Nanomolar affinity small molecule correctors of defective ΔF508-CFTR chloride channel gating

Journal of Biological Chemistry

Volumn 278, Issue 37, 2003, Pages 35079-35085

  Yang, Hong ^a   Shelat, Anang A ^b   Guy, R Kiplin ^b   Gopinath, Vadiraj S ^a   Ma, Tonghui ^a   Du, Kai ^d   Lukacs, Gergely L ^d   Taddei, Alessandro ^c   Folli, Chiara ^c   Pedemonte, Nicoletta ^c   Galietta, Luis J V ^c   Verkman, A S ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c G GASLINI INSTITUTE   (Italy)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; CELLS; MUTAGENESIS; PHYSIOLOGICAL MODELS;

CHANNEL GATING;

BIOCHEMISTRY;

ANTHRAQUINONE DERIVATIVE; BENZOFURAN DERIVATIVE; CHLORIDE CHANNEL; CYCLIC AMP; DIHYDROPYRIDINE DERIVATIVE; HALIDE; PYRAMIDETRIONE; TETRAHYDROBENZOTHIOPHENE; THIOPHENE DERIVATIVE; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BAYES THEOREM; BINDING AFFINITY; BRONCHUS MUCOSA; CELL CULTURE; CELL MEMBRANE; CHANNEL GATING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYSTIC FIBROSIS; DRUG MECHANISM; DRUG STRUCTURE; ENDOPLASMIC RETICULUM; EPITHELIUM CELL; GENE DELETION; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN STRUCTURE; RAT; VOLTAGE CLAMP;

ANIMALIA; BRONCHUS;

EID: 0042317111     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M303098200     Document Type: Article

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