-
1
-
-
77953589054
-
Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase
-
doi:10.1677/ERC-09-0252
-
Algire C, Amrein L, Panasci L & Pollak M 2010 Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase. Endocrine-Related Cancer 17 351-360. (doi:10.1677/ERC-09-0252)
-
(2010)
Endocrine-Related Cancer
, vol.17
, pp. 351-360
-
-
Algire, C.1
Amrein, L.2
Panasci, L.3
Pollak, M.4
-
2
-
-
44849099894
-
The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level
-
doi:10.1038/ sj.onc.1211024
-
Ben Sahra I, Laurent K, Loubat A, Giorgetti-Peraldi S, Colosetti P, Auberger P, Tanti JF, Le Marchand-Brustel Y & Bost F 2008 The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. Oncogene 27 3576-3586. (doi:10.1038/ sj.onc.1211024)
-
(2008)
Oncogene
, vol.27
, pp. 3576-3586
-
-
Ben Sahra, I.1
Laurent, K.2
Loubat, A.3
Giorgetti-Peraldi, S.4
Colosetti, P.5
Auberger, P.6
Tanti, J.F.7
Le Marchand-Brustel, Y.8
Bost, F.9
-
3
-
-
3543072186
-
Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms
-
doi:10.1038/nrc1408
-
Calle EE & Kaaks R 2004 Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nature Reviews. Cancer 4 579-591. (doi:10.1038/nrc1408)
-
(2004)
Nature Reviews. Cancer
, vol.4
, pp. 579-591
-
-
Calle, E.E.1
Kaaks, R.2
-
4
-
-
84866079242
-
The role of adiponectin in cancer: A review of current evidence
-
doi:10.1210/er.2011-1015
-
Dalamaga M, Diakopoulos KN & Mantzoros CS 2012 The role of adiponectin in cancer: a review of current evidence. Endocrine Reviews 33 547-594. (doi:10.1210/er.2011-1015)
-
(2012)
Endocrine Reviews
, vol.33
, pp. 547-594
-
-
Dalamaga, M.1
Diakopoulos, K.N.2
Mantzoros, C.S.3
-
5
-
-
36348950449
-
Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells
-
doi:10.1158/0008-5472.CAN-07-2310
-
Dowling RJ, Zakikhani M, Fantus IG, Pollak M & Sonenberg N 2007 Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Research 67 10804-10812. (doi:10.1158/0008-5472.CAN-07-2310)
-
(2007)
Cancer Research
, vol.67
, pp. 10804-10812
-
-
Dowling, R.J.1
Zakikhani, M.2
Fantus, I.G.3
Pollak, M.4
Sonenberg, N.5
-
6
-
-
63449105969
-
Elevated circulating adiponectin and elevated insulin sensitivity in adiponectin transgenic mice are not associated with reduced susceptibility to colon carcinogenesis
-
doi:10.1002/ijc.24187
-
Ealey KN & Archer MC 2009 Elevated circulating adiponectin and elevated insulin sensitivity in adiponectin transgenic mice are not associated with reduced susceptibility to colon carcinogenesis. International Journal of Cancer 124 2226-2230. (doi:10.1002/ijc.24187)
-
(2009)
International Journal of Cancer
, vol.124
, pp. 2226-2230
-
-
Ealey, K.N.1
Archer, M.C.2
-
7
-
-
47249088612
-
Vitro metformin anti-neoplastic activity in epithelial ovarian cancer
-
doi:10.1016/j.ygyno.200804.008
-
Gotlieb WH, Saumet J, Beauchamp MC, Gu J, Lau S, PollakMN & Bruchim I 2008 In vitro metformin anti-neoplastic activity in epithelial ovarian cancer. Gynecologic Oncology 110 246-250. (doi:10.1016/j.ygyno.2008. 04.008)
-
(2008)
Gynecologic Oncology
, vol.110
, pp. 246-250
-
-
Gotlieb, W.H.1
Saumet, J.2
Beauchamp, M.C.3
Gu, J.4
Pollakmn, L.S.5
Bruchim, I.6
-
8
-
-
32644485492
-
Obesity and colorectal cancer: Epidemiology, mechanisms and candidate genes
-
doi:10.1016/j.jnutbio.2005.06.011
-
Gunter MJ & Leitzmann MF 2006 Obesity and colorectal cancer: epidemiology, mechanisms and candidate genes. Journal of Nutritional Biochemistry 17 145-156. (doi:10.1016/j.jnutbio.2005.06.011)
-
(2006)
Journal of Nutritional Biochemistry
, vol.17
, pp. 145-156
-
-
Gunter, M.J.1
Leitzmann, M.F.2
-
9
-
-
15044358594
-
New roles for the LKB1/AMPK pathway
-
doi:10.1016/j.ceb.2005.01.006
-
Hardie DG 2005 New roles for the LKB1/AMPK pathway. Current Opinion in Cell Biology 17 167-173. (doi:10.1016/j.ceb.2005.01.006)
-
(2005)
Current Opinion in Cell Biology
, vol.17
, pp. 167-173
-
-
Hardie, D.G.1
-
10
-
-
0035929359
-
Cell cycle regulation via p53 phosphorylation by a 50-AMP activated protein kinase activator, 5-Aminoimidazole-4-carboxamide-1-b-D-ribofuranoside, in a human hepatocellular carcinoma cell line
-
doi:10.1006/bbrc 2001 5627
-
Imamura K, Ogura T, Kishimoto A, KaminishiM & Esumi H 2011 Cell cycle regulation via p53 phosphorylation by a 50-AMP activated protein kinase activator, 5-Aminoimidazole-4-carboxamide-1-b-D-ribofuranoside, in a human hepatocellular carcinoma cell line. Biochemical and Biophysical Research Communications 287 562-567. (doi:10.1006/bbrc. 2001.5627)
-
(2011)
Biochemical and Biophysical Research Communications
, vol.287
, pp. 562-567
-
-
Imamura, K.1
Ogura, T.2
Kishimoto, A.3
Kaminishi, M.4
Esumi, H.5
-
11
-
-
34249069215
-
Dual antiglioma action of metformin: Cell cycle arrest and mitochondria-dependent apoptosis
-
doi:10.1007/s00018- 007-7080-4
-
Isakovic A, Harhaji L, Stevanovic D, Markovic Z, Sumarac-Dumanovic M, Starcevic V, Micic D & Trajkovic V 2007 Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis. Cellular and Molecular Life Sciences 64 1290-1302. (doi:10.1007/s00018- 007-7080-4)
-
(2007)
Cellular and Molecular Life Sciences
, vol.64
, pp. 1290-1302
-
-
Isakovic, A.1
Harhaji, L.2
Stevanovic, D.3
Markovic, Z.4
Sumarac-Dumanovic, M.5
Starcevic, V.6
Micic, D.7
Trajkovic, V.8
-
12
-
-
41349099104
-
Cancer statistics
-
doi:10.3322/ CA 2007 0010
-
Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T & Thun MJ 2008 Cancer statistics. CA: A Cancer Journal for Clinicians 58 71-96. (doi:10.3322/ CA.2007.0010)
-
(2008)
CA: A Cancer Journal for Clinicians
, vol.58
, pp. 71-96
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
Hao, Y.4
Xu, J.5
Murray, T.6
Thun, M.J.7
-
13
-
-
0034752938
-
Association of the interleukin-1b genetic polymorphism and gastric cancer risk in Japanese
-
doi:10.1007/s005350170033
-
Kato S, Onda M, Yamada S, Matsuda N, Tokunaga A & Matsukura N 2001 Association of the interleukin-1b genetic polymorphism and gastric cancer risk in Japanese. Journal of Gastroenterology 36 696-699. (doi:10.1007/s005350170033)
-
(2001)
Journal of Gastroenterology
, vol.36
, pp. 696-699
-
-
Kato, S.1
Onda, M.2
Yamada, S.3
Matsuda, N.4
Tokunaga, A.5
Matsukura, N.6
-
14
-
-
34347255023
-
Adiponectin stimulates AMP-Activated protein kinase in the hypothalamus and increases food intake
-
doi:10.1016/ j.cmet 2007 06.003
-
Kubota N, Yano W, Kubota T, Yamauchi T, Itoh S, Kumagai H, Kozono H, Takamoto I, Okamoto S, Shiuchi T et al. 2007 Adiponectin stimulates AMP-Activated protein kinase in the hypothalamus and increases food intake. Cell Metabolism 6 55-68. (doi:10.1016/ j.cmet.2007.06.003)
-
(2007)
Cell Metabolism
, vol.6
, pp. 55-68
-
-
Kubota, N.1
Yano, W.2
Kubota, T.3
Yamauchi, T.4
Itoh, S.5
Kumagai, H.6
Kozono, H.7
Takamoto, I.8
Okamoto, S.9
Shiuchi, T.10
-
15
-
-
33645227422
-
Genetic polymorphisms of interleukin-1b (IL-1B) and IL-1 receptor antagonist (IL-1RN) and breast cancer risk in Korean women
-
doi:10.1007/s10549-005-9079-6
-
Lee KM, Park SK, Hamajima N, Tajima K, Choi JY, Noh DY, Ahn SH, Yoo KY, Hirvonen A & Kang D 2006 Genetic polymorphisms of interleukin-1b (IL-1B) and IL-1 receptor antagonist (IL-1RN) and breast cancer risk in Korean women. Breast Cancer Research and Treatment 96 197-202. (doi:10.1007/s10549-005-9079-6)
-
(2006)
Breast Cancer Research and Treatment
, vol.96
, pp. 197-202
-
-
Lee, K.M.1
Park, S.K.2
Hamajima, N.3
Tajima, K.4
Choi, J.Y.5
Noh, D.Y.6
Ahn, S.H.7
Yoo, K.Y.8
Hirvonen, A.9
Kang, D.10
-
16
-
-
54549094827
-
Obesity and type 2 diabetes are associated with an increased risk of developing cancer and a worse prognosis; Epidemiological and mechanistic evidence
-
doi:10.1055/s-2008-1081488
-
LeRoith D, Novosyadlyy R, Gallagher EJ, Lann D, Vijayakumar A & Yakar S 2008 Obesity and type 2 diabetes are associated with an increased risk of developing cancer and a worse prognosis; epidemiological and mechanistic evidence. Experimental and Clinical Endocrinology & Diabetes 116 (Suppl 1) S4-S6. (doi:10.1055/s-2008-1081488)
-
(2008)
Experimental and Clinical Endocrinology & Diabetes
, vol.116 SUPPL. 1
-
-
Leroith, D.1
Novosyadlyy, R.2
Gallagher, E.J.3
Lann, D.4
Vijayakumar, A.5
Yakar, S.6
-
17
-
-
80051607846
-
Antidiabetic drug metformin induces apoptosis in human MCF breast cancer via targeting ERK signaling
-
doi:10.3727/096504011X13021877989838
-
Malki A & Youssef A 2011 Antidiabetic drug metformin induces apoptosis in human MCF breast cancer via targeting ERK signaling. Oncology Research 19 275-285. (doi:10.3727/096504011X13021877989838)
-
(2011)
Oncology Research
, vol.19
, pp. 275-285
-
-
Malki, A.1
Youssef, A.2
-
18
-
-
0141456030
-
Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivity
-
doi:10.1182/blood-2003-01-0190
-
Melani C, Chiodoni C, Forni G & Colombo MP 2003 Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivity. Blood 102 2138-2145. (doi:10.1182/blood-2003-01-0190)
-
(2003)
Blood
, vol.102
, pp. 2138-2145
-
-
Melani, C.1
Chiodoni, C.2
Forni, G.3
Colombo, M.P.4
-
19
-
-
83355163337
-
Direct role of adiponectin and adiponectin receptors in endometrial cancer: In vitro and ex vivo studies in humans
-
doi:10.1158/1535-7163.MCT-11-0545
-
Moon HS, Chamberland JP, Aronis K, Tseleni-Balafouta S & Mantzoros CS 2011 Direct role of adiponectin and adiponectin receptors in endometrial cancer: in vitro and ex vivo studies in humans. Molecular Cancer Therapeutics 10 2234-2243. (doi:10.1158/1535-7163.MCT-11-0545)
-
(2011)
Molecular Cancer Therapeutics
, vol.10
, pp. 2234-2243
-
-
Moon, H.S.1
Chamberland, J.P.2
Aronis, K.3
Tseleni-Balafouta, S.4
Mantzoros, C.S.5
-
20
-
-
84874594105
-
Salutary effects of adiponectin on colon cancer: In vivo and in vitro studies in mice
-
doi:10.1136/gutjnl-2012-302092
-
MoonHS, LiuX,Nagel JM,ChamberlandJP, DiakopoulosKN, BrinkoetterMT, Hatziapostolou M, Wu Y, Robson SC, Iliopoulos D et al. 2013 Salutary effects of adiponectin on colon cancer: in vivo and in vitro studies in mice. Gut 62 561-570. (doi:10.1136/gutjnl-2012-302092)
-
(2013)
Gut
, vol.62
, pp. 561-570
-
-
Liuxnagel Jmchamberlandjp, M.1
Brinkoettermt, D.2
Hatziapostolou, M.3
Wu, Y.4
Robson, S.C.5
Iliopoulos, D.6
-
21
-
-
0036782017
-
P27, cyclin E, and CDK2 expression in normal and cancerous endometrium
-
Oshita T, Shigemasa K, Nagai N & Ohama K 2002 p27, cyclin E, and CDK2 expression in normal and cancerous endometrium. International Journal of Oncology 21 737-743.
-
(2002)
International Journal of Oncology
, vol.21
, pp. 737-743
-
-
Oshita, T.1
Shigemasa, K.2
Nagai, N.3
Ohama, K.4
-
22
-
-
28244466264
-
5-Aminoimidazole-4- carboxamide-1-b-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-Activated protein kinase
-
doi:10.1074/jbc.M507443200
-
Rattan R, Giri S, Singh AK & Singh I 2005 5-Aminoimidazole-4- carboxamide-1-b-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-Activated protein kinase. Journal of Biological Chemistry 280 39582-39593. (doi:10.1074/jbc.M507443200)
-
(2005)
Journal of Biological Chemistry
, vol.280
, pp. 39582-39593
-
-
Rattan, R.1
Giri, S.2
Singh, A.K.3
Singh, I.4
-
23
-
-
78751692291
-
Metformin attenuates ovarian cancer cell growth in an AMP-kinase dispensable manner
-
doi:10.1111/ j.1582-4934 2009.00954.x
-
Rattan R, Giri S, Hartmann LC & Shridhar V 2011 Metformin attenuates ovarian cancer cell growth in an AMP-kinase dispensable manner. Journal of Cellular and Molecular Medicine 15 166-178. (doi:10.1111/ j.1582-4934.2009. 00954.x)
-
(2011)
Journal of Cellular and Molecular Medicine
, vol.15
, pp. 166-178
-
-
Rattan, R.1
Giri, S.2
Hartmann, L.C.3
Shridhar, V.4
-
24
-
-
77953293446
-
Sphingosine Kinase: Role in regulation of bioactive sphingolipid mediators in inflammation
-
doi:10.1016/j.biochi.2010.02.008
-
Snider AJ, Orr-Gandy KA & Obeid LM 2010 Sphingosine kinase: role in regulation of bioactive sphingolipid mediators in inflammation. Biochimie 92 707-715. (doi:10.1016/j.biochi.2010.02.008)
-
(2010)
Biochimie
, vol.92
, pp. 707-715
-
-
Snider, A.J.1
Orr-Gandy, K.A.2
Obeid, L.M.3
-
25
-
-
84879552899
-
Metformin and sulfonylureas in relation to cancer risk in type II diabetes patients: A meta-Analysis using primary data of published studies
-
doi:10.1016/j.metabol.2013.01.014
-
Thakkar B, Aronis KN, Vamvini MT, Shields K & Mantzoros CS 2013 Metformin and sulfonylureas in relation to cancer risk in type II diabetes patients: a meta-Analysis using primary data of published studies. Metabolism 62 922-934. (doi:10.1016/j.metabol.2013.01.014)
-
(2013)
Metabolism
, vol.62
, pp. 922-934
-
-
Thakkar, B.1
Aronis, K.N.2
Vamvini, M.T.3
Shields, K.4
Mantzoros, C.S.5
-
26
-
-
27944506001
-
Low plasma adiponectin levels and risk of colorectal cancer in men: A prospective study
-
doi:10.1093/jnci/dji376
-
Wei EK, Giovannucci E, Fuchs CS, Willett WC & Mantzoros CS 2005 Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study. Journal of the National Cancer Institute 97 1688-1694. (doi:10.1093/jnci/dji376)
-
(2005)
Journal of the National Cancer Institute
, vol.97
, pp. 1688-1694
-
-
Wei, E.K.1
Giovannucci, E.2
Fuchs, C.S.3
Willett, W.C.4
Mantzoros, C.S.5
-
27
-
-
84865317251
-
Metformin inhibits the development and metastasis of ovarian cancer
-
doi:10.3892/or.2012.1890
-
Wu B, Li S, Sheng L, Zhu J, Gu L, Shen H, La D, Hambly BD, Bao S & Di W 2012 Metformin inhibits the development and metastasis of ovarian cancer. Oncology Reports 28 903-908. (doi:10.3892/or.2012.1890)
-
(2012)
Oncology Reports
, vol.28
, pp. 903-908
-
-
Wu, B.1
Li, S.2
Sheng, L.3
Zhu, J.4
Gu, L.5
Shen, H.6
La Hambly, D.B.D.7
Bao, S.8
Di, W.9
-
28
-
-
3543025724
-
AMP-Activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms
-
doi:10.1016/j.bbrc.2004 06.133
-
Xiang X, Saha AK, Wen R, Ruderman NB & Luo Z 2004 AMP-Activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms. Biochemical and Biophysical Research Communications 321 161-167. (doi:10.1016/j.bbrc.2004. 06.133)
-
(2004)
Biochemical and Biophysical Research Communications
, vol.321
, pp. 161-167
-
-
Xiang, X.1
Saha, A.K.2
Wen, R.3
Ruderman, N.B.4
Luo, Z.5
-
29
-
-
0036851817
-
Adiponectin stimulates glucose utilization and fatty-Acid oxidation by activating AMP-Activated protein kinase
-
doi:10.1038/nm788
-
Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K et al. 2002 Adiponectin stimulates glucose utilization and fatty-Acid oxidation by activating AMP-Activated protein kinase. Nature Medicine 8 1288-1295. (doi:10.1038/nm788)
-
(2002)
Nature Medicine
, vol.8
, pp. 1288-1295
-
-
Yamauchi, T.1
Kamon, J.2
Minokoshi, Y.3
Ito, Y.4
Waki, H.5
Uchida, S.6
Yamashita, S.7
Noda, M.8
Kita, S.9
Ueki, K.10
-
30
-
-
0037494960
-
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
-
doi:10.1038/nature01705
-
Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M et al. 2003 Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423 762-769. (doi:10.1038/nature01705)
-
(2003)
Nature
, vol.423
, pp. 762-769
-
-
Yamauchi, T.1
Kamon, J.2
Ito, Y.3
Tsuchida, A.4
Yokomizo, T.5
Kita, S.6
Sugiyama, T.7
Miyagishi, M.8
Hara, K.9
Tsunoda, M.10
-
31
-
-
33845865825
-
Crosstalk between cancer and immune cells: Role of STAT3 in the tumour microenvironment
-
doi:10.1038/nri1995
-
Yu H, Kortylewski M & Pardoll D 2007 Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nature Reviews. Immunology 7 41-51. (doi:10.1038/nri1995)
-
(2007)
Nature Reviews. Immunology
, vol.7
, pp. 41-51
-
-
Yu, H.1
Kortylewski, M.2
Pardoll, D.3
-
32
-
-
33751284806
-
Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells
-
doi:10.1158/0008-5472. CAN-06-1500
-
Zakikhani M, Dowling R, Fantus IG, Sonenberg N & Pollak M 2006 Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Research 66 10269-10273. (doi:10.1158/0008-5472. CAN-06-1500)
-
(2006)
Cancer Research
, vol.66
, pp. 10269-10273
-
-
Zakikhani, M.1
Dowling, R.2
Fantus, I.G.3
Sonenberg, N.4
Pollak, M.5
|