Discovery of 5-substituted pyrrolo[2,3- d ]pyrimidine antifolates as dual-acting inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis: Implications of inhibiting 5-aminoimidazole-4- carboxamide ribonucleotide formyltransferase to AMPK activation and antitumor activity

Journal of Medicinal Chemistry

Volumn 56, Issue 24, 2013, Pages 10016-10032

  Mitchell Ryan, Shermaine ^a   Wang, Yiqiang ^b,d   Raghavan, Sudhir ^b   Ravindra, Manasa Punaha ^b   Hales, Eric ^a,c   Orr, Steven ^a,c   Cherian, Christina ^a,c   Hou, Zhanjun ^a,c   Matherly, Larry H ^a,c   Gangjee, Aleem ^b  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUQUESNE UNIVERSITY   (United States)

^c KARMANOS CANCER INSTITUTE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 [(2 AMINO 4 OXO 4,7 DIHYDRO 3 H PYRROLO[2,3 D]PYRIMIDIN 5 YL)BUTYL]BENZMIDO]PENTANEIOIC ACID; 2 [4 [(2 AMINO 4 OXO 4,7 DIHYDRO 3 H PYRROLO[2,3 D]PYRIMIDIN 5 YL)ETHYL]BENZMIDO]PENTANEIOIC ACID; 2 [4 [(2 AMINO 4 OXO 4,7 DIHYDRO 3 H PYRROLO[2,3 D]PYRIMIDIN 5 YL)HEXYL]BENZMIDO]PENTANEIOIC ACID; 2 [4 [(2 AMINO 4 OXO 4,7 DIHYDRO 3 H PYRROLO[2,3 D]PYRIMIDIN 5 YL)METHYL]BENZMIDO]PENTANEIOIC ACID; 2 [4 [(2 AMINO 4 OXO 4,7 DIHYDRO 3 H PYRROLO[2,3 D]PYRIMIDIN 5 YL)PENTYL]BENZMIDO]PENTANEIOIC ACID; 2 [4 [(2 AMINO 4 OXO 4,7 DIHYDRO 3 H PYRROLO[2,3 D]PYRIMIDIN 5 YL)PROPYL]BENZMIDO]PENTANEIOIC ACID; ANTINEOPLASTIC AGENT; LOMETREXOL; METHOTREXATE; PEMETREXED; PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE FORMYLTRANSFERASE; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; PRALATREXATE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BIOSYNTHESIS; CELL CYCLE S PHASE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; SUBSTITUTION REACTION; TUMOR CELL;

EID: 84891292577     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401328u     Document Type: Article

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