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Volumn 26, Issue 4, 2013, Pages 511-522

Distinct profile of driver mutations and clinical features in immunomarker-defined subsets of pulmonary large-cell carcinoma

Author keywords

ALK; DNp63 p40; EGFR; KRAS; large cell carcinoma; TTF 1

Indexed keywords

AKT1 PROTEIN; ANAPLASTIC LYMPHOMA KINASE; B RAF KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE CATALYTIC SUBUNIT ALPHA; PROTEIN KINASE B; PROTEIN P40; THYROID TRANSCRIPTION FACTOR 1; TUMOR MARKER; UNCLASSIFIED DRUG;

EID: 84876475175     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2012.195     Document Type: Article
Times cited : (92)

References (60)
  • 3
    • 79551563284 scopus 로고    scopus 로고
    • International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung ade-nocarcinoma
    • Travis WD, Brambilla E, Noguchi M, et al. International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung ade-nocarcinoma. J Thorac Oncol 2011;6:244-285.
    • (2011) J Thorac Oncol , vol.6 , pp. 244-285
    • Travis, W.D.1    Brambilla, E.2    Noguchi, M.3
  • 4
    • 0017808867 scopus 로고
    • The fine structure of large cell undifferentiated carcinoma of the lung. Evidence for its relation to squamous cell carcinomas and adenocarcinomas
    • Churg A. The fine structure of large cell undifferen-tiated carcinoma of the lung. Evidence for its relation to squamous cell carcinomas and adenocarcinomas. Hum Pathol 1978;9:143-156. (Pubitemid 8385141)
    • (1978) Human Pathology , vol.9 , Issue.2 , pp. 143-156
    • Churg, A.1
  • 5
    • 0019506540 scopus 로고
    • Ultrastructural features of large cell carcinoma of the lung with reference to the prognosis of patients
    • DOI 10.1016/S0046-8177(81)80022-6
    • Horie A, Ohta M. Ultrastructural features of large cell carcinoma of the lung with reference to the prognosis of patients. Hum Pathol 1981;12:423-432. (Pubitemid 11057621)
    • (1981) Human Pathology , vol.12 , Issue.5 , pp. 423-432
    • Horie, A.1    Ohta, M.2
  • 6
    • 0021929393 scopus 로고
    • Large cell carcinoma of the lung. Ultrastructural differentiation and clinicopathologic correlations
    • DOI 10.1002/1097-0142(19851001)56:7<1618::AID-CNCR2820560726>3.0. CO;2-W
    • Albain KS, True LD, Golomb HM, et al. Large cell carcinoma of the lung. Ultrastructural differentiation and clinicopathologic correlations. Cancer 1985;56:1618-1623. (Pubitemid 15228512)
    • (1985) Cancer , vol.56 , Issue.7 , pp. 1618-1623
    • Albain, K.S.1    True, L.D.2    Golomb, H.M.3
  • 8
    • 77956418156 scopus 로고    scopus 로고
    • Gene expression-based classification of non-small cell lung carcinomas and survival prediction
    • Hou J, Aerts J, den Hamer B, et al. Gene expression-based classification of non-small cell lung carcinomas and survival prediction. PLoS One 2010;5:e10312.
    • (2010) PLoS One , vol.5
    • Hou, J.1    Aerts, J.2    Den Hamer, B.3
  • 9
    • 33645804773 scopus 로고    scopus 로고
    • Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors
    • DOI 10.1200/JCO.2005.03.8224
    • Takeuchi T, Tomida S, Yatabe Y, et al. Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors. J Clin Oncol 2006;24:1679-1688. (Pubitemid 46622139)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.11 , pp. 1679-1688
    • Takeuchi, T.1    Tomida, S.2    Yatabe, Y.3    Kosaka, T.4    Osada, H.5    Yanagisawa, K.6    Mitsudomi, T.7    Takahashi, T.8
  • 10
    • 0022233114 scopus 로고
    • Large cell carcinoma of the lung
    • Yesner R. Large cell carcinoma of the lung. Semin Diagn Pathol 1985;2:255-269. (Pubitemid 16249166)
    • (1985) Seminars in Diagnostic Pathology , vol.2 , Issue.4 , pp. 255-269
    • Yesner, R.1
  • 11
    • 78650384780 scopus 로고    scopus 로고
    • Optimal immunohis-tochemical markers for distinguishing lung adenocar-cinomas from squamous cell carcinomas in small tumor samples
    • Terry J, Leung S, Laskin J, et al. Optimal immunohis-tochemical markers for distinguishing lung adenocar-cinomas from squamous cell carcinomas in small tumor samples. Am J Surg Pathol 2010;34:1805-1811.
    • (2010) Am J Surg Pathol , vol.34 , pp. 1805-1811
    • Terry, J.1    Leung, S.2    Laskin, J.3
  • 14
    • 67349207430 scopus 로고    scopus 로고
    • Desmocollin-3: A new marker of squamous differentiation in undifferen-tiated large-cell carcinoma of the lung
    • Monica V, Ceppi P, Righi L, et al. Desmocollin-3: a new marker of squamous differentiation in undifferen-tiated large-cell carcinoma of the lung. Mod Pathol 2009;22:709-717.
    • (2009) Mod Pathol , vol.22 , pp. 709-717
    • Monica, V.1    Ceppi, P.2    Righi, L.3
  • 15
    • 80355129921 scopus 로고    scopus 로고
    • Heterogeneity of large cell carcinoma of the lung: An immunophenotypic and miRNA-based analysis
    • Barbareschi M, Cantaloni C, Del Vescovo V, et al. Heterogeneity of large cell carcinoma of the lung: an immunophenotypic and miRNA-based analysis. Am J Clin Pathol 2011;136:773-782.
    • (2011) Am J Clin Pathol , vol.136 , pp. 773-782
    • Barbareschi, M.1    Cantaloni, C.2    Del Vescovo, V.3
  • 16
    • 77957900146 scopus 로고    scopus 로고
    • The use of P63 immunohistochemistry for the identification of squamous cell carcinoma of the lung
    • Conde E, Angulo B, Redondo P, et al. The use of P63 immunohistochemistry for the identification of squamous cell carcinoma of the lung. PLoS One 2010;5:e12209.
    • (2010) PLoS One , vol.5
    • Conde, E.1    Angulo, B.2    Redondo, P.3
  • 18
    • 73349084270 scopus 로고    scopus 로고
    • Differential thymidylate synthase expression in different variants of large-cell carcinoma of the lung
    • Monica V, Scagliotti GV, Ceppi P, et al. Differential thymidylate synthase expression in different variants of large-cell carcinoma of the lung. Clin Cancer Res 2009;15:7547-7552.
    • (2009) Clin Cancer Res , vol.15 , pp. 7547-7552
    • Monica, V.1    Scagliotti, G.V.2    Ceppi, P.3
  • 19
    • 80053570615 scopus 로고    scopus 로고
    • Immuno-histochemical algorithm for differentiation of lung adenocarcinoma and squamous cell carcinoma based on large series of whole-tissue sections with validation in small specimens
    • Rekhtman N, Ang DC, Sima CS, et al. Immuno-histochemical algorithm for differentiation of lung adenocarcinoma and squamous cell carcinoma based on large series of whole-tissue sections with validation in small specimens. Mod Pathol 2011;24:1348-1359.
    • (2011) Mod Pathol , vol.24 , pp. 1348-1359
    • Rekhtman, N.1    Ang, D.C.2    Sima, C.S.3
  • 20
    • 84857794792 scopus 로고    scopus 로고
    • P40 (DNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma
    • Bishop JA, Teruya-Feldstein J, Westra WH, et al. p40 (DNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma. Mod Pathol 2012;25:405-415.
    • (2012) Mod Pathol , vol.25 , pp. 405-415
    • Bishop, J.A.1    Teruya-Feldstein, J.2    Westra, W.H.3
  • 21
    • 84858342603 scopus 로고    scopus 로고
    • D(delta) np63 (p40) and thyroid transcription factor-1 (ttf1) immunoreac-tivity upon small biopsies or cellblocks for typing non-small cell lung cancer: A novel two-hit, sparing-material approach
    • Pelosi G, Fabbri A, Bianchi F, et al. D(delta)np63 (p40) and thyroid transcription factor-1 (ttf1) immunoreac-tivity upon small biopsies or cellblocks for typing non-small cell lung cancer: a novel two-hit, sparing-material approach. J Thor Oncol 2012;7:281-290.
    • (2012) J Thor Oncol , vol.7 , pp. 281-290
    • Pelosi, G.1    Fabbri, A.2    Bianchi, F.3
  • 22
    • 84861231326 scopus 로고    scopus 로고
    • A study of deltaNp63 expression in lung non-small cell carcinomas
    • Nonaka D. A study of deltaNp63 expression in lung non-small cell carcinomas. Am J Surg Pathol 2012;36:895-899.
    • (2012) Am J Surg Pathol , vol.36 , pp. 895-899
    • Nonaka, D.1
  • 23
    • 79960674310 scopus 로고    scopus 로고
    • Immunohisto-chemical subtyping of nonsmall cell lung cancer not otherwise specified in fine-needle aspiration cytology: A retrospective study of 103 cases with surgical correlation
    • Righi L, Graziano P, Fornari A, et al. Immunohisto-chemical subtyping of nonsmall cell lung cancer not otherwise specified in fine-needle aspiration cytology: a retrospective study of 103 cases with surgical correlation. Cancer 2011;117:3416-3423.
    • (2011) Cancer , vol.117 , pp. 3416-3423
    • Righi, L.1    Graziano, P.2    Fornari, A.3
  • 24
    • 84861990751 scopus 로고    scopus 로고
    • Individualized therapy for patients with non-small cell lung cancer: Emerging trends and challenges
    • Langer CJ. Individualized therapy for patients with non-small cell lung cancer: emerging trends and challenges. Crit Rev Oncol/Hematol 2012;83:130-144.
    • (2012) Crit Rev Oncol/Hematol , vol.83 , pp. 130-144
    • Langer, C.J.1
  • 25
    • 84857087591 scopus 로고    scopus 로고
    • Clarifying the spectrum of driver oncogene mutations in biomarker-verified squamous carcinoma of lung: Lack of EGFR/KRAS and presence of PIK3CA/AKT1 mutations
    • Rekhtman N, Paik PK, Arcila ME, et al. Clarifying the spectrum of driver oncogene mutations in biomarker-verified squamous carcinoma of lung: lack of EGFR/KRAS and presence of PIK3CA/AKT1 mutations. Clin Cancer Res 2012;18:1167-1176.
    • (2012) Clin Cancer Res , vol.18 , pp. 1167-1176
    • Rekhtman, N.1    Paik, P.K.2    Arcila, M.E.3
  • 26
    • 77149130499 scopus 로고    scopus 로고
    • Clinico-pathologic features of non-small-cell lung cancer with EML4-ALK fusion gene
    • Takahashi T, Sonobe M, Kobayashi M, et al. Clinico-pathologic features of non-small-cell lung cancer with EML4-ALK fusion gene. Ann Surg Oncol 2010;17:889-897.
    • (2010) Ann Surg Oncol , vol.17 , pp. 889-897
    • Takahashi, T.1    Sonobe, M.2    Kobayashi, M.3
  • 27
    • 80053014471 scopus 로고    scopus 로고
    • Clinical features and outcome of patients with non-small-cell lung cancer harboring BRAF mutations
    • Marchetti A, Felicioni L, Malatesta S, et al. Clinical features and outcome of patients with non-small-cell lung cancer harboring BRAF mutations. J Clin Oncol 2011;29:3574-3579.
    • (2011) J Clin Oncol , vol.29 , pp. 3574-3579
    • Marchetti, A.1    Felicioni, L.2    Malatesta, S.3
  • 28
    • 84866865231 scopus 로고    scopus 로고
    • Squamous cell carcinomas of the lung: Emerging biology, controversies, and the promise of targeted therapy
    • Drilon A, Rekhtman N, Ladanyi M, et al. Squamous cell carcinomas of the lung: emerging biology, controversies, and the promise of targeted therapy. Lancet Oncol 2012;13:e418-e426.
    • (2012) Lancet Oncol , vol.13
    • Drilon, A.1    Rekhtman, N.2    Ladanyi, M.3
  • 30
    • 33645290760 scopus 로고    scopus 로고
    • Mutations within the tyrosine kinase domain of EGFR gene specifically occur in lung adenocarcinoma patients with a low exposure of tobacco smoking
    • Sugio K, Uramoto H, Ono K, et al. Mutations within the tyrosine kinase domain of EGFR gene specifically occur in lung adenocarcinoma patients with a low exposure of tobacco smoking. Br J Cancer 2006;94:896-903.
    • (2006) Br J Cancer , vol.94 , pp. 896-903
    • Sugio, K.1    Uramoto, H.2    Ono, K.3
  • 31
    • 65349167234 scopus 로고    scopus 로고
    • EGFR and K-ras mutations along the spectrum of pulmonary epithelial tumors of the lung and elaboration of a combined clinicopathologic and molecular scoring system to predict clinical responsiveness to EGFR inhibitors
    • Sartori G, Cavazza A, Sgambato A, et al. EGFR and K-ras mutations along the spectrum of pulmonary epithelial tumors of the lung and elaboration of a combined clinicopathologic and molecular scoring system to predict clinical responsiveness to EGFR inhibitors. Am J Clin Pathol 2009;131:478-489.
    • (2009) Am J Clin Pathol , vol.131 , pp. 478-489
    • Sartori, G.1    Cavazza, A.2    Sgambato, A.3
  • 34
    • 0026680448 scopus 로고
    • Clinical significance of ras oncogene activation in human lung cancer
    • Rodenhuis S, Slebos RJ. Clinical significance of ras oncogene activation in human lung cancer. Cancer Res 1992;52:2665s-2669ss.
    • (1992) Cancer Res , vol.52
    • Rodenhuis, S.1    Slebos, R.J.2
  • 35
    • 78651071913 scopus 로고    scopus 로고
    • Detection of KRAS and BRAF mutations in colorectal carcinoma roles for high-sensitivity locked nucleic acid-PCR sequencing and broad-spectrum mass spectrometry genotyping
    • Arcila M, Lau C, Nafa K, et al. Detection of KRAS and BRAF mutations in colorectal carcinoma roles for high-sensitivity locked nucleic acid-PCR sequencing and broad-spectrum mass spectrometry genotyping. J Mol Diagn 2011;13:64-73.
    • (2011) J Mol Diagn , vol.13 , pp. 64-73
    • Arcila, M.1    Lau, C.2    Nafa, K.3
  • 36
    • 33846706090 scopus 로고    scopus 로고
    • Identical epidermal growth factor receptor mutations in adenocarcinomatous and squamous cell carcinomatous components of adenosquamous carcinoma of the lung
    • DOI 10.1002/cncr.22413
    • Kang SM, Kang HJ, Shin JH, et al. Identical epidermal growth factor receptor mutations in adenocarcinoma-tous and squamous cell carcinomatous components of adenosquamous carcinoma of the lung. Cancer 2007;109:581-587. (Pubitemid 46190967)
    • (2007) Cancer , vol.109 , Issue.3 , pp. 581-587
    • Kang, S.M.1    Kang, H.J.2    Shin, J.H.3    Kim, H.4    Shin, D.H.5    Kim, S.K.6    Kim, J.-H.7    Chung, K.Y.8    Kim, S.K.9    Chang, J.10
  • 37
    • 33644502521 scopus 로고    scopus 로고
    • Mutations of epidermal growth factor receptor and K-ras genes in adenosquamous carcinoma of the lung
    • Toyooka S, Yatabe Y, Tokumo M, et al. Mutations of epidermal growth factor receptor and K-ras genes in adenosquamous carcinoma of the lung. Int J Cancer 2006;118:1588-1590.
    • (2006) Int J Cancer , vol.118 , pp. 1588-1590
    • Toyooka, S.1    Yatabe, Y.2    Tokumo, M.3
  • 38
    • 53249145767 scopus 로고    scopus 로고
    • Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma
    • Riely GJ, Kris MG, Rosenbaum D, et al. Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma. Clin Cancer Res 2008;14:5731-5734.
    • (2008) Clin Cancer Res , vol.14 , pp. 5731-5734
    • Riely, G.J.1    Kris, M.G.2    Rosenbaum, D.3
  • 39
    • 79954626149 scopus 로고    scopus 로고
    • Pathological diagnosis and classification of lung cancer in small biopsies and cytology: Strategic management of tissue for molecular testing
    • Travis WD, Rekhtman N. Pathological diagnosis and classification of lung cancer in small biopsies and cytology: strategic management of tissue for molecular testing. Semin Respir Crit Care Med 2011;32:22-31.
    • (2011) Semin Respir Crit Care Med , vol.32 , pp. 22-31
    • Travis, W.D.1    Rekhtman, N.2
  • 40
    • 84888057004 scopus 로고    scopus 로고
    • Two year results of LC-MAP: An institutional program to routinely profile tumor specimens for the presence of mutations in targetable pathways in all patients with non-small cell lung cancers
    • Kris MG, Arcila ME, Lau C, et al. Two year results of LC-MAP: an institutional program to routinely profile tumor specimens for the presence of mutations in targetable pathways in all patients with non-small cell lung cancers. J Thorac Oncol 2011;6:S346-S347.
    • (2011) J Thorac Oncol , vol.6
    • Kris, M.G.1    Arcila, M.E.2    Lau, C.3
  • 41
    • 76349090221 scopus 로고    scopus 로고
    • Clinicopathological predictors of EGFR/KRAS mutational status in primary lung adenocarcinomas
    • Dacic S, Shuai Y, Yousem S, et al. Clinicopathological predictors of EGFR/KRAS mutational status in primary lung adenocarcinomas. Mod Pathol 2010;23:159-168.
    • (2010) Mod Pathol , vol.23 , pp. 159-168
    • Dacic, S.1    Shuai, Y.2    Yousem, S.3
  • 42
    • 46249096082 scopus 로고    scopus 로고
    • Lung adenocarcinoma: Modification of the 2004 WHO mixed subtype to include the major histologic subtype suggests correlations between papillary and micropapillary adenocarcinoma subtypes, EGFR mutations and gene expression analysis
    • Motoi N, Szoke J, Riely GJ, et al. Lung adenocarcinoma: modification of the 2004 WHO mixed subtype to include the major histologic subtype suggests correlations between papillary and micropapillary adenocarcinoma subtypes, EGFR mutations and gene expression analysis. Am J Surg Pathol 2008;32:810-827.
    • (2008) Am J Surg Pathol , vol.32 , pp. 810-827
    • Motoi, N.1    Szoke, J.2    Riely, G.J.3
  • 43
    • 79551506559 scopus 로고    scopus 로고
    • Characteristic morphology and immunoprofile of lung adenocarci-noma with kras mutations: Propensity for solid growth pattern and correlation with TTF-1 expression
    • Ang DC, Zakowski MF, Ladanyi M, et al. Characteristic morphology and immunoprofile of lung adenocarci-noma with kras mutations: propensity for solid growth pattern and correlation with TTF-1 expression. Mod Pathol 2010;23:396A.
    • (2010) Mod Pathol , vol.23
    • Ang, D.C.1    Zakowski, M.F.2    Ladanyi, M.3
  • 44
    • 79251490374 scopus 로고    scopus 로고
    • New driver mutations in non-small-cell lung cancer
    • Pao W, Girard N. New driver mutations in non-small-cell lung cancer. Lancet Oncol 2011;12:175-180.
    • (2011) Lancet Oncol , vol.12 , pp. 175-180
    • Pao, W.1    Girard, N.2
  • 45
    • 78650026316 scopus 로고    scopus 로고
    • KRAS and BRAF: Drug targets and predictive biomarkers
    • Vakiani E, Solit DB. KRAS and BRAF: drug targets and predictive biomarkers. J Pathol 2011;223:219-229.
    • (2011) J Pathol , vol.223 , pp. 219-229
    • Vakiani, E.1    Solit, D.B.2
  • 46
    • 79961099514 scopus 로고    scopus 로고
    • Comprehensive histologic analysis of ALK-rearranged lung carcinomas
    • Yoshida A, Tsuta K, Nakamura H, et al. Comprehensive histologic analysis of ALK-rearranged lung carcinomas. Am J Surg Pathol 2011;35:1226-1234.
    • (2011) Am J Surg Pathol , vol.35 , pp. 1226-1234
    • Yoshida, A.1    Tsuta, K.2    Nakamura, H.3
  • 47
    • 78650862148 scopus 로고    scopus 로고
    • Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: Utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6
    • Mukhopadhyay S, Katzenstein AL. Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6. Am J Surg Pathol 2011;35:15-25.
    • (2011) Am J Surg Pathol , vol.35 , pp. 15-25
    • Mukhopadhyay, S.1    Katzenstein, A.L.2
  • 48
    • 79958106556 scopus 로고    scopus 로고
    • Immunohistochem-istry by means of widely agreed-upon markers (cyto-keratins 5/6 and 7, p63, thyroid transcription factor-1, and Vimentin) on small biopsies of non-small cell lung cancer effectively parallels the corresponding profiling and eventual diagnoses on surgical specimens
    • Pelosi G, Rossi G, Bianchi F, et al. Immunohistochem-istry by means of widely agreed-upon markers (cyto-keratins 5/6 and 7, p63, thyroid transcription factor-1, and Vimentin) on small biopsies of non-small cell lung cancer effectively parallels the corresponding profiling and eventual diagnoses on surgical specimens. J Thorac Oncol 2011;6:1039-1049.
    • (2011) J Thorac Oncol , vol.6 , pp. 1039-1049
    • Pelosi, G.1    Rossi, G.2    Bianchi, F.3
  • 49
    • 79959893168 scopus 로고    scopus 로고
    • Utility of 10 immunohistochemical markers including novel markers (desmocollin-3, glypican 3, S100A2, S100A7, and Sox-2) for differential diagnosis of squamous cell carcinoma from adenocarcinoma of the lung
    • Tsuta K, Tanabe Y, Yoshida A, et al. Utility of 10 immunohistochemical markers including novel markers (desmocollin-3, glypican 3, S100A2, S100A7, and Sox-2) for differential diagnosis of squamous cell carcinoma from adenocarcinoma of the lung. J Thorac Oncol 2011;6:1190-1199.
    • (2011) J Thorac Oncol , vol.6 , pp. 1190-1199
    • Tsuta, K.1    Tanabe, Y.2    Yoshida, A.3
  • 50
    • 79955571953 scopus 로고    scopus 로고
    • Impact of proposed IASLC/ATS/ERS classification of lung ade-nocarcinoma: Prognostic subgroups and implications for further revision of staging based on analysis of 514 stage i cases
    • Yoshizawa A, Motoi N, Riely GJ, et al. Impact of proposed IASLC/ATS/ERS classification of lung ade-nocarcinoma: prognostic subgroups and implications for further revision of staging based on analysis of 514 stage I cases. Mod Pathol 2011;24:653-664.
    • (2011) Mod Pathol , vol.24 , pp. 653-664
    • Yoshizawa, A.1    Motoi, N.2    Riely, G.J.3
  • 51
    • 84861309355 scopus 로고    scopus 로고
    • Histologic patterns and molecular characteristics of lung adeno-carcinoma associated with clinical outcome
    • Solis LM, Behrens C, Raso MG, et al. Histologic patterns and molecular characteristics of lung adeno-carcinoma associated with clinical outcome. Cancer 2012;118:2889-2899.
    • (2012) Cancer , vol.118 , pp. 2889-2899
    • Solis, L.M.1    Behrens, C.2    Raso, M.G.3
  • 52
    • 77955172727 scopus 로고    scopus 로고
    • A grading system of lung adenocarcinomas based on histologic pattern is predictive of disease recurrence in stage i tumors
    • Sica G, Yoshizawa A, Sima CS, et al. A grading system of lung adenocarcinomas based on histologic pattern is predictive of disease recurrence in stage I tumors. Am J Surg Pathol 2010;34:1155-1162.
    • (2010) Am J Surg Pathol , vol.34 , pp. 1155-1162
    • Sica, G.1    Yoshizawa, A.2    Sima, C.S.3
  • 53
    • 24944524154 scopus 로고    scopus 로고
    • Positive thyroid transcription factor I staining strongly correlates with survival of patients with adenocarcinoma of the lung
    • DOI 10.1038/sj.bjc.6602717, PII 6602717
    • Barlesi F, Pinot D, Legoffic A, et al. Positive thyroid transcription factor 1 staining strongly correlates with survival of patients with adenocarcinoma of the lung. Br J Cancer 2005;93:450-452. (Pubitemid 43080019)
    • (2005) British Journal of Cancer , vol.93 , Issue.4 , pp. 450-452
    • Barlesi, F.1    Pinot, D.2    LeGoffic, A.3    Doddoli, C.4    Chetaille, B.5    Torre, J.-P.6    Astoul, P.7
  • 54
    • 58249091530 scopus 로고    scopus 로고
    • Thyroid transcription factor 1 is an independent prognostic factor for patients with stage i lung adenocarcinoma
    • Anagnostou VK, Syrigos KN, Bepler G, et al. Thyroid transcription factor 1 is an independent prognostic factor for patients with stage I lung adenocarcinoma. J Clin Oncol 2009;27:271-278.
    • (2009) J Clin Oncol , vol.27 , pp. 271-278
    • Anagnostou, V.K.1    Syrigos, K.N.2    Bepler, G.3
  • 56
    • 84866709500 scopus 로고    scopus 로고
    • Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer
    • Hammerman PS, Sos ML, Ramos AH, et al. Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. Cancer Discov 2011;1:78-89.
    • (2011) Cancer Discov , vol.1 , pp. 78-89
    • Hammerman, P.S.1    Sos, M.L.2    Ramos, A.H.3
  • 57
    • 78650451788 scopus 로고    scopus 로고
    • Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
    • Weiss J, Sos ML, Seidel D, et al. Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer. Sci Transl Med 2010;2:62ra93.
    • (2010) Sci Transl Med , vol.2
    • Weiss, J.1    Sos, M.L.2    Seidel, D.3
  • 58
    • 84867087348 scopus 로고    scopus 로고
    • Multiplex testing for driver mutations in squamous cell carcinomas of the lung
    • abstr 7505
    • Paik PK, Hasanovic A, Wang L, et al. Multiplex testing for driver mutations in squamous cell carcinomas of the lung. J Clin Oncol 2012;30(Suppl):abstr 7505.
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Paik, P.K.1    Hasanovic, A.2    Wang, L.3
  • 60
    • 49049089802 scopus 로고    scopus 로고
    • Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer
    • Scagliotti GV, Parikh P, von Pawel J, et al. Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 2008;26:3543-3551.
    • (2008) J Clin Oncol , vol.26 , pp. 3543-3551
    • Scagliotti, G.V.1    Parikh, P.2    Von Pawel, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.