Rho-kinase signaling regulates pulmonary infiltration of neutrophils in abdominal sepsis via attenuation of CXC chemokine formation and Mac-1 expression on neutrophils

Shock

Volumn 37, Issue 3, 2012, Pages 282-288

  Hasan, Zirak ^a   Palani, Karzan ^a   Rahman, Milladur ^a   Zhang, Su ^a   Syk, Ingvar ^a   Jeppsson, Bengt ^a   Thorlacius, Henrik ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Adhesion; inflammation; leukocyte and platelet; lung

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ALPHA CHEMOKINE; CD11B ANTIGEN; CD40 LIGAND; GELATINASE B; RHO KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; BLOOD SAMPLING; C57BL 6 MOUSE; CECUM; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; LAPAROTOMY; LIGATION; LUNG ALVEOLUS MACROPHAGE; LUNG EDEMA; LUNG INFILTRATE; LUNG INJURY; LUNG LAVAGE; LUNG PARENCHYMA; MALE; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PROTEIN BLOOD LEVEL; PUNCTURE; SEPSIS; SIGNAL TRANSDUCTION; THROMBOCYTE; TISSUE INJURY; UPREGULATION;

AMIDES; ANIMALS; BLOOD PLATELETS; CD40 LIGAND; CECUM; CHEMOKINES, CXC; LIGATION; LUNG INJURY; MACROPHAGE-1 ANTIGEN; MALE; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; NEUTROPHIL INFILTRATION; NEUTROPHILS; PYRIDINES; RHO-ASSOCIATED KINASES; SEPSIS; SIGNAL TRANSDUCTION;

EID: 84862776568     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0b013e3182426be4     Document Type: Article

References (35)

1. Cohen J: The immunopathogenesis of sepsis. Nature 420(6917):885-891, 2002. (Pubitemid 36019643)
2. Maier S, Traeger T, Entleutner M, Westerholt A, Kleist B, Hüser N, Holzmann B, Stier A, Pfeffer K, Heidecke CD: Cecal ligation and puncture versus colon ascendens stent peritonitis: two distinct animal models for polymicrobial sepsis. Shock 21(6):505-512, 2004.
3. Babayigit H, Kucuk C, Sozuer E, Yazici C, Kose K, Akgun H: Protective effect of beta-glucan on lung injury after cecal ligation and puncture in rats. Intensive Care Med 31(6):865-870, 2005. (Pubitemid 40897544)
4. Asaduzzaman M, Zhang S, Lavasani S, Wang YS, Thorlacius H: LFA-1 and Mac-1 mediate pulmonary recruitment of neutrophils and tissue damage in abdominal sepsis. Shock 30(3):254-259, 2008.
5. Hasan Z, Palani K, Rahman M, Thorlacius H: Targeting CD44 expressed on neutrophils inhibits lung damage in abdominal sepsis. Shock 35(6):567-572, 2011.
6. Salomão R, Martins PS, Brunialti MK, Fernandes Mda L, Martos LS, Mendes ME, Gomes NE, Rigato O: TLR signaling pathway in patients with sepsis. Shock (Suppl 1):73-77, 2008.
7. Alves-Filho JC, de Freitas A, Spiller F, Souto F, Cunha FQ: The role of neutrophils in severe sepsis. Shock 30(7):3-9, 2008.
8. Remick DG: Pathophysiology of sepsis. Am J Pathol 170(5):1435-1444, 2007. (Pubitemid 47339289)
9. Narumiya S: The small GTPase Rho: cellular functions and signal transduction. J Biochem 120(2):215-228, 1996. (Pubitemid 26335910)
10. Loirand G, Guerin P, Pacaud P: Rho kinases in cardiovascular physiology and pathophysiology. Circ Res 98(3):322-334, 2006.
11. Shimokawa H, Takeshita A: Rho-kinase is an important therapeutic target in cardiovascular medicine. Arterioscler Thromb Vasc Biol 25(9):1767-1775, 2005. (Pubitemid 41243442)
12. Slotta JE, Laschke MW, Menger MD, Thorlacius H: Rho-kinase signalling mediates endotoxin hypersensitivity after partial hepatectomy. Br J Surg 95(8) :976-984, 2008.
13. Kitamura K, Tada S, Nakamoto N, Toda K, Horikawa H, Kurita S, Tsunematsu S, Kumagai N, Ishii H, Saito H, et al.: Rho/Rho kinase is a key enzyme system involved in the angiotensin II signaling pathway of liver fibrosis and steatosis. J Gastroenterol Hepatol 22(11):2022-2033, 2007. (Pubitemid 47525076)
14. Laschke MW, Dold S, Jeppsson B, Schilling MK, Menger MD, Thorlacius H: Rho-kinase inhibitor attenuates cholestasis-induced CXC chemokine formation, leukocyte recruitment, and hepatocellular damage in the liver. J Surg Res 159(2): 666-673, 2010.
15. Shin HK, Salomone S, Potts EM, Lee SW, Millican E, Noma K, Huang PL, Boas DA, Liao JK, Moskowitz MA, et al.: Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms. J Cereb Blood Flow Metab 27(5):998-1009, 2007. (Pubitemid 46659030)
16. Santen S, Wang YS, Laschke MW, Menger MD, Jeppsson B, Thorlacius H: Rho-kinase signalling regulates CXC chemokine formation and leukocyte recruitment in colonic ischemia-reperfusion. Int J Colorectal Dis 25(9): 1063-1070, 2010.
17. Awla D, Hartman H, Abdulla A, Zhang S, Rahman M, Regner S, Thorlacius H: Rho-kinase signalling regulates trypsinogen activation and tissue damage in severe acute pancreatitis. Br J Pharmacol 162(3):648-658, 2011.
18. Oka M, Fagan KA, Jones PL, McMurtry IF: Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension. Br J Pharmacol 155(4):444-454, 2008.
19. Asaduzzaman M, Lavasani S, Rahman M, Zhang S, Braun OO, Jeppsson B, Thorlacius H: Platelets support pulmonary recruitment of neutrophils in abdominal sepsis. Crit Care Med 37(4):1389-1396, 2009.
20. Rahman M, Zhang S, Chew M, Ersson A, Jeppsson B, Thorlacius H: Plateletderived CD40L (CD154) mediates neutrophil upregulation of Mac-1 and recruitment in septic lung injury. Ann Surg 250(5): 783-790, 2009.
21. Klages B, Brandt U, Simon MI, Schultz G, Offermanns S: Activation of G(12)/G(13) results in shape change and Rho/Rho-kinaseYmediated myosin light chain phosphorylation in mouse platelets. J Cell Biol 144(4):745-754, 1999. (Pubitemid 29234552)
22. Krawisz JE, Sharon P, Stenson WF: Quantitative assay for acute intestinal inflammation based on myeloperoxidase activityVassessment of inflammation in rat and hamster models. Gastroenterology 87(6):1344-1350, 1984. (Pubitemid 15201434)
23. Borzone G, Liberona L, Olmos P, Saez C, Meneses M, Reyes T, Moreno R, Lisboa C: Rat and hamster species differences in susceptibility to elastaseinduced pulmonary emphysema relate to differences in elastase inhibitory capacity. Am J Physiol Regul Integr Comp Physiol 293(3):R1342YR1349, 2007. (Pubitemid 47358959)
24. Zhang X, Goncalves R, Mosser DM: The isolation and characterization of murine macrophages. Curr Protoc Immunol Chapter 14:Unit 14.1, 2008.
25. Riento K, Ridley AJ: Rocks: multifunctional kinases in cell behaviour. Nat Rev Mol Cell Biol 4(6):446-456, 2003. (Pubitemid 36648590)
26. Bokoch GM: Regulation of innate immunity by Rho GTPases. Trends Cell Biol 15(3):163-171, 2005. (Pubitemid 40332539)
27. Thorlacius K, Slotta JE, Laschke MW, Wang Y, Menger MD, Jeppsson B, Thorlacius H: Protective effect of fasudil, a Rho-kinase inhibitor, on chemokine expression, leukocyte recruitment, and hepatocellular apoptosis in septic liver injury. J Leukoc Biol 79(5):923-931, 2006. (Pubitemid 44835579)
28. Li Y, Wu Y, Wang Z, Zhang XH, Wu WK: Fasudil attenuates lipopolysaccharide-induced acute lung injury in mice through the Rho/Rho kinase pathway. Med Sci Monit 16(4):BR112YBR118, 2010.
29. Zhang S, Zhang S, Rahman M, Herwald H, Thorlacius H: Streptococcal M1 proteinYinduced lung injury is independent of platelets in mice. Shock 35(1): 86-91, 2011.
30. Reutershan J, Basit A, Galkina EV, Ley K: Sequential recruitment of neutrophils into lung and bronchoalveolar lavage fluid in LPS-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol 289(5):L807YL815, 2005. (Pubitemid 41504412)
31. Schramm R, Thorlacius H: Staphylococcal enterotoxin BYinduced acute inflammation is inhibited by dexamethasone: Important role of CXC chemokines KC and macrophage inflammatory protein 2. Infect Immun 71(5):2542-2547, 2003. (Pubitemid 36519867)
32. Tekamp-olson P, Gallegos C, Bauer D, McClain J, Sherry B, Fabre M, Vandeventer S, Cerami A: Cloning and characterization of cdnas for murine macrophage inflammatory protein-2 and its human homologs. J Exp Med 172(3): 911-919, 1990. (Pubitemid 20301237)
33. Mihaescu A, Santen S, Jeppsson B, Thorlacius H: Rho kinase signalling mediates radiation-induced inflammation and intestinal barrier dysfunction. Br J Surg 98(1):124-131, 2011.
34. Matoba K, Kawanami D, Ishizawa S, Kanazawa Y, Yokota T, Utsunomiya K: Rhokinase mediates TNF-alphaYinduced MCP-1 expression via p38 MAPK signaling pathway in mesangial cells. Biochem Biophys Res Commun 402(4):725-730, 2010.
35. Hattori T, Shimokawa H, Higashi M, Hiroki J, Mukai Y, Tsutsui H, Kaibuchi K, Takeshita A: Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice. Circulation 109(18):2234-2239, 2004. (Pubitemid 38625402)