Therapeutic hypercapnia prevents bleomycin-induced pulmonary hypertension in neonatal rats by limiting macrophage-derived tumor necrosis factor-α

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 303, Issue 1, 2012, Pages

  Sewing, A Charlotte P ^a   Kantores, Crystal ^a   Ivanovska, Julijana ^a   Lee, Alvin H ^a   Masood, Azhar ^a,c   Jain, Amish ^a,b,c   McNamara, Patrick J ^a,b,c   Keith Tanswell, A ^a,b,c   Jankov, Robert P ^a,b,c  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Carbon dioxide; Inflammation; Neonatal lung injury

Indexed keywords

BLEOMYCIN; CARBON DIOXIDE; CXCL1 CHEMOKINE; ETANERCEPT; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTERIAL GAS; ARTICLE; BODY WEIGHT; BRAIN CORTEX; BRAIN WEIGHT; CONTROLLED STUDY; CYTOKINE PRODUCTION; HEART RIGHT VENTRICLE FUNCTION; HEART RIGHT VENTRICLE HYPERTROPHY; KIDNEY MASS; LIVER WEIGHT; LUNG ALVEOLUS MACROPHAGE; LUNG HYPOPLASIA; LUNG VASCULAR RESISTANCE; LUNG WEIGHT; NEUTROPHIL; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PH; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PULMONARY HYPERTENSION; RAT; SIGNAL TRANSDUCTION; THERAPEUTIC HYPERCAPNIA; THERAPY;

ANIMALS; ANIMALS, NEWBORN; BLEOMYCIN; CARBON DIOXIDE; HYPERCAPNIA; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; INFLAMMATION; LUNG; LUNG INJURY; MACROPHAGES; NEUTROPHILS; PULMONARY ALVEOLI; PULMONARY ARTERY; RATS; TUMOR NECROSIS FACTOR-ALPHA; VENTRICULAR FUNCTION, RIGHT;

EID: 84863434876     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00072.2012     Document Type: Article

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