In vivo and in vitro metabolism of lefucoxib in rats

Journal of Pharmaceutical and Biomedical Analysis

Volumn 48, Issue 1, 2008, Pages 134-139

  Bi, Xuezhi ^a   Meng, Zhiyun ^a   Chen, Hebing ^b   Zhu, Xiaoxia ^a   Dou, Guifang ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^b NATIONAL CENTER OF BIOMEDICAL ANALYSIS   (China)

Author keywords

LC MS; Lefucoxib; Liver microsomes; Metabolism; NMR; Rat

Indexed keywords

CYCLOOXYGENASE 2 INHIBITOR; DRUG METABOLITE; LEFUCOXIB; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG BLOOD LEVEL; DRUG FECES LEVEL; DRUG METABOLISM; DRUG URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; QUALITATIVE ANALYSIS; RAT;

ANIMALS; BIOTRANSFORMATION; CHROMATOGRAPHY, LIQUID; CYCLOOXYGENASE 2 INHIBITORS; ISOMERISM; MALE; MASS SPECTROMETRY; METABOLIC NETWORKS AND PATHWAYS; MICROSOMES, LIVER; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PYRAZOLES; RATS; RATS, WISTAR; SULFHYDRYL COMPOUNDS;

EID: 49749132806     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2008.04.024     Document Type: Article

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