Alteration of miRNA profiles by ionizing radiation in A549 human non-small cell lung cancer cells

International Journal of Oncology

Volumn 35, Issue 1, 2009, Pages 81-86

  Shin, Sangsu ^a   Cha, Hwa Jun ^a   Lee, Eun Mee ^a   Lee, Su Jae ^b   Seo, Sung Keum ^c   Jin, Hyeon Ok ^c   Park, In Chul ^c   Jin, Young Woo ^d   An, Sungkwan ^a,e  

^a Konkuk University   (South Korea)

^b Hanyang University   (South Korea)

^c Korea Institute of Radiation and Medical Science   (South Korea)

^d Korea Hydro & Nuclear Power Co   (South Korea)

^e LIFEnGENE Inc   (South Korea)

Author keywords

A549; Human non small cell lung cancer cell; Ionizing radiation; MicroRNA

Indexed keywords

ATR PROTEIN; BONE MORPHOGENETIC PROTEIN 4; BRCA1 PROTEIN; CASPASE 10; CASPASE 8; CD27 ANTIGEN; CD28 ANTIGEN; CD70 ANTIGEN; CELL ADHESION MOLECULE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 7; CYCLINE; DNA; DNA DIRECTED DNA POLYMERASE; EPIDERMAL GROWTH FACTOR; EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; EXONUCLEASE; FAS ANTIGEN; FURIN; MICRORNA; PROTEIN BAX; PROTEIN BID; PROTEIN KINASE B; PROTEIN MSH2; REPLICATION LICENSING FACTOR CDT1; SPHINGOSINE KINASE 1;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE REGULATION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IONIZING RADIATION; LUNG NON SMALL CELL CANCER; MICROARRAY ANALYSIS; PREDICTION; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, RADIATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MICRORNAS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 67649445759     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000315     Document Type: Article

References (48)

1. Lee RC, Feinbaum RL and Ambros V: The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75: 843-854, 1993.
2. Lagos-Quintana M, Rauhut R, Lendeckel W and Tuschl T: Identification of novel genes coding for small expressed RNAs. Science 294: 853-858, 2001.
3. Lau NC, Lim LP, Weinstein EG and Bartel DP: An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 294: 858-862, 2001.
4. Lee RC and Ambros V: An extensive class of small RNAs in Caenorhabditis elegans. Science 294: 862-864, 2001.
5. Bernstein E, Caudy AA, Hammond SM and Hannon GJ: Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409: 363-366, 2001.
6. Lai EC: MicroRNAs are complementary to 3′-UTR motifs that mediate negative post-transcriptional regulation. Nat Genet 3: 363-364, 2002.
7. Gregory RI, Chendrimada TP, Cooch N and Shiekhattar R: Human RISC couples microRNA biogenesis and post-transcriptional gene silencing. Cell 123: 631-640, 2005.
8. Ørom UA, Nielsen FC and Lund AH: MicroRNA-10a binds the 5′UTR of ribosomal protein mRNAs and enhances their translation. Mol Cell 30: 460-471, 2008.
9. Place RF, Li LC, Pookot D, Noonan EJ and Dahiya R: MicroRNA-373 induces expression of genes with complementary promoter sequences. Proc Natl Acad Sci USA 105: 1608-1613, 2008.
10. Lee Y, Jeon K, Lee JT, Kim S and Kim VN: MicroRNA maturation: stepwise processing and subcellular localization. EMBO J 21: 4663-4670, 2002.
11. Lee Y, Kim M, Han J, et al: MicroRNA genes are transcribed by RNA polymerase II. EMBO J 23: 4051-4060, 2004.
12. Denli AM, Tops BB, Plasterk RH, Ketting RF and Hannon GJ: Processing of primary microRNAs by the microprocessor complex. Nature 432: 231-235, 2004.
13. Hammond SM, Bernstein E, Beach D and Hannon GJ: An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature 404: 293-296, 2000.
14. Ketting RF, Fischer SE, Bernstein E, et al: Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev 15: 2654-2659, 2001.
15. Yi R, Qin Y, Macara IG and Cullen BR: Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev 17: 3011-3016, 2003.
16. Alvarez-Garcia I and Miska EA: MicroRNA functions in animal development and human disease. Development 132: 4653-4662, 2005.
17. Kent OA and Mendell JT: A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes. Oncogene 2: 6188-6196, 2006.
18. Zhang B, Pan X, Cobb GP and Anderson TA: MicroRNAs as oncogenes and tumor suppressors. Dev Biol 302: 1-12, 2007.
19. Lin SL, Chang DC, Chang-Lin S, et al: Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state. RNA 14: 2115-2124, 2008.
20. Marson A, Levine SS, Cole MF, et al: Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell 134: 521-533, 2008.
21. Berezikov E, Guryev V, van de Belt J, et al: Phylogenetic shadowing and computational identification of human microRNA genes. Cell 120: 21-24, 2005.
22. Lewis BP, Burge CB and Bartel DP: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120: 15-20, 2005.
23. Baek D, Villén J, Shin C, et al: The impact of microRNAs on protein output. Nature 455: 64-71, 2008.
24. Selbach M, Schwanhäusser B, Thierfelder N, et al: Widespread changes in protein synthesis induced by microRNAs. Nature 455: 58-63, 2008.
25. Rosenfeld N, Aharonov R, Meiri E, et al: MicroRNAs accurately identify cancer tissue origin. Nat Biotechnol 26: 462-469, 2008.
26. Schmidt-Ullrich RK, Dent P, Grant S, Mikkelsen RB and Valeie K: Signal transduction and cellular radiation responses. Radiat Res 153: 245-257, 2000.
27. Barlow C, Brown KD, Deng CX, Tagle DA and Wynshaw-Boris A: Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways. Nat Genet 17: 453-456, 1997.
28. Canman CE, Lim DS, Cimprich KA, et al: Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281: 1677-1679, 1998.
29. Iliakis G, Wang Y, Guan J and Wang H: DNA damage checkpoint control in cells exposed to ionizing radiation. Oncogene 22: 5834-5847, 2003.
30. Cann KL and Hicks GG: Regulation of the cellular DNA double-strand break response. Biochem Cell Biol 85: 663-674, 2007.
31. Schwartz JL: The radiosensitivity of the chromosomes of the cells of human squamous cell carcinoma cell lines. Radiat Res 129: 96-101, 1992.
32. Schwartz JL, Murnane J and Weichselbaum RR: The contribution of DNA ploidy to radiation sensitivity in human tumour cell lines. Br J Cancer 79: 744-747, 1999.
33. Cuneo KC, Fu A, Osusky K, Huamani J, Hallahan DE and Geng L: Histone deacetylase inhibitor NVP-LAQ824 sensitizes human nonsmall cell lung cancer to the cytotoxic effects of ionizing radiation. Anticancer Drugs 18: 793-800, 2007.
34. Kasten-Pisula U, Windhorst S, Dahm-Daphi J, Mayr G and Dikomey E: Radiosensitization of tumour cell lines by the polyphenol Gossypol results from depressed double-strand break repair and not from enhanced apoptosis. Radiother Oncol 83: 296-303, 2007.
35. Brognard J, Clark AS, Ni Y and Dennis PA: Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res 61: 3986-3997, 2001.
36. Toulany M, Kehlbach R, Florczak U, et al: Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair. Mol Cancer Ther 7: 1772-1781, 2008.
37. Pfaffle MW: A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29: e45, 2001.
38. Rasmussen R: Quantification on the light cycler. In: Rapid Cycle Real-time PCR: Methods and Applications. Meuer S, Wittwer C and Nakagawara K (eds.) Springer Press, Heidelberg, pp21-34, 2001.
39. John B, Enright AJ, Aravin A, et al: Human microRNA targets. PLoS Biol 2: e363, 2004.
40. Chang TC, Wentzel EA, Kent OA, et al: Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell 26: 745-752, 2007.
41. Tarasov V, Jung P, Verdoodt B, et al: Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest. Cell Cycle 6: 1586-1593, 2007.
42. Rokhlin W, Scheinker VS, Taghiyev AF, et al: MicroRNA-34 mediates AR-dependent p53-induced apoptosis in prostate cancer. Cancer Biol Ther 7: 1288-1296, 2008.
43. Sun F, Fu H, Liu Q, et al: Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest. FEBS Lett 582: 1564-1568, 2008.
44. Tazawa H, Tsuchiya N, Izumiya M and Nakagama H: Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. Proc Natl Acad Sci USA 104: 15472-15477, 2008.
45. Yamakuchi M, Ferlito M and Lowenstein CJ: miR-34a repression of SIRT1 regulates apoptosis. Proc Natl Acad Sci USA 105: 13421-13426, 2008.
46. Cole KA, Attiyeh EF, Mosse YP, et al: A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene. Mol Cancer Res 6: 735-742, 2008.
47. Lodygin D, Tarasov V, Epanchintsev A, et al: Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer. Cell Cycle 7: 2591-2600, 2008.
48. Wei JS, Song YK, Durinck S, et al: The MYCN oncogene is a direct target of miR-34a. Oncogene 27: 5204-5213, 2008.