RNA interference targeting Bcl-6 ameliorates experimental autoimmune myasthenia gravis in mice

Molecular and Cellular Neuroscience

Volumn 58, Issue , 2014, Pages 85-94

  Xin, Ning ^a   Fu, Linlin ^a   Shao, Zhen ^a   Guo, Mingfeng ^a   Zhang, Xiuying ^a   Zhang, Yong ^a   Dou, Changxin ^a   Zheng, Shuangshuang ^a   Shen, Xia ^a   Yao, Yuanhu ^a   Wang, Jiao ^a   Wang, Jinhua ^a   Cui, Guiyun ^a   Liu, Yonghai ^a   Geng, Deqin ^a   Xiao, Chenghua ^a   Zhang, Zunsheng ^a   Dong, Ruiguo ^a  

^a XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Bcl 6; Myasthenia gravis; RNA interference; Tfh cells

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 17; INTERLEUKIN 21; LENTIVIRUS VECTOR; PROTEIN BCL 6; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EXPERIMENTAL AUTOIMMUNE MYASTHENIA GRAVIS; GENE EXPRESSION; IN VIVO GENE TRANSFER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA INTERFERENCE; TH2 CELL;

BCL-6; MYASTHENIA GRAVIS; RNA INTERFERENCE; TFH CELLS;

ANIMALS; B-LYMPHOCYTES; DNA-BINDING PROTEINS; GENETIC THERAPY; MICE; MICE, INBRED C57BL; MYASTHENIA GRAVIS, AUTOIMMUNE, EXPERIMENTAL; RNA INTERFERENCE; RNA, SMALL INTERFERING; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 84891715933     PISSN: 10447431     EISSN: 10959327     Source Type: Journal    
DOI: 10.1016/j.mcn.2013.12.006     Document Type: Article

References (37)

1. Conti-Fine B.M., Milani M., Kaminski H.J. Myasthenia gravis: past, present, and future. J. Clin. Invest. 2006, 116(11):2843-2854. (Nov).
2. Crotty S. Follicular helper CD4 T cells (TFH). Annu. Rev. Immunol. 2011, 29:621-663.
3. Crotty S., Johnston R.J., Schoenberger S.P. Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation. Nat. Immunol. 2010, 11(2):114-120. (Feb).
4. Dalakas M.C. Biologics and other novel approaches as new therapeutic options in myasthenia gravis: a view to the future. Ann. N. Y. Acad. Sci. 2012, 1274:1-8. (Dec).
5. Du C., Sriram S. Increased severity of experimental allergic encephalomyelitis in lyn-/- mice in the absence of elevated proinflammatory cytokine response in the central nervous system. J. Immunol. 2002, 168(6):3105-3112. (Mar 15).
6. Elson C.J., Barker R.N. Helper T cells in antibody-mediated, organ specific autoimmunity. Curr. Opin. Immunol. 2000, 12:664-669.
7. Fazilleau N., Mark L., McHeyzer-Williams L.J., McHeyzer-Williams M.G. Follicular helper T cells: lineage and location. Immunity 2009, 30(3):324-335. (Mar 20).
8. Follenzi A., Battaglia M., Lombardo A., Annoni A., Roncarolo M.G., Naldini L. Targeting lentiviral vector expression to hepatocytes limits transgene-specific immune response and establishes long-term expression of human antihemophilic factor IX in mice. Blood 2004, 103(10):3700-3709. (May 15).
9. Hughes B.W., Moro De Casillas M.L., Kaminski H.J. Pathophysiology of myasthenia gravis. Semin. Neurol. 2004, 24:21-30.
10. Ichikawa M., Koh C.S., Inaba Y., Seki C., Inoue A., Itoh M., Ishihara Y., Bernard C.C., Komiyama A. IgG subclass switching is associated with the severity of experimental autoimmune encephalomyelitis induced with myelin oligodendrocyte glycoprotein peptide in NOD mice. Cell. Immunol. 1999, 191(2):97-104. (Feb 1).
11. Iwata D., Kitamura M., Kitaichi N., Saito Y., Kon S., Namba K., Morimoto J., Ebihara A., Kitamei H., Yoshida K., Ishida S., Ohno S., Uede T., Onoé K., Iwabuchi K. Prevention of experimental autoimmune uveoretinitis by blockade of osteopontin with small interfering RNA. Exp. Eye Res. 2010, 90(1):41-48. (Jan).
12. Johnston R.J., Poholek A.C., DiToro D., Yusuf I., Eto D., Barnett B., Dent A.L., Craft J., Crotty S. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 2009, 325(5943):1006-1010. (Aug 21).
13. Kuchen S., Robbins R., Sims G.P., Sheng C., Phillips T.M., Lipsky P.E., Ettinger R. Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration. J. Immunol. 2007, 179(9):5886-5896. (Nov 1).
14. Lazarevic V., Chen X., Shim J.H., Hwang E.S., Jang E., Bolm A.N., Oukka M., Kuchroo V.K., Glimcher L.H. T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt. Nat. Immunol. 2011, 12(1):96-104. (Jan).
15. Lee C.C., Huang H.Y., Chiang B.L. Lentiviral-mediated GATA-3 RNAi decreases allergic airway inflammation and hyperresponsiveness. Mol. Ther. 2008, 16(1):60-65. (Jan).
16. Lüthje K., Kallies A., Shimohakamada Y., Belz G.T., Light A., Tarlinton D.M., Nutt S.L. The development and fate of follicular helper T cells defined by an IL-21 reporter mouse. Nat. Immunol. 2012, 13(5):491-498. (May).
17. Ma C.S., Deenick E.K., Batten M., Tangye S.G. The origins, function, and regulation of T follicular helper cells. J. Exp. Med. 2012, 209(7):1241-1253. (Jul 2).
18. Ma J., Zhu C., Ma B., Tian J., Baidoo S.E., Mao C., Wu W., Chen J., Tong J., Yang M., Jiao Z., Xu H., Lu L., Wang S. Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis. Clin. Dev. Immunol. 2012, 2012:827480.
19. Nurieva R.I., Chung Y., Hwang D., Yang X.O., Kang H.S., Ma L., Wang Y.H., Watowich S.S., Jetten A.M., Tian Q., Dong C. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 2008, 29(1):138-149. (Jul 18).
20. Nurieva R.I., Chung Y., Martinez G.J., Yang X.O., Tanaka S., Matskevitch T.D., Wang Y.H., Dong C. Bcl6 mediates the development of T follicular helper cells. Science 2009, 325(5943):1001-1005. (Aug 21).
21. Oestreich K.J., Weinmann A.S. Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors. Nat. Rev. Immunol. 2012, 12(11):799-804. (Nov).
22. O'Shea J.J., Paul W.E. Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science 2010, 327(5969):1098-1102. (Feb 26).
23. Rubinson D.A., Dillon C.P., Kwiatkowski A.V., Sievers C., Yang L., Kopinja J., Rooney D.L., Zhang M., Ihrig M.M., McManus M.T., Gertler F.B., Scott M.L., Van Parijs L. A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat. Genet. 2003, 33(3):401-406. (Mar).
24. Saito R., Onodera H., Tago H., Suzuki Y., Shimizu M., Matsumura Y., Kondo T., Itoyama Y. Altered expression of chemokine receptor CXCR5 on T cells of myasthenia gravis patients. J. Neuroimmunol. 2005, 170(1-2):172-178. (Dec 30).
25. Sarra M., Pallone F., Monteleone G. Interleukin-21 in chronic inflammatory diseases. Biofactors 2013, (Mar 29). 10.1002/biof.1105.
26. Simpson N., Gatenby P.A., Wilson A., Malik S., Fulcher D.A., Tangye S.G., Manku H., Vyse T.J., Roncador G., Huttley G.A., Goodnow C.C., Vinuesa C.G., Cook M.C. Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. Arthritis Rheum. 2010, 62(1):234-244. (Jan).
27. van Hamburg J.P., Mus A.M., de Bruijn M.J., de Vogel L., Boon L., Cornelissen F., Asmawidjaja P., Hendriks R.W. Lubberts EGATA-3 protects against severe joint inflammation and bone erosion and reduces differentiation of Th17 cells during experimental arthritis. Arthritis Rheum. 2009, 60(3):750-759. (Mar).
28. Vincent A., Palace J., Hilton-Jones D. Myasthenia gravis. Lancet 2001, 357(9274):2122-2128. (Jun 30).
29. Wu B., Goluszko E., Huda R., Tüzün E., Christadoss P. Experimental autoimmune myasthenia gravis in the mouse. Curr. Protoc. Immunol. 2011, 15.23.1-15.23.26. (Nov;Chapter 15:Unit 15.23).
30. Yang H., Goluszko E., David C., Okita D.K., Conti-Fine B., Chan T.S., Poussin M.A., Christadoss P. Mapping myasthenia gravis-associated T cell epitopes on human acetylcholine receptors in HLA transgenic mice. J. Clin. Invest. 2002, 109(8):1111-1120. (Apr).
31. Yang H., Kala M., Scott B.G., Goluszko E., Chapman H.A., Christadoss P. Cathepsin S is required for murine autoimmune myasthenia gravis pathogenesis. J Immunol 2005 Feb 1, 174(3):1729-1737.
32. Yu D., Rao S., Tsai L.M., Lee S.K., He Y., Sutcliffe E.L., Srivastava M., Linterman M., Zheng L., Simpson N., Ellyard J.I., Parish I.A., Ma C.S., Li Q.J., Parish C.R., Mackay C.R., Vinuesa C.G. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 2009, 31(3):457. (Sep 18).
33. Zhang Y., Yang H., Xiao B., Wu M., Zhou W., Li J., Li G., Christadoss P. Dendritic cells transduced with lentiviral-mediated RelB-specific ShRNAs inhibit the development of experimental autoimmune myasthenia gravis. Mol. Immunol. 2009, 46(4):657-667. (Feb).
34. Zheng X., Suzuki M., Zhang X., Ichim T.E., Zhu F., Ling H., Shunnar A., Wang M.H., Garcia B., Inman R.D., Min W.P. RNAi-mediated CD40-CD154 interruption promotes tolerance in autoimmune arthritis. Arthritis Res. Ther. 2010, 12(1):R13.
35. Zhu J., Paul W.E. CD4 T cells: fates, functions, and faults. Blood 2008, 112(5):1557-1569. (Sep 1).
36. Zhu J., Yamane H., Paul W.E. Differentiation of effector CD4 T cell populations (*). Annu. Rev. Immunol. 2010, 28:445-489.
37. Zhu C., Ma J., Liu Y., Tong J., Tian J., Chen J., Tang X., Xu H., Lu L., Wang S. Increased frequency of follicular helper T cells in patients with autoimmune thyroid disease. J. Clin. Endocrinol. Metab. 2012, 97(3):943-950. (Mar).