Disruption of the viral polymerase complex assembly as a novel approach to attenuate influenza A virus

Journal of Biological Chemistry

Volumn 286, Issue 10, 2011, Pages 8414-8424

  Mänz, Benjamin ^a   Götz, Veronika ^a   Wunderlich, Kerstin ^a   Eisel, Jessica ^a   Kirchmair, Johannes ^b   Stech, Jürgen ^c   Stech, Olga ^c   Chase, Geoffrey ^a   Frank, Ronald ^d   Schwemmle, Martin ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF INNSBRUCK   (Austria)

^c FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

^d HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SUBSTITUTION; BINDING AFFINITIES; IN-VIVO; INFLUENZA A VIRUS; INTERACTION DOMAIN; KNOCK OUTS; NOVEL STRATEGIES; POLYMERASE ACTIVITIES; POLYMERASE COMPLEX; PROOF OF CONCEPT; PROOF OF PRINCIPLES; PROTEIN-BINDING; PROTEIN-PROTEIN INTERACTIONS; VIRAL REPLICATION;

AMINO ACIDS; BINDING ENERGY; CELL CULTURE; VIRUSES;

POLYMERS;

ALPHA INTERFERON RECEPTOR; BETA INTERFERON RECEPTOR; POLYMERASE SUBUNIT PA; POLYMERASE SUBUNIT PB1; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONTROLLED STUDY; GROWTH INHIBITION; INFLUENZA VIRUS A; INFLUENZA VIRUS A H5N1; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; VIRUS ATTENUATION; VIRUS RECOMBINANT; VIRUS REPLICATION; VIRUS STRAIN;

ANIMALS; DOGS; HUMANS; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA A VIRUS, H7N7 SUBTYPE; INFLUENZA VACCINES; INFLUENZA, HUMAN; INTERFERON-ALPHA; INTERFERON-BETA; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MUTATION; RNA REPLICASE; VACCINES, ATTENUATED; VIRAL PROTEINS; VIRUS REPLICATION;

INFLUENZA A VIRUS; MUS;

EID: 79953140161     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.205534     Document Type: Article

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