Structural investigation of cycloheptathiophene-3-carboxamide derivatives targeting influenza virus polymerase assembly

Journal of Medicinal Chemistry

Volumn 56, Issue 24, 2013, Pages 10118-10131

  Massari, Serena ^a   Nannetti, Giulio ^b   Goracci, Laura ^a   Sancineto, Luca ^a   Muratore, Giulia ^b   Sabatini, Stefano ^a   Manfroni, Giuseppe ^a   Mercorelli, Beatrice ^b   Cecchetti, Violetta ^a   Facchini, Marzia ^c   Palù, Giorgio ^b   Cruciani, Gabriele ^a   Loregian, Arianna ^b   Tabarrini, Oriana ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 CHLOROBENZAMIDO) N (PYRIDIN 2 YL) 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOXAMIDE; 2 (BENZOYLAMINO) N PYRIDIN 2 YL 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOXAMIDE; 2 [(2 CHLORO 4 FLUOROBENZOYL)AMINO] N PYRIDIN 2 YL 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOXAMIDE; 2 [(2 CHLOROBENZOYL)AMINO] N (2 PYRIDINYL) 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOXAMIDE; 2 [(2 FLUOROBENZOYL)AMINO] 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOXAMIDE; 2 [(2 FLUOROBENZOYL)AMINO] N (2 PYRIDINYL) 4,5,6,7 TETRAHYDRO 1 BENZOTHIOPHENE 3 CARBOXAMIDE; 2 [(2 FLUOROBENZOYL)AMINO] N (2 PYRIDINYL) 5,6 DIHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOXAMIDE; 2 [(2 FLUOROBENZOYL)AMINO] N (2 PYRIDINYL) 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOXAMIDE; 2 [(2,4 DICHLOROBENZOYL)AMINO] N PYRIDIN 2 YL 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOXAMIDE; 2 [(3 FLUOROBENZOYL)AMINO] N (2 PYRIDINYL) 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOXAMIDE; 2 [(3 PHENYLPROPANOYL)AMINO] N PYRIDIN 2 YL 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOXAMIDE; 2 [(4 FLUOROBENZOYL)AMINO] N (2 PYRIDINYL) 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOXAMIDE; 2 [(CYCLOHEXYLACETYL)AMINO] N PYRIDIN 2 YL 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOXAMIDE; 2 [(CYCLOHEXYLCARBONYL)AMINO] N PYRIDIN 2 YL 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOXAMIDE; 2 [(PHENYLACETYL)AMINO] N PYRIDIN 2 YL 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOXAMIDE; 2 [[(4 CHLOROPHENYL)ACETYL]AMINO] N PYRIDIN 2 YL 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOXAMIDE; 2 [[(4 FLUOROPHENYL)ACETYL]AMINO] N PYRIDIN 2 YL 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOXAMIDE; 2 [[3 (4 CHLOROPHENYL)PROPANOYL]AMINO] N PYRIDIN 2 YL 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOXAMIDE; 2 [[3 (4 FLUOROPHENYL)PROPANOYL]AMINO] N PYRIDIN 2 YL 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOXAMIDE; 2 AMINO N (2 PYRIDINYL) 4,5,6,7 TETRAHYDRO 1 BENZOTHIOPHENE 3 CARBOXAMIDE; 2 AMINO N (2 PYRIDINYL) 5,6 DIHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOXAMIDE; 2 AMINO N (2 PYRIDINYL) 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOXAMIDE; ANTIVIRUS AGENT; CYCLOHEPTATHIOPHENE 3 CARBOXAMIDE DERIVATIVE; ETHYL 2 [(2 CHLOROBENZOYL)AMINO] 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOXAMIDE; ETHYL 2 [(4 FLUOROBENZOYL)AMINO] 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOXAMIDE; ETHYL 2 [(4 METHOXYBENZOYL)AMINO] 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOXAMIDE; N PYRIDIN 2 YL 2 [(QUINOLIN 6 YLACETYL)AMINO] 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOXAMIDE; RNA POLYMERASE; THIOPHENE 3 CARBOXAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INFLUENZA VIRUS; INFLUENZA VIRUS A; INFLUENZA VIRUS B; NONHUMAN; PROTEIN PROTEIN INTERACTION; X RAY CRYSTALLOGRAPHY;

EID: 84891280434     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401560v     Document Type: Article

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