Biomimetic and Bio-responsive materials in regenerative medicine intelligent materials for healing living tissues

Strategies in Regenerative Medicine: Integrating Biology with Materials Design

Volumn , Issue , 2009, Pages 97-154

  Pollock, Jacob F ^a   Healy, Kevin E ^b  

^a University of California at Berkeley   (United States)

^b Lawrence Berkeley National Laboratory   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84891437725     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-0-387-74660-9_4     Document Type: Chapter

References (177)

1. Ehrbar M, Metters A, Zammaretti P, et al. (2005) Endothelial cell proliferation and progenitor maturation by fibrin-bound VEGF variants with differential susceptibilities to local cellular activity. J Control Release 101(1-3):93-109.
2. Elisseeff J, Anseth K, Sims D, et al. (1999) Transdermal photopolymerization for minimally invasive implantation. Proc Natl Acad Sci U S A 96(6):3104-3107.
3. Engler AJ, Sen S, Sweeney HL, et al. (2006) Matrix elasticity directs stem cell lineage specification. Cell 126(4):677-689.
4. Ghosh K, Ren XD, Shu XZ, et al. (2006) Fibronectin functional domains coupled to hyaluronan stimulate adult human dermal fibroblast responses critical for wound healing. Tissue Eng 12(3):601-613.
5. Kim S, Chung EH, Gilbert M, et al. (2005) Synthetic MMP-13 degradable ECMs based on poly (N-isopropylacrylamide-co-acrylic acid) semi-interpenetrating polymer networks. I. Degradation and cell migration. J Biomed Mater Res A 75(1):73-88.
6. Kuhl PR, Griffith-Cima LG, (1996) Tethered epidermal growth factor as a paradigm for growth factor-induced stimulation from the solid phase. Nat Med 2(9):1022-1027.
7. Lutolf MP, Weber FE, Schmoekel HG, et al. (2003) Repair of bone defects using synthetic mimetics of collagenous extracellular matrices. Nat Biotechnol 21(5):513-518.
8. Rajangam K, Behanna HA, Hui MJ, et al. (2006) Heparin binding nanostructures to promote growth of blood vessels. Nano Lett 6(9):2086-2090.
9. West JL, Hubbell JA. (1999) Polymeric biomaterials with degradation sites for proteases involved in cell migration. Macromolecules 32(1):241-244.
10. Zaman MH, Trapani LM, Sieminski AL, et al. (2006) Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis. Proc Natl Acad Sci U S A 103(29):10889-10894.
11. Abbott A (2003) Cell culture: biology's new dimension. Nature 424:870-872
12. Alenghat FJ, Ingber DE (2002) Mechanotransduction: all signals point to cytoskeleton, matrix, and integrins. Sci STKE 2002: PE6
13. Anseth KS, Metters AT, Bryant SJ, et al. (2002) In situ forming degradable networks and their application in tissue engineering and drug delivery. J Control Release 78:199-209
14. Augst AD, Kong HJ, Mooney DJ (2006) Alginate hydrogels as biomaterials. Macromol Biosci. 6:623-633
15. Barber TA, Golledge SL, Castner DG et al. (2003) Peptide-modified p (AAm-co-EG/AAc) IPNs grafted to bulk titanium modulate osteoblast behavior in vitro. J Biomed Mater Res A 64:38-47
16. Bearinger JP, Castner DG, Healy KE (1998) Biomolecular modification of p (AAm-co-EG/AA) IPNs supports osteoblast adhesion and phenotypic expression. J Biomater Sci Polym Ed 9:629-652
17. Behravesh E, Zygourakis K, Mikos AG (2003) Adhesion and migration of marrow-derived osteoblasts on injectable in situ crosslinkable poly (propylene fumarate-co-ethylene glycol)-based hydrogels with a covalently linked RGDS peptide. J Biomed Mater Res A 65:260-270
18. Bhattarai N, Matsen FA, Zhang M (2005) PEG-grafted chitosan as an injectable thermoreversible hydrogel. Macromol Biosci 5:107-111
19. Brandley BK, Schnaar RL (1988) Covalent attachment of an Arg-Gly-Asp sequence peptide to derivatizable polyacrylamide surfaces: support of fibroblast adhesion and long-term growth. Anal Biochem 172:270-278
20. Burdick JA, Anseth KS (2002) Photoencapsulation of osteoblasts in injectable RGD-modified PEG hydrogels for bone tissue engineering. Biomaterials 22:4315-4323
21. Cai S, Liu Y, Zheng Shu X, et al. (2005) Injectable glycosaminoglycan hydrogels for controlled release of human basic fibroblast growth factor. Biomaterials 26:6054-6067
22. Cellesi F, Tirelli N (2005) A new process for cell microencapsulation and other biomaterial applications: Thermal gelation and chemical cross-linking in "tandem". J Mater Sci Mater Med 16:559-565
23. Chaikof EL, Matthew H, Kohn J, et al. (2002) Biomaterials and scaffolds in reparative medicine. Ann NY Acad Sci 961:96-105
24. Chen JS, Noah EM, Pallua N, et al. (2002) The use of bifunctional polyethyleneglycol derivatives for coupling of proteins to and cross-linking of collagen matrices. J Mater Sci Mater Med 13:1029-1035
25. Chung EH, Gilbert M, Virdi AS, et al. (2006) Biomimetic artificial ECMs stimulate bone regeneration. J Biomed Mater Res A 79 A: 815-826
26. Cutler SM, Garcia AJ (2003) Engineering cell adhesive surfaces that direct integrin a5/31 binding using a recombinant fragment of fibronectin. Biomaterials May 24:1759-1770
27. Davis ME, Hsieh PC, Takahashi T, et al. (2006) Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction. Proc Natl Acad Sci USA 103:8155-8160
28. De Las Heras Alarcon C, Pennadam S, Alexander C (2005) Stimuli responsive polymers for biomedical applications. Chem Soc Rev 34:276-285
29. Dee KC, Andersen TT, Bizios R (1998) Design and function of novel osteoblast-adhesive peptides for chemical modification of biomaterials. J Biomed Mater Res 40:371-377
30. DeLong SA, Gobin AS, West JL (2005) Covalent immobilization of RGDS on hydrogel surfaces to direct cell alignment and migration. J Control Release 109:139-148
31. DeLong SA, Moon JJ, West JL (2005) Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration. Biomaterials 26:3227-3234
32. Dettin M, Conconi MT, Gambaretto R, et al. (2005) Effect of synthetic peptides on osteoblast adhesion. Biomaterials 26:4507-4515
33. Dikovsky D, Bianco-Peled H, Seliktar D (2006) The effect of structural alterations of PEG-fibrinogen hydrogel scaffolds on 3-D cellular morphology and cellular migration. Biomaterials 27:1496-1506
34. Discher DE, Janmey P, Wang YL (2005) Tissue cells feel and respond to the stiffness of their substrate. Science 310:1139-1143
35. Drotleff S, Lungwitz U, Breunig M, et al. (2004) Biomimetic polymers in pharmaceutical and biomedical sciences. Eur J Pharm Biopharm 58:385-407
36. Drumheller PD, Hubbell JA. (1994) Polymer networks with grafted cell adhesion peptides for highly biospecific cell adhesive substrates. Anal Biochem 222:380-388
37. Ehrbar M, Djonov VG, Schnell C, et al. (2004) Cell-demanded liberation of VEGF121 from fibrin implants induces local and controlled blood vessel growth. Circ Res 94:1124-1132
38. Ehrbar M, Metters A, Zammaretti P, et al. (2005) Endothelial cell proliferation and progenitor maturation by fibrin-bound VEGF variants with differential susceptibilities to local cellular activity. J Control Release 101:93-109
39. Elbert DL, Hubbell JA (2001) Conjugate addition reactions combined with free-radical cross-linking for the design of materials for tissue engineering. Biomacromolecules 2:430-441
40. Elbert DL, Pratt AB, Lutolf MP, et al. (2001) Protein delivery from materials formed by self-selective conjugate addition reactions. J Control Release 76:11-25
41. Engler A, Bacakova L, Newman C, et al. (2004) Substrate compliance versus ligand density in cell on gel responses. Biophys J 86:617-628
42. Engler AJ, Sen S, Sweeney HL, et al. (2006) Matrix elasticity directs stem cell lineage specification. Cell 126:677-689
43. Fisher JP, Jo S, Mikos AG, et al. (2004) Thermoreversible hydrogel scaffolds for articular cartilage engineering. J Biomed Mater Res A 71:268-274
44. Forget MA, Desrosiers RR, Beliveau R (1999) Physiological roles of matrix metalloproteinases: implications for tumor growth and metastasis. Can J Physiol Pharmacol 77:465-480
45. Fujita M, Ishihara M, Morimoto Y, et al. (2005) Efficacy of photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2 in a rabbit model of chronic myocardial infarction. J Surg Res 126:27-33
46. Gallant ND, Garcia AJ (2007) Quantitative analysis of cell adhesion strength. Methods Mol Biol 370:83-96
47. Garcia AJ, Boettiger D (1999) Integrin-fibronectin interactions at the cell-material interface: initial integrin binding and signaling. Biomaterials 20:2427-243
48. Geer DJ, Swartz DD, Andreadis ST (2005) Biomimetic delivery of keratinocyte growth factor upon cellular demand for accelerated wound healing in vitro and in vivo. Am J Pathol 167:1575-1586
49. Ghosh K, Ren XD, Shu XZ, et al. (2006) Fibronectin functional domains coupled to hyaluronan stimulate adult human dermal fibroblast responses critical for wound healing. Tissue Eng 12:601-613
50. Giancotti FG, Ruoslahti E (1999) Integrin signaling. Science 285:1028-1032
51. Gilbert M, Giachelli CM, Stayton PS (2003) Biomimetic peptides that engage specific integrin-dependent signaling pathways and bind to calcium phosphate surfaces. J Biomed Mater Res A 67:69-77
52. Gilbert ME, Kirker KR, Gray SD, et al. (2004) Chondroitin sulfate hydrogel and wound healing in rabbit maxillary sinus mucosa. Laryngoscope 114:1406-1409
53. Girotti A, Reguera J, Rodriguez-Cabello JC, et al. (2004) Design and bioproduction of a recombinant multi (bio) functional elastin-like protein polymer containing cell adhesion sequences for tissue engineering purposes. J Mater Sci Mater Med 15:479-484
54. Gobin AS, West JL (2002) Cell migration through defined, synthetic ECM analogs. Faseb J 16:751-753
55. Gobin AS, West JL (2003) Effectsof epidermal growth factor on fibroblast migration through biomimetic hydrogels. Biotechnol Prog. 19:1781-1785
56. Gobin AS, West JL (2003) Val-ala-pro-gly, an elastin-derived non-integrin ligand: smooth muscle cell adhesion and specificity. J Biomed Mater Res A 67:255-259
57. Gonzalez AL, Gobin AS, West JL, et al. (2006) Integrin interactions with immobilized peptides in polyethylene glycol diacrylate hydrogels. Tissue Eng 10:1775-1786
58. Griffith LG, Swartz MA (2006) Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol 7:211-224
59. Guler MO, Hsu L, Soukasene S, et al. (2006) Presentation of RGDS epitopes on self-assembled nanofibers of branched peptide amphiphiles. Biomacromolecules. 7:1855-1863
60. Halstenberg S, Panitch A, Rizzi S, et al. (2002) Biologically engineered protein-graft-poly (ethylene glycol) hydrogels: a cell adhesive and plasmin-degradable biosynthetic material for tissue repair. Biomacromolecules 3:710-723
61. Harbers GM, Gamble LJ, Irwin EF, et al. (2005) Development and characterization of ahighthroughput system for assessing cell-surface receptor-ligand engagement. Langmuir 21:8374-8384
62. Harbers GM, Healy KE (2005) The effect of ligand type and density on osteoblast adhesion, proliferation, and matrix mineralization. J Biomed Mater Res A 75:855-869
63. Hartgerink JD, Beniash E, Stupp SI (2002) Peptide-amphiphile nanofibers: a versatile scaffold for the preparation of self-assembling materials. Proc Natl Acad Sci U S A 99:5133-5138
64. Healy KE, Rezania A, Stile RA (1999) Designing biomaterials to direct biological responses. Bioartificial Organs Ii: Technology, Medicine, and Materials 875:24-35
65. Heilshorn SC, DiZio KA, Welsh ER, et al. (2003) Endothelial cell adhesion to the fibronectin CS5 domain in artificial extracellular matrix proteins. Biomaterials 24:4245-4252
66. Hern DL, Hubbell JA (1998) Incorporation of adhesion peptides into nonadhesive hydrogels useful for tissue resurfacing. J Biomed Mater Res 39:266-276
67. Hertl W, Ramsey WS, Nowlan ED (1984) Assessment of cell-substrate adhesion by a centrifugal method. In Vitro 20:796-801
68. Hirano Y, Kando Y, Hayashi T, et al. (1991) Synthesis and cell attachment activity of bioactive oligopeptides: RGD, RGDS, RGDV, and RGDT. J Biomed Mater Res 25:1523-1534
69. Holland TA, Tabata Y, Mikos AG (2005) Dual growth factor delivery from degradable oligo (poly (ethylene glycol) fumarate) hydrogel scaffolds for cartilage tissue engineering. J Control Release 101:111-125
70. Hoshikawa A, Nakayama Y, Matsuda T, et al. (2006) Encapsulation of chondrocytes in photopolymerizable styrenated gelatin for cartilage tissue engineering. Tissue Eng. 12:2333-2341
71. Hosseinkhani H, Hosseinkhani M, Khademhosseini A, et al. (2006) Enhanced angiogenesis through controlled release of basic fibroblast growth factor from peptide amphiphile for tissue regeneration. Biomaterials 27:5836-5844
72. Hsieh PC, Davis ME, Gannon J, et al. (2006) Controlled delivery of PDGF-BB for myocardial protection using injectable self-assembling peptide nanofibers. J Clin Invest 116:237-248
73. Hsieh PC, MacGillivray C, Gannon J, et al. (2006) Local controlled intramyocardial delivery of platelet-derived growth factor improves postinfarction ventricular function without pulmonary toxicity. Circulation 114:637-644
74. Hubbell JA (2004) Biomaterials science and high-throughput screening. Nat Biotechnol 22:828-829
75. Humphries JD, Byron A, Humphries MJ (2006) Integrin ligands at a glance. J Cell Sci 119:3901-3903
76. Hutchings H, Ortega N, Plouet J (2003) Extracellular matrix-bound vascular endothelial growth factor promotes endothelial cell adhesion, migration, and survival through integrin ligation. Faseb J 17:1520-1522
77. Irvine DJ, Mayes AM, Griffith LG (2001) Nanoscale clustering of RGD peptides at surfaces using Comb polymers. 1. Synthesis and characterization of Comb thin films. Biomacromolecules 2:85-94
78. Itle LJ, Koh WG, Pishko MV (2005) Hepatocyte viability and protein expression within hydrogel microstructures. Biotechnol Prog 21:926-932
79. Jiang XS, Chai C, Zhang Y, et al. (2006) Surface-immobilization of adhesion peptides on substrate for ex vivo expansion of cryopreserved umbilical cord blood CD34+ cells. Biomaterials 27:2723-2732
80. Jo S, Shin H, Mikos AG (2001) Modification of oligo (poly (ethylene glycol) fumarate) macromer with a GRGD peptide for the preparation of functionalized polymer networks. Biomacromolecules 2:255-261
81. Kao WJ, Lee D, Schense JC, et al. (2001) Fibronectin modulates macrophage adhesion and FBGC formation: the role of RGD, PHSRN, and PRRARV domains. J Biomed Mater Res 55:79-88
82. Kim S, Chung EH, Gilbert M, et al. (2005) Synthetic MMP-13 degradable ECMs based on poly (N-isopropylacrylamide-co-acrylic acid) semi-interpenetrating polymer networks. I. Degradation and cell migration. J Biomed Mater Res A 75:73-88
83. Kim S, Healy KE (2003) Synthesis and characterization of injectable poly (N-isopropylacrylamideco-acrylic acid) hydrogels with proteolytically degradable cross-links. Biomacromolecules. 4:1214-1223
84. Kirker KR, Luo Y, Nielson JH, et al. (2002) Glycosaminoglycan hydrogel films as biointeractive dressings for wound healing. Biomaterials 23:3661-3671
85. Kleiner DE, Stetler-Stevenson WG (1999) Matrix metalloproteinases and metastasis. Cancer Chemother Pharmacol 43:S42-51
86. Koch S, Yao C, Grieb G, et al. (2006) Enhancing angiogenesis in collagen matrices by covalent incorporation of VEGF. J Mater Sci Mater Med 17:735-741
87. Koo LY, Irvine DJ, Mayes AM, et al. (2002) Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus. J Cell Sci 115:1423-1433
88. Kopecek J (2003) Smart and genetically engineered biomaterials and drug delivery systems. Eur J Pharm Sci 20:1-16
89. Lai PH, Chang Y, Chen SC, et al. (2006) Acellular biological tissues containing inherent glycosaminoglycans for loading basic fibroblast growth factor promote angiogenesis and tissue regeneration. Tissue Eng 12:2499-2508
90. Leach JB, Bivens KA, Collins CN, et al. (2004) Development of photocrosslinkable hyaluronic acid-polyethylene glycol-peptide composite hydrogels for soft tissue engineering. J Biomed Mater Res A 70:74-82
91. Lee BH, West B, McLemore R, et al. (2006) In-situ injectable physically and chemically gelling NIPAAm-based copolymer system for embolization. Biomacromolecules. 7:2059-2064
92. Lee KY, Mooney DJ (2001) Hydrogels for tissue engineering. Chem Rev 101:1869-1879
93. Lee MH, Murphy G (2004) Matrix metalloproteinases at a glance. J Cell Sci 117:4015-4016
94. Li R, Hoess RH, Bennett JS, et al. (2003) Use of phage display to probe the evolution of binding specificity and affinity in integrins. Protein Eng 16:65-72
95. Luo Y, Kirker KR, Prestwich GD (2000) Cross-linked hyaluronic acid hydrogel films: new biomaterials for drug delivery. J Control Release 69:169-184
96. Lutolf MP, Lauer-Fields JL, Schmoekel HG, et al. (2003) Synthetic matrix metalloproteinasesensitive hydrogels for the conduction of tissue regeneration: engineering cell-invasion characteristics. Proc Natl Acad Sci U S A 100:5413-5418
97. Lutolf MP, Tirelli N, Cerritelli S, et al. (2001) Systematic modulation of Michael-type reactivity of thiols through the use of charged amino acids. Bioconjug Chem 12:1051-1056
98. Lutolf MP, Weber FE, Schmoekel HG, et al. (2003) Repair of bone defects using synthetic mimetics of collagenous extracellular matrices. Nat Biotechnol 21:513-518
99. Maheshwari G, Brown G, Lauffenburger DA, et al. (2000) Cell adhesion and motility depend on nanoscale RGD clustering. J Cell Sci 113:1677-1686
100. Mann BK, Gobin AS, Tsai AT, et al. (2001) Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineering. Biomaterials 22:3045-3051
101. Mann BK, Schmedlen RH, West JL (2001) Tethered-TGF-beta increases extracellular matrix production of vascular smooth muscle cells. Biomaterials 22:439-444
102. Mann BK, Tsai AT, Scott-Burden T, et al. (1999) Modification of surfaces with cell adhesion peptides alters extracellular matrix deposition. Biomaterials 20:2281-2286
103. Mann BK, West JL (2002) Cell adhesion peptides alter smooth muscle cell adhesion, proliferation, migration, and matrix protein synthesis on modified surfaces and in polymer scaffolds. J Biomed Mater Res 60:86-93
104. Mardilovich A, Craig JA, McCammon MQ, et al. (2006) Design of a novel fibronectinmimetic peptide-amphiphile for functionalized biomaterials. Langmuir 22:3259-3264
105. Marler JJ, Guha A, Rowley J, et al. (2000) Soft-tissue augmentation with injectable alginate and syngeneic fibroblasts. Plast Reconstr Surg 105:2049-2058
106. Massia SP, Hubbell JA (1990) Covalent surface immobilization of Arg-Gly-Asp-and Tyr-Ile-Gly-Ser-Arg-containing peptides to obtain well-defined cell-adhesive substrates. Anal Biochem 187:292-301
107. Massia SP, Hubbell JA (1992) Immobilized amines and basic amino acids as mimetic heparinbinding domains for cell surface proteoglycan-mediated adhesion. J Biol Chem 267:10133-10141
108. Massia SP, Hubbell JA (1992) Vascular endothelial cell adhesion and spreading promoted by the peptide REDV of the IIICS region of plasma fibronectin is mediated by integrin alpha 4 beta 1. J Biol Chem 267:14019-14026
109. Morikawa N, Matsuda T (2002) Thermoresponsive artificial extracellular matrix: N-isopropylacrylamide-graft-copolymerized gelatin. J Biomater Sci Polym Ed 13:167-183
110. Myles JL, Burgess BT, Dickinson RB (2000) Modification of the adhesive properties of collagen by covalent grafting with RGD peptides. J Biomater Sci Polym Ed 11:69-86
111. Na K, Park JH, Kim SW, et al. (2006) Delivery of dexamethasone, ascorbate, and growth factor (TGF beta-3) in thermo-reversible hydrogel constructs embedded with rabbit chondrocytes. Biomaterials 27:5951-5957
112. Obara K, Ishihara M, Fujita M, et al. (2005) Acceleration of wound healing in healingimpaired db/db mice with a photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2. Wound Repair Regen 13:390-397
113. Ohya S, Nakayama Y, Matsuda T (2001) Thermoresponsive artificial extracellular matrix for tissue engineering: hyaluronic acid bioconjugated with poly (N-isopropylacrylamide) grafts. Biomacromolecules 2:856-863
114. Pantoliano MW, Horlick RA, Springer BA, et al. (1994) Multivalent ligand-receptor binding interactions in the fibroblast growth factor system produce a cooperative growth factor and heparin mechanism for receptor dimerization. Biochemistry 33:10229-10248
115. Park H, Temenoff JS, Holland TA, et al. (2005) Delivery of TGF-beta1 and chondrocytes via injectable, biodegradable hydrogels for cartilage tissue engineering applications. Biomaterials 26:7095-7103
116. Park KH, Kim MH, Park SH, et al. (2004) Synthesis of Arg-Gly-Asp (RGD) sequence conjugated thermo-reversible gel via the PEG spacer arm as an extracellular matrix for a pheochromocytoma cell (PC12) culture. Biosci Biotechnol Biochem 68:2224-2229
117. Park Y, Lutolf MP, Hubbell JA, et al. (2004) Bovine primary chondrocyte culture in synthetic matrix metalloproteinase-sensitive poly (ethylene glycol)-based hydrogels as a scaffold for cartilage repair. Tissue Eng 10:515-522
118. Park YD, Tirelli N, Hubbell JA (2003) Photopolymerized hyaluronic acid-based hydrogels and interpenetrating networks. Biomaterials 24:893-900
119. Paszek MJ, Zahir N, Johnson KR, et al. (2005) Tensional homeostasis and the malignant phenotype. Cancer Cell 8:241-254
120. Peattie RA, Nayate AP, Firpo MA, et al. (2004) Stimulation of in vivo angiogenesis by cytokine-loaded hyaluronic acid hydrogel implants. Biomaterials 25:2789-2798
121. Peattie RA, Rieke ER, Hewett EM, et al. (2006) Dual growth factor-induced angiogenesis in vivo using hyaluronan hydrogel implants. Biomaterials 27:1868-1875
122. Pelham RJ, Jr., Wang YL (1998) Cell locomotion and focal adhesions are regulated by the mechanical properties of the substrate. Biol Bull 194:348-349; discussion 349-350
123. Pike DB, Cai S, Pomraning KR, et al. (2006) Heparin-regulated release of growth factors in vitro and angiogenic response in vivo to implanted hyaluronan hydrogels containing VEGF and bFGF. Biomaterials 27:5242-5251
124. Pouyani T, Prestwich GD (1994) Functionalized derivatives of hyaluronic acid oligosaccharides: drug carriers and novel biomaterials. Bioconjug Chem 5:339-347
125. Pratt AB, Weber FE, Schmoekel HG, et al. (2004) Synthetic extracellular matrices for in situ tissue engineering. Biotechnol Bioeng 86:27-36
126. Raeber GP, Lutolf MP, Hubbell JA (2005) Molecularly engineered PEG hydrogels: a novel model system for proteolytically mediated cell migration. Biophys J 89:1374-1388
127. Rajangam K, Behanna HA, Hui MJ, et al. (2006) Heparin binding nanostructures to promote growth of blood vessels. Nano Lett 6:2086-2090
128. Ranieri JP, Bellamkonda R, Bekos EJ, et al. (1994) Spatial control of neuronal cell attachment and differentiation on covalently patterned laminin oligopeptide substrates. Int J Dev Neurosci 12:725-735
129. Ratner BD, Bryant SJ (2004) Biomaterials: where wehave been and where weare going. Annu Rev Biomed Eng 6:41-75
130. Reyes CD, Garcia AJ (2004) Alpha2beta1 integrin-specific collagen-mimetic surfaces supporting osteoblastic differentiation. J Biomed Mater Res A 69:591-600
131. Rezania A, Healy KE (1999) Biomimetic peptide surfaces that regulate adhesion, spreading, cytoskeletal organization, and mineralization of the matrix deposited by osteoblast-like cells. Biotechnol Prog 15:19-32
132. Richardson TP, Peters MC, Ennett AB, et al. (2001) Polymeric system for dual growth factor delivery. Nat Biotechnol 19:1029-1034
133. Rizzi SC, Ehrbar M, Halstenberg S, et al. (2006) Recombinant protein-co-PEG networks as cell-adhesive and proteolytically degradable hydrogel matrixes. Part II: biofunctional characteristics. Biomacromolecules. 7:3019-3029
134. Rizzi SC, Hubbell JA (2005) Recombinant protein-co-PEG networks as cell-adhesive and proteolytically degradable hydrogel matrixes. Part I: Development and physicochemical characteristics. Biomacromolecules 6:1226-1238
135. Rosso F, Marino G, Giordano A, et al. (2005) Smart materials as scaffolds for tissue engineering. J Cell Physiol 203:465-470
136. Ruel-Gariepy E, Leroux JC (2004) In situ-forming hydrogels-review of temperature-sensitive systems. Eur J Pharm Biopharm 58:409-426
137. Rundhaug JE. (2005) Matrix metalloproteinases and angiogenesis J Cell Mol Med 9:267-285
138. Sakiyama SE, Schense JC, Hubbell JA (1999) Incorporation of heparin-binding peptides into fibrin gels enhances neurite extension: an example of designer matrices in tissue engineering. Faseb J 13:2214-2224
139. Saha K, Pollock JF, Schaffer DV, et al. (2007) Designing synthetic materials to control stem cell phenotype. Curr Opin Chem Biol 11:381-387
140. Sakiyama-Elbert SE, Hubbell JA (2000) Controlled release of nerve growth factor from a heparin-containing fibrin-based cell ingrowth matrix. J Control Release 69:149-158
141. Sakiyama-Elbert SE, Hubbell JA (2000) Development of fibrin derivatives for controlled release of heparin-binding growth factors. J Control Release 65:389-402
142. Sakiyama-Elbert SE, Panitch A, Hubbell JA (2001) Development of growth factor fusion proteins for cell-triggered drug delivery. Faseb J 15:1300-1302
143. Schense JC, Bloch J, Aebischer P, et al. (2000) Enzymatic incorporation of bioactive peptides into fibrin matrices enhances neurite extension. Nat Biotechnol 18:415-419
144. Schense JC, Hubbell JA (1999) Cross-linking exogenous bifunctional peptides into fibrin gels with factor XIIIa. Bioconjug Chem 10:75-81
145. Schense JC, Hubbell JA (2000) Three-dimensional migration of neurites is mediated by adhesion site density and affinity. J Biol Chem 275:6813-6818
146. Schmoekel H, Schense JC, Weber FE, et al. (2004) Bone healing in the rat and dog with nonglycosylated BMP-2 demonstrating low solubility in fibrin matrices. J Orthop Res 22:376-381
147. Schmoekel HG, Weber FE, Schense JC, et al. (2005) Bone repair with a form of BMP-2 engineered for incorporation into fibrin cell ingrowth matrices. Biotechnol Bioeng 89:253-262
148. Seal BL, Panitch A (2003) Physical polymer matrices based on affinity interactions between peptides and polysaccharides. Biomacromolecules 4:1572-1582
149. Seliktar D, Zisch AH, Lutolf MP, et al. (2004) MMP-2 sensitive, VEGF-bearing bioactive hydrogels for promotion of vascular healing. J Biomed Mater Res A 68:704-716
150. Shin H, Jo S, Mikos AG (2003) Biomimetic materials for tissue engineering. Biomaterials 24:4353-4364
151. Shin H, Jo S, Mikos AG (2002) Modulation of marrow stromal osteoblast adhesion on biomimetic oligo[poly (ethylene glycol) fumarate] hydrogels modified with Arg-Gly-Asp peptides and a poly (ethyleneglycol) spacer. J Biomed Mater Res 61:169-179
152. Shin H, Zygourakis K, Farach-Carson MC, et al. (2004) Attachment, proliferation, and migration of marrow stromal osteoblasts cultured on biomimetic hydrogels modified with an osteopontin-derived peptide. Biomaterials 25:895-906
153. Shin H, Zygourakis K, Farach-Carson MC, et al. (2004) Modulation of differentiation and mineralization of marrow stromal cells cultured on biomimetic hydrogels modified with Arg-Gly-Asp containing peptides. J Biomed Mater Res A 69:535-543
154. Shu XZ, Ahmad S, Liu Y, et al. (2006) Synthesis and evaluation of injectable, in situ crosslinkable synthetic extracellular matrices for tissue engineering. J Biomed Mater Res A 79:902-912
155. Shu XZ, Ghosh K, Liu Y, et al. (2004) Attachment and spreading of fibroblasts on an RGD peptide-modified injectable hyaluronan hydrogel. J Biomed Mater Res A 68:365-375
156. Shu XZ, Liu Y, Palumbo F, et al. (2003) Disulfide-crosslinked hyaluronan-gelatin hydrogel films: a covalent mimic of the extracellular matrix for in vitro cell growth. Biomaterials 24:3825-3834
157. Silva GA, Czeisler C, Niece KL, et al. (2004) Selective differentiation of neural progenitor cells by high-epitope density nanofibers. Science 303:1352-1355
158. Smeds KA, Pfister-Serres A, Miki D, et al. (2001) Photocrosslinkable polysaccharides for in situ hydrogel formation. J Biomed Mater Res 54:115-121
159. Stabenfeldt SE, Garcia AJ, LaPlaca MC (2006) Thermoreversible laminin-functionalized hydrogel for neural tissue engineering. J Biomed Mater Res A 77:718-725
160. Stamenkovic I (2003) Extracellular matrix remodelling: the role of matrix metalloproteinases. J Pathol 200:448-464
161. Steffensen B, Hakkinen L, Larjava H (2001) Proteolytic events of wound-healing-coordinated interactions among matrix metalloproteinases (MMPs), integrins, and extracellular matrix molecules. Crit Rev Oral Biol Med 12:373-398
162. Suzuki Y, Tanihara M, Suzuki K, et al. (2000) Alginate hydrogel linked with synthetic oligopeptide derived from BMP-2 allows ectopic osteoinduction in vivo. J Biomed Mater Res 50:405-409
163. Tae G, Scatena M, Stayton PS, et al. (2006) PEG-cross-linked heparin is an affinity hydrogel for sustained release of vascular endothelial growth factor. J Biomater Sci Polym Ed 17:187-197
164. Tanihara M, Suzuki Y, Yamamoto E, et al. (2001) Sustained release ofbasic fibroblast growth factor and angiogenesis in a novel covalently crosslinked gel of heparin and alginate. J Biomed Mater Res 56:216-221
165. Wang N, Naruse K, Stamenovic D, et al. (2001) Mechanical behavior in living cells consistent with the tensegrity model. Proc Natl Acad Sci U S A 98:7765-7770
166. West JL, Hubbell JA (1999) Polymeric biomaterials with degradation sites for proteases involved in cell migration. Macromolecules 32:241-244
167. Whang K, Tsai DC, Nam EK, et al. (1998) Ectopic bone formation via rhBMP-2 delivery from porous bioabsorbable polymer scaffolds. J Biomed Mater Res 42:491-499
168. Wissink MJ, Beernink R, Pieper JS, et al. (2001) Binding and release of basic fibroblast growth factor from heparinized collagen matrices. Biomaterials 22:2291-2299
169. Xiao Y, Truskey GA (1996) Effect of receptor-ligand affinity on the strength of endothelial cell adhesion. Biophys J 71:2869-2884
170. Yeo Y, Geng W, Ito T, et al. (2006) Photocrosslinkable hydrogel for myocyte cell culture and injection. J Biomed Mater Res B Appl Biomater. Sep. 12 2006.
171. Zaari N, Rajagopalan P, Kim SK, et al. (2004) Photopolymerization in microfluidic gradient generators: Microscale control of substrate compliance to manipulate cell response. Advanced Materials 16:2133
172. Zaman MH, Trapani LM, Sieminski AL, et al. (2006) Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis. Proc Natl Acad Sci U S A 103:10889-10894
173. Zhang S, Holmes T, Lockshin C, et al. (2003) Spontaneous assembly of a self-complementary oligopeptide to form a stable macroscopic membrane. Proc Natl Acad Sci U S A 90:3334-3338
174. Zhang S (2003) Fabrication of novel biomaterials through molecular self-assembly. Nat Biotechnol 21:1171-1178
175. Zisch AH, Lutolf MP, Ehrbar M, et al. (2003) Cell-demanded release of VEGF from synthetic, biointeractive cell ingrowth matrices for vascularized tissue growth. Faseb J 17:2260-2262
176. Zisch AH, Schenk U, Schense JC, et al. (2001) Covalently conjugated VEGF-fibrin matrices for endothelialization. J Control Release 72:101-113
177. Zisch AH, Zeisberger SM, Ehrbar M, et al. (2004) Engineered fibrin matrices for functional display of cell membrane-bound growth factor-like activities: study of angiogenic signaling by ephrin-B2. Biomaterials 25:3245-3257