Cardiovascular effects of NA+/H+ exchanger inhibition with BIIB513 following hypovolemic circulatory shock

Shock

Volumn 23, Issue 3, 2005, Pages 269-274

  Wu, Dongmei ^a   Bassuk, Jorge ^a   Arias, Jaqueline ^a   Doods, Henri ^b   Adams, Jose A ^a  

^a MOUNT SINAI MEDICAL CENTER   (United States)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Cardiac function; Ischemia reperfusion; Metabolic acidosis; Pigs; Resuscitation

Indexed keywords

[4 [4 (2 FUROYL) 1 PIPERAZINYL] 3 (METHYLSULFONYL)BENZOYL]GUANIDINE; CREATINE KINASE; SODIUM PROTON EXCHANGE PROTEIN; TROPONIN I;

ARTICLE; BLEEDING; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; FEMALE; HEART MUSCLE INJURY; HEART PERFORMANCE; HEMODYNAMICS; HYPOVOLEMIC SHOCK; ISCHEMIA; MALE; METABOLIC ACIDOSIS; NONHUMAN; REPERFUSION; RESUSCITATION; SWINE; TISSUE OXYGENATION;

ANIMALS; BLOOD PRESSURE; ECHOCARDIOGRAPHY; FEMALE; HEMODYNAMIC PROCESSES; MALE; MESYLATES; MYOCARDIAL REPERFUSION INJURY; OXYGEN; SHOCK; SODIUM-HYDROGEN ANTIPORTER; SUS SCROFA; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 14344265433     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.shk.0000150774.93741.26     Document Type: Article

References (31)

1. Zager RA: Adenine nucleotide changes in kidney, liver, and small intestine during different forms of ischemic injury. Circ Res 68:185-196, 1991.
2. Chaudry IH, Sayeed MM, Baue AE: Depletion and restoration of tissue ATP in hemorrhagic shock. Arch Surg 108:208-211, 1974.
3. Horton JW, McDonald G: Heart and brain nucleotide pools during hemorrhage and resuscitation. Am J Physiol 259:H1781-H1788, 1990.
4. Karmazyn M: Mechanisms of protection of the ischemic and reperfused myocardium by sodium-hydrogen exchange inhibition. J Thromb Thrombolysis 8:33-38, 1999.
5. + exchanger activity: potential pathophysiological significance of endogenous mediators and oxidant stress. J Thromb Thrombolysis 8:25-32, 1999.
6. Orlowski J, Grinstein S: Diversity of the mammalian sodium/proton exchanger SLC9 gene family. Pflugers Arch 447:549-565, 2004.
7. Gumina RJ, Gross GJ: If ischemic preconditioning is the gold standard, has a platinum standard of cardioprotection arrived? Comparison with NHE inhibition. J Thromb Thrombolysis 8:39-44, 1999.
8. Ryan JB, Hicks M, Cropper JR, Garlick SR, Kesteven SH, Wilson MK, Feneley MP, Macdonald PS: Cariporide (HOE-642) improves cardiac allograft preservation in a porcine model of orthotopic heart transplantation. Transplantation 75:625-631, 2003.
9. Ayoub IM, Kolarova J, Yi Z, Trevedi A, Deshmukh H, Lubell DL, Franz MR, Maldonado FA, Gazmuri RJ: Sodium-hydrogen exchange inhibition during ventricular fibrillation: beneficial effects on ischemic contracture, action potential duration, reperfusion arrhythmias, myocardial function, and resuscitability. Circulation 107:1804-1809, 2003.
10. + exchanger inhibitor during cardioplegic arrest and cardiopulmonary bypass. Chest 123:187-194, 2003.
11. Suzuki Y, Matsumoto Y, Ikeda Y, Kondo K, Ohashi N, Umemura K: SM-20220, a Na(+)/H(+) exchanger inhibitor: effects on ischemic brain damage through edema and neutrophil accumulation in a rat middle cerebral artery occlusion model. Brain Res 945:242-248, 2002.
12. Wu D, Stassen JM, Seidler R, Doods H: Effects of BIIB513 on ischemia-induced arrhythmias and myocardial infarction in anesthetized rats. Basic Res Cardiol 95:449-456, 2000.
13. De Paepe P, Belpaire FM, Rosseel MT, Van Hoey G, Boon PA, Buylaert WA: Influence of hypovolemia on the pharmacokinetics and the electroencephalographic effect of propofol in the rat. Anesthesiology 93:1482-1490, 2000.
14. Schiller NB, Shah PM, Crawford M, DeMaria A, Devereux R, Feigenbaum H, Gutgesell H, Reichek N, Sahn D, Schnittger I: Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. J Am Soc Echocardiogr 2:358-367, 1989.
15. Haljamae H: Pathophysiology of shock-induced disturbances in tissue homeostasis. Acta Anaesthesiol Scand Suppl 82:38-44, 1985.
16. Haljamae H: The pathophysiology of shock. Acta Anaesthesiol Scand Suppl 98:3-6, 1993.
17. Berne RM, Levy MN: Cardiovascular Physiology, 8th ed. St. Louis: Mosby, 1997.
18. Zakaria el R: Garrison RN, Spain DA. Harris PD. Impairment of endothelium-dependent dilation response after resuscitation from hemorrhagic shock involved postreceptor mechanisms. Shock 21:175-181, 2004.
19. Osband AJ, Deitch EA, Lu Q, Zaets S, Dayal S, Lukose B, Xu DZ: The role of oxidant-mediated pathways in the cytotoxicity of endothelial cells exposed to mesenteric lymph from rats subjected to trauma-hemorrhagic shock. Shock 20:269-273, 2003.
20. Prasad K, Kalra J, Bharadwaj L: Cardiac depressant effects of oxygen free radicals. Angiology 44:257-270, 1993.
21. Siegel HW, Downing SE: Contributions of coronary perfusion pressure, metabolic acidosis and adrenergic factors to the reduction of myocardial contractility during hemorrhagic shock in the cat. Circ Res 27:875-889, 1970.
22. Craft DV, Lefer DJ, Hock CE, Lefer AM: Significance of production of peptide leukotrienes in murine traumatic shock. Am J Physiol 251:H80-H85, 1986.
23. McCloskey CA, Zuckerbraun BS, Gallo DJ, Vodovotz Y, Billiar TR: A role for angiotensin II in the activation of extracellular signal-regulated kinases in the liver during hemorrhagic shock. Shock 20:316-319, 2003.
24. Zakaria el R: Garrison RN, Kawabe T, Harris PD. Role of neutrophils on shock/resuscitation-mediated intestinal arteriolar derangements. Shock 21:248-253, 2004.
25. Szabo C: The pathophysiological role of peroxynitrite in shock, inflammation, and ischemia-reperfusion injury. Shock 6:79-88, 1996.
26. Szabo C, Cuzzocrea S, Zingarelli B, O'Connor M, Salzman AL: Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite. J Clin Invest 100:723-735, 1997.
27. Gumina RJ, Auchampach J, Wang R, Buerger E, Eickmeier C, Moore J, Daemmgen J, Gross GJ: Na(+)/H(+) exchange inhibition-induced cardioprotection in dogs: effects on neutrophils versus cardiomyocytes. Am J Physiol Heart Circ Physiol 279:H1563-H1570, 2000.
28. + exchange inhibitor SM-20220 attenuates leukocyte adhesion induced by ischemia-reperfusion. J Cardiovasc Pharmacol 37:668-677, 2001.
29. + exchange inhibitor SM-20220 i 1F4 mproves endothelial dysfunction induced by ischemia-reperfusion. Jpn J Pharmacol 85:271-277, 2001.
30. Hropot M, Juretschke HP, Langer KH, Schwart JR: S3226, a novel NHE3 inhibitor, attenuates ischemia-induced acute renal failure in rats. Kidney Int 60:2283-2289, 2001.
31. Nemeth ZH, Deitch EA, Lu Q, Szabo C, Hasko G: NHE blockade inhibits chemokine production and NF-kappaB activation in immunostimulated endothelial cells. Am J Physiol Cell Physiol 283:C396-C403, 2002.