메뉴 건너뛰기




Volumn 8, Issue 1, 2014, Pages 15-28

Effect of grafting BMP2-derived peptide to nanoparticles on osteogenic and vasculogenic expression of stromal cells

Author keywords

Bone morphogenetic peptide; Gene expression; Grafting; Marrow stromal cells; Nanoparticles; Osteogenesis

Indexed keywords

AMINO ACIDS; BIODEGRADABLE POLYMERS; BONE; CELL MEMBRANES; CELL SIGNALING; CYTOLOGY; ETHYLENE; GRAFTING (CHEMICAL); PEPTIDES; STEM CELLS; TRANSCRIPTION;

EID: 84891635564     PISSN: 19326254     EISSN: 19327005     Source Type: Journal    
DOI: 10.1002/term.1487     Document Type: Article
Times cited : (19)

References (74)
  • 1
    • 0035974431 scopus 로고    scopus 로고
    • The transcriptional role of Smads and FAST (FoxH1) in TGFβ and activin signalling
    • Attisano L, Silvestri C, Izzi L, et al. 2001; The transcriptional role of Smads and FAST (FoxH1) in TGFβ and activin signalling. Mol Cell Endocrinol 180: 3-11.
    • (2001) Mol Cell Endocrinol , vol.180 , pp. 3-11
    • Attisano, L.1    Silvestri, C.2    Izzi, L.3
  • 2
    • 0029129229 scopus 로고
    • Osteoblast and chondroblast differentiation
    • Aubin JE, Liu F, Malaval L, et al. 1995; Osteoblast and chondroblast differentiation. Bone 17: 77-83S.
    • (1995) Bone , vol.17
    • Aubin, J.E.1    Liu, F.2    Malaval, L.3
  • 3
    • 32044468546 scopus 로고    scopus 로고
    • Phosphorylation, acetylation and ubiquitination: the molecular basis of RUNX regulation
    • Bae SC, Lee YH. 2006; Phosphorylation, acetylation and ubiquitination: the molecular basis of RUNX regulation. Gene 366: 58-66.
    • (2006) Gene , vol.366 , pp. 58-66
    • Bae, S.C.1    Lee, Y.H.2
  • 4
    • 11044230764 scopus 로고    scopus 로고
    • BMP binding peptide: a BMP-2 enhancing factor deduced from the sequence of native bovine bone morphogenetic protein/non-collagenous protein
    • Behnam K, Phillips ML, Silva JD, et al. 2005; BMP binding peptide: a BMP-2 enhancing factor deduced from the sequence of native bovine bone morphogenetic protein/non-collagenous protein. J Orthop Res 23: 175-180.
    • (2005) J Orthop Res , vol.23 , pp. 175-180
    • Behnam, K.1    Phillips, M.L.2    Silva, J.D.3
  • 5
    • 1642473157 scopus 로고    scopus 로고
    • The transforming growth factor-β superfamily of receptors
    • Caestecker MD. 2004; The transforming growth factor-β superfamily of receptors. Cyto Grow Fact Rev 15: 1-11.
    • (2004) Cyto Grow Fact Rev , vol.15 , pp. 1-11
    • Caestecker, M.D.1
  • 6
    • 24644482494 scopus 로고    scopus 로고
    • The BMP signaling and in vivo bone formation
    • Cao X, Chen D. 2005; The BMP signaling and in vivo bone formation. Gene 357: 1-8.
    • (2005) Gene , vol.357 , pp. 1-8
    • Cao, X.1    Chen, D.2
  • 7
    • 7644220887 scopus 로고    scopus 로고
    • Skeletal hormones and the C/EBP and Runx transcription factors: interactions that integrate and redefine gene expression
    • Centrella M, Christakos S, McCarthy TL. 2004; Skeletal hormones and the C/EBP and Runx transcription factors: interactions that integrate and redefine gene expression. Gene 342: 13-24.
    • (2004) Gene , vol.342 , pp. 13-24
    • Centrella, M.1    Christakos, S.2    McCarthy, T.L.3
  • 8
    • 28844475647 scopus 로고    scopus 로고
    • Release of bioactive BMP from dextran-derived microspheres: a novel delivery concept
    • Chen FM, Wu ZF, Sun HH, et al. 2006; Release of bioactive BMP from dextran-derived microspheres: a novel delivery concept. Int J Pharm 307: 23-32.
    • (2006) Int J Pharm , vol.307 , pp. 23-32
    • Chen, F.M.1    Wu, Z.F.2    Sun, H.H.3
  • 9
    • 33847156395 scopus 로고    scopus 로고
    • Novel glycidyl methacrylated dextran (Dex-GMA)/gelatin hydrogel scaffolds containing microspheres loaded with bone morphogenetic proteins: formulation and characteristics
    • Chen FM, Zhao YM, Sun HH, et al. 2007; Novel glycidyl methacrylated dextran (Dex-GMA)/gelatin hydrogel scaffolds containing microspheres loaded with bone morphogenetic proteins: formulation and characteristics. J Control Release 118: 65-77.
    • (2007) J Control Release , vol.118 , pp. 65-77
    • Chen, F.M.1    Zhao, Y.M.2    Sun, H.H.3
  • 10
    • 34547197434 scopus 로고    scopus 로고
    • Enhanced bone regeneration with BMP-2 loaded functional nanoparticle-hydrogel complex
    • Chung Y-I, Ahn K-M, Jeon S-H, et al. 2007; Enhanced bone regeneration with BMP-2 loaded functional nanoparticle-hydrogel complex. J Control Release 121: 91-99.
    • (2007) J Control Release , vol.121 , pp. 91-99
    • Chung, Y.-I.1    Ahn, K.-M.2    Jeon, S.-H.3
  • 11
    • 59649119051 scopus 로고    scopus 로고
    • Presence, actions, and regulation of myostatin in rat uterus and myometrial cells
    • Ciarmela P, Wiater E, Smith SM, et al. 2009; Presence, actions, and regulation of myostatin in rat uterus and myometrial cells. Endocrinology 150: 906-914.
    • (2009) Endocrinology , vol.150 , pp. 906-914
    • Ciarmela, P.1    Wiater, E.2    Smith, S.M.3
  • 12
    • 0033881829 scopus 로고    scopus 로고
    • Transcriptional autoregulation of the bone related CBFA1/RUNX2 gene
    • Drissi H, Luc Q, Shakoori R, et al. 2000; Transcriptional autoregulation of the bone related CBFA1/RUNX2 gene. J Cell Physiol 184: 341-350.
    • (2000) J Cell Physiol , vol.184 , pp. 341-350
    • Drissi, H.1    Luc, Q.2    Shakoori, R.3
  • 13
    • 22844443525 scopus 로고    scopus 로고
    • Rotary culture enhances pre-osteoblast aggregation and mineralization
    • Facer SR, Zaharias RS, Andracki ME, et al. 2005; Rotary culture enhances pre-osteoblast aggregation and mineralization. J Dent Res 84: 542-547.
    • (2005) J Dent Res , vol.84 , pp. 542-547
    • Facer, S.R.1    Zaharias, R.S.2    Andracki, M.E.3
  • 14
    • 0035140581 scopus 로고    scopus 로고
    • Microparticulate uptake mechanisms of in vitro cell culture models of the respiratory epithelium
    • Foster KA, Yazdanian M, Audus KL. 2001; Microparticulate uptake mechanisms of in vitro cell culture models of the respiratory epithelium. J Pharm Pharmacol 53: 57-66.
    • (2001) J Pharm Pharmacol , vol.53 , pp. 57-66
    • Foster, K.A.1    Yazdanian, M.2    Audus, K.L.3
  • 15
    • 39549119382 scopus 로고    scopus 로고
    • Optimized bone regeneration based on sustained release from three-dimensional fibrous PLGA/HAp composite scaffolds loaded with BMP-2
    • Fu YC, Nie H, Ho ML, et al. 2008; Optimized bone regeneration based on sustained release from three-dimensional fibrous PLGA/HAp composite scaffolds loaded with BMP-2. Biotechnol Bioeng 99: 996-1006.
    • (2008) Biotechnol Bioeng , vol.99 , pp. 996-1006
    • Fu, Y.C.1    Nie, H.2    Ho, M.L.3
  • 16
    • 2942739131 scopus 로고    scopus 로고
    • Osteogenic growth peptide modulates fracture callus structural and mechanical properties
    • Gabet Y, Muller R, Regev E, et al. 2004; Osteogenic growth peptide modulates fracture callus structural and mechanical properties. Bone 35: 65-73.
    • (2004) Bone , vol.35 , pp. 65-73
    • Gabet, Y.1    Muller, R.2    Regev, E.3
  • 18
    • 35548996239 scopus 로고    scopus 로고
    • Synthetic osteopontin-derived peptide SVVYGLR can induce neovascularization in artificial bone marrow scaffold biomaterials
    • Hamada Y, Egusa H, Kaneda Y, et al. 2007; Synthetic osteopontin-derived peptide SVVYGLR can induce neovascularization in artificial bone marrow scaffold biomaterials. Dent Mater J 26: 487-492.
    • (2007) Dent Mater J , vol.26 , pp. 487-492
    • Hamada, Y.1    Egusa, H.2    Kaneda, Y.3
  • 19
    • 33749586993 scopus 로고    scopus 로고
    • Different routes of bone morphogenic protein (BMP) receptor endocytosis influence BMP signaling
    • Hartung A, Bitton-Worms K, Rechtman MM, et al. 2006; Different routes of bone morphogenic protein (BMP) receptor endocytosis influence BMP signaling. Mol Cell Biol 26: 7791-7805.
    • (2006) Mol Cell Biol , vol.26 , pp. 7791-7805
    • Hartung, A.1    Bitton-Worms, K.2    Rechtman, M.M.3
  • 20
    • 33846027131 scopus 로고    scopus 로고
    • BMP2 Commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network
    • Hassan MQ, Tare RS, Lee SH, et al. 2006; BMP2 Commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network. J Biol Chem 281: 40515-40526.
    • (2006) J Biol Chem , vol.281 , pp. 40515-40526
    • Hassan, M.Q.1    Tare, R.S.2    Lee, S.H.3
  • 21
    • 33947671985 scopus 로고    scopus 로고
    • Material properties and cytocompatibility of injectable MMP degradable poly(lactide ethylene oxide fumarate) hydrogel as a carrier for marrow stromal cells
    • He X, Jabbari E. 2007; Material properties and cytocompatibility of injectable MMP degradable poly(lactide ethylene oxide fumarate) hydrogel as a carrier for marrow stromal cells. Biomacromolecules 8: 780-792.
    • (2007) Biomacromolecules , vol.8 , pp. 780-792
    • He, X.1    Jabbari, E.2
  • 22
    • 38349014284 scopus 로고    scopus 로고
    • Synthesis and characterization of bioresorbable in situ crosslinkable ultra-low molecular weight poly(lactide) macromer
    • He X, Jabbari E. 2008; Synthesis and characterization of bioresorbable in situ crosslinkable ultra-low molecular weight poly(lactide) macromer. J Mater Sci Mater Med 19: 311-318.
    • (2008) J Mater Sci Mater Med , vol.19 , pp. 311-318
    • He, X.1    Jabbari, E.2
  • 23
    • 56449125956 scopus 로고    scopus 로고
    • Effect of grafting RGD and BMP-2 protein-derived peptides to a hydrogel substrate on osteogenic differentiation of marrow stromal cells
    • He X, Ma J, Jabbari E. 2008; Effect of grafting RGD and BMP-2 protein-derived peptides to a hydrogel substrate on osteogenic differentiation of marrow stromal cells. Langmuir 24: 12508-12516.
    • (2008) Langmuir , vol.24 , pp. 12508-12516
    • He, X.1    Ma, J.2    Jabbari, E.3
  • 24
    • 77951497921 scopus 로고    scopus 로고
    • Migration of marrow stromal cells in response to sustained release of stromal-derived factor-1α from poly(lactide ethylene oxide fumarate) hydrogels
    • He X, Ma J, Jabbari E. 2010; Migration of marrow stromal cells in response to sustained release of stromal-derived factor-1α from poly(lactide ethylene oxide fumarate) hydrogels. Int J Pharm 390: 107-116.
    • (2010) Int J Pharm , vol.390 , pp. 107-116
    • He, X.1    Ma, J.2    Jabbari, E.3
  • 25
    • 44749086167 scopus 로고    scopus 로고
    • Cytotoxicity of paclitaxel in biodegradable self-assembled core-shell poly(lactide-co-glycolide ethylene oxide fumarate) nanoparticles
    • He X, Ma J, Mercado AE, et al. 2008; Cytotoxicity of paclitaxel in biodegradable self-assembled core-shell poly(lactide-co-glycolide ethylene oxide fumarate) nanoparticles. Pharm Res 25: 1552-1562.
    • (2008) Pharm Res , vol.25 , pp. 1552-1562
    • He, X.1    Ma, J.2    Mercado, A.E.3
  • 26
    • 55049086364 scopus 로고    scopus 로고
    • Concurrent differentiation of marrow stromal cells to osteogenic and vasculogenic lineages
    • Henderson JA, He X, Jabbari E. 2008; Concurrent differentiation of marrow stromal cells to osteogenic and vasculogenic lineages. Macromol Biosci 8: 499-507.
    • (2008) Macromol Biosci , vol.8 , pp. 499-507
    • Henderson, J.A.1    He, X.2    Jabbari, E.3
  • 27
    • 17644407766 scopus 로고    scopus 로고
    • Biophysical comparison of BMP-2, ProBMP-2, and the free pro-peptide reveals stabilization of the pro-peptide by the mature growth factor
    • Hillger F, Herr G, Rudolph R, et al. 2005; Biophysical comparison of BMP-2, ProBMP-2, and the free pro-peptide reveals stabilization of the pro-peptide by the mature growth factor. J Biol Chem 280: 14974-14980.
    • (2005) J Biol Chem , vol.280 , pp. 14974-14980
    • Hillger, F.1    Herr, G.2    Rudolph, R.3
  • 28
    • 33646985153 scopus 로고    scopus 로고
    • Role of bovine bone morphogenetic proteins in bone matrix protein and osteoblast-related gene expression during rat bone marrow stromal cell differentiation
    • Hu Z, Peel SA, Ho SK, et al. 2005; Role of bovine bone morphogenetic proteins in bone matrix protein and osteoblast-related gene expression during rat bone marrow stromal cell differentiation. J Craniofac Surg 16: 1006-1014.
    • (2005) J Craniofac Surg , vol.16 , pp. 1006-1014
    • Hu, Z.1    Peel, S.A.2    Ho, S.K.3
  • 29
    • 0028908419 scopus 로고
    • Contact- and growth factor-dependent survival in a canine marrow-derived stromal cell line
    • Huss R, Hoy CA, Deeg HJ. 1995; Contact- and growth factor-dependent survival in a canine marrow-derived stromal cell line. Blood 85: 2414-2421.
    • (1995) Blood , vol.85 , pp. 2414-2421
    • Huss, R.1    Hoy, C.A.2    Deeg, H.J.3
  • 30
    • 62249129230 scopus 로고    scopus 로고
    • Material properties and bone marrow stromal cells response to in situ crosslinkable RGD-functionlized lactide-co-glycolide scaffolds
    • Jabbari E, He X, Valarmathi M, et al. 2009; Material properties and bone marrow stromal cells response to in situ crosslinkable RGD-functionlized lactide-co-glycolide scaffolds. J Biomed Mater Res A 89: 124-137.
    • (2009) J Biomed Mater Res A , vol.89 , pp. 124-137
    • Jabbari, E.1    He, X.2    Valarmathi, M.3
  • 31
    • 74549129401 scopus 로고    scopus 로고
    • Molecular mechanisms of BMP-induced bone formation: Cross-talk between BMP and NF-κB signaling pathways in osteoblastogenesis
    • Jimi E, Hirata S, Shin M, et al. 2010; Molecular mechanisms of BMP-induced bone formation: Cross-talk between BMP and NF-κB signaling pathways in osteoblastogenesis. Jpn Dent Sci Rev 46: 33-42.
    • (2010) Jpn Dent Sci Rev , vol.46 , pp. 33-42
    • Jimi, E.1    Hirata, S.2    Shin, M.3
  • 32
    • 33745713060 scopus 로고    scopus 로고
    • Recombinant human BMP-2 and allograft compared with autogenous bone graft for reconstruction of diaphyseal tibial fractures with cortical defects. A randomized, controlled trial
    • Jones AL, Bucholz RW, Bosse MJ, et al. 2006; Recombinant human BMP-2 and allograft compared with autogenous bone graft for reconstruction of diaphyseal tibial fractures with cortical defects. A randomized, controlled trial. J Bone Joint Surg Am 88: 1431-1441.
    • (2006) J Bone Joint Surg Am , vol.88 , pp. 1431-1441
    • Jones, A.L.1    Bucholz, R.W.2    Bosse, M.J.3
  • 33
    • 0014772602 scopus 로고
    • Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides
    • Kaiser E, Colescott RL, Bossinger CD, et al. 1970; Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides. Anal Biochem 34: 595-598.
    • (1970) Anal Biochem , vol.34 , pp. 595-598
    • Kaiser, E.1    Colescott, R.L.2    Bossinger, C.D.3
  • 34
    • 0032908128 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2 exerts diverse effects on cell growth in vitro and is expressed in human pancreatic cancer in vivo
    • Kleeff J, Maruyama H, Ishiwata T, et al. 1999; Bone morphogenetic protein 2 exerts diverse effects on cell growth in vitro and is expressed in human pancreatic cancer in vivo. Gastroenterology 116: 1202-1216.
    • (1999) Gastroenterology , vol.116 , pp. 1202-1216
    • Kleeff, J.1    Maruyama, H.2    Ishiwata, T.3
  • 35
    • 3543145020 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 stimulates angiogenesis in developing tumors
    • Langenfeld EM, Langenfeld J. 2004; Bone morphogenetic protein-2 stimulates angiogenesis in developing tumors. Mol Cancer Res 2: 141-149.
    • (2004) Mol Cancer Res , vol.2 , pp. 141-149
    • Langenfeld, E.M.1    Langenfeld, J.2
  • 36
    • 0141814613 scopus 로고    scopus 로고
    • The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells
    • Langenfeld EM, Calvano SE, Abou-Nukta F, et al. 2003; The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells. Carcinogenesis 24: 1445-1454.
    • (2003) Carcinogenesis , vol.24 , pp. 1445-1454
    • Langenfeld, E.M.1    Calvano, S.E.2    Abou-Nukta, F.3
  • 37
    • 0035643980 scopus 로고    scopus 로고
    • Molecular modelling of bone morphogenetic protein-2 (BMP-2) by 3D-rapid prototyping
    • Laub M, Seul T, Schmachtenberg E, et al. 2001; Molecular modelling of bone morphogenetic protein-2 (BMP-2) by 3D-rapid prototyping. Materialwiss Werkstofftech 32: 926-930.
    • (2001) Materialwiss Werkstofftech , vol.32 , pp. 926-930
    • Laub, M.1    Seul, T.2    Schmachtenberg, E.3
  • 38
    • 0038108800 scopus 로고    scopus 로고
    • Osteopontin (Eta-1) and fibroblast growth factor-2 cross-talk in angiogenesis
    • Leali D, Dell'Era P, Stabile H, et al. 2003; Osteopontin (Eta-1) and fibroblast growth factor-2 cross-talk in angiogenesis. J Immunol 171: 1085-1093.
    • (2003) J Immunol , vol.171 , pp. 1085-1093
    • Leali, D.1    Dell'Era, P.2    Stabile, H.3
  • 39
    • 34249938497 scopus 로고    scopus 로고
    • Matrices and scaffolds for delivery of bioactive molecules in bone and cartilage tissue engineering
    • Lee SH, Shin H. 2007; Matrices and scaffolds for delivery of bioactive molecules in bone and cartilage tissue engineering. Adv Drug Deliv Rev 59: 339-59.
    • (2007) Adv Drug Deliv Rev , vol.59 , pp. 339-359
    • Lee, S.H.1    Shin, H.2
  • 40
    • 0042891942 scopus 로고    scopus 로고
    • BMP-2-induced Runx2 expression is mediated by Dlx5, and TGFβ opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression
    • Lee M-H, Kim Y-J, Kim H-J, et al. 2003a; BMP-2-induced Runx2 expression is mediated by Dlx5, and TGFβ opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression. J Biol Chem 278: 34387-34394.
    • (2003) J Biol Chem , vol.278 , pp. 34387-34394
    • Lee, M.-H.1    Kim, Y.-J.2    Kim, H.-J.3
  • 41
    • 0034460993 scopus 로고    scopus 로고
    • Runx2 is a common target of transforming growth factor-β1 and bone morphogenetic protein-2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12
    • Lee K-S, Kim H-J, Li Q-L, et al. 2000; Runx2 is a common target of transforming growth factor-β1 and bone morphogenetic protein-2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12. Mol Cell Biol 20: 8783-8792.
    • (2000) Mol Cell Biol , vol.20 , pp. 8783-8792
    • Lee, K.-S.1    Kim, H.-J.2    Li, Q.-L.3
  • 42
    • 0041328856 scopus 로고    scopus 로고
    • BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2
    • Lee M-H, Kwon T-G, Park H-S, et al. 2003b; BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2. Biochem Biophys Res Commun 309: 689-694.
    • (2003) Biochem Biophys Res Commun , vol.309 , pp. 689-694
    • Lee, M.-H.1    Kwon, T.-G.2    Park, H.-S.3
  • 43
    • 38348999366 scopus 로고    scopus 로고
    • The effect of crosslinking heparin to demineralized bone matrix on mechanical strength and specific binding to human bone morphogenetic protein-2
    • Lin H, Zhao Y, Sun W, et al. 2008; The effect of crosslinking heparin to demineralized bone matrix on mechanical strength and specific binding to human bone morphogenetic protein-2. Biomaterials 29: 1189-1197.
    • (2008) Biomaterials , vol.29 , pp. 1189-1197
    • Lin, H.1    Zhao, Y.2    Sun, W.3
  • 44
    • 12244303631 scopus 로고    scopus 로고
    • Tooth morphogenesis and pattern of odontoblast differentiation
    • Lisi S, Peterkova R, Peterka M, et al. 2003; Tooth morphogenesis and pattern of odontoblast differentiation. Connect Tissue Res 44(suppl 1): 167-170.
    • (2003) Connect Tissue Res , vol.44 , Issue.SUPPL. 1 , pp. 167-170
    • Lisi, S.1    Peterkova, R.2    Peterka, M.3
  • 45
    • 33748135082 scopus 로고    scopus 로고
    • Targeted delivery system for juxtacrine signaling growth factor based on rhBMP-2-mediated carrier-protein conjugation
    • Liu HW, Chen CH, Tsai CL, et al. 2006; Targeted delivery system for juxtacrine signaling growth factor based on rhBMP-2-mediated carrier-protein conjugation. Bone 39: 825-836.
    • (2006) Bone , vol.39 , pp. 825-836
    • Liu, H.W.1    Chen, C.H.2    Tsai, C.L.3
  • 46
    • 1042289619 scopus 로고    scopus 로고
    • Osteogenic differentiation of human bone marrow stromal cells on partially demineralized bone scaffolds in vitro
    • Mauney JR, Blumberg J, Pirun M, et al. 2004; Osteogenic differentiation of human bone marrow stromal cells on partially demineralized bone scaffolds in vitro. Tissue Eng 10: 81-92.
    • (2004) Tissue Eng , vol.10 , pp. 81-92
    • Mauney, J.R.1    Blumberg, J.2    Pirun, M.3
  • 47
    • 0037102590 scopus 로고    scopus 로고
    • Use of recombinant human bone morphogenetic protein-2 in spinal fusion applications
    • McKay B, Sandhu HS. 2002; Use of recombinant human bone morphogenetic protein-2 in spinal fusion applications. Spine 27: S66-85.
    • (2002) Spine , vol.27
    • McKay, B.1    Sandhu, H.S.2
  • 48
    • 47249121637 scopus 로고    scopus 로고
    • The release characteristics of a model protein from self-assembled succinimide-terminated poly(lactide-co-glycolide ethylene oxide fumarate) nanoparticles
    • Mercado AE, He XZ, Xu WJ, et al. 2008; The release characteristics of a model protein from self-assembled succinimide-terminated poly(lactide-co-glycolide ethylene oxide fumarate) nanoparticles. Nanotechnology 19: 325609.
    • (2008) Nanotechnology , vol.19 , pp. 325609
    • Mercado, A.E.1    He, X.Z.2    Xu, W.J.3
  • 49
    • 70350618786 scopus 로고    scopus 로고
    • Release characteristics and osteogenic activity of recombinant human bone morphogenetic protein-2 grafted to novel self-assembled poly(lactide-co-glycolide fumarate) nanoparticles
    • Mercado AE, Ma J, He X, et al. 2009; Release characteristics and osteogenic activity of recombinant human bone morphogenetic protein-2 grafted to novel self-assembled poly(lactide-co-glycolide fumarate) nanoparticles. J Control Release 140: 148-156.
    • (2009) J Control Release , vol.140 , pp. 148-156
    • Mercado, A.E.1    Ma, J.2    He, X.3
  • 50
    • 36749034286 scopus 로고    scopus 로고
    • An efficient method for isolation of murine bone marrow mesenchymal stem cells
    • Nadri S, Soleimani M, Hosseni RH, et al. 2007; An efficient method for isolation of murine bone marrow mesenchymal stem cells. Int J Dev Biol 51: 723-729.
    • (2007) Int J Dev Biol , vol.51 , pp. 723-729
    • Nadri, S.1    Soleimani, M.2    Hosseni, R.H.3
  • 51
    • 0025316785 scopus 로고
    • Progressive development of the rat osteoblast phenotype in vitro: reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix
    • Owen TA, Aronow M, Shalhoub V, et al. 1990; Progressive development of the rat osteoblast phenotype in vitro: reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix. J Cell Physiol 143: 420-430.
    • (1990) J Cell Physiol , vol.143 , pp. 420-430
    • Owen, T.A.1    Aronow, M.2    Shalhoub, V.3
  • 52
    • 78651341882 scopus 로고    scopus 로고
    • BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways
    • Perez VAD, Ali Z, Alastalo TP, et al. 2011; BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways. J Cell Biol 192: 171-188.
    • (2011) J Cell Biol , vol.192 , pp. 171-188
    • Perez, V.A.D.1    Ali, Z.2    Alastalo, T.P.3
  • 53
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl MW. 2001; A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29: e45.
    • (2001) Nucleic Acids Res , vol.29
    • Pfaffl, M.W.1
  • 54
    • 2342499807 scopus 로고    scopus 로고
    • The effect of rhBMP-2 on canine osteoblasts seeded onto 3D bioactive polycaprolactone scaffolds
    • Rai B, Teoh SH, Ho KH, et al. 2004; The effect of rhBMP-2 on canine osteoblasts seeded onto 3D bioactive polycaprolactone scaffolds. Biomaterials 25: 5499-5506.
    • (2004) Biomaterials , vol.25 , pp. 5499-5506
    • Rai, B.1    Teoh, S.H.2    Ho, K.H.3
  • 55
    • 27644508801 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2 (BMP-2) and induction of tumor angiogenesis
    • Raida M, Clement JH, Leek RD, et al. 2005; Bone morphogenetic protein 2 (BMP-2) and induction of tumor angiogenesis. J Cancer Res Clin Oncol 131: 741-750.
    • (2005) J Cancer Res Clin Oncol , vol.131 , pp. 741-750
    • Raida, M.1    Clement, J.H.2    Leek, R.D.3
  • 56
    • 0035936975 scopus 로고    scopus 로고
    • Drug delivery in poly(lactide-co-glycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: in vitro characterisation and in vivo evaluation
    • Redhead HM, Davis SS, Illum L. 2001; Drug delivery in poly(lactide-co-glycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: in vitro characterisation and in vivo evaluation. J Control Release 70: 353-363.
    • (2001) J Control Release , vol.70 , pp. 353-363
    • Redhead, H.M.1    Davis, S.S.2    Illum, L.3
  • 57
    • 0031009749 scopus 로고    scopus 로고
    • Tissue engineering, morphogenesis, and regeneration of the periodontal tissues by bone morphogenetic proteins
    • Ripamonti U, Reddi AH. 1997; Tissue engineering, morphogenesis, and regeneration of the periodontal tissues by bone morphogenetic proteins. Crit Rev Oral Biol Med 8: 154-163.
    • (1997) Crit Rev Oral Biol Med , vol.8 , pp. 154-163
    • Ripamonti, U.1    Reddi, A.H.2
  • 59
    • 39049121312 scopus 로고    scopus 로고
    • How the Smads regulate transcription
    • Ross S, Hill CS. 2008; How the Smads regulate transcription. Int J Biochem Cell B 40: 383-408.
    • (2008) Int J Biochem Cell B , vol.40 , pp. 383-408
    • Ross, S.1    Hill, C.S.2
  • 60
    • 0141679540 scopus 로고    scopus 로고
    • Development of new multivalent-bispecific agents for pretargeting tumor localization and therapy
    • Rossi EA, Sharkey RM, McBride W, et al. 2003; Development of new multivalent-bispecific agents for pretargeting tumor localization and therapy. Clin Cancer Res 9: 3886-3896S.
    • (2003) Clin Cancer Res , vol.9
    • Rossi, E.A.1    Sharkey, R.M.2    McBride, W.3
  • 61
    • 0037130209 scopus 로고    scopus 로고
    • Residual polyvinyl alcohol associated with poly (d,l-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake
    • Sahoo SK, Panyam J, Prabha S, et al. 2002; Residual polyvinyl alcohol associated with poly (d, l-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake. J Control Release 82: 105-114.
    • (2002) J Control Release , vol.82 , pp. 105-114
    • Sahoo, S.K.1    Panyam, J.2    Prabha, S.3
  • 62
    • 3042727188 scopus 로고    scopus 로고
    • Prolonged ectopic calcification induced by BMP-2-derived synthetic peptide
    • Saito A, Suzuki Y, Ogata S-I, et al. 2004; Prolonged ectopic calcification induced by BMP-2-derived synthetic peptide. J Biomed Mater Res A 70: 115-121.
    • (2004) J Biomed Mater Res A , vol.70 , pp. 115-121
    • Saito, A.1    Suzuki, Y.2    Ogata, S.-I.3
  • 63
    • 0642341968 scopus 로고    scopus 로고
    • Activation of osteo-progenitor cells by a novel synthetic peptide derived from the bone morphogenetic protein-2 knuckle epitope
    • Saito A, Suzuki Y, Ogata S-i, et al. 2003; Activation of osteo-progenitor cells by a novel synthetic peptide derived from the bone morphogenetic protein-2 knuckle epitope. Biochim Biophys Acta 1651: 60-67.
    • (2003) Biochim Biophys Acta , vol.1651 , pp. 60-67
    • Saito, A.1    Suzuki, Y.2    S-i, O.3
  • 64
    • 73749083416 scopus 로고    scopus 로고
    • Microsphere-based drug releasing scaffolds for inducing osteogenesis of human mesenchymal stem cells in vitro
    • Shi X, Wang Y, Varshney RR, et al. 2010; Microsphere-based drug releasing scaffolds for inducing osteogenesis of human mesenchymal stem cells in vitro. Eur J Pharm Sci 39: 59-67.
    • (2010) Eur J Pharm Sci , vol.39 , pp. 59-67
    • Shi, X.1    Wang, Y.2    Varshney, R.R.3
  • 65
    • 33645508135 scopus 로고    scopus 로고
    • Adverse effects associated with high-dose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion
    • Shields LBE, Raque GH, Glassman SD, et al. 2006; Adverse effects associated with high-dose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion. Spine 31: 542-547.
    • (2006) Spine , vol.31 , pp. 542-547
    • Shields, L.B.E.1    Raque, G.H.2    Glassman, S.D.3
  • 66
    • 70649083092 scopus 로고    scopus 로고
    • Recent advances in BMP receptor signaling
    • Sieber C, Kopf J, Hiepen C, et al. 2009; Recent advances in BMP receptor signaling. Cyto Grow Fact Rev 20: 343-355.
    • (2009) Cyto Grow Fact Rev , vol.20 , pp. 343-355
    • Sieber, C.1    Kopf, J.2    Hiepen, C.3
  • 67
    • 0034897021 scopus 로고    scopus 로고
    • Influence of rhBMP-2 on rat bone marrow stromal cells cultured on titanium fiber mesh
    • Vehof JWM, Ruijter AED, Spauwen PHM, et al. 2001; Influence of rhBMP-2 on rat bone marrow stromal cells cultured on titanium fiber mesh. Tissue Eng 7: 373-383.
    • (2001) Tissue Eng , vol.7 , pp. 373-383
    • Vehof, J.W.M.1    Ruijter, A.E.D.2    Spauwen, P.H.M.3
  • 68
    • 33846657400 scopus 로고    scopus 로고
    • The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rhBMP-7 nanospheres
    • Wei G, Jin Q, Giannobile WV, et al. 2007; The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rhBMP-7 nanospheres. Biomaterials 28: 2087-2096.
    • (2007) Biomaterials , vol.28 , pp. 2087-2096
    • Wei, G.1    Jin, Q.2    Giannobile, W.V.3
  • 69
    • 0037102589 scopus 로고    scopus 로고
    • Overview of bone morphogenetic proteins
    • Wozney JM. 2002; Overview of bone morphogenetic proteins. Spine 27: S2-8.
    • (2002) Spine , vol.27
    • Wozney, J.M.1
  • 70
    • 29244491101 scopus 로고    scopus 로고
    • Self-assembled biodegradable nanoparticles developed by direct dialysis for the delivery of paclitaxel
    • Xie JW, Wang CH. 2005; Self-assembled biodegradable nanoparticles developed by direct dialysis for the delivery of paclitaxel. Pharm Res 22: 2079-2090.
    • (2005) Pharm Res , vol.22 , pp. 2079-2090
    • Xie, J.W.1    Wang, C.H.2
  • 71
    • 0035163234 scopus 로고    scopus 로고
    • In vivo bone-forming capacity of human bone marrow-derived stromal cells is stimulated by recombinant human bone morphogenetic protein-2
    • Yamagiwa H, Endo N, Tokunaga K, et al. 2001; In vivo bone-forming capacity of human bone marrow-derived stromal cells is stimulated by recombinant human bone morphogenetic protein-2. J Bone Miner Metab 19: 20-28.
    • (2001) J Bone Miner Metab , vol.19 , pp. 20-28
    • Yamagiwa, H.1    Endo, N.2    Tokunaga, K.3
  • 72
    • 77950846241 scopus 로고    scopus 로고
    • Heparin-conjugated fibrin as an injectable system for sustained delivery of bone morphogenetic protein-2
    • Yang HS, La W-G, Bhang SH, et al. 2010; Heparin-conjugated fibrin as an injectable system for sustained delivery of bone morphogenetic protein-2. Tissue Eng Part A 16: 1225-1233.
    • (2010) Tissue Eng Part A , vol.16 , pp. 1225-1233
    • Yang, H.S.1    La, W.-G.2    Bhang, S.H.3
  • 73
    • 0031281248 scopus 로고    scopus 로고
    • Osteogenic responses to extraskeletally implanted synthetic porous calcium phosphate ceramics: an early stage histomorphological study in dogs
    • Yang ZJ, Yuan H, Zou P, et al. 1997; Osteogenic responses to extraskeletally implanted synthetic porous calcium phosphate ceramics: an early stage histomorphological study in dogs. J Mater Sci Mater Med 8: 697-701.
    • (1997) J Mater Sci Mater Med , vol.8 , pp. 697-701
    • Yang, Z.J.1    Yuan, H.2    Zou, P.3
  • 74
    • 0026757708 scopus 로고
    • The healing of segmental bone defects induced by recombinant human bone morphogenetic protein (rhBMP-2)
    • Yasko AW, Lane JM, Fellinger EJ, et al. 1992; The healing of segmental bone defects induced by recombinant human bone morphogenetic protein (rhBMP-2). J Bone Jt Surg Am 74: 659-670.
    • (1992) J Bone Jt Surg Am , vol.74 , pp. 659-670
    • Yasko, A.W.1    Lane, J.M.2    Fellinger, E.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.