Inhibition of the PI3K pathway sensitizes fludarabine-induced apoptosis in human leukemic cells through an inactivation of MAPK-dependent pathway

Biochemical and Biophysical Research Communications

Volumn 331, Issue 2, 2005, Pages 391-397

  Yu, C ^a   Mao, X ^a   Li, W X ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

Apoptosis; Fludarabine; JNK; Leukemia; MAPK; PI3K

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE; FLUDARABINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAPAMYCIN; STRESS ACTIVATED PROTEIN KINASE; WORTMANNIN;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOSOL; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION;

EID: 18044365018     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.03.182     Document Type: Article

References (30)

1. L. Chang, and M. Karin Mammalian MAP kinase signaling cascades Nature 410 6824 2001 37 40
2. L.C. Cantley The phosphoinositide 3-kinase pathway Science (Wash. DC.) 296 2002 1655 1657
3. C. Widmann, S. Gibson, M.B. Jarpe, and G.L. Johnson Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human Physiol. Rev. 79 1999 143 180
4. A. Brunet, and J. Pouyssegur Mammalian MAP kinase modules: how to transduce specific signals Essays Biochem. 32 1997 1 16
5. Z. Xia, M. Dickens, J. Raingeaud, R.J. Davis, and M.E. Greenberg Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis Science (Wash. DC.) 270 1995 1326 1331
6. K.M. Nicholson, and N.G. Anderson The protein kinase B/Akt signalling pathway in human malignancy Cell Signal. 14 2002 381 395
7. L.P. Weng, W.M. Smith, P.L. Dahia, U. Ziebold, E. Gil, J.A. Lees, and C. Eng PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death Cancer Res. 59 1999 5808 5814
8. L. Simpson, and R. Parsons PTEN: life as a tumor suppressor Exp. Cell Res. 264 2001 29 41
9. J.Q. Cheng, B. Ruggeri, W.M. Klein, G. Sonoda, D.A. Altomare, D.K. Watson, and J.R. Testa Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA Proc. Natl. Acad. Sci. USA 93 1996 3636 3641
10. A. Bellacosa, D. de Feo, A.K. Godwin, D.W. Bell, J.Q. Cheng, D.A. Altomare, M. Wan, L. Dubeau, G. Scambia, and V. Masciullo Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas Int. J. Cancer 64 1995 280 285
11. C. Page, H.J. Lin, Y. Jin, V.P. Castle, G. Nunez, M. Huang, and J. Lin Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis Anticancer Res. 20 2000 407 416
12. J. Brognard, A.S. Clark, Y. Ni, and P.A. Dennis Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation Cancer Res. 61 2001 3986 3997
13. L. Hu, J. Hofmann, Y. Lu, G.B. Mills, and R.B. Jaffe Inhibition of phosphatidylinositol 3′-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models Cancer Res. 62 2002 1087 1092
14. S.S.W. Ng, M.S. Tsao, S. Chow, and D.W. Hedley Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells Cancer Res. 60 2000 5451 5455
15. C. Recher, O. Beyne-Rauzy, C. Demur, G. Chicanne, C. Dos Santos, V. Mansat-De Mas, D. Benzaquen, G. Laurent, F. Huguet, and B. Payrastre Anti-leukemic activity of rapamycin in acute myeloid leukemia Blood 105 6 2005 2527 2534
16. M. Bjornsti, and P.J. Houghton The TOR pathway: a target for cancer therapy Nat. Rev. Cancer 4 2004 335 348 10.1038/nrc1362
17. R.T. Abraham Identification of TOR signaling complexes: more TORC for the cell growth engine Cell 111 1 2002 9 12
18. S. Huang, and P.J. Houghton Inhibitors of mammalian target of rapamycin as novel antitumor agents: from bench to clinic Curr. Opin. Invest. Drugs 3 2002 295 304
19. M.S. Neshat, I.K. Mellinghoff, C. Tran, B. Stiles, G. Thomas, R. Petersen, P. Frost, J.J. Gibbons, H. Wu, and C.L. Sawyers Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR Proc. Natl. Acad. Sci. USA 98 2001 10314 10319
20. V. Gandhi, P. Huang, and W. Plunkett Fludarabine inhibits DNA replication: a rationale for its use in the treatment of acute leukemias Leuk. Lymphoma 14 Suppl. 2 1994 3 9
21. P. Huang, A. Sandoval, E. Van Den Neste, M.J. Keating, and W. Plunkett Inhibition of RNA transcription: a biochemical mechanism of action against chronic lymphocytic leukemia cells by fludarabine Leukemia 14 8 2000 1405 1413
22. M.J. Keating, H. Kantarjian, M. Talpaz, J. Redman, C. Koller, B. Barlogie, W. Velasquez, W. Plunkett, E.J. Freireich, and K.B. McCredie Fludarabine: a new agent with major activity against chronic lymphocytic leukemia Blood 74 1989 19 25
23. M. Barragan, B. Bellosillo, C. Campas, D. Colomer, G. Pons, and J. Gil Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells Blood 99 8 2002 2969 2976
24. H.M. Hull, R.W. Hoshaw, and J.C. Wang Stain Technol. 57 1982 273 282
25. J. Sambrook, E.F. Fritsch, and T. Maniatis Molecular cloning: A laboratory manual third ed. 2001 Cold Spring Harbor Laboratory Press New York
26. M. Leist, C. Volbracht, E. Fava, and P. Nicotera 1-Methyl-4- phenylpyridinium induces autocrine excitotoxicity, protease activation, and neuronal apoptosis Mol. Pharmacol. 54 1998 789 801
27. V. Gurtu, S.R. Kain, and G. Zhang Fluorometric and colorimetric detection of caspase activity associated with apoptosis Anal. Biochem. 251 1997 98 102
28. Y. Sun, D. Gou, H. Liu, X. Peng, and W. Li The KRAB domain of zinc finger gene ZNF268: a potential transcriptional repressor IUBMB Life 55 3 2003 127 131
29. T.-C. Chou, and P. Talalay Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors Adv. Enzyme Regul. 22 1884 27 55
30. S. Yamagishi, M. Yamada, H. Koshimizu, S. Takai, H. Hatanaka, K. Takeda, H. Ichijo, K. Shimoke, and T. Ikeuchi Apoptosis-signal regulating kinase-1 is involved in the low potassium-induced activation of p38 mitogen-activated protein kinase and c-Jun in cultured cerebellar granule neurons J. Biochem. (Tokyo) 133 6 2003 719 724