The interaction between the helicase DHX33 and IPS-1 as a novel pathway to sense double-stranded RNA and RNA viruses in myeloid dendritic cells

Cellular and Molecular Immunology

Volumn 11, Issue 1, 2014, Pages 49-57

  Liu, Ying ^a   Lu, Ning ^b   Yuan, Bin ^b   Weng, Leiyun ^c   Wang, Feng ^a   Liu, Yong Jun ^c   Zhang, Zhiqiang ^c  

^a JILIN UNIVERSITY   (China)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c BAYLOR INSTITUTE FOR IMMUNOLOGY RESEARCH   (United States)

Author keywords

DHX33; Helicase; Innate immunity; IPS 1; Myeloid dendritic cell; Viral nucleic acid

Indexed keywords

DHX33 HELICASE; DOUBLE STRANDED RNA; HELICASE; I KAPPA B KINASE BETA; INTERFERON; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 6; IPS 1 HELICASE; MITOGEN ACTIVATED PROTEIN KINASE; RECOMBINANT PROTEIN; SHORT HAIRPIN RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOKINE RESPONSE; EMBRYO; ENZYME ACTIVATION; LENTIVIRUS INFECTION; MOUSE; MYELOID DENDRITIC CELL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; RNA VIRUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; CYTOKINES; DEAD-BOX RNA HELICASES; DENDRITIC CELLS; EMBRYO, MAMMALIAN; FIBROBLASTS; IMMUNOPRECIPITATION; MICE; MYELOID CELLS; NF-KAPPA B; POLY I-C; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA VIRUSES; RNA, DOUBLE-STRANDED; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84891802708     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2013.40     Document Type: Article

References (30)

1. Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat Immunol 2004; 5: 987-995.
2. Takeuchi O, Akira S. Recognition of viruses by innate immunity. Immunol Rev 2007; 220: 214-224.
3. Blasius AL, Beutler B. Intracellular Toll-like receptors. Immunity 2010; 32: 305-315.
4. Martinon F, Tschopp J. NLRs join TLRs as innate sensors of pathogens. Trends Immunol 2005; 26: 447-454.
5. Kufer TA, Fritz JH, Philpott DJ. NACHT-LRR proteins (NLRs) in bacterial infection and immunity. Trends Microbiol 2005; 13: 381-388.
6. Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 2006; 441: 101-105.
7. Myong S, Cui S, Cornish PV, Kirchhofer A, Gack MU, Jung JU et al. Cytosolic viral sensor RIG-I is a 59-triphosphate-dependent translocase on double-stranded RNA. Science 2009; 323: 1070-1074.
8. Pippig DA, Hellmuth JC, Cui S, Kirchhofer A, Lammens K, Lammens A et al. The regulatory domain of the RIG-I family AT Pase LGP2 senses double-stranded RNA. Nucleic Acids Res 2009; 37: 2014-2025.
9. Takeuchi O, Akira S. Innate immunity to virus infection. Immunol Rev 2009; 227: 75-86.
10. Deddouche S, Matt N, Budd A, Mueller S, Kemp C, Galiana-Arnoux D et al. The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila. Nat Immunol 2008; 9: 1425-1432.
11. Oshiumi H, Sakai k, Matsumoto M, Seya T. 2010. DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFNbeta-inducing potential. Eur J Immunol 2010; 40: 940-948.
12. Kim T, Pazhoor S, Bao M, Zhang Z, Hanabuchi S, Facchinetti V et al. Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells. Proc Natl Acad Sci USA 2010; 107: 15181-15186.
13. Zhang Z, Kim T, Bao M, Facchinetti V, Jung SY, Ghaffari AA et al. Helicases pair with TRIF to sense dsRNA in dendritic cells. Immunity 2011; 34: 866-878.
14. Zhang Z, Yuan B, Lu N, Facchinetti V, Liu YJ. DHX9 pairs with IPS-1 to sense ds RNA in myeloid dendritic cells. J Immunol 2011; 187: 4501-4508.
15. Miyashita M, Oshiumi H, Matsumoto M, Seya T. DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptormediated signaling. Mol Cell Biol 2011; 31: 3802-3819.
16. Kawai T, Takahashi K, Sato S, Coban C, Kumar H, Kato H et al. IPS-1, an adaptor triggering RIG-I-and Mda5-mediated type I interferon induction. Nat Immunol 2005; 6: 981-988.
17. Xu LG, Wang YY, Han KJ, Li LY, Zhai Z, Shu HB. VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol Cell 2005; 19: 727-740.
18. Seth RB, Sun L, Ea CK, Chen ZJ. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NFkappaB and IRF 3. Cell 2005; 122: 669-682.
19. Sun Q, Sun L, Liu HH, Chen X, Seth RB, Forman J et al. The specific and essential role of MAVS in antiviral innate immune responses. Immunity 2006; 24: 633-642.
20. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-B by Toll-like receptor 3. Nature 2001; 413: 732-738.
21. Edelmann KH, Richardson-Burns S, Alexopoulou L, Tyler KL, Flavell RA, Oldstone MB. Does Toll-like receptor 3 play a biological role in virus infections? Virology 2004; 322: 231-238.
22. Balachandran S, Roberts PC, Brown LE, Truong H, Pattnaik AK, Archer DR et al. Essential role for the ds RNA-dependent protein kinase PKR in innate immunity to viral infection. Immunity 2000; 13: 129-141.
23. Schröder HC, Suhadolnik RJ, Pfleiderer W, Charubala R, Müller WE. (2′-5′) Oligoadenylate and intracellular immunity against retrovirus infection. Int J Biochem 1992; 24: 55-63.
24. Yang YL, Reis LF, Pavlovic J, Aguzzi A, Schäfer R, Kumar A et al. Deficient signaling in mice devoid of double-stranded RNA dependent protein kinase. EMBO J 1995; 14: 6095-6106.
25. Maggi LB Jr, Heitmeier MR, Scheuner D, Kaufman RJ, Buller RM, Corbett JA. Potential role of PKR in double-stranded RNA-induced macrophage activation. EMBO J 2000; 19: 3630-3638.
26. Chu WM, Ostertag D, Li ZW, Chang L, Chen Y, Hu Y et al. JNK2 and IKKbeta are required for activating the innate response to viral infection. Immunity 1999; 11: 721-731.
27. Samuel CE. Antiviral actions of interferons. Clin Microbiol Rev 2001; 14: 778-809.
28. Ueta M, Kawai T, Yokoi N, Akira S, Kinoshita S. Contribution of IPS-1 to polyI:C-induced cytokine production in conjunctival epithelial cells. Biochem Biophys Res Commun 2011; 404: 419-423.
29. Linder P. Dead-box proteins: a family affair-active and passive players in RNP-remodeling. Nucleic Acids Res 2006; 34: 4168-4180.
30. Lee MS, Kim YJ. Signaling pathways downstream of patternrecognition receptors and their cross talk. Annu Rev Biochem 2007; 76: 447-480.