Histone demethylase JMJD2A regulates Kaposi's sarcoma-associated herpesvirus replication and is targeted by a viral transcriptional factor

Journal of Virology

Volumn 85, Issue 7, 2011, Pages 3283-3293

  Chang, Pei Ching ^a,b   Fitzgerald, Latricia D ^a,b   Hsia, Datsun A ^a   Izumiya, Yoshihiro ^b,c   Wu, Chun Yi ^b,c   Hsieh, Wen Ping ^e   Lin, Su Fang ^f   Campbell, Mel ^a,b   Lam, Kit S ^b,c   Luciw, Paul A ^d   Tepper, Clifford G ^a,b   Kung, Hsing Jien ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^f NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; HISTONE DEMETHYLASE; HISTONE H3; PROTEIN JMJD2A; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHROMATIN; CHROMOSOME; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; GENE OVEREXPRESSION; GENE REPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN TARGETING; REGULATORY MECHANISM; VIRUS GENE; VIRUS REACTIVATION; VIRUS REPLICATION;

BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; GENE KNOCKDOWN TECHNIQUES; GENETIC COMPLEMENTATION TEST; HERPESVIRUS 8, HUMAN; HOST-PATHOGEN INTERACTIONS; HUMANS; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; REPRESSOR PROTEINS; VIRAL LOAD; VIRAL PROTEINS; VIRUS LATENCY; VIRUS REPLICATION;

HUMAN HERPESVIRUS 8;

EID: 79952602772     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02485-10     Document Type: Article

References (40)

1. Agger, K., J. Christensen, P. A. Cloos, and K. Helin. 2008. The emerging functions of histone demethylases. Curr. Opin. Genet. Dev. 18:159-168.
2. Chang, P. C., et al. 2009. Kruppel-associated box domain-associated protein-1 as a latency regulator for Kaposi's sarcoma-associated herpesvirus and its modulation by the viral protein kinase. Cancer Res. 69:5681-5689.
3. Chang, P. C., et al. 2010. Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a SUMO E3 ligase that is SIM-dependent and SUMO-2/3-specific. J. Biol. Chem. 285:5266-5273.
4. Chen, Z., et al. 2007. Structural basis of the recognition of a methylated histone tail by JMJD2A. Proc. Natl. Acad. Sci. U. S. A. 104:10818-10823.
5. Chen, Z., et al. 2006. Structural insights into histone demethylation by JMJD2 family members. Cell 125:691-702.
6. Couture, J. F., E. Collazo, P. A. Ortiz-Tello, J. S. Brunzelle, and R. C. Trievel. 2007. Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase. Nat. Struct. Mol. Biol. 14:689-695.
7. Covarrubias, S., J. M. Richner, K. Clyde, Y. J. Lee, and B. A. Glaunsinger. 2009. Host shutoff is a conserved phenotype of gammaherpesvirus infection and is orchestrated exclusively from the cytoplasm. J. Virol. 83:9554-9566.
8. Dupin, N., et al. 1999. Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma. Proc. Natl. Acad. Sci. U. S. A. 96:4546-4551.
9. Ellison, T. J., Y. Izumiya, C. Izumiya, P. A. Luciw, and H. J. Kung. 2009. A comprehensive analysis of recruitment and transactivation potential of KRta and K-bZIP during reactivation of Kaposi's sarcoma-associated herpesvirus. Virology 387:76-88.
10. Glaunsinger, B. A., and D. E. Ganem. 2006. Messenger RNA turnover and its regulation in herpesviral infection. Adv. Virus Res. 66:337-394.
11. Gray, S. G., et al. 2005. Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. J. Biol. Chem. 280:28507-28518.
12. Gunther, T., and A. Grundhoff. 2010. The epigenetic landscape of latent Kaposi sarcoma-associated herpesvirus genomes. PLoS Pathog. 6:e1000935.
13. Hsia, D. A., et al. 2010. KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation. Proc. Natl. Acad. Sci. U. S. A. 107:9671-9676.
14. Huang, Y., J. Fang, M. T. Bedford, Y. Zhang, and R. M. Xu. 2006. Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A. Science 312:748-751.
15. Izumiya, Y., et al. 2003. Kaposi's sarcoma-associated herpesvirus K-bZIP is a coregulator of K-Rta: physical association and promoter-dependent transcriptional repression. J. Virol. 77:1441-1451. (Pubitemid 36055565)
16. Izumiya, Y., et al. 2003. Cell cycle regulation by Kaposi's sarcoma-associated herpesvirus K-bZIP: direct interaction with cyclin-CDK2 and induction of G1 growth arrest. J. Virol. 77:9652-9661. (Pubitemid 37011058)
17. Kato-Noah, T., et al. 2007. Overexpression of the Kaposi's sarcoma-associated herpesvirus transactivator K-Rta can complement a K-bZIP deletion BACmid and yields an enhanced growth phenotype. J. Virol. 81:13519-13532. (Pubitemid 350247846)
18. Kim, J., et al. 2006. Tudor, MBT and chromo domains gauge the degree of lysine methylation. EMBO Rep. 7:397-403.
19. Klose, R. J., E. M. Kallin, and Y. Zhang. 2006. JmjC-domain-containing proteins and histone demethylation. Nat. Rev. Genet. 7:715-727.
20. Klose, R. J., et al. 2006. The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36. Nature 442:312-316. (Pubitemid 44114907)
21. Lee, J., J. R. Thompson, M. V. Botuyan, and G. Mer. 2008. Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor. Nat. Struct. Mol. Biol. 15:109-111.
22. Lefort, S., and L. Flamand. 2009. Kaposi's sarcoma-associated herpesvirus K-bZIP protein is necessary for lytic viral gene expression, DNA replication, and virion production in primary effusion lymphoma cell lines. J. Virol. 83:5869-5880.
23. Lefort, S., A. Gravel, and L. Flamand. 2010. Repression of interferon-alpha stimulated genes expression by Kaposi's sarcoma-associated herpesvirus K-bZIP protein. Virology 408:14-30.
24. Lefort, S., A. Soucy-Faulkner, N. Grandvaux, and L. Flamand. 2007. Binding of Kaposi's sarcoma-associated herpesvirus K-bZIP to interferon-responsive factor 3 elements modulates antiviral gene expression. J. Virol. 81:10950-10960. (Pubitemid 47536069)
25. Liao, W., Y. Tang, S. F. Lin, H. J. Kung, and C. Z. Giam. 2003. K-bZIP of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV-8) binds KSHV/HHV-8 Rta and represses Rta-mediated transactivation. J. Virol. 77:3809-3815.
26. Lim, S., E. Metzger, R. Schule, J. Kirfel, and R. Buettner. 2010. Epigenetic regulation of cancer growth by histone demethylases. Int. J. Cancer 127:1991-1998.
27. Nakamura, H., et al. 2003. Global changes in Kaposi's sarcoma-associated virus gene expression patterns following expression of a tetracycline-inducible Rta transactivator. J. Virol. 77:4205-4220. (Pubitemid 36350959)
28. Park, J., et al. 2000. The K-bZIP protein from Kaposi's sarcoma-associated herpesvirus interacts with p53 and represses its transcriptional activity. J. Virol. 74:11977-11982. (Pubitemid 32222350)
29. Pasini, D., et al. 2008. Regulation of stem cell differentiation by histone methyltransferases and demethylases. Cold Spring Harb. Symp. Quant. Biol. 73:253-263.
30. Sakakibara, S., et al. 2004. Accumulation of heterochromatin components on the terminal repeat sequence of Kaposi's sarcoma-associated herpesvirus mediated by the latency-associated nuclear antigen. J. Virol. 78:7299-7310. (Pubitemid 38915876)
31. Secombe, J., L. Li, L. Carlos, and R. N. Eisenman. 2007. The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth. Genes Dev. 21:537-551.
32. Shi, Y., et al. 2004. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 119:941-953. (Pubitemid 40037608)
33. Shin, S., and R. Janknecht. 2007. Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D. Biochem. Biophys. Res. Commun. 359:742-746.
34. Tomita, M., J. Choe, T. Tsukazaki, and N. Mori. 2004. The Kaposi's sarcoma-associated herpesvirus K-bZIP protein represses transforming growth factor beta signaling through interaction with CREB-binding protein. Oncogene 23:8272-8281. (Pubitemid 39531838)
35. Toth, Z., et al. 2010. Epigenetic analysis of KSHV latent and lytic genomes. PLoS Pathog. 6:e1001013.
36. Tsukada, Y., T. Ishitani, and K. I. Nakayama. 2010. KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development. Genes Dev. 24:432-437.
37. Vieira, J., and P. M. O'Hearn. 2004. Use of the red fluorescent protein as a marker of Kaposi's sarcoma-associated herpesvirus lytic gene expression. Virology 325:225-240.
38. Whetstine, J. R., et al. 2006. Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell 125:467-481.
39. Wu, F. Y., et al. 2002. Lytic replication-associated protein (RAP) encoded by Kaposi sarcoma-associated herpesvirus causes p21CIP-1-mediated G1 cell cycle arrest through CCAAT/enhancer-binding protein-alpha. Proc. Natl. Acad. Sci. U. S. A. 99:10683-10688.
40. Zhang, D., H. G. Yoon, and J. Wong. 2005. JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2). Mol. Cell. Biol. 25:6404-6414.