Micro-RNA30c Negatively Regulates REDD1 Expression in Human Hematopoietic and Osteoblast Cells after Gamma-Irradiation

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Li, Xiang Hong ^a   Ha, Cam T ^a   Fu, Dadin ^a   Xiao, Mang ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA 30; MICRORNA 30B; MICRORNA 30C; MICRORNA 30D; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ARTICLE; CD34 SELECTION; CELL CULTURE; CELL DAMAGE; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; FETUS; GAMMA IRRADIATION; GENE; GENE EXPRESSION REGULATION; GENE REPRESSION; GENETIC TRANSFECTION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; OSTEOBLAST; RADIATION DOSE; REAL TIME POLYMERASE CHAIN REACTION; REDD1 GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ANTIGENS, CD34; CELL DIFFERENTIATION; CELL LINE; CLUSTER ANALYSIS; GAMMA RAYS; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELLS; HUMANS; MICRORNAS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOBLASTS; REAL-TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS;

EID: 84868689176     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0048700     Document Type: Article

References (29)

1. Bentzen SM, (2006) Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology. Nat Rev Cancer 6: 702-713.
2. Baskar R, Lee KA, Yeo R, Yeoh KW, (2012) Cancer and radiation therapy: current advances and future directions. Int J Med Sci 9: 193-199.
3. Xiao M, Inal CE, Parekh VI, Chang CM, Whitnall MH, (2007) 5-Androstenediol promotes survival of gamma-irradiated human hematopoietic progenitors through induction of nuclear factor-kappaB activation and granulocyte colony-stimulating factor expression. Mol Pharmacol 72: 370-379.
4. Li XH, Ha CT, Fu D, Xiao M, (2012) REDD1 Protects Osteoblast Cells from Gamma Radiation-Induced Premature Senescence. PLoS ONE 7: e36604.
5. Saito T, Saetrom P, (2010) MicroRNAs - targeting and target prediction. N Biotechnol 27: 243-249.
6. Grimson A, Farh KK, Johnston WK, Garrett-Engele P, Lim LP, et al. (2007) MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell 27: 91-105.
7. Djuranovic S, Nahvi A, Green R, (2011) A parsimonious model for gene regulation by miRNAs. Science 331: 550-553.
8. Pesole G, Mignone F, Gissi C, Grillo G, Licciulli F, et al. (2001) Structural and functional features of eukaryotic mRNA untranslated regions. Gene 276: 73-81.
9. Mendell JT, Olson EN, (2012) MicroRNAs in stress signaling and human disease. Cell 148: 1172-1187.
10. Boominathan L, (2010) The guardians of the genome (p53, TA-p73, and TA-p63) are regulators of tumor suppressor miRNAs network. Cancer Metastasis Rev 29: 613-639.
11. Li J, Donath S, Li Y, Qin D, Prabhakar BS, et al. (2010) miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway. PLoS Genet 6: e1000795.
12. Martinez I, Cazalla D, Almstead LL, Steitz JA, DiMaio D, (2011) miR-29 and miR-30 regulate B-Myb expression during cellular senescence. Proc Natl Acad Sci U S A 108: 522-527.
13. Ozcan S, (2009) MiR-30 family and EMT in human fetal pancreatic islets. Islets 1: 283-285.
14. Zhang J, Zhang H, Liu J, Tu X, Zang Y, et al. (2012) miR-30 inhibits TGF-beta1-induced epithelial-to-mesenchymal transition in hepatocyte by targeting Snail1. Biochem Biophys Res Commun 417: 1100-1105.
15. Wu T, Zhou H, Hong Y, Li J, Jiang X, et al. (2012) miR-30 family members negatively regulate osteoblast differentiation. J Biol Chem 287: 7503-7511.
16. Ellisen LW, Ramsayer KD, Johannessen CM, Yang A, Beppu H, et al. (2002) REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. Mol Cell 10: 995-1005.
17. Shoshani T, Faerman A, Mett I, Zelin E, Tenne T, et al. (2002) Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Mol Cell Biol 22: 2283-2293.
18. Xiao M, Inal CE, Parekh VI, Li XH, Whitnall MH, (2009) Role of NF-kappaB in hematopoietic niche function of osteoblasts after radiation injury. Exp Hematol 37: 52-64.
19. Leung AK, Sharp PA, (2010) MicroRNA functions in stress responses. Mol Cell 40: 205-215.
20. Xiao M, Whitnall M, (2009) Pharmacological Countermeasures for the Acute Radiation Syndrome. Current Molecular Pharmacology 2: 122-133.
21. Hu H, Gatti RA, (2011) MicroRNAs: new players in the DNA damage response. J Mol Cell Biol 3: 151-158.
22. Chaudhry MA, Kreger B, Omaruddin RA, (2010) Transcriptional modulation of micro-RNA in human cells differing in radiation sensitivity. Int J Radiat Biol 86: 569-583.
23. Roush S, Slack FJ, (2008) The let-7 family of microRNAs. Trends Cell Biol 18: 505-516.
24. Dickey JS, Zemp FJ, Martin OA, Kovalchuk O, (2011) The role of miRNA in the direct and indirect effects of ionizing radiation. Radiat Environ Biophys 50: 491-499.
25. Merkerova M, Belickova M, Bruchova H, (2008) Differential expression of microRNAs in hematopoietic cell lineages. Eur J Haematol 81: 304-310.
26. Zaragosi LE, Wdziekonski B, Brigand KL, Villageois P, Mari B, et al. (2011) Small RNA sequencing reveals miR-642a-3p as a novel adipocyte-specific microRNA and miR-30 as a key regulator of human adipogenesis. Genome Biol 12: R64.
27. Joglekar MV, Patil D, Joglekar VM, Rao GV, Reddy DN, et al. (2009) The miR-30 family microRNAs confer epithelial phenotype to human pancreatic cells. Islets 1: 137-147.
28. Yen ML, Chien CC, Chiu IM, Huang HI, Chen YC, et al. (2007) Multilineage differentiation and characterization of the human fetal osteoblastic 1.19 cell line: a possible in vitro model of human mesenchymal progenitors. Stem Cells 25: 125-131.
29. Li XH, Fu D, Latif NH, Mullaney CP, Ney PH, et al. (2010) Delta-tocotrienol protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling. Haematologica 95: 1996-2004.