Determination of chamaechromone in rat plasma by liquid chromatography-tandem mass spectrometry: Application to pharmacokinetic study

Journal of Pharmaceutical and Biomedical Analysis

Volumn 55, Issue 5, 2011, Pages 1163-1169

  Lou, Yan ^a   Hu, Haihong ^a   Liu, Yao ^a   Yu, Qinqin ^a   Li, Li ^a   Ping, Li ^a   Yu, Lushan ^a   Jiang, Huidi ^a   Zeng, Su ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Chamaechromone; LC MS MS; Method validation; Pharmacokinetics; Rat plasma

Indexed keywords

ACETIC ACID ETHYL ESTER; ANTINEOPLASTIC AGENT; CHAMAECHROMONE; CHROMONE DERIVATIVE; FORMIC ACID; HERBACEOUS AGENT; METHANOL; ROSUVASTATIN; UNCLASSIFIED DRUG; WATER;

ACCURACY; ACIDIFICATION; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG ISOLATION; ELECTROSPRAY MASS SPECTROMETRY; FLOW RATE; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PLANT ROOT; PLASMA; POSITIVE ION ELECTROSPRAY; PRIORITY JOURNAL; RAT; SEPARATION TECHNIQUE; STANDARD; TANDEM MASS SPECTROMETRY; THYMELAEACEAE; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, LIQUID; FLAVONES; FLUOROBENZENES; IONS; MALE; METHANOL; PLANT EXTRACTS; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFONAMIDES; TANDEM MASS SPECTROMETRY;

EID: 79956126370     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2011.04.009     Document Type: Article

References (18)

1. The State Pharmacopoeia Commission of P.R.China Pharmacopoeia of the P.R. China 2010, Vol. 1. Beijing Chinese Medicine and Technology Publishing House, Beijing, pp. 269-269.
2. Xu Z.H., Qin G.W., Li X.Y., Xu R.S. New biflavanones and bioactive compounds from Stellera chamaejasme L. Acta Pharmacol. Sin. 2001, 36:668-671.
3. Zhang X., Yao Y., Lou Y., Jiang H.D., Wang X.W., Chai X.J., Zeng S. Metabolism of ebracteolata compound B studied in vitro with human liver microsomes, HepG2 cells and recombinant human enzymes. Drug Metab. Dispos. 2010, 38:2157-2165.
4. Fan J.J., Jia Z.P., Xie J.W. Antitumor activity of Chinese Stellera (Stellera chamadjasme L.). J. Pharm. Pract. 1996, 14:9-11.
5. Kim H.K., Son K.H., Chang H.W., Kang S.S., Kim H.P. Amentoflavone, a plant biflavone: a new potential anti-inflammatory agent. Arch. Pharm. Res. 1998, 21:406-410.
6. Banerjee T., Valacchi G., Ziboh V.A., van der Vliet A. Inhibition of TNFα-induced cyclooxygenase-2 expression by amentoflavone through suppression of NF-κB activation in A549 cells. Mol. Cell. Biochem. 2002, 238:105-110.
7. Farombi E.O., Moller P., Dragsted L.O. Ex vivo and in vivo protective effects of kolaviron against oxygen derived radical-induced DNA damage and oxidative stress in human lymphocytes and rat liver cells. Cell Biol. Toxicol. 2004, 20:71-82.
8. Su X.L., Lin R.C., Wong S.K., Tsui S.K., Kwan S.Y. Identification and characterisation of the Chinese herb Langdu by LC-MS/MS analysis. Phytochem. Anal. 2003, 14:40-47.
9. Yang G.H., Chen D.F. Biflavanones, flavonoids, and coumarins from the roots of Stellera chamaejasme and their antiviral effect on hepatitis B virus. Chem. Biodivers. 2008, 5:1419-1424.
10. Zhao L., Lou Z.Y., Zhu Z.Y., Zhang H., Zhang G.Q., Chai Y.F. Characterization of constituents in Stellera chamaejasme L. by rapid-resolution liquid chromatography-diode array detection and electrospray ionization time-of-flight mass spectrometry. Biomed. Chromatogr. 2008, 22:64-72.
11. Jin C., Michetich R.G., Daneshtalab M. Flavonoids from Stellera chamaejasme. Phytochemistry 1999, 50:505-508.
12. Niwa M., Liu G.Q., Atematsu H. Chamaechromone, a novel rearranged biflavonoid from Stellera chamaejasme L. Tetrahedron Lett. 1984, 25:3735-3738.
13. US Department of Health and Human Services Food and Drug Administration, Center for Drug Evaluation and Research (CDER) Guidance for Industry, Bioanalytical Method Validation 2001, http://www/fda.gov/cder/guidance/index.htm.
14. Michler H., Laakmann G., Wagner H. Development of an LC-MS method for simultaneous quantitation of amentoflavone and biapigenin, the minor and major biflavones from Hypericum perforatum L., in human plasma and its application to real blood. Phytochem. Anal. 2011, 22:42-50.
15. Colovic M., Fracasso C., Caccia S. Brain-to-plasma distribution ratio of the biflavone amentoflavone in the mouse. Drug Metab. Lett. 2008, 2:90-94.
16. Colovic M., Caccia S.J. Liquid chromatography-tandem mass spectrometry of I3,II8-biapigenin, the major biflavone in Hypericum perforatum extracts. J. Chromatogr. B 2008, 863:74-79.
17. Wang G.N., Pan R.L., Liao Y.H., Chen Y., Tang J.T., Chang Q. An LC-MS/MS method for determination of forsythiaside in rat plasma and application to a pharmacokinetic study. J. Chromatogr. B 2010, 878:102-106.
18. Dai J.Y., Yang J.L., Li C. Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu-tang across human intestinal Caco-2 cell monolayers. Acta Pharmacol. Sin. 2008, 29:1086-1093.