A practical synthesis of multitargeted antifolate LY231514

Organic Process Research and Development

Volumn 3, Issue 3, 1999, Pages 184-188

  Barnett, Charles J ^a   Wilson, Thomas M ^a   Kobierski, Michael E ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0033442326     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op9802172     Document Type: Article

References (4)

1. For recent overviews of antifolate research related to antitumor therapy, see: Berman E. M.; Werbel, L. M. J. Med. Chem. 1991, 34, 479 and references therein. Taylor, E. C. J. Heterocycl. Chem. 1990, 27, 1-12 and references therein.
2. For recent overviews of antifolate research related to antitumor therapy, see: Berman E. M.; Werbel, L. M. J. Med. Chem. 1991, 34, 479 and references therein. Taylor, E. C. J. Heterocycl. Chem. 1990, 27, 1-12 and references therein.
3. Taylor, E. C.; Kuhnt, D.; Shih, C.; Rinzel S. M.; Grindey, G. B.; Barredo, J.; Jannatipour, M.; Moran, R. G. J. Med. Chem. 1992, 35, 4450-4454.
4. Shih, C.; Chen, V. J.; Gossett, L. S.; Gates, S. B.; MacKellar, W. C.; Habeck, L. L.; Shackelford, K. A.; Mendelsohn, L. G.; Soose, D. J.; Patel, V. F.; Andis, S. L.; Bewley, J. R.; Rayl, E. A.; Moroson, B. A.; Beardsley, G. P.; Kohler, W.; Ratnam, M.; Schultz, R. M. Cancer Res. 1997, 57, 1116-1123.