miR-221/222 confers radioresistance in glioblastoma cells through activating Akt independent of PTEN status

Current Molecular Medicine

Volumn 14, Issue 1, 2014, Pages 185-195

  Li, W ^a   Guo, F ^b   Wang, P ^a   Hong, S ^a   Zhang, C ^a  

^a Tianjin Huanhu Hospital   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Akt; DDR; Glioblastoma; miR 221; Radiosensitivity

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANTI MICRORNA 221; ANTI MICRORNA 222; ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; MICRORNA 221; MICRORNA 222; PHOSPHATIDYLINOSITOL 3, 4, 5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN C JUN; PROTEIN KINASE B; UNCLASSIFIED DRUG; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOINFORMATICS; CHROMATIN IMMUNOPRECIPITATION; COLONY FORMATION; CONTROLLED STUDY; DNA REPAIR; FEMALE; GENETIC TRANSFECTION; GLIOBLASTOMA; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IRRADIATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RADIOSENSITIVITY; REAL TIME POLYMERASE CHAIN REACTION; TUMOR GROWTH; TUMOR VOLUME; WESTERN BLOTTING; CANCER RADIOTHERAPY; CANCER RESISTANCE; DNA DAMAGE; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; GLIOBLASTOMA CELL LINE; LUCIFERASE ASSAY; RNA ISOLATION; UPREGULATION;

ANIMALS; BASE PAIRING; BASE SEQUENCE; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; DNA DAMAGE; DNA REPAIR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; GENE REGULATORY NETWORKS; GLIOBLASTOMA; HUMANS; MICE; MICRORNAS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-JUN; PTEN PHOSPHOHYDROLASE; RADIATION TOLERANCE; RADIATION, IONIZING; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84891854609     PISSN: 15665240     EISSN: 18755666     Source Type: Journal    
DOI: 10.2174/1566524013666131203103147     Document Type: Article

References (37)

1. Dolecek TA, Propp JM, Stroup NE, Kruchko C. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2005-2009. Neuro Oncol 2012; Suppl 5: v1-49.
2. Ho J, Ondos J, Ning H, et al. Chemoirradiation for glioblastoma multiforme: the national cancer institute experience. PLoS One 2013; 8: e70745.
3. Stupp R, Hegi ME, Mason WP, et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 2009; 10: 459-66.
4. Patel M, Siddiqui F, Jin JY, et al. Salvage reirradiation for recurrent glioblastoma with radiosurgery: radiographic response and improved survival. J Neurooncol 2009; 92: 185-91.
5. Van Meir EG, Hadjipanayis CG, Norden AD, et al. Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma. CA Cancer J Clin 2010; 60: 166-93.
6. Wan G, Zhang X, Langley RR, et al. DNA-damage-induced nuclear export of precursor microRNAs is regulated by the ATM-AKT pathway. Cell Rep 2013; 3: 2100-12.
7. Curtin NJ. DNA repair dysregulation from cancer driver to therapeutic target. Nat Rev Cancer 2012; 12: 801-17.
8. Martin NM. DNA repair inhibition and cancer therapy. J Photochem Photobiol B 2001; 63: 162-70.
9. Wang Y, Taniguchi T. MicroRNAs and DNA damage response: implications for cancer therapy. Cell Cycle 2013; 12: 32-42.
10. Shin S, Cha HJ, Lee EM, et al. Alteration of miRNA profiles by ionizing radiation in A549 human non-small cell lung cancer cells. Int J Oncol. 2009; 35: 81-6.
11. Josson S, Sung SY, Lao K, et al. Radiation modulation of microRNA in prostate cancer cell lines. Prostate 2008; 68: 1599-606.
12. Chaudhry MA, Sachdeva H, Omaruddin RA. Radiation-induced micro-RNA modulation in glioblastoma cells differing in DNA-repair pathways. DNA Cell Biol 2010; 29: 553-61.
13. Niemoeller OM, Niyazi M, Corradini S, et al. MicroRNA expression profiles in human cancer cells after ionizing radiation. Radiat Oncol 2011; 6: 29.
14. Zhao L, Lu X, Cao Y. MicroRNA and signal transduction pathways in tumor radiation response. Cell Signal 2013; 25: 1625-34.
15. Galardi S, Mercatelli N, Farace MG, et al. NF-kB and c-Jun induce the expression of the oncogenic miR-221 and miR-222 in prostate carcinoma and glioblastoma cells. Nucleic Acids Res 2011; 39: 3892-902.
16. Zhang C, Kang C, You Y, et al. Co-suppression of miR-221/222 cluster suppresses human glioma cell growth by targeting p27kip1 in vitro and in vivo. Int J Oncol 2009; 34: 1653-60.
17. Garofalo M, Di Leva G, Romano G, et al. miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation. Cancer Cell 2009; 16: 498-509.
18. Deng Z, Sui G, Rosa PM, et al. Radiation-induced c-Jun activation depends on MEK1-ERK1/2 signaling pathway in microglial cells. PLoS One 2012; 7: e36739.
19. Squatrito M, Holland EC. DNA damage response and growth factor signaling pathways in gliomagenesis and therapeutic resistance. Cancer Res 2011; 71: 5945-9.
20. Inaba N, Kimura M, Fujioka K, et al. The effect of PTEN on proliferation and drug-, and radiosensitivity in malignant glioma cells. Anticancer Res 2011; 31: 1653-8.
21. Alam R, Schultz CR, Golembieski WA, et al. PTEN suppresses SPARC-induced pMAPKAPK2 and inhibits SPARC-induced Ser78 HSP27 phosphorylation in glioma. Neuro Oncol 2013; 15: 451-61.
22. Schuurbiers OC, Kaanders JH, van der Heijden HF, et al. The PI3-K/AKT-pathway and radiation resistance mechanisms in non-small cell lung cancer. J Thorac Oncol 2009; 4: 761-7.
23. Zhao G, Cai C, Yang T, et al. MicroRNA-221 induces cell survival and cisplatin resistance through PI3K/Akt pathway in human osteosarcoma. PLoS One 2013; 8: e53906.
24. Zhang J, Han L, Ge Y, et al. miR-221/222 promote malignant progression of glioma through activation of the Akt pathway. Int J Oncol 2010; 36: 913-20.
25. Jiang N, Shen Y, Fei X, et al. Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells. Cell Death Dis 2013; 4: e647.
26. Kang KB, Zhu C, Wong YL, et al. Gefitinib radiosensitizes stem-like glioma cells: inhibition of epidermal growth factor receptor-Akt-DNA-PK signaling, accompanied by inhibition of DNA double-strand break repair. Int J Radiat Oncol Biol Phys 2012; 83: e43-52.
27. Zhang C, Zhang J, Hao J, et al. High level of miR-221/222 confers increased cell invasion and poor prognosis in glioma. J Transl Med 2012; 10: 119.
28. Zhang CZ, Zhang JX, Zhang AL, et al. MiR-221 and miR-222 target PUMA to induce cell survival in glioblastoma. Mol Cancer 2010; 9: 229.
29. Salama JK, Vokes EE. New radiotherapy and chemoradiotherapy approaches for non-small-cell lung cancer. J Clin Oncol 2013; 31: 1029-38.
30. Wazer DE. Measuring the value of radiotherapy in older women with breast cancer. J Clin Oncol 2012; 30: 2809-11.
31. Zelefsky MJ, Eastham JA, Cronin AM, et al. Metastasis after radical prostatectomy or external beam radiotherapy for patients with clinically localized prostate cancer: a comparison of clinical cohorts adjusted for case mix. J Clin Oncol 2010; 28: 1508-13.
32. Stupp R, Hegi ME, Neyns B, et al. Phase I/IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma. J Clin Oncol 2010; 28: 2712-8.
33. Chowdhury D, Choi YE, Brault ME. DNA DAMAGE - OPINION Charity begins at home: non-coding RNA functions in DNA repair. Nat Rev Mol Cell Biol 2013; 14: 181-9.
34. Liu Y, Lu X. Non-coding RNAs in DNA damage response. Am J Cancer Res 2012; 2: 658-75.
35. Pothof J, Verkaik NS, van IJcken W, et al. MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response. EMBO J 2009; 28: 2090-9.
36. Bennetzen MV, Larsen DH, Dinant C, et al. Acetylation dynamics of human nuclear proteins during the ionizing radiation-induced DNA damage response. Cell Cycle 2013; 12: 1688-95.
37. Chun-Zhi Z, Lei H, An-Ling Z, et al. MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN. BMC Cancer 2010; 10: 367.