Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity

Journal of Medicinal Chemistry

Volumn 51, Issue 16, 2008, Pages 5052-5063

  Deng, Yijun ^a   Wang, Yiqiang ^b   Cherian, Christina ^c   Hou, Zhanjun ^c   Buck, Steven A ^d   Matherly, Larry H ^a,c   Gangjee, Aleem ^b  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUQUESNE UNIVERSITY   (United States)

^c KARMANOS CANCER INSTITUTE   (United States)

^d CHILDREN'S HOSPITAL OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [5 [[(1,2 DIHYDRO 3 METHYL 1 OXOBENZO[F]QUINAZOLIN 9 YL)METHYL]AMINO] 1 OXO 2 ISOINDOLINYL]GLUTARIC ACID; 2,4 DIAMINO 4 OOPYRIMIDINE; ALPHA BROMOMETHYLKETONE DERIVATIVE; ANTINEOPLASTIC AGENT; BENZOIC ACID DERIVATIVE; BROMINE DERIVATIVE; FOLATE RECEPTOR; GLUTAMIC ACID DIETHYL ESTER; KETONE DERIVATIVE; LOMETREXOL; METHOTREXATE; METHYL 4 FORMYLBENZOATE; N [4 [4 (2 AMINO 4 OXO 4,7 DIHYDRO 3H PYRROLO[2,3 D]PYRIMIDIN 6 YL)BUTYL]BENZOYL]GLUTAMIC ACID; N [4 [5 (2 AMINO 4 OXO 4,7 DIHYDRO 3H PYRROLO[2,3 D]PYRIMIDIN 6 YL)PENTYL]BENZOYL]GLUTAMIC ACID; N [4 [6 (2 AMINO 4 OXO 4,7 DIHYDRO 3H PYRROLO[2,3 D]PYRIMIDIN 6 YL)HEXYL]BENZOYL]GLUTAMIC ACID; OSI 7904; PEMETREXED; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE INHIBITOR; PYRIMIDINE DERIVATIVE; RALTITREXED; TRIMETREXATE; TRIPHENYLPHOSPHONIUM BROMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CULTURE; CHO CELL; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; POLYMERIZATION; PROTEIN EXPRESSION; REDUCTION; SAPONIFICATION; WITTIG REACTION;

ANIMALS; ANTINEOPLASTIC AGENTS; CARRIER PROTEINS; CELL LINE; CELL PROLIFERATION; CHO CELLS; CRICETINAE; CRICETULUS; ENZYME INHIBITORS; FOLIC ACID ANTAGONISTS; HUMANS; KB CELLS; MEMBRANE TRANSPORT PROTEINS; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; PYRIMIDINES; PYRROLES; RECEPTORS, CELL SURFACE;

EID: 50249144557     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8003366     Document Type: Article

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