메뉴 건너뛰기




Volumn 32, Issue 17, 2012, Pages 3382-3391

Loss of endothelial furin leads to cardiac malformation and early postnatal death

Author keywords

[No Author keywords available]

Indexed keywords

ADRENOMEDULLIN; BONE MORPHOGENETIC PROTEIN 4; ENDOTHELIN 1; FURIN; PROTEIN PRECURSOR; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84866280245     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.06331-11     Document Type: Article
Times cited : (38)

References (59)
  • 2
    • 0037205739 scopus 로고    scopus 로고
    • Processing of proendothelin-1 by members of the subtilisin-like pro-protein convertase family
    • Blais V, et al. 2002. Processing of proendothelin-1 by members of the subtilisin-like pro-protein convertase family. FEBS Lett. 524:43-48.
    • (2002) FEBS Lett , vol.524 , pp. 43-48
    • Blais, V.1
  • 3
    • 0035895276 scopus 로고    scopus 로고
    • Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional adrenomedullin gene
    • Caron KM, Smithies O. 2001. Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional adrenomedullin gene. Proc. Natl. Acad. Sci. U. S. A. 98:615-619.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 615-619
    • Caron, K.M.1    Smithies, O.2
  • 4
    • 0033545215 scopus 로고    scopus 로고
    • Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases
    • Constam DB, Robertson EJ. 1999. Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases. J. Cell Biol. 144:139-149.
    • (1999) J. Cell Biol. , vol.144 , pp. 139-149
    • Constam, D.B.1    Robertson, E.J.2
  • 5
    • 0034194471 scopus 로고    scopus 로고
    • SPC4/PACE4 regulates a TGF-beta signaling network during axis formation
    • Constam DB, Robertson EJ. 2000. SPC4/PACE4 regulates a TGF-beta signaling network during axis formation. Genes Dev. 14:1146-1155.
    • (2000) Genes Dev , vol.14 , pp. 1146-1155
    • Constam, D.B.1    Robertson, E.J.2
  • 6
    • 0035498979 scopus 로고    scopus 로고
    • The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor
    • Cui Y, et al. 2001. The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor. Genes Dev. 15:2797-2802.
    • (2001) Genes Dev , vol.15 , pp. 2797-2802
    • Cui, Y.1
  • 7
    • 0032541405 scopus 로고    scopus 로고
    • BMP- 4 is proteolytically activated by furin and/or PC6 during vertebrate embryonic development
    • Cui Y, Jean F, Thomas G, Christian JL. 1998. BMP-4 is proteolytically activated by furin and/or PC6 during vertebrate embryonic development. EMBO J. 17:4735-4743.
    • (1998) EMBO J , vol.17 , pp. 4735-4743
    • Cui, Y.1    Jean, F.2    Thomas, G.3    Christian, J.L.4
  • 8
    • 6344272882 scopus 로고    scopus 로고
    • Cleavages within the prodomain direct intracellular trafficking and degradation of mature bone morphogenetic protein-4
    • Degnin C, Jean F, Thomas G, Christian JL. 2004. Cleavages within the prodomain direct intracellular trafficking and degradation of mature bone morphogenetic protein-4. Mol. Biol. Cell 15:5012-5020.
    • (2004) Mol. Biol. Cell , vol.15 , pp. 5012-5020
    • Degnin, C.1    Jean, F.2    Thomas, G.3    Christian, J.L.4
  • 9
    • 0028916603 scopus 로고
    • Processing of proendothelin-1 by human furin convertase
    • Denault JB, et al. 1995. Processing of proendothelin-1 by human furin convertase. FEBS Lett. 362:276-280.
    • (1995) FEBS Lett , vol.362 , pp. 276-280
    • Denault, J.B.1
  • 10
    • 0035141634 scopus 로고    scopus 로고
    • Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme
    • Dubois CM, et al. 2001. Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme. Am. J. Pathol. 158:305-316.
    • (2001) Am. J. Pathol. , vol.158 , pp. 305-316
    • Dubois, C.M.1
  • 11
    • 0037192792 scopus 로고    scopus 로고
    • Biosynthesis and cellular trafficking of the convertase SKI-1/S1P, ectodomain shedding requires SKI-1 activity
    • Elagoz A, Benjannet S, Mammarbassi A, Wickham L, Seidah NG. 2002. Biosynthesis and cellular trafficking of the convertase SKI-1/S1P: ectodomain shedding requires SKI-1 activity. J. Biol. Chem. 277:11265-11275.
    • (2002) J. Biol. Chem. , vol.277 , pp. 11265-11275
    • Elagoz, A.1    Benjannet, S.2    Mammarbassi, A.3    Wickham, L.4    Seidah, N.G.5
  • 12
    • 44449128120 scopus 로고    scopus 로고
    • vivo functions of the proprotein convertase PC5/6 during mouse development Gdf11 is a likely substrate
    • Essalmani R, et al. 2008. In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate. Proc. Natl. Acad. Sci. U. S. A. 105:5750-5755.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 5750-5755
    • Essalmani, R.1
  • 13
    • 0037040872 scopus 로고    scopus 로고
    • Inhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomains
    • Fugere M, et al. 2002. Inhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomains. J. Biol. Chem. 277:7648-7656.
    • (2002) J. Biol. , vol.277 , pp. 7648-7656
    • Fugere, M.1
  • 14
    • 33745094372 scopus 로고    scopus 로고
    • Mutation of an upstream cleavage site in the BMP4 prodomain leads to tissue-specific loss of activity
    • Goldman DC, et al 2006. Mutation of an upstream cleavage site in the BMP4 prodomain leads to tissue-specific loss of activity. Development 133:1933-1942.
    • (2006) Development , vol.133 , pp. 1933-1942
    • Goldman, D.C.1
  • 15
    • 0028855419 scopus 로고
    • Targeted disruption of the murine VCAM1 gene, essential role of VCAM-1 in chorioallantoic fusion and placentation
    • Gurtner GC, et al. 1995. Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation. Genes Dev. 9:1-14.
    • (1995) Genes Dev , vol.9 , pp. 1-14
    • Gurtner, G.C.1
  • 16
    • 84859905736 scopus 로고    scopus 로고
    • Presentation of congestive cardiac failure in children with ventricular septal defect
    • Hussain M, Hussain S, Krishin J, Abbasi S. 2010. Presentation of congestive cardiac failure in children with ventricular septal defect. J. Ayub. Med. Coll. Abbottabad. 22:135-138.
    • (2010) J. Ayub. Med. Coll. Abbottabad. , vol.22 , pp. 135-138
    • Hussain, M.1    Hussain, S.2    Krishin, J.3    Abbasi, S.4
  • 17
    • 0024427985 scopus 로고
    • The human preproendothelin-1 gene Complete nucleotide sequence and regulation of expression
    • Inoue A, et al. 1989. The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression. J. Biol. Chem. 264: 14954-14959.
    • (1989) J. Biol. Chem. , vol.264 , pp. 14954-14959
    • Inoue, A.1
  • 18
    • 0023897658 scopus 로고
    • Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin, identity of human and porcine endothelin
    • Itoh Y, et al. 1988. Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin. FEBS Lett. 231:440-444.
    • (1988) FEBS Lett , vol.231 , pp. 440-444
    • Itoh, Y.1
  • 19
    • 0141445966 scopus 로고    scopus 로고
    • An essential role of Bmp4 in the atrioventricular septation of the mouse heart
    • Jiao K, et al. 2003. An essential role of Bmp4 in the atrioventricular septation of the mouse heart. Genes Dev. 17:2362-2367.
    • (2003) Genes Dev , vol.17 , pp. 2362-2367
    • Jiao, K.1
  • 20
    • 27644578453 scopus 로고    scopus 로고
    • Proprotein convertases are responsible for proteolysis and inactivation of endothelial lipase
    • Jin W, et al. 2005. Proprotein convertases are responsible for proteolysis and inactivation of endothelial lipase. J. Biol. Chem. 280:36551-36559.
    • (2005) J. Biol. Chem. , vol.280 , pp. 36551-36559
    • Jin, W.1
  • 21
    • 0141987870 scopus 로고    scopus 로고
    • Expression and function of bone morphogenetic proteins in the development of the embryonic endocardial cushions
    • Keyes WM, Logan C, Parker E, Sanders EJ. 2003. Expression and function of bone morphogenetic proteins in the development of the embryonic endocardial cushions. Anat. Embryol. (Berl.) 207:135-147.
    • (2003) Anat. Embryol. (Berl.) , vol.207 , pp. 135-147
    • Keyes, W.M.1    Logan, C.2    Parker, E.3    Sanders, E.J.4
  • 22
    • 0035903230 scopus 로고    scopus 로고
    • Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells, importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions
    • Khatib AM, et al. 2001. Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions. J. Biol. Chem. 276:30686-30693.
    • (2001) J. Biol. Chem. , vol.276 , pp. 30686-30693
    • Khatib, A.M.1
  • 23
    • 0031637667 scopus 로고    scopus 로고
    • The processing pathway of endothelin-1 production
    • Kido T, Sawamura T, Masaki T. 1998. The processing pathway of endothelin-1 production. J. Cardiovasc. Pharmacol. 31(Suppl 1):S13-S15.
    • (1998) J. Cardiovasc. Pharmacol. , vol.31 , Issue.SUPPL. 1
    • Kido, T.1    Sawamura, T.2    Masaki, T.3
  • 24
    • 77953762427 scopus 로고    scopus 로고
    • Low blood pressure in endothelial cell-specific endothelin 1 knockout mice
    • Kisanuki YY, et al. 2010. Low blood pressure in endothelial cell-specific endothelin 1 knockout mice. Hypertension 56:121-128.
    • (2010) Hypertension , vol.56 , pp. 121-128
    • Kisanuki, Y.Y.1
  • 25
    • 0035865048 scopus 로고    scopus 로고
    • Tie2- Cre transgenic mice, a new model for endothelial cell-lineage analysis in vivo
    • Kisanuki YY, et al. 2001. Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo. Dev. Biol. 230:230-242.
    • (2001) Dev. Biol. , vol.230 , pp. 230-242
    • Kisanuki, Y.Y.1
  • 26
    • 0032539746 scopus 로고    scopus 로고
    • The intermediate form of glycine-extended adrenomedullin is the major circulating molecular form in human plasma
    • Kitamura K, et al. 1998. The intermediate form of glycine-extended adrenomedullin is the major circulating molecular form in human plasma. Biochem. Biophys. Res. Commun. 244:551-555.
    • (1998) Biochem. Biophys. Res. Commun. , vol.244 , pp. 551-555
    • Kitamura, K.1
  • 27
    • 0027181496 scopus 로고
    • Cloning and characterization of cDNA encoding a precursor for human adrenomedullin
    • Kitamura K, et al. 1993. Cloning and characterization of cDNA encoding a precursor for human adrenomedullin. Biochem. Biophys. Res. Commun. 194:720-725.
    • (1993) Biochem. Biophys. Res. Commun. , vol.194 , pp. 720-725
    • Kitamura, K.1
  • 28
    • 0029092767 scopus 로고
    • Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1
    • Kurihara Y, et al. 1995. Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1. J. Clin. Invest. 96:293-300.
    • (1995) J. Clin. Invest. , vol.96 , pp. 293-300
    • Kurihara, Y.1
  • 29
    • 0032502679 scopus 로고    scopus 로고
    • vitro cleavage of internally quenched fluorogenic human proparathyroid hormone and proparathyroid-related peptide substrates by furin Generation of a potent inhibitor
    • Lazure C, et al. 1998. In vitro cleavage of internally quenched fluorogenic human proparathyroid hormone and proparathyroid-related peptide substrates by furin. Generation of a potent inhibitor. J. Biol. Chem. 273: 8572-8580.
    • (1998) J. Biol. Chem. , vol.273 , pp. 8572-8580
    • Lazure, C.1
  • 30
    • 50449083525 scopus 로고    scopus 로고
    • Role of furin in granular acidification in the endocrine pancreas, identification of the V-ATPase subunit Ac45 as a candidate substrate
    • Louagie E, et al. 2008. Role of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate. Proc. Natl. Acad. Sci. U. S. A. 105:12319-12324.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 12319-12324
    • Louagie, E.1
  • 31
    • 0023890616 scopus 로고
    • Phenotypic modulation of endothelial cells by transforming growth factor-beta depends upon the composition and organization of the extracellular matrix
    • Madri JA, Pratt BM, Tucker AM. 1988. Phenotypic modulation of endothelial cells by transforming growth factor-beta depends upon the composition and organization of the extracellular matrix. J. Cell Biol. 106: 1375-1384.
    • (1988) J. Cell Biol. , vol.106 , pp. 1375-1384
    • Madri, J.A.1    Pratt, B.M.2    Tucker, A.M.3
  • 32
    • 80755153564 scopus 로고    scopus 로고
    • Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system, role of fibroblast autophagy
    • Marchesi C, et al. 2011. Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy. J. Mol. Med. 89:1103-1111.
    • (2011) J. Mol. Med. , vol.89 , pp. 1103-1111
    • Marchesi, C.1
  • 33
    • 0025222517 scopus 로고
    • The transforming growth factor-beta family
    • Massague J. 1990. The transforming growth factor-beta family. Annu. Rev. Cell Biol. 6:597-641.
    • (1990) Annu. Rev. Cell Biol. , vol.6 , pp. 597-641
    • Massague, J.1
  • 34
    • 33947670424 scopus 로고    scopus 로고
    • Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2
    • Mccoll BK, et al. 2007. Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2. FASEB J. 21:1088-1098.
    • (2007) FASEB J , vol.21 , pp. 1088-1098
    • Mccoll, B.K.1
  • 35
    • 0021137710 scopus 로고
    • Interstitial colloid osmotic and hydrostatic pressures in human subcutaneous tissue during early stages of heart failure
    • Noddeland H, Omvik P, Lund-Johansen P, Ofstad J, Aukland K. 1984. Interstitial colloid osmotic and hydrostatic pressures in human subcutaneous tissue during early stages of heart failure. Clin. Physiol. 4:283-297.
    • (1984) Clin. Physiol. , vol.4 , pp. 283-297
    • Noddeland, H.1    Omvik, P.2    Lund-Johansen, P.3    Ofstad, J.4    Aukland, K.5
  • 36
    • 51649112340 scopus 로고    scopus 로고
    • T- cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance
    • Pesu M, et al. 2008. T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance. Nature 455:246-250.
    • (2008) Nature , vol.455 , pp. 246-250
    • Pesu, M.1
  • 37
    • 51049092759 scopus 로고    scopus 로고
    • Substrate cleavage analysis of furin and related proprotein convertases A comparative study
    • Remacle AG, et al. 2008. Substrate cleavage analysis of furin and related proprotein convertases. A comparative study. J. Biol. Chem. 283:20897-20906.
    • (2008) J. Biol. Chem. , vol.283 , pp. 20897-20906
    • Remacle, A.G.1
  • 38
    • 19944414287 scopus 로고    scopus 로고
    • Limited redundancy of the proprotein convertase furin in mouse liver
    • Roebroek AJ, et al. 2004. Limited redundancy of the proprotein convertase furin in mouse liver. J. Biol. Chem. 279:53442-53450.
    • (2004) J. Biol. Chem. , vol.279 , pp. 53442-53450
    • Roebroek, A.J.1
  • 39
    • 0032443652 scopus 로고    scopus 로고
    • Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase furin
    • Roebroek AJ, et al. 1998. Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase furin. Development 125:4863-4876.
    • (1998) Development , vol.125 , pp. 4863-4876
    • Roebroek, A.J.1
  • 40
    • 0033452452 scopus 로고    scopus 로고
    • Proprotein and prohormone convertases, a family of subtilases generating diverse bioactive polypeptides
    • Seidah NG, Chretien M. 1999. Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides. Brain Res. 848:45-62.
    • (1999) Brain Res , vol.848 , pp. 45-62
    • Seidah, N.G.1    Chretien, M.2
  • 41
    • 33746216577 scopus 로고    scopus 로고
    • The proprotein convertases and their implication in sterol and/or lipid metabolism
    • Seidah NG, Khatib AM, Prat A. 2006. The proprotein convertases and their implication in sterol and/or lipid metabolism. Biol. Chem. 387:871-877.
    • (2006) Biol. Chem. , vol.387 , pp. 871-877
    • Seidah, N.G.1    Khatib, A.M.2    Prat, A.3
  • 42
    • 43049141452 scopus 로고    scopus 로고
    • The activation and physiological functions of the proprotein convertases
    • Seidah NG, et al. 2008. The activation and physiological functions of the proprotein convertases. Int. J. Biochem. Cell Biol. 40:1111-1125.
    • (2008) Int. J. Biochem. Cell Biol. , vol.40 , pp. 1111-1125
    • Seidah, N.G.1
  • 43
    • 0038394566 scopus 로고    scopus 로고
    • Precursor convertases in the secretory pathway, cytosol and extracellular milieu
    • Seidah NG, Prat A. 2002. Precursor convertases in the secretory pathway, cytosol and extracellular milieu. Essays Biochem. 38:79-94.
    • (2002) Essays Biochem , vol.38 , pp. 79-94
    • Seidah, N.G.1    Prat, A.2
  • 44
    • 0026799402 scopus 로고
    • Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease
    • Shull MM, et al. 1992. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 359:693-699.
    • (1992) Nature , vol.359 , pp. 693-699
    • Shull, M.M.1
  • 45
    • 0038481179 scopus 로고    scopus 로고
    • The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis
    • Siegfried G, et al. 2003. The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis. J. Clin. Invest. 111: 1723-1732.
    • (2003) J. Clin. Invest. , vol.111 , pp. 1723-1732
    • Siegfried, G.1
  • 46
    • 27144488288 scopus 로고    scopus 로고
    • Regulation of the stepwise proteolytic cleavage and secretion of PDGF-B by the proprotein convertases
    • Siegfried G, et al. 2005. Regulation of the stepwise proteolytic cleavage and secretion of PDGF-B by the proprotein convertases. Oncogene 24: 6925-6935.
    • (2005) Oncogene , vol.24 , pp. 6925-6935
    • Siegfried, G.1
  • 47
    • 0037379743 scopus 로고    scopus 로고
    • The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity
    • Siegfried G, Khatib AM, Benjannet S, Chretien M, Seidah NG. 2003. The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity. Cancer Res. 63:1458-1463.
    • (2003) Cancer Res , vol.63 , pp. 1458-1463
    • Siegfried, G.1    Khatib, A.M.2    Benjannet, S.3    Chretien, M.4    Seidah, N.G.5
  • 48
    • 0032915460 scopus 로고    scopus 로고
    • Early embryonic lethality in Bmp5; Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup
    • Solloway MJ, Robertson EJ. 1999. Early embryonic lethality in Bmp5; Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup. Development 126:1753-1768.
    • (1999) Development , vol.126 , pp. 1753-1768
    • Solloway, M.J.1    Robertson, E.J.2
  • 49
    • 0027965188 scopus 로고
    • Endothelial cells actively synthesize and secrete adrenomedullin
    • Sugo S, et al. 1994. Endothelial cells actively synthesize and secrete adrenomedullin. Biochem. Biophys. Res. Commun. 201:1160-1166.
    • (1994) Biochem. Biophys. Res. Commun. , vol.201 , pp. 1160-1166
    • Sugo, S.1
  • 50
    • 0028120332 scopus 로고
    • Production and secretion of adrenomedullin from vascular smooth muscle cells, augmented production by tumor necrosis factor-alpha
    • Sugo S, et al. 1994. Production and secretion of adrenomedullin from vascular smooth muscle cells: augmented production by tumor necrosis factor-alpha. Biochem. Biophys. Res. Commun. 203:719-726.
    • (1994) Biochem. Biophys. Res. Commun. , vol.203 , pp. 719-726
    • Sugo, S.1
  • 51
    • 44849135766 scopus 로고    scopus 로고
    • VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5
    • Szumska D, et al. 2008. VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5. Genes Dev. 22:1465-1477.
    • (2008) Genes Dev , vol.22 , pp. 1465-1477
    • Szumska, D.1
  • 52
    • 0036791359 scopus 로고    scopus 로고
    • Furin at the cutting edge, from protein traffic to embryogenesis and disease
    • Thomas G. 2002. Furin at the cutting edge: from protein traffic to embryogenesis and disease. Nat. Rev. Mol. Cell Biol. 3:753-766.
    • (2002) Nat. Rev. Mol. Cell Biol. , vol.3 , pp. 753-766
    • Thomas, G.1
  • 53
    • 0024555682 scopus 로고
    • Expression of transforming growth factorbeta 1 in specific cells and tissues of adult and neonatal mice
    • Thompson NL, et al. 1989. Expression of transforming growth factorbeta 1 in specific cells and tissues of adult and neonatal mice. J. Cell Biol. 108:661-669.
    • (1989) J. Cell Biol. , vol.108 , pp. 661-669
    • Thompson, N.L.1
  • 54
    • 0029149656 scopus 로고
    • Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse
    • Winnier G, Blessing M, Labosky PA, Hogan BL. 1995. Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev. 9:2105-2116.
    • (1995) Genes Dev , vol.9 , pp. 2105-2116
    • Winnier, G.1    Blessing, M.2    Labosky, P.A.3    Hogan, B.L.4
  • 55
    • 0037830773 scopus 로고    scopus 로고
    • Furin-mediated processing of Pro-C-type natriuretic peptide
    • Wu C, Wu F, Pan J, Morser J, Wu Q. 2003. Furin-mediated processing of Pro-C-type natriuretic peptide. J. Biol. Chem. 278:25847-25852.
    • (2003) J. Biol. Chem. , vol.278 , pp. 25847-25852
    • Wu, C.1    Wu, F.2    Pan, J.3    Morser, J.4    Wu, Q.5
  • 56
    • 0027992642 scopus 로고
    • ECE- 1, a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1
    • Xu D, et al. 1994. ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1. Cell 78:473-485.
    • (1994) Cell , vol.78 , pp. 473-485
    • Xu, D.1
  • 57
    • 0023859136 scopus 로고
    • A novel potent vasoconstrictor peptide produced by vascular endothelial cells
    • Yanagisawa M, et al. 1988. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332:411-415.
    • (1988) Nature , vol.332 , pp. 411-415
    • Yanagisawa, M.1
  • 58
    • 0028955748 scopus 로고
    • Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development
    • Yang JT, Rayburn H, Hynes RO. 1995. Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development. Development 121:549-560.
    • (1995) Development , vol.121 , pp. 549-560
    • Yang, J.T.1    Rayburn, H.2    Hynes, R.O.3
  • 59
    • 0035871471 scopus 로고    scopus 로고
    • Cooperation of endoderm-derived BMP2 and extraembryonic ectoderm-derived BMP4 in primordial germ cell generation in the mouse
    • Ying Y, Zhao GQ. 2001. Cooperation of endoderm-derived BMP2 and extraembryonic ectoderm-derived BMP4 in primordial germ cell generation in the mouse. Dev. Biol. 232:484-492.
    • (2001) Dev. Biol. , vol.232 , pp. 484-492
    • Ying, Y.1    Zhao, G.Q.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.