Elucidation of estrogen receptor function in bone with the use of mouse models

Trends in Endocrinology and Metabolism

Volumn 13, Issue 5, 2002, Pages 195-200

  Windahl, Sara H ^a   Andersson, Göran ^b   Gustafsson, Jan Åke ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGEN RECEPTOR;

ANIMAL MODEL; BONE CELL; BONE DEVELOPMENT; ESTROGEN ACTIVITY; FEMALE; GROWTH; HORMONAL REGULATION; HUMAN; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; ANIMAL; BONE; BONE REMODELING; METABOLISM; MOUSE MUTANT; PHYSIOLOGY;

ANIMALS; AROMATASE; BONE AND BONES; BONE REMODELING; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; HUMANS; MALE; MICE; MICE, KNOCKOUT; RECEPTORS, ESTROGEN;

EID: 0036632231     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-2760(02)00594-5     Document Type: Review

References (31)

1. Rodan, G.A. et al. (2000) Therapeutic approaches to bone diseases. Science 289, 1508-1514
2. Törring, O. (2001) Osteoporosis among the elderly is a 'silent epidemic'. Insufficient prophylaxis and underdiagnosing are big problems. Lakartidningen 98, 3220-3224
3. Nilsson, S. et al. (2001) Mechanisms of estrogen action. Physiol. Rev. 81, 1535-1565
4. Bland, R. (2000) Steroid hormone receptor expression and action in bone. Clin. Sci. 98, 217-240
5. Smith, E.P. et al. (1994) Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N. Engl. J. Med. 331, 1056-1061
6. Morishima, A. et al. (1995)Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J. Clin. Endocrinol. Metab. 80, 3689-3698
7. Carani, C. et al. (1997) Effect of testosterone and estradiol in a man with aromatase deficiency. N. Engl. J. Med. 337, 91-95
8. Couse, J.F. et al. (1995) Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene. Mol. Endocrinol. 9, 1441-1454
9. Flouriot, G. et al. (2000) Identification of a new isoform of the human estrogen receptor-α (hER-α) that is encoded by distinct transcripts and that is able to repress hER-α activation function 1. EMBO J. 19, 4688-4700
10. Denger, S. et al. (2001) ERα gene expression in human primary osteoblasts: evidence for the expression of two receptor proteins. Mol. Endocrinol. 15, 2064-2077
11. Krege, J.H. et al. (1998) Generation and reproductive phenotypes of mice lacking estrogen receptor beta. Proc. Natl. Acad. Sci. U. S. A. 95, 15677-15682
12. Dupont, S. et al. (2000) Effect of single and compound knockouts of estrogen receptors α (ERα) and β (ERβ) on mouse reproductive phenotypes. Development 127, 4277-4291
13. Ke, H.Z. et al. (2001) The role of estrogen receptor-β (ERβ) in the early age-related bone gain and later age-related bone loss. J. Bone Miner. Res. 1095, S160
14. Fisher, C.R. et al. (1998) Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene. Proc. Natl. Acad. Sci. U. S. A. 95, 6965-6970
15. Lindberg, M.K. et al. (2001) Estrogen receptor specificity in the regulation of the skeleton in female mice. J. Endocrinol. 171, 229-236
16. Sims, N.A. et al. (2002) Deletion of estrogen receptors reveals a regulatory role for estrogen receptors-β in bone remodeling in females but not in males. Bone 30, 18-25
17. -/- mice are partially protected against age-related trabecular bone loss. J. Bone Miner. Res. 16, 1388-1398
18. Oz, O.K. et al. (2000) Bone has a sexually dimorphic response to aromatase deficiency. J. Bone Miner. Res. 15, 507-514
19. Vidal, O. et al. (1999) Disproportional body growth in female estrogen receptor-α-inactivated mice. Biochem. Biophys. Res. Commun. 265, 569-571
20. Vidal, O. et al. (2000) Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice. Proc. Natl. Acad. Sci. U. S. A. 97, 5474-5479
21. Windahl, S.H. et al. (1999) Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERβ(-/-) mice. J. Clin. Invest. 104, 895-901
22. Jones, M.E. et al. (2000) Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity. Proc. Natl. Acad. Sci. U. S. A. 97, 12735-12740
23. Heine, P.A. et al. (2000) Increased adipose tissue in male and female estrogen receptor-α-knockout mice. Proc. Natl. Acad. Sci. U. S. A. 97, 12729-12734
24. Schmidt, A. et al. (1999) Femoral bone density and length in male and female estrogen receptor-α (ERa)-knockout mice. J. Bone Miner. Res. SU098, S456
25. Gentile, M.A. et al. (2001) Bone response to estrogen replacement in βERKO (estrogen receptor-β) null mice. J. Bone Miner. Res. SA331, S282
26. Lindberg, M. et al. (2001) Estrogen exerts both estrogen receptor α/β dependent and independent effects. J. Bone Miner. Res. F501, S230
27. Sims, N.A. et al. (2001) Estrogen receptor α is the major receptor regulating bone response to estradiol in gonadectomized female mice and testosterone plays a role in intact male and female ERα-knockout mice. J. Bone Miner. Res. SU515, S431
28. Windahl, S.H. et al. (2001) In the absence of estrogen receptor α, estrogen promotes bone resorption via estrogen receptor β in female mice. J. Bone Miner. Res. M107, S551
29. Gentile, M.A. et al. (2001) Bone response to estrogen replacement in ovx double estrogen receptor-(α and β)-knockout mice. J. Bone Miner. Res. 1040, S146
30. Vandenput, L. et al. (2001) Testosterone prevents orchidectomy-induced bone loss in estrogen receptor-α-knockout mice. Biochem. Biophys. Res. Commun. 285, 70-76
31. Lindberg, M.K. et al. (2002) Two different pathways for the maintenance oftrabecular bone in adult male mice. J. Bone Miner. Res. 17, 555-562