XIAP antisense oligonucleotide (AEG35156) achieves target knockdown and induces apoptosis preferentially in CD34+38- cells in a phase 1/2 study of patients with relapsed/refractory AML

Apoptosis

Volumn 16, Issue 1, 2011, Pages 67-74

  Carter, Bing Z ^a   Mak, Duncan H ^a   Morris, Stephen J ^b   Borthakur, Gautam ^a   Estey, Elihu ^c   Byrd, Anna L ^a   Konopleva, Marina ^a   Kantarjian, Hagop ^a   Andreeff, Michael ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

AML; Antisense oligonucleotide AEG35156; Apoptosis; Clinical trial; XIAP

Indexed keywords

AEG 35156; ANTISENSE OLIGONUCLEOTIDE; CD34 ANTIGEN; CD38 ANTIGEN; CYTARABINE; IDARUBICIN; MESSENGER RNA; X LINKED INHIBITOR OF APOPTOSIS;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; APOPTOSIS; ARTICLE; BLOOD SAMPLING; CANCER CHEMOTHERAPY; CANCER RELAPSE; CD34 SELECTION; CLINICAL PROTOCOL; CONTINUOUS INFUSION; DRUG MEGADOSE; FEMALE; GENE INDUCTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PHARMACODYNAMICS; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN TARGETING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL;

AGED; ANTIGENS, CD; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CASPASES; CYTARABINE; DRUG ADMINISTRATION SCHEDULE; DRUG DOSAGE CALCULATIONS; FEMALE; GENE EXPRESSION; HUMANS; IDARUBICIN; LEUKEMIA, MYELOID, ACUTE; MALE; MIDDLE AGED; MYELOID PROGENITOR CELLS; OLIGONUCLEOTIDES; RECURRENCE; RNA, MESSENGER; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 79951553370     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-010-0545-1     Document Type: Article

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