Inhibition of Na+/H+ exchanger 1 by cariporide alleviates burn-induced multiple organ injury

Journal of Surgical Research

Volumn 185, Issue 2, 2013, Pages 797-804

  Yang, Xuekang ^a   Bai, Hua ^b   Cai, Weixia ^a   Liu, Jiaqi ^a   Wang, Yunchuan ^a   Xu, Yuqiao ^a   Li, Jun ^a   Zhou, Qin ^a   Han, Juntao ^a   Zhu, Xiongxiang ^a   Dong, Maolong ^a   Hu, Dahai ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Burns; Inflammation; Multiple organ injury

Indexed keywords

CARIPORIDE; INTERLEUKIN 6; MYELOPEROXIDASE; SODIUM PROTON EXCHANGE PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; ANTIARRHYTHMIC AGENT; GUANIDINE DERIVATIVE; SLC9A1 PROTEIN, RAT; SODIUM PROTON EXCHANGE PROTEIN; SULFONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY SURFACE; BURN; CHEMICAL PARAMETERS; CONTROLLED STUDY; CYTOKINE PRODUCTION; EDEMA; ENZYME ACTIVITY; HEART INJURY; HISTOPATHOLOGY; INTESTINE INJURY; KIDNEY INJURY; LUNG INJURY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TISSUE INJURY; ANIMAL; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION; GENETICS; HEART CONTRACTION; INFLAMMATION; INTESTINE; KIDNEY; LUNG; MULTIPLE ORGAN FAILURE; MULTIPLE ORGAN INJURY; NA(+)/H(+) EXCHANGER 1; PHYSIOLOGY; SPRAGUE DAWLEY RAT; ANTAGONISTS AND INHIBITORS; BURNS; COMPLICATION; DRUG EFFECTS;

BURNS; INFLAMMATION; MULTIPLE ORGAN INJURY; NA(+)/H(+) EXCHANGER 1;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; BURNS; DISEASE MODELS, ANIMAL; GENE EXPRESSION; GUANIDINES; INTESTINES; KIDNEY; LUNG; MALE; MULTIPLE ORGAN FAILURE; MYOCARDIAL CONTRACTION; RATS; RATS, SPRAGUE-DAWLEY; SODIUM-HYDROGEN ANTIPORTER; SULFONES;

EID: 84891687335     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2013.06.049     Document Type: Article

References (36)

1. Fitzwater J, Purdue GF, Hunt JL, O'Keefe GE. The risk factors and time course of sepsis and organ dysfunction after burn trauma. J Trauma 2003;54:959.
2. Bloemsma GC, Dokter J, Boxma H, Oen IM. Mortality and causes of death in a burn centre. Burns 2008;34:1103.
3. Schwacha MG Macrophages and post-burn immune dysfunction. Burns 2003;29:1.
4. Kallinen O, Maisniemi K, Bohling T, Tukiainen E, Koljonen V. Multiple organ failure as a cause of death in patients with severe burns. J Burn Care Res 2012;33:206.
5. Fliegel L. The Na+/H+ exchanger isoform 1. Int J Biochem Cell Biol 2005;37:33.
6. Baumgartner M, Patel H, Barber DL. Na(+)/H(+) exchanger NHE1 as plasma membrane scaffold in the assembly of signaling complexes. Am J Physiol Cell Physiol 2004;287:C844.
7. Yang X, Wang D, Dong W, Song Z, Dou K. Expression and modulation of Na(+)/H(+) exchanger 1 gene in hepatocellular carcinoma: a potential therapeutic target. J Gastroenterol Hepatol 2011;26:364.
8. Yang X, Wang D, Dong W, Song Z, Dou K. Inhibition of Na+/H+ exchanger 1 by 5-(N-ethyl-N-isopropyl) amiloride reduces hypoxia-induced hepatocellular carcinoma invasion and motility. Cancer Lett 2010;295:198.
9. Masereel B, Pochet L, Laeckmann D. An overview of inhibitors of Na(+)/H(+) exchanger. Eur J Med Chem 2003;38:547.
10. Karmazyn M, Moffat MP. Role of Na+/H+ exchange in cardiac physiology and pathophysiology: mediation of myocardial reperfusion injury by the pH para-dox. Cardiovasc Res 1993;27:915.
11. Suzuki Y, Matsumoto Y, Ikeda Y, Kondo K, Ohashi N, Umemura K. SM-20220, a Na(+)/H(+) exchanger inhibitor: effects on ischemic brain damage through edema and neutrophil accumulation in a rat middle cerebral artery occlusion model. Brain Res 2002;945:242.
12. Matteucci E, Carmellini M, Mosca F, Giampietro O. The contribution of Na+/H+ exchange to postreperfusion injury and recovery of transplanted kidney. Biomed Pharmacother 1999;53:438.
13. Wang D, Dou K, Song Z, Liu Z. The Na+/H+ exchange inhibitor: a new therapeutic approach for hepatic ischemia injury in rats. Transpl Proc 2003;35:3134.
14. De Vito P. The sodium/hydrogen exchanger: a possible mediator of immunity. Cell Immunol 2006;240:69.
15. Shi Y, Kim D, Caldwell M, Sun D. The role of Na(+)/h (+) exchanger isoform 1 in inflammatory responses: maintaining H(+) homeostasis of immune cells. Adv Exp Med Biol 2013;961:411.
16. Civitelli R, Teitelbaum SL, Hruska KA, Lacey DL. IL-1 activates the Na+/H+ antiport in a murine T cell. J Immunol 1989;143: 4000.
17. Vairo G, Royston AK, Hamilton JA. Biochemical events accompanying macrophage activation and the inhibition of colony-stimulating factor-1-induced macrophage proliferation by tumor necrosis factor-alpha, interferon-gamma, and lipopolysaccharide. J Cell Physiol 1992;151:630.
18. Horikawa N, Kuribayashi Y, Matsui K, Kawamura N, Ohashi N. Na+/H+ exchange inhibitor SM-20220 attenuates leukocyte adhesion induced by ischemia-reperfusion. J Cardiovasc Pharmacol 2001;37:668.
19. Nemeth ZH, Deitch EA, Lu Q, Szabo C, Hasko G. NHE blockade inhibits chemokine production and NF-kappaB activation in immunostimulated endothelial cells. Am J Physiol Cell Physiol 2002;283:C396.
20. Wu D, Dai H, Arias J, Latta L, Abraham WM. Low-volume resuscitation from traumatic hemorrhagic shock with Na+/H+ exchanger inhibitor. Crit Care Med 2009;37:1994.
21. Wu D, Arias J, Bassuk J, et al. Na+/H+ exchange inhibition delays the onset of hypovolemic circulatory shock in pigs. Shock 2008;29:519.
22. Wu D, Bassuk J, Arias J, Doods H, Adams JA. Cardiovascular effects of NA+/H+ exchanger inhibition with BIIB513 following hypovolemic circulatory shock. Shock 2005;23:269.
23. Wu D, Qi J, Dai H, Doods H, Abraham WM. Resuscitation with Na+/H+ exchanger inhibitor in traumatic haemorrhagic shock: cardiopulmonary performance, oxygen transport and tissue inflammation. Clin Exp Pharmacol Physiol 2010;37:337.
24. Wu D, Qi J. Mechanisms of the beneficial effect of NHE1 inhibitor in traumatic hemorrhage: inhibition of inflammatory pathways. Resuscitation 2012;83:774.
25. Geny B, Khun H, Fitting C, et al. Clostridium sordellii lethal toxin kills mice by inducing a major increase in lung vascular permeability. Am J Pathol 2007;170:1003.
26. MacMicking J, Xie Q-W, Nathan C. Nitric oxide and macrophage function. Annu Rev Immunol 1997;15:323.
27. Yamada Y, Endo S, Inada K, et al. Tumor necrosis factor-alpha and tumor necrosis factor receptor I, II levels in patients with severe burns. Burns 2000;26:239.
28. Orlinska U, Newton RC. Modification of tumor necrosis factor-alpha (TNF-alpha) production by the Na(+)-dependent HCO3-cotransport in lipopolysaccharide-activated human monocytes. Immunopharmacology 1995;30:41.
29. Wang J, Cheng X, Xiang MX, et al. IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/-mice. J Clin Invest 2011; 121:3564.
30. Cakir B, Cevik H, Contuk G, Ercan F, Eksioglu-Demiralp E, Yegen BC. Leptin ameliorates burn-induced multiple organ damage and modulates postburn immune response in rats. Regul Pept 2005;125:135.
31. Sherwood ER, Toliver-Kinsky T. Mechanisms of the inflammatory response. Best Pract Res Clin Anaesthesiol 2004;18:385.
32. Kovach MA, Standiford TJ. The function of neutrophils in sepsis. Curr Opin Infect Dis 2012;25:321.
33. Fujiyoshi N, Deitch EA, Feketeova E, et al. Amiloride combined with small-volume resuscitation with hypertonic saline is superior in ameliorating trauma-hemorrhagic shock-induced lung injury in rats to the administration of either agent alone. Crit Care Med 2005;33:2592.
34. Jeschke MG, Gauglitz GG, Song J, et al. Calcium and ER stress mediate hepatic apoptosis after burn injury. J Cell Mol Med 2009;13:1857.
35. Song HP, Zhang L, Dang YM, Yan H, Chu ZG, Huang YS. The phosphatidylinositol 3-kinase-Akt pathway protects cardiomyocytes from ischaemic and hypoxic apoptosis via mitochondrial function. Clin Exp Pharmacol Physiol 2010; 37:598.
36. Liang WY, Tang LX, Yang ZC, Huang YS. Calcium induced the damage of myocardial mitochondrial respiratory function in the early stage after severe burns. Burns 2002;28:143.