Antidiabetic drug metformin induces apoptosis in human MCF breast cancer via targeting ERK signaling

Oncology Research

Volumn 19, Issue 6, 2011, Pages 275-285

  Malki, Ahmed ^a   Youssef, Amal ^b  

^a Alexandria University Faculty Of Science   (Egypt)

^b Alexandria University Faculty of Pharmacy   (Egypt)

Author keywords

Bax; Breast cancer; ERK; JNK; Metformin; p21; p53

Indexed keywords

CYCLIN D; CYCLIN E; INSULIN RECEPTOR; METFORMIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; SOMATOMEDIN C RECEPTOR; STAT3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; WORTMANNIN; ANTIDIABETIC AGENT; CCNE1 PROTEIN, HUMAN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; ONCOPROTEIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER GROWTH; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL PROLIFERATION; CELL STRAIN MCF 7; CLINICAL ASSESSMENT; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; NICK END LABELING; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; BREAST TUMOR; DRUG EFFECT; GENETICS; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL PROLIFERATION; CYCLIN E; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; FLOW CYTOMETRY; G1 PHASE; HUMANS; HYPOGLYCEMIC AGENTS; METFORMIN; ONCOGENE PROTEINS; RECEPTOR, INSULIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 80051607846     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: 10.3727/096504011X13021877989838     Document Type: Article

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