Heparin-regulated release of growth factors in vitro and angiogenic response in vivo to implanted hyaluronan hydrogels containing VEGF and bFGF

Biomaterials

Volumn 27, Issue 30, 2006, Pages 5242-5251

  Pike, Daniel B ^a   Cai, Shenshen ^b   Pomraning, Kyle R ^a   Firpo, Matthew A ^c   Fisher, Robert J ^d   Shu, Xiao Zheng ^b   Prestwich, Glenn D ^b   Peattie, Robert A ^a  

^a Oregon State University   (United States)

^b UNIVERSITY OF UTAH   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Angiogenesis; Controlled drug release; Cytokine; Glycosaminoglycans; Growth factors

Indexed keywords

CELLS; CHEMICAL BONDS; CROSSLINKING; INCLUSIONS; POLYETHYLENE GLYCOLS;

ANGIOGENESIS; CONTROLLED DRUG RELEASE; CYTOKINE; GLYCOSAMINOGLYCANS; GROWTH FACTORS;

HYDROGELS;

BASIC FIBROBLAST GROWTH FACTOR; GELATIN; HEPARIN; HYALURONIC ACID; MACROGOL DERIVATIVE; THIOL GROUP; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; BLOOD VESSEL; CHEMICAL MODIFICATION; CONCENTRATION (PARAMETERS); CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CROSS LINKING; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; EVALUATION; EXTERNAL EAR; HYDROGEL; HYPOTHESIS; IMPLANT; IN VITRO STUDY; IN VIVO STUDY; MEASUREMENT; MICROVASCULATURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; REGULATORY MECHANISM; SAMPLE;

ANGIOGENESIS INDUCING AGENTS; ANIMALS; CAPILLARIES; DRUG IMPLANTS; EAR; FIBROBLAST GROWTH FACTOR 2; HEPARIN; HUMANS; HYALURONIC ACID; HYDROGELS; MICE; MICE, INBRED BALB C; NEOVASCULARIZATION, PHYSIOLOGIC; POLYETHYLENE GLYCOLS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33746036846     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2006.05.018     Document Type: Article

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