
    • Epigenetic inactivation of the Secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosis
    • 10.1093/carcin/bgn076, 18356147
    • Veeck J, Geisler C, Noetzel E, Alkaya S, Hartmann A, Knuchel R, Dahl E. Epigenetic inactivation of the Secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosis. Carcinogenesis 2008, 29:991-998. 10.1093/carcin/bgn076, 18356147.
    • (2008) Carcinogenesis , vol.29 , pp. 991-998
    • Veeck, J.1    Geisler, C.2    Noetzel, E.3    Alkaya, S.4    Hartmann, A.5    Knuchel, R.6    Dahl, E.7
  • 12
    • 0242677806 scopus 로고    scopus 로고
    • DNA methylation of RASSF1A, HIN-1, RAR-beta, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma
    • 10.1002/ijc.11508, 14601057
    • Fackler MJ, McVeigh M, Evron E, Garrett E, Mehrotra J, Polyak K, Sukumar S, Argani P. DNA methylation of RASSF1A, HIN-1, RAR-beta, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma. Int J Cancer 2003, 107:970-975. 10.1002/ijc.11508, 14601057.
    • (2003) Int J Cancer , vol.107 , pp. 970-975
    • Fackler, M.J.1    McVeigh, M.2    Evron, E.3    Garrett, E.4    Mehrotra, J.5    Polyak, K.6    Sukumar, S.7    Argani, P.8
  • 13
    • 67549095233 scopus 로고    scopus 로고
    • Methylation of homeobox genes is a frequent and early epigenetic event in breast cancer
    • 10.1186/bcr2233, 2687719, 19250546
    • Tommasi S, Karm DL, Wu X, Yen Y, Pfeifer GP. Methylation of homeobox genes is a frequent and early epigenetic event in breast cancer. Breast Cancer Res 2009, 11:R14. 10.1186/bcr2233, 2687719, 19250546.
    • (2009) Breast Cancer Res , vol.11
    • Tommasi, S.1    Karm, D.L.2    Wu, X.3    Yen, Y.4    Pfeifer, G.P.5
  • 14
    • 1642503735 scopus 로고    scopus 로고
    • Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program
    • 10.1016/S1535-6108(04)00023-6, 15050918
    • Crawford YG, Gauthier ML, Joubel A, Mantei K, Kozakiewicz K, Afshari CA, Tlsty TD. Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program. Cancer Cell 2004, 5:263-273. 10.1016/S1535-6108(04)00023-6, 15050918.
    • (2004) Cancer Cell , vol.5 , pp. 263-273
    • Crawford, Y.G.1    Gauthier, M.L.2    Joubel, A.3    Mantei, K.4    Kozakiewicz, K.5    Afshari, C.A.6    Tlsty, T.D.7
  • 15
    • 0035252089 scopus 로고    scopus 로고
    • Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes
    • 10.1038/35054579, 11214324
    • Romanov SR, Kozakiewicz BK, Holst CR, Stampfer MR, Haupt LM, Tlsty TD. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes. Nature 2001, 409:633-637. 10.1038/35054579, 11214324.
    • (2001) Nature , vol.409 , pp. 633-637
    • Romanov, S.R.1    Kozakiewicz, B.K.2    Holst, C.R.3    Stampfer, M.R.4    Haupt, L.M.5    Tlsty, T.D.6
  • 17
    • 33644979481 scopus 로고    scopus 로고
    • P16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells
    • 10.1371/journal.pbio.0040051, 1361797, 16464125
    • McDermott KM, Zhang J, Holst CR, Kozakiewicz BK, Singla V, Tlsty TD. p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells. PLoS Biol 2006, 4:e51. 10.1371/journal.pbio.0040051, 1361797, 16464125.
    • (2006) PLoS Biol , vol.4
    • McDermott, K.M.1    Zhang, J.2    Holst, C.R.3    Kozakiewicz, B.K.4    Singla, V.5    Tlsty, T.D.6
  • 18
    • 0037380886 scopus 로고    scopus 로고
    • Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia
    • Holst CR, Nuovo GJ, Esteller M, Chew K, Baylin SB, Herman JG, Tlsty TD. Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia. Cancer Res 2003, 63:1596-1601.
    • (2003) Cancer Res , vol.63 , pp. 1596-1601
    • Holst, C.R.1    Nuovo, G.J.2    Esteller, M.3    Chew, K.4    Baylin, S.B.5    Herman, J.G.6    Tlsty, T.D.7
  • 19
    • 16444386879 scopus 로고    scopus 로고
    • P38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue
    • 10.1158/0008-5472.CAN-04-3507, 15753376
    • Gauthier ML, Pickering CR, Miller CJ, Fordyce CA, Chew KL, Berman HK, Tlsty TD. p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue. Cancer Res 2005, 65:1792-1799. 10.1158/0008-5472.CAN-04-3507, 15753376.
    • (2005) Cancer Res , vol.65 , pp. 1792-1799
    • Gauthier, M.L.1    Pickering, C.R.2    Miller, C.J.3    Fordyce, C.A.4    Chew, K.L.5    Berman, H.K.6    Tlsty, T.D.7
  • 20
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • 10.1016/S0092-8674(00)81902-9, 9054499
    • Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997, 88:593-602. 10.1016/S0092-8674(00)81902-9, 9054499.
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 21
    • 0345178412 scopus 로고
    • Serum-free growth of human mammary epithelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extract
    • 10.1073/pnas.81.17.5435, 391719, 6591199
    • Hammond SL, Ham RG, Stampfer MR. Serum-free growth of human mammary epithelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extract. Proc Natl Acad Sci USA 1984, 81:5435-5439. 10.1073/pnas.81.17.5435, 391719, 6591199.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 5435-5439
    • Hammond, S.L.1    Ham, R.G.2    Stampfer, M.R.3
  • 22
    • 0029843950 scopus 로고    scopus 로고
    • Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands
    • 10.1073/pnas.93.18.9821, 38513, 8790415
    • Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996, 93:9821-9826. 10.1073/pnas.93.18.9821, 38513, 8790415.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9821-9826
    • Herman, J.G.1    Graff, J.R.2    Myohanen, S.3    Nelkin, B.D.4    Baylin, S.B.5
  • 23
    • 4744366750 scopus 로고    scopus 로고
    • Hypermethylation of the RASSF1A gene in gliomas
    • 10.1016/j.cccn.2004.07.006, 15469871
    • Gao Y, Guan M, Su B, Liu W, Xu M, Lu Y. Hypermethylation of the RASSF1A gene in gliomas. Clin Chim Acta 2004, 349:173-179. 10.1016/j.cccn.2004.07.006, 15469871.
    • (2004) Clin Chim Acta , vol.349 , pp. 173-179
    • Gao, Y.1    Guan, M.2    Su, B.3    Liu, W.4    Xu, M.5    Lu, Y.6
  • 26
    • 50049121830 scopus 로고    scopus 로고
    • Hypermethylation of the thrombospondin-1 gene is associated with poor prognosis in penile squamous cell carcinoma
    • 10.1111/j.1464-410X.2008.07603.x, 18336597
    • Guerrero D, Guarch R, Ojer A, Casas JM, Ropero S, Mancha A, Pesce C, Lloveras B, Garcia-Bragado F, Puras A. Hypermethylation of the thrombospondin-1 gene is associated with poor prognosis in penile squamous cell carcinoma. BJU Int 2008, 102:747-755. 10.1111/j.1464-410X.2008.07603.x, 18336597.
    • (2008) BJU Int , vol.102 , pp. 747-755
    • Guerrero, D.1    Guarch, R.2    Ojer, A.3    Casas, J.M.4    Ropero, S.5    Mancha, A.6    Pesce, C.7    Lloveras, B.8    Garcia-Bragado, F.9    Puras, A.10
  • 27
    • 21044455045 scopus 로고    scopus 로고
    • Mammary epithelial cell transformation: insights from cell culture and mouse models
    • 10.1186/bcr1275, 1175079, 15987472
    • Dimri G, Band H, Band V. Mammary epithelial cell transformation: insights from cell culture and mouse models. Breast Cancer Res 2005, 7:171-179. 10.1186/bcr1275, 1175079, 15987472.
    • (2005) Breast Cancer Res , vol.7 , pp. 171-179
    • Dimri, G.1    Band, H.2    Band, V.3
  • 29
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • 10.1016/j.cell.2005.02.034, 15882617
    • Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, Carey VJ, Richardson AL, Weinberg RA. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005, 121:335-348. 10.1016/j.cell.2005.02.034, 15882617.
    • (2005) Cell , vol.121 , pp. 335-348
    • Orimo, A.1    Gupta, P.B.2    Sgroi, D.C.3    Arenzana-Seisdedos, F.4    Delaunay, T.5    Naeem, R.6    Carey, V.J.7    Richardson, A.L.8    Weinberg, R.A.9
  • 30
    • 19344363035 scopus 로고    scopus 로고
    • Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds
    • 10.1371/journal.pbio.0020007, 314300, 14737219
    • Chang HY, Sneddon JB, Alizadeh AA, Sood R, West RB, Montgomery K, Chi JT, Rijn M, Botstein D, Brown PO. Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds. PLoS Biol 2004, 2:E7. 10.1371/journal.pbio.0020007, 314300, 14737219.
    • (2004) PLoS Biol , vol.2
    • Chang, H.Y.1    Sneddon, J.B.2    Alizadeh, A.A.3    Sood, R.4    West, R.B.5    Montgomery, K.6    Chi, J.T.7    Rijn, M.8    Botstein, D.9    Brown, P.O.10
  • 31
    • 4344646902 scopus 로고    scopus 로고
    • Species- and cell type-specific requirements for cellular transformation
    • 10.1016/j.ccr.2004.07.009, 15324700
    • Rangarajan A, Hong SJ, Gifford A, Weinberg RA. Species- and cell type-specific requirements for cellular transformation. Cancer Cell 2004, 6:171-183. 10.1016/j.ccr.2004.07.009, 15324700.
    • (2004) Cancer Cell , vol.6 , pp. 171-183
    • Rangarajan, A.1    Hong, S.J.2    Gifford, A.3    Weinberg, R.A.4
  • 32
    • 0037038681 scopus 로고    scopus 로고
    • P16(INK4a) inactivation is not required to immortalize human mammary epithelial cells
    • 10.1038/sj.onc.1205902, 12420227
    • Herbert BS, Wright WE, Shay JW. p16(INK4a) inactivation is not required to immortalize human mammary epithelial cells. Oncogene 2002, 21:7897-7900. 10.1038/sj.onc.1205902, 12420227.
    • (2002) Oncogene , vol.21 , pp. 7897-7900
    • Herbert, B.S.1    Wright, W.E.2    Shay, J.W.3
  • 35
    • 0021953918 scopus 로고
    • Atypical hyperplastic lesions of the female breast. A long-term follow-up study
    • 10.1002/1097-0142(19850601)55:11<2698::AID-CNCR2820551127>3.0.CO;2-A, 2986821
    • Page DL, Dupont WD, Rogers LW, Rados MS. Atypical hyperplastic lesions of the female breast. A long-term follow-up study. Cancer 1985, 55:2698-2708. 10.1002/1097-0142(19850601)55:11<2698::AID-CNCR2820551127>3.0.CO;2-A, 2986821.
    • (1985) Cancer , vol.55 , pp. 2698-2708
    • Page, D.L.1    Dupont, W.D.2    Rogers, L.W.3    Rados, M.S.4
  • 36
    • 62449209064 scopus 로고    scopus 로고
    • RASSF1A Mediates p21Cip1/Waf1-Dependent Cell Cycle Arrest and Senescence through Modulation of the Raf-MEK-ERK Pathway and Inhibition of Akt
    • Thaler S, Hahnel PS, Schad A, Dammann R, Schuler M. RASSF1A Mediates p21Cip1/Waf1-Dependent Cell Cycle Arrest and Senescence through Modulation of the Raf-MEK-ERK Pathway and Inhibition of Akt. Cancer Res 2009,
    • (2009) Cancer Res
    • Thaler, S.1    Hahnel, P.S.2    Schad, A.3    Dammann, R.4    Schuler, M.5
  • 37
    • 0036264815 scopus 로고    scopus 로고
    • The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation
    • 10.1128/MCB.22.12.4309-4318.2002, 133879, 12024041
    • Shivakumar L, Minna J, Sakamaki T, Pestell R, White MA. The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation. Mol Cell Biol 2002, 22:4309-4318. 10.1128/MCB.22.12.4309-4318.2002, 133879, 12024041.
    • (2002) Mol Cell Biol , vol.22 , pp. 4309-4318
    • Shivakumar, L.1    Minna, J.2    Sakamaki, T.3    Pestell, R.4    White, M.A.5
  • 41
    • 34548249665 scopus 로고    scopus 로고
    • Methylation-dependent silencing of CST6 in primary human breast tumors and metastatic lesions
    • 10.1016/j.yexmp.2007.03.008, 2693953, 17540367
    • Rivenbark AG, Livasy CA, Boyd CE, Keppler D, Coleman WB. Methylation-dependent silencing of CST6 in primary human breast tumors and metastatic lesions. Exp Mol Pathol 2007, 83:188-197. 10.1016/j.yexmp.2007.03.008, 2693953, 17540367.
    • (2007) Exp Mol Pathol , vol.83 , pp. 188-197
    • Rivenbark, A.G.1    Livasy, C.A.2    Boyd, C.E.3    Keppler, D.4    Coleman, W.B.5
  • 42
    • 57449112113 scopus 로고    scopus 로고
    • Methylation of the TWIST1 promoter, TWIST1 mRNA levels, and immunohistochemical expression of TWIST1 in breast cancer
    • 10.1158/1055-9965.EPI-08-0472, 19064546
    • Gort EH, Suijkerbuijk KP, Roothaan SM, Raman V, Vooijs M, Wall E, van Diest PJ. Methylation of the TWIST1 promoter, TWIST1 mRNA levels, and immunohistochemical expression of TWIST1 in breast cancer. Cancer Epidemiol Biomarkers Prev 2008, 17:3325-3330. 10.1158/1055-9965.EPI-08-0472, 19064546.
    • (2008) Cancer Epidemiol Biomarkers Prev , vol.17 , pp. 3325-3330
    • Gort, E.H.1    Suijkerbuijk, K.P.2    Roothaan, S.M.3    Raman, V.4    Vooijs, M.5    Wall, E.6    van Diest, P.J.7
  • 44
    • 33847304609 scopus 로고    scopus 로고
    • Gene body-specific methylation on the active X chromosome
    • 10.1126/science.1136352, 17322062
    • Hellman A, Chess A. Gene body-specific methylation on the active X chromosome. Science 2007, 315:1141-1143. 10.1126/science.1136352, 17322062.
    • (2007) Science , vol.315 , pp. 1141-1143
    • Hellman, A.1    Chess, A.2


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