메뉴 건너뛰기




Volumn 22, Issue 1, 2014, Pages 1-9

Practicing pathology in the era of big data and personalized medicine

Author keywords

advanced personalized diagnostics; big data; companion diagnostics; diagnostic molecular pathology; digital pathology; genomics; immunohistochemistry; liquid morphology; mass spectrometry; metabolomics; molecular pathology; morphologic classification; nextgeneration sequencing; PCR; personalized medicine; predictive markers; proteomics; surgical pathology; targeted therapy

Indexed keywords

ANTINEOPLASTIC AGENT;

EID: 84891683794     PISSN: 15412016     EISSN: 15334058     Source Type: Journal    
DOI: 10.1097/PAI.0000000000000022     Document Type: Review
Times cited : (38)

References (49)
  • 1
    • 0030945581 scopus 로고    scopus 로고
    • Computerized three- and four-dimensional modeling of biomedical images for morphologists and pathologists
    • Gu J. Computerized three-and four-dimensional modeling of biomedical images for morphologists and pathologists. Cell Vision. 1997;4:6-15. (Pubitemid 27201515)
    • (1997) Cell Vision - Journal of Analytical Morphology , vol.4 , Issue.1 , pp. 6-15
    • Gu, J.1
  • 3
    • 81755188362 scopus 로고    scopus 로고
    • From microscopy to whole slide digital images: A century and a half of image
    • Taylor CR. From microscopy to whole slide digital images: a century and a half of image. Appl Histochem Mol Morph. 2011;19: 491-493.
    • (2011) Appl Histochem Mol Morph , vol.19 , pp. 491-493
    • Taylor, C.R.1
  • 4
    • 84891666412 scopus 로고    scopus 로고
    • Catalogue of Somatic Mutations in Cancer (COSMIC) Available at: Accessed October 20, 2013
    • Catalogue of Somatic Mutations in Cancer (COSMIC). Cell line project. Available at: http://www.cancer.sanger.ac.uk/. Accessed October 20, 2013.
    • Cell Line Project
  • 5
    • 82655176916 scopus 로고    scopus 로고
    • Multiplex mutation screening by mass spectrometry evaluation of 820 cases from a personalized cancer medicine registry
    • Beadling C, Heinrich MC, Warrick A, et al. Multiplex mutation screening by mass spectrometry evaluation of 820 cases from a personalized cancer medicine registry. JMol Diagn. 2011;13:504-513.
    • (2011) JMol Diagn , vol.13 , pp. 504-513
    • Beadling, C.1    Heinrich, M.C.2    Warrick, A.3
  • 6
    • 79952431304 scopus 로고    scopus 로고
    • Predictive, personalized, preventive, participatory (P4) cancer medicine.
    • Hood L, Friend SH. Predictive, personalized, preventive, participatory (P4) cancer medicine. Nat Rev Clin Oncol. 2011;8:184-187.
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 184-187
    • Hood, L.1    Friend, S.H.2
  • 7
    • 84865739425 scopus 로고    scopus 로고
    • Architecture of the human regulatory network derived from ENCODE data
    • Gerstein MB, Kundaje A, Hariharan M, et al. Architecture of the human regulatory network derived from ENCODE data. Nature. 2012;489:91-100.
    • (2012) Nature , vol.489 , pp. 91-100
    • Gerstein, M.B.1    Kundaje, A.2    Hariharan, M.3
  • 8
    • 84858433310 scopus 로고    scopus 로고
    • Personal omics profiling reveals dynamic molecular and medical phenotypes
    • Chen R, Mias GI, Li-Pook-Than J, et al. Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell. 2012;148: 1293-1307.
    • (2012) Cell , vol.148 , pp. 1293-1307
    • Chen, R.1    Mias, G.I.2    Li-Pook-Than, J.3
  • 9
    • 84891683039 scopus 로고    scopus 로고
    • Whole slide imaging-issues for use in diagnostic pathology: Routine; Stains, immunohistochemistry and predictive markers
    • In press
    • Taylor CR. Whole slide imaging-issues for use in diagnostic pathology: "routine;" stains, immunohistochemistry and predictive markers. Biotehnics and Histochem. 2013. In press.
    • (2013) Biotehnics and Histochem
    • Taylor, C.R.1
  • 10
    • 64849083705 scopus 로고    scopus 로고
    • The role of pathologists in the era of personalized medicine
    • Walk EE. The role of pathologists in the era of personalized medicine. Arch Pathol Lab Med. 2009;133:605-610.
    • (2009) Arch Pathol Lab Med , vol.133 , pp. 605-610
    • Walk, E.E.1
  • 11
    • 79954592811 scopus 로고    scopus 로고
    • A national agenda for the future of pathology in personalized medicine: Report of the proceedings of a meeting at the Banbury Conference Center on genome-era pathology, precision diagnostics, and preemptive care: A stakeholder summit
    • Tonellato PJ, Crawford JM, Boguski MS, et al. A national agenda for the future of pathology in personalized medicine: report of the proceedings of a meeting at the Banbury Conference Center on genome-era pathology, precision diagnostics, and preemptive care: a stakeholder summit. Am J Clin Pathol. 2011;135:668-672.
    • (2011) Am J Clin Pathol. , vol.135 , pp. 668-672
    • Tonellato, P.J.1    Crawford, J.M.2    Boguski, M.S.3
  • 12
    • 50149111390 scopus 로고    scopus 로고
    • Direct to confusion: Lessons learned from marketing BRCA testing
    • Matloff E, Caplan A. Direct to confusion: lessons learned from marketing BRCA testing. Am J Bioeth. 2008;8:5-8.
    • (2008) Am J Bioeth , vol.8 , pp. 5-8
    • Matloff, E.1    Caplan, A.2
  • 13
    • 52949089274 scopus 로고    scopus 로고
    • The current landscape for direct-toconsumer genetic testing: Legal, ethical, and policy issues
    • Hogarth S, Javitt G, Melzer D. The current landscape for direct-toconsumer genetic testing: legal, ethical, and policy issues. Annu Rev Genomics Hum Genet. 2008;9:161-182.
    • (2008) Annu Rev Genomics Hum Genet , vol.9 , pp. 161-182
    • Hogarth, S.1    Javitt, G.2    Melzer, D.3
  • 14
    • 33748269365 scopus 로고    scopus 로고
    • Quantification of immunohistochemistry - Issues concerning methods, utility and semiquantitative assessment II
    • DOI 10.1111/j.1365-2559.2006.02513.x
    • Taylor CR, Levenson RM. Quantification of immunohistochemistry-issues concerning methods, utility and semiquantitative assessment II. Histopathology. 2006;49:411-424. (Pubitemid 44401549)
    • (2006) Histopathology , vol.49 , Issue.4 , pp. 411-424
    • Taylor, C.R.1    Levenson, R.M.2
  • 15
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons DW, Jones S, Zhang X, et al. An integrated genomic analysis of human glioblastoma multiforme. Science. 2008;321: 1807-1812.
    • (2008) Science , vol.321 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3
  • 16
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • The Cancer Genome Atlas Network
    • The Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature. 2012;487:330-337.
    • (2012) Nature , vol.487 , pp. 330-337
  • 17
    • 84880156317 scopus 로고    scopus 로고
    • Implementing genomic medicine in pathology
    • Williams ES, Hegde M. Implementing genomic medicine in pathology. Adv Anat Pathol. 2013;20:238-244.
    • (2013) Adv Anat Pathol , vol.20 , pp. 238-244
    • Williams, E.S.1    Hegde, M.2
  • 18
  • 19
    • 84875520648 scopus 로고    scopus 로고
    • Analysis of circulating tumor DNA to monitor metastatic breast cancer
    • Dawson SJ, Tsui DW, Murtaza M, et al. Analysis of circulating tumor DNA to monitor metastatic breast cancer. N Engl J Med. 2013;368:1199-1209.
    • (2013) N Engl J Med , vol.368 , pp. 1199-1209
    • Dawson, S.J.1    Tsui, D.W.2    Murtaza, M.3
  • 20
    • 79551512452 scopus 로고    scopus 로고
    • Biomarkers for early detection and as surrogate endpoints in cancer prevention trials: Issues and opportunities
    • Dunn BK, Jegalian K, Greenwald P. Biomarkers for early detection and as surrogate endpoints in cancer prevention trials: issues and opportunities. Recent Results Cancer Res. 2011;188:21-47.
    • (2011) Recent Results Cancer Res , vol.188 , pp. 21-47
    • Dunn, B.K.1    Jegalian, K.2    Greenwald, P.3
  • 22
    • 79953158399 scopus 로고    scopus 로고
    • Exploring the genomes of cancer cells: Progress and promise
    • Stratton MR. Exploring the genomes of cancer cells: progress and promise. Science. 2011;331:1553-1558.
    • (2011) Science , vol.331 , pp. 1553-1558
    • Stratton, M.R.1
  • 23
    • 84861576201 scopus 로고    scopus 로고
    • The landscape of cancer genes and mutational processes in breast cancer
    • Stephens PJ, Tarpey PS, Davies H, et al. The landscape of cancer genes and mutational processes in breast cancer. Nature. 2012;486: 400-404.
    • (2012) Nature , vol.486 , pp. 400-404
    • Stephens, P.J.1    Tarpey, P.S.2    Davies, H.3
  • 24
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones S, Zhang X, Parsons DW, et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science. 2008;321:1801-1806.
    • (2008) Science , vol.321 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3
  • 26
    • 79251629946 scopus 로고    scopus 로고
    • The genetic landscape of the childhood cancer medulloblastoma
    • Parsons DW, Li M, Zhang X, et al. The genetic landscape of the childhood cancer medulloblastoma. Science. 2011;331:435-439.
    • (2011) Science , vol.331 , pp. 435-439
    • Parsons, D.W.1    Li, M.2    Zhang, X.3
  • 28
    • 74449085934 scopus 로고    scopus 로고
    • A small-cell lung cancer genome with complex signatures of tobacco exposure
    • Pleasance ED, Stephens PJ, O'Meara S, et al. A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature. 2010;463:184-190.
    • (2010) Nature , vol.463 , pp. 184-190
    • Pleasance, E.D.1    Stephens, P.J.2    O'Meara, S.3
  • 29
    • 54549094903 scopus 로고    scopus 로고
    • Somatic mutations affect key pathways in lung adenocarcinoma
    • Ding L, Getz G, Wheeler DA, et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature. 2008;455:1069-1075.
    • (2008) Nature , vol.455 , pp. 1069-1075
    • Ding, L.1    Getz, G.2    Wheeler, D.A.3
  • 31
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • DOI 10.1056/NEJMra0706596
    • Kerbel RS. Tumor angiogenesis. N Engl J Med. 2008;358: 2039-2049. (Pubitemid 351656458)
    • (2008) New England Journal of Medicine , vol.358 , Issue.19 , pp. 2039-2049
    • Kerbel, R.S.1
  • 33
    • 80054012347 scopus 로고    scopus 로고
    • Developmental and pathological angiogenesis
    • Chung AS, Ferrara N. Developmental and pathological angiogenesis. Annu Rev Cell Dev Biol. 2011;27:563-584.
    • (2011) Annu Rev Cell Dev Biol , vol.27 , pp. 563-584
    • Chung, A.S.1    Ferrara, N.2
  • 34
    • 84885735554 scopus 로고    scopus 로고
    • Mutational landscape and significance across 12 major cancer types
    • Kandoth C, McLellan MD, Vandin F, et al. Mutational landscape and significance across 12 major cancer types. Nature. 2013;502: 333-339.
    • (2013) Nature , vol.502 , pp. 333-339
    • Kandoth, C.1    McLellan, M.D.2    Vandin, F.3
  • 35
    • 78650842361 scopus 로고    scopus 로고
    • Liquid morphology: Immunochemical analysis of proteins extracted from formalin fixed paraffin embedded tissues: Combining proteomics with immunohistochemistry
    • Taylor CR, Becker KF. Liquid morphology: immunochemical analysis of proteins extracted from formalin fixed paraffin embedded tissues: combining proteomics with immunohistochemistry. Appl Immunohistochem Mol Morphol. 2011;19:1-9.
    • (2011) Appl Immunohistochem Mol Morphol , vol.19 , pp. 1-9
    • Taylor, C.R.1    Becker, K.F.2
  • 37
    • 78049398107 scopus 로고    scopus 로고
    • Distant metastasis occurs late during the genetic evolution of pancreatic cancer
    • Yachida S, Jones S, Bozic I, et al. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature. 2010;467: 1114-1117.
    • (2010) Nature , vol.467 , pp. 1114-1117
    • Yachida, S.1    Jones, S.2    Bozic, I.3
  • 38
    • 84859132868 scopus 로고    scopus 로고
    • Applying what we know to accelerate cancer prevention
    • Colditz GA, Wolin KY, Gehlert S. Applying what we know to accelerate cancer prevention. Sci Transl Med. 2012;4:127rv124.
    • (2012) Sci Transl Med , vol.4 , pp. 127-124
    • Colditz, G.A.1    Wolin, K.Y.2    Gehlert, S.3
  • 39
    • 79959832394 scopus 로고    scopus 로고
    • The DNA methylome
    • Pelizzola M, Ecker JR. The DNA methylome. FEBS Lett. 2011; 585:1994-2000.
    • (2011) FEBS Lett , vol.585 , pp. 1994-2000
    • Pelizzola, M.1    Ecker, J.R.2
  • 40
    • 63749109364 scopus 로고    scopus 로고
    • Linking somatic genetic alterations in cancer to therapeutics
    • Stuart D, Sellers WR. Linking somatic genetic alterations in cancer to therapeutics. Curr Opin Cell Biol. 2009;21:304-310.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 304-310
    • Stuart, D.1    Sellers, W.R.2
  • 42
    • 84878366889 scopus 로고    scopus 로고
    • Targeted therapy for HER2 positive breast cancer
    • Incorvati JA, Shah S, Mu Y, et al. Targeted therapy for HER2 positive breast cancer. J Hematol Oncol. 2013;6:38.
    • (2013) J Hematol Oncol , vol.6 , pp. 38
    • Incorvati, J.A.1    Shah, S.2    Mu, Y.3
  • 43
    • 79960042770 scopus 로고    scopus 로고
    • Targeted therapy in non-smallcell lung cancer-is it becoming a reality
    • Janku F, Stewart DJ, Kurzrock R. Targeted therapy in non-smallcell lung cancer-is it becoming a reality Nat Rev Clin Oncol. 2010; 7:401-414.
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 401-414
    • Janku, F.1    Stewart, D.J.2    Kurzrock, R.3
  • 44
    • 33748261211 scopus 로고    scopus 로고
    • Quantifiable internal reference standards for immunohistochemistry: The measurement of quantity by weight
    • PII 0012903920060900000001
    • Taylor CR. Quantifiable internal reference standards for immunohistochemistry; the measurement of quantity by weight. Appl Immunohistochem Mol Morph. 2006;14:253-259. (Pubitemid 44319049)
    • (2006) Applied Immunohistochemistry and Molecular Morphology , vol.14 , Issue.3 , pp. 253-259
    • Taylor, C.R.1
  • 46
    • 79951883428 scopus 로고    scopus 로고
    • Focus on Biospecimens: The issue is the tissue. Observations on the NCI-NIST fitness for purpose quality assessment and standards workshop" October 2010
    • Taylor CR. Focus on Biospecimens: the issue is the tissue. Observations on the "NCI-NIST fitness for purpose quality assessment and standards workshop". October 2010. Appl Histochem Mol Morph. 2011;19:95-98.
    • (2011) Appl Histochem Mol Morph , vol.19 , pp. 95-98
    • Taylor, C.R.1
  • 47
    • 78650841742 scopus 로고    scopus 로고
    • Symbiosis of immunohistochemistry and proteomics: Marching to a new era
    • Shi S-R, Taylor CR, eds Hoboken, NJ: JohnWiley and Sons, Inc
    • Shi SR, Balgley BM, Taylor CR. Symbiosis of Immunohistochemistry and Proteomics: Marching to a New Era. In: Shi S-R, Taylor CR, eds. Antigen Retrieval Immunohistochemistry Based Research and Diagnostics. Hoboken, NJ: JohnWiley and Sons, Inc.; 2010:391-398.
    • (2010) Antigen Retrieval Immunohistochemistry Based Research and Diagnostics , pp. 391-398
    • Shi, S.R.1    Balgley, B.M.2    Taylor, C.R.3
  • 48
    • 84876313066 scopus 로고    scopus 로고
    • Complete solubilization of formalin-fixed paraffin embedded tissues may improve proteomic studies
    • doi.10.1002.prca.201200031
    • Shi SR, Taylor CR, Fowler CB, et al. Complete solubilization of formalin-fixed paraffin embedded tissues may improve proteomic studies. Proteomics Clin Appl. 2013. doi.10.1002.prca.201200031.
    • (2013) Proteomics Clin Appl
    • Shi, S.R.1    Taylor, C.R.2    Fowler, C.B.3
  • 49
    • 84876475175 scopus 로고    scopus 로고
    • Distinct profile of driver mutations and clinical features in immunomarker-defined subsets of pulmonary large-cell carcinoma
    • Rekhtman N, Tafe LJ, Chaft JE, et al. Distinct profile of driver mutations and clinical features in immunomarker-defined subsets of pulmonary large-cell carcinoma. Mod Pathol. 2013;26:511-522.
    • (2013) Mod Pathol , vol.26 , pp. 511-522
    • Rekhtman, N.1    Tafe, L.J.2    Chaft, J.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.