Antagonism between binding site affinity and conformational dynamics tunes alternative cis-interactions within Shp2

Nature Communications

Volumn 4, Issue , 2013, Pages

  Sun, Jie ^a,b,c   Lu, Shaoying ^b   Ouyang, Mingxing ^b   Lin, Li Jung ^b   Zhuo, Yue ^b   Liu, Bo ^b   Chien, Shu ^d   Neel, Benjamin G ^e,f   Wang, Yingxiao ^a,b,c,g  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b University of Illinois at Urbana Champaign   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e PRINCESS MARGARET HOSPITAL   (Canada)

^f UNIVERSITY OF TORONTO   (Canada)

^g UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTYROSINE; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN TYROSINE PHOSPHATASE SHP 2; MUTANT PROTEIN; PEPTIDE; PROTEIN BINDING;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CIS ISOMER; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISSOCIATION CONSTANT; ENZYME CONFORMATION; ENZYME PHOSPHORYLATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; IN VITRO STUDY; MOLECULAR DYNAMICS; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; TRANS ISOMER; ANIMAL; ANIMAL EMBRYO; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CYTOLOGY; FIBROBLAST; GENETICS; HEK293 CELL LINE; HUMAN; KINETICS; METABOLISM; MOLECULAR GENETICS; MOUSE; MUTATION; PHOSPHORYLATION; PROTEIN CONFORMATION; REPORTER GENE; CELL STRAIN HEK293; DRUG ANTAGONISM; PROTEIN BINDING;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; EMBRYO, MAMMALIAN; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENES, REPORTER; GRB2 ADAPTOR PROTEIN; HEK293 CELLS; HUMANS; KINETICS; MICE; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; MUTATION; PEPTIDES; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11;

EID: 84891589105     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms3037     Document Type: Article

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