Forkhead box protein 3 (FOXP3) mutations lead to increased TH17 cell numbers and regulatory T-cell instability

Journal of Allergy and Clinical Immunology

Volumn 128, Issue 6, 2011, Pages

  Passerini, Laura ^a   Olek, Sven ^b   Di Nunzio, Sara ^a   Barzaghi, Federica ^a   Hambleton, Sophie ^c   Abinun, Mario ^c   Tommasini, Alberto ^d   Vignola, Silvia ^e   Cipolli, Marco ^f   Amendola, Mario ^a   Naldini, Luigi ^a,g   Guidi, Luisa ^h   Cecconi, Massimiliano ⁱ   Roncarolo, Maria G ^a,g   Bacchetta, Rosa ^a  

^a SAN RAFFAELE SCIENTIFIC INSTITUTE   (Italy)

^b EPIONTIS GMBH   (Germany)

^c NEWCASTLE UPON TYNE HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^d INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

^e G GASLINI INSTITUTE   (Italy)

^f Cystic Fybrosis Center   (Italy)

^g VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^h CATHOLIC UNIVERSITY   (Italy)

ⁱ GALLIERA HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD161 ANTIGEN; CD28 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 6; RECOMBINANT INTERLEUKIN 2; RETINOID RELATED ORPHAN RECEPTOR ALPHA; TRANSCRIPTION FACTOR FOXP3;

ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL EXPANSION; CYTOKINE PRODUCTION; GENE MUTATION; HUMAN; IPEX SYNDROME; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; TH17 CELL;

EID: 82555165817     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2011.09.010     Document Type: Article

References (9)

1. E. Gambineri, L. Perroni, L. Passerini, L. Bianchi, C. Doglioni, and F. Meschi Clinical and molecular profile of a new series of patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: inconsistent correlation between forkhead box protein 3 expression and disease severity J Allergy Clin Immunol 122 2008 1105 1112 e1
2. S.E. Allan, S.Q. Crome, N.K. Crellin, L. Passerini, T.S. Steiner, and R. Bacchetta Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production Int Immunol 19 2007 345 354 (Pubitemid 46523383)
3. S.Q. Crome, A.Y. Wang, and M.K. Levings Translational mini-review series on Th17 cells: function and regulation of human T helper 17 cells in health and disease Clin Exp Immunol 159 2010 109 119
4. E. d'Hennezel, M. Ben-Shoshan, H.D. Ochs, T.R. Torgerson, L.J. Russell, and C. Lejtenyi FOXP3 forkhead domain mutation and regulatory T cells in the IPEX syndrome N Engl J Med 361 2009 1710 1713
5. N. Moes, F. Rieux-Laucat, B. Begue, J. Verdier, B. Neven, and N. Patey Reduced expression of FOXP3 and regulatory T-cell function in severe forms of early-onset autoimmune enteropathy Gastroenterology 139 2010 770 778
6. S. Hori Developmental plasticity of Foxp3+ regulatory T cells Curr Opin Immunol 22 2010 575 582
7. G. Wieczorek, A. Asemissen, F. Model, I. Turbachova, S. Floess, and V. Liebenberg Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue Cancer Res 69 2009 599 608
8. M. Amendola, L. Passerini, F. Pucci, B. Gentner, R. Bacchetta, and L. Naldini Regulated and multiple miRNA and siRNA delivery into primary cells by a lentiviral platform Mol Ther 17 2009 1039 1052
9. C.S. Hsieh, Y. Liang, A.J. Tyznik, S.G. Self, D. Liggitt, and A.Y. Rudensky Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors Immunity 21 2004 267 277 (Pubitemid 39094055)