Importance of H-abstraction in the final step of nitrosoalkane formation in the mechanism-based inactivation of cytochrome P450 by amine-containing drugs

International Journal of Molecular Sciences

Volumn 14, Issue 12, 2013, Pages 24692-24705

  Hirao, Hajime ^a   Thellamurege, Nandun M ^a   Chuanprasit, Pratanphorn ^a   Xu, Kai ^a  

^a Nanyang Technological University   (Singapore)

Author keywords

Cytochrome P450; Density functional theory; Energy decomposition analysis; Mechanism based inactivation; Metabolic intermediate complex; Reaction mechanism

Indexed keywords

CYTOCHROME P450; METHOXYAMINE; NITROSO DERIVATIVE; NITROSOALKANE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHEMICAL PHENOMENA; HYDROGEN ABSTRACTION; HYDROGEN BOND; METABOLISM;

ALKANES; CALCIUM CHANNEL BLOCKERS; CYTOCHROME P-450 ENZYME SYSTEM; HYDROGEN; HYDROXYLAMINES; MODELS, MOLECULAR; THERMODYNAMICS;

EID: 84890945484     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms141224692     Document Type: Article

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