Proprotein Convertase Subtilisin/Kexin Type 7 (PCSK7) Is Essential for the Zebrafish Development and Bioavailability of Transforming Growth Factor β1a (TGFβ1a)

Journal of Biological Chemistry

Volumn 288, Issue 51, 2013, Pages 36610-36623

  Turpeinen, Hannu ^a   Oksanen, Anna ^a   Kivinen, Virpi ^a   Kukkurainen, Sampo ^b   Uusimäki, Annemari ^a   Rämet, Mika ^a,c,d,e   Parikka, Mataleena ^a   Hytönen, Vesa P ^b,f   Nykter, Matti ^a   Pesu, Marko ^a,f  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b Protein Dynamics ^*  (United States)

^c TAMPERE UNIVERSITY HOSPITAL   (Finland)

^d OULU UNIVERSITY HOSPITAL   (Finland)

^e UNIVERSITY OF OULU   (Finland)

^f PIRKANMAA HOSPITAL DISTRICT   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN DISEASE; IN-VIVO; PROTEOLYTIC CLEAVAGE; SUBTILISIN; TRANSFORMING GROWTH FACTORS; ZEBRAFISH; ZEBRAFISH DEVELOPMENT;

GENE EXPRESSION;

BIOCHEMISTRY;

MESSENGER RNA; PCSK7 PROTEIN; SERINE PROTEINASE; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA1A; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; EMBRYO; EMBRYO DEATH; EMBRYO DEVELOPMENT; EMBRYONIC STRUCTURES; ENZYME INHIBITION; EYE; GENE; GENE EXPRESSION; GENETIC ASSOCIATION; LARVA; MAMMAL; NONHUMAN; OTIC VESICLE; PCSK GENE; PCSK7 GENE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; TRANSFORMING GROWTH FACTOR BETA1A GENE; ZEBRA FISH;

DEVELOPMENT; GENE EXPRESSION; HOMOLOGY MODELING; OTOLITH; PC7; PCSK7; PROPROTEIN CONVERTASE; PROTEASE; TRANSFORMING GROWTH FACTOR Β (TGFΒ); ZEBRAFISH;

AMINO ACID SEQUENCE; ANIMALS; BRAIN; CATALYTIC DOMAIN; CONSERVED SEQUENCE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; LARVA; MOLECULAR SEQUENCE DATA; ORGAN SPECIFICITY; PROTEOLYSIS; RNA, MESSENGER; SEQUENCE HOMOLOGY; SUBTILISINS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84890943703     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.453183     Document Type: Article

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