Rho-Kinase inhibitor prevents bleomycin-induced injury in neonatal rats independent of effects on lung inflammation

American Journal of Respiratory Cell and Molecular Biology

Volumn 50, Issue 1, 2014, Pages 61-73

  Lee, Alvin H ^a   Dhaliwal, Rupinder ^a   Kantores, Crystal ^a   Ivanovska, Julijana ^a   Gosal, Kiran ^a,b   McNamara, Patrick J ^a,b   Letarte, Michelle ^a,b   Jankov, Robert P ^a,b  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Angiogenesis; Bronchopulmonary dysplasia; Neutrophils; Thrombospondin 1; Y 27632

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; BLEOMYCIN; CHEMOKINE RECEPTOR CXCR2 ANTAGONIST; ETANERCEPT; SB 265610; SMAD2 PROTEIN; THROMBOSPONDIN 1; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEOMYCIN INDUCED LUNG INJURY; BODY WEIGHT; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIUM CELL; EXPERIMENTAL DISEASE; HEART RIGHT VENTRICLE HYPERTROPHY; HISTOPATHOLOGY; IN VITRO STUDY; INFLAMMATORY CELL; LUNG ALVEOLUS; LUNG ARTERY; LUNG CAPILLARY; LUNG DYSPLASIA; LUNG INJURY; LUNG RESISTANCE; LUNG VASCULAR RESISTANCE; LUNG WEIGHT; MACROPHAGE; NEUTROPHIL CHEMOTAXIS; NEWBORN; NONHUMAN; PERINATAL PERIOD; PNEUMONIA; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT;

AMIDES; ANIMALS; ANIMALS, NEWBORN; BLEOMYCIN; CHEMOKINES; DOWN-REGULATION; ENZYME INHIBITORS; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; LUNG; LUNG INJURY; MACROPHAGES; NEOVASCULARIZATION, PATHOLOGIC; NEUTROPHILS; PNEUMONIA; PULMONARY ARTERY; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RHO-ASSOCIATED KINASES; THROMBOSPONDIN 1; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR RESISTANCE;

EID: 84891787531     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2013-0131OC     Document Type: Article

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