Delta-Tocotrienol protects mice from radiation-induced gastrointestinal injury

Radiation Research

Volumn 180, Issue 6, 2013, Pages 649-657

  Li, Xiang Hong ^a   Ghosh, Sanchita P ^a   Ha, Cam T ^a   Fu, Dadin ^a   Elliott, Thomas B ^a   Bolduc, David L ^a   Villa, Vilmar ^a   Whitnall, Mark H ^a   Landauer, Michael R ^a   Xiao, Mang ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DELTA TOCOTRIENOL; EOSIN; HEMATOXYLIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE 6; TOCOPHEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BACTERIAL TRANSLOCATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIGESTIVE SYSTEM INJURY; DRUG EFFECT; DRUG MECHANISM; INTESTINE EPITHELIUM CELL; MALE; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RADIATION INJURY; RADIATION PROTECTION; WHOLE BODY RADIATION;

EID: 84891810677     PISSN: 00337587     EISSN: 19385404     Source Type: Journal    
DOI: 10.1667/RR13398.1     Document Type: Article

References (47)

1. Xiao M, Whitnall MH, Pharmacological countermeasures for the acute radiation syndrome. Curr Mol Pharmacol 2009; 2:122-33.
2. Booth C, Tudor G, Tudor J, Katz BP, MacVittie TJ, Acute gastrointestinal syndrome in high-dose irradiated mice. Health Phys 2012; 103:383-99.
3. MacVittie TJ, Farese AM, Bennett A, Gelfond D, Shea-Donohue T, Tudor G, et al. The acute gastrointestinal subsyndrome of the acute radiation syndrome: a rhesus macaque model. Health Phys 2012; 103:411-26.
4. Hotz ME, Fliedner TM, Meineke V, Radiation accident preparedness: a European approach to train physicians to manage mass radiation casualties. Health Phys 2010; 98:894-7.
5. Coleman CN, Stone HB, Moulder JE, Pellmar TC, Medicine. Modulation of radiation injury. Science 2004; 304:693-4.
6. Somosy Z, Horvath G, Telbisz A, Rez G, Palfia Z, Morphological aspects of ionizing radiation response of small intestine. Micron 2002; 33:167-78. (Pubitemid 32997017)
7. Shaker A, Rubin DC, Intestinal stem cells and epithelialmesenchymal interactions in the crypt and stem cell niche. Translational research: the journal of laboratory and clinical medicine 2010; 156:180-7.
8. Otterson MF, Effects of radiation upon gastrointestinal motility. World J Gastroenterol 2007; 13:2684-92. (Pubitemid 46958723)
9. Potten CS, Gandara R, Mahida YR, Loeffler M, Wright NA, The stem cells of small intestinal crypts: where are they? Cell Prolif 2009; 42:731-50.
10. Waselenko JK, MacVittie TJ, Blakely WF, Pesik N, Wiley AL, Dickerson WE, et al. Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group. Ann Intern Med 2004; 140:1037-51.
11. Moulder JE, Post-irradiation approaches to treatment of radiation injuries in the context of radiological terrorism and radiation accidents: a review. Int J Radiat Biol 2004; 80:3-10. (Pubitemid 38365707)
12. Williams JP, McBride WH, After the bomb drops: a new look at radiation-induced multiple organ dysfunction syndrome (MODS). Int J Radiat Biol 2011; 87:851-68.
13. Brown M, What causes the radiation gastrointestinal syndrome?: overview. Int J Radiat Oncol Biol Phys 2008; 70:799-800. (Pubitemid 351199745)
14. Kirsch DG, Santiago PM, di Tomaso E, Sullivan JM, Hou WS, Dayton T, et al. p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. Science 2010; 327:593-6.
15. Weiss JF, Landauer MR, History and development of radiationprotective agents. Int J Radiat Biol 2009; 85:539-73.
16. Li XH, Fu D, Latif NH, Mullaney CP, Ney PH, Mog SR, et al. Delta-tocotrienol protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signalregulated kinase/mammalian target of rapamycin signaling. Haematologica 2010; 95:1996-2004.
17. Sen CK, Khanna S, Roy S, Tocotrienols: Vitamin E beyond tocopherols. Life Sci 2006; 78:2088-98.
18. Nesaretnam K, Multitargeted therapy of cancer by tocotrienols. Cancer Lett 2008; 269:388-95.
19. Kamat JP, Sarma HD, Devasagayam TP, Nesaretnam K, Basiron Y, Tocotrienols from palm oil as effective inhibitors of protein oxidation and lipid peroxidation in rat liver microsomes. Mol Cell Biochem 1997; 170:131-7. (Pubitemid 27182942)
20. Tan SW, Ramasamy R, Abdullah M, Vidyadaran S, Inhibitory effects of palm alpha-, gamma-and delta-tocotrienol on lipopolysaccharide-induced nitric oxide production in BV2 microglia. Cellular immunology 2011; 271:205-9.
21. Yam ML, Abdul Hafid SR, Cheng HM, Nesaretnam K, Tocotrienols suppress proinflammatory markers and cyclooxygenase-2 expression in RAW264.7 macrophages. Lipids 2009; 44:787-97.
22. Satyamitra MM, Kulkarni S, Ghosh SP, Mullaney CP, Condliffe D, Srinivasan V, Hematopoietic Recovery and Amelioration of Radiation-Induced Lethality by the Vitamin E Isoform delta-Tocotrienol. Radiat Res 2011; 175:736-45.
23. Withers HR, Elkind MM, Microcolony survival assay for cells of mouse intestinal mucosa exposed to radiation. Int J Radiat Biol Relat Stud Phys Chem Med 1970; 17:261-7.
24. Singh PK, Wise SY, Ducey EJ, Fatanmi OO, Elliott TB, Singh VK, alpha-Tocopherol succinate protects mice against radiationinduced gastrointestinal injury. Radiat Res 2012; 177:133-45.
25. AVMA Guidelines for the Euthanasia of Animals. 1st ed. Schaumburg, American Veterinary Medical Association; 2013.
26. Elliott TB, Brook I, Harding RA, Bouhaouala SS, Shoemaker MO, Knudson GB, Antimicrobial therapy for bacillus anthracis-induced polymicrobial infection in (60)Co gamma-irradiated mice. Antimicrob Agents Chemother 2002; 46:3463-71. (Pubitemid 35192912)
27. Li XH, Ha CT, Fu D, Xiao M, Micro-RNA30c negatively regulates REDD1 expression in human hematopoietic and osteoblast cells after gamma-irradiation. PLoS ONE 2012; 7:e48700.
28. Williams JP, Brown SL, Georges GE, Hauer-Jensen M, Hill RP, Huser AK, et al. Animal models for medical countermeasures to radiation exposure. Radiat Res 2010; 173:557-78.
29. Mason KA, Withers HR, McBride WH, Davis CA, Smathers JB, Comparison of the gastrointestinal syndrome after total-body or total-abdominal irradiation. Radiat Res 1989; 117:480-8. (Pubitemid 19100298)
30. Paris F, Fuks Z, Kang A, Capodieci P, Juan G, Ehleiter D, et al. Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science 2001; 293:293-7. (Pubitemid 32694744)
31. Quastler H, The nature of intestinal radiation death. Radiat Res 2012; 178:173-82.
32. Schaue D, Kachikwu EL, McBride WH, Cytokines in radiobiological responses: a review. Radiat Res 2012; 178:505-23.
33. Li XH, Ha CT, Fu D, Xiao M, REDD1 protects osteoblast cells from gamma radiation-induced premature senescence. PLoS ONE 2012; 7:e36604.
34. Ha C, Li, XH., Fu D., Xiao M and Landauer M R., Genistein nanoparticles protect mouse hematopoietic system and prevent pro-inflammatory factors after gamma radiation Radiat Res 2013; 180:316-25.
35. Haegebarth A, Nunez R, Tyner AL, The intracellular tyrosine kinase Brk sensitizes non-transformed cells to inducers of apoptosis. Cell Cycle 2005; 4:1239-46. (Pubitemid 41365396)
36. Haegebarth A, Perekatt AO, Bie W, Gierut JJ, Tyner AL, Induction of protein tyrosine kinase 6 in mouse intestinal crypt epithelial cells promotes DNA damage-induced apoptosis. Gastroenterology 2009; 137:945-54.
37. Chessells JM, Hall E, Prentice HG, Durrant J, Bailey CC, Richards SM, The impact of age on outcome in lymphoblastic leukaemia; MRC UKALL X and XA compared: a report from the MRC Paediatric and Adult Working Parties. Leukemia 1998; 12:463-73. (Pubitemid 28197568)
38. Satyamitra M, Ney P, Graves J, 3rd, Mullaney C, Srinivasan V, Mechanism of radioprotection by delta-tocotrienol: pharmacokinetics, pharmacodynamics and modulation of signalling pathways. Br J Radiol 2012; 85:e1093-103.
39. MacNaughton WK, Review article: new insights into the pathogenesis of radiation-induced intestinal dysfunction. Aliment Pharmacol Ther 2000; 14:523-8.
40. Rotolo JA, Kolesnick R, Fuks Z, Timing of lethality from gastrointestinal syndrome in mice revisited. Int J Radiat Oncol Biol Phys 2009; 73:6-8.
41. Vogel HH, Jr., Clark JW, Hammond CW, Cooper DB, Miller CP, Endogenous infection in mice irradiated with fast neutrons or gamma rays. Proc Soc Exp Biol Med 1954; 87:114-9.
42. Berg RD, Garlington AW, Translocation of certain indigenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs in a gnotobiotic mouse model. Infect Immun 1979; 23:403-11. (Pubitemid 9119845)
43. McBride WH, Mason K, Withers HR, Davis C, Effect of interleukin 1, inflammation, and surgery on the incidence of adhesion formation and death after abdominal irradiation in mice. Cancer Res 1989; 49:169-73. (Pubitemid 19024427)
44. Herodin F, Grenier N, Drouet M, Revisiting therapeutic strategies in radiation casualties. Exp Hematol 2007; 35:28-33. (Pubitemid 46427979)
45. Ostrander JH, Daniel AR, Lange CA, Brk/PTK6 signaling in normal and cancer cell models. Current opinion in pharmacology 2010; 10:662-9.
46. Brauer PM, Tyner AL, Building a better understanding of the intracellular tyrosine kinase PTK6-BRK by BRK. Biochim Biophys Acta 2010; 1806:66-73.
47. Kasprzycka M, Majewski M, Wang ZJ, Ptasznik A, Wysocka M, Zhang Q, et al. Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes. Am J Pathol 2006; 168:1631-41.