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Volumn 84, Issue 3, 2001, Pages 308-312
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Phase I dose-escalation and pharmacokinetic study of a novel folate analogue AG2034
a
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Author keywords
AG2034; Folate analogue; GARFT inhibitor
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Indexed keywords
FOLIC ACID DERIVATIVE;
N [[5 [2 (2 AMINO 4,6,7,8 TETRAHYDRO 4 OXO 1H PYRIMIDO[5,4 B][1,4]THIAZIN 6 YL)ETHYL] 2 THIENYL]CARBONYL]GLUTAMIC ACID;
PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE;
PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE INHIBITOR;
ADULT;
AGED;
ANEMIA;
ARTICLE;
CARCINOID;
CHEMOTHERAPY INDUCED EMESIS;
CLINICAL ARTICLE;
CLINICAL TRIAL;
COLORECTAL CANCER;
CONTROLLED CLINICAL TRIAL;
CONTROLLED STUDY;
DIARRHEA;
DOSE TIME EFFECT RELATION;
DRUG BLOOD LEVEL;
DRUG EFFICACY;
DRUG HALF LIFE;
DRUG METABOLISM;
DRUG SAFETY;
FEMALE;
GALLBLADDER CANCER;
HUMAN;
LIVER CELL CARCINOMA;
MALE;
MELANOMA;
MESOTHELIOMA;
MUCOSA INFLAMMATION;
NAUSEA;
NEUTROPENIA;
OVARY CANCER;
PANCREAS CANCER;
PHASE 1 CLINICAL TRIAL;
PRIORITY JOURNAL;
SARCOMA;
THROMBOCYTOPENIA;
UTERINE CERVIX CANCER;
VOMITING;
ADULT;
AGED;
ANTINEOPLASTIC AGENTS;
AREA UNDER CURVE;
DIARRHEA;
DOSE-RESPONSE RELATIONSHIP, DRUG;
FEMALE;
GLUTAMATES;
HUMANS;
MALE;
MIDDLE AGED;
MOUTH MUCOSA;
NAUSEA;
NEOPLASMS;
NEUTROPENIA;
PYRIMIDINES;
STOMATITIS;
THROMBOCYTOPENIA;
TREATMENT OUTCOME;
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EID: 0035122009
PISSN: 00070920
EISSN: None
Source Type: Journal
DOI: 10.1054/bjoc.2000.1601 Document Type: Article |
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Times cited : (25)
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References (9)
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