Intravenous immunoglobulin induces a functional silencing program similar to anergy in human B cells

Journal of Allergy and Clinical Immunology

Volumn 133, Issue 1, 2014, Pages

  Séïté, Jean François ^a   Goutsmedt, Carole ^a   Youinou, Pierre ^a   Pers, Jacques Olivier ^a   Hillion, Sophie ^a  

^a Universite de Brest   (France)

Author keywords

anergy; autoimmunity; B cells; chronic inflammatory diseases; immune tolerance; Intravenous immunoglobulin

Indexed keywords

ANTIGEN; B LYMPHOCYTE RECEPTOR; CALCIUM; IMMUNOGLOBULIN; IMMUNOGLOBULIN M ANTIBODY; PHOSPHATIDYLINOSITOL 3 KINASE; TYROSINE;

ARTICLE; B LYMPHOCYTE; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL FATE; CELL FUNCTION; CLONAL ANERGY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG EFFECT; FLOW CYTOMETRY; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; INTERNALIZATION; MEDIATOR; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

ANERGY; AUTOIMMUNITY; B CELLS; B-CELL RECEPTOR; BCR; CHOLERA TOXIN B; CHRONIC INFLAMMATORY DISEASES; CTB; FACS; FITC; FLUORESCEIN ISOTHIOCYANATE; FLUORESCENCE-ACTIVATED CELL SORTING; IMMUNE TOLERANCE; INTRAVENOUS IMMUNOGLOBULIN; IVIG; NF-ΚB; NFAT; NUCLEAR FACTOR OF ACTIVATED T CELLS; NUCLEAR FACTOR ΚB; P-TYR; PE; PHOSPHATASE AND TENSIN HOMOLOG; PHOSPHATIDYLINOSITOL (3,4,5)-TRISPHOSPHATE; PHOSPHOINOSITIDE 3-KINASE; PHOSPHOTYROSINE; PHYCOERYTHRIN; PI3K; PIP3; PTEN; SA-IVIG; SHIP; SHP; SIALYLATED INTRAVENOUS IMMUNOGLOBULIN; SRC HOMOLOGY DOMAIN 2-CONTAINING INOSITOL PHOSPHATASE; SRC HOMOLOGY DOMAIN 2-CONTAINING PROTEIN TYROSINE PHOSPHATASE; TETRARHODAMINE ISOTHIOCYANATE; TRITC;

ANTIBODIES, ANTI-IDIOTYPIC; AUTOIMMUNE DISEASES; B-LYMPHOCYTES; CALCIUM SIGNALING; CELLS, CULTURED; CHILD; CLONAL ANERGY; HUMANS; IMMUNE TOLERANCE; IMMUNOGLOBULINS, INTRAVENOUS; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTE ACTIVATION; RECEPTOR AGGREGATION; RECEPTORS, ANTIGEN, B-CELL;

EID: 84891735723     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.08.042     Document Type: Article

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