Molecular basis of the interaction for an essential subunit PA-PB1 in influenza virus RNA polymerase: Insights from molecular dynamics simulation and free energy calculation

Molecular Pharmaceutics

Volumn 7, Issue 1, 2010, Pages 75-85

  Liu, Huanxiang ^a,b   Yao, Xiaojun ^a,b  

^a LANZHOU UNIVERSITY   (China)

^b LANZHOU UNIVERSITY   (China)

Author keywords

Free energy calculation; Influenza virus RNA polymerase; Molecular dynamics simulation; Protein protein interaction; Structure based drug design

Indexed keywords

RNA POLYMERASE;

ARTICLE; BINDING SITE; DRUG TARGETING; INFLUENZA VIRUS; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN RNA BINDING; RNA REPLICATION; RNA TRANSCRIPTION; SIMULATION;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CONSERVED SEQUENCE; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS; ORTHOMYXOVIRIDAE; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN SUBUNITS; RNA REPLICASE; SEQUENCE HOMOLOGY, AMINO ACID; THERMODYNAMICS; USER-COMPUTER INTERFACE;

EID: 76249105085     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp900131p     Document Type: Article

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